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Music Therapy in Newly Diagnosed Glioblastoma After Chemoradiation Therapy (MELODY-GBM) J2556

NCT ID: NCT07375992Sponsor: Sidney Kimmel Comprehensive Cancer Center at Johns HopkinsLast updated: 2026-06-18

Summary

The Brain Cancer Program, in partnership with the Center for Music and Medicine at Johns Hopkins, will study whether music therapy is feasible in newly diagnosed GBM patients undergoing standard care.

Detailed description

Virtually via Zoom, all participants will meet with Music Therapists to create playlists and learn how to complete surveys measuring quality of life. Participants will be randomly assigned, half to each arm. Arm A will interact with Music Therapists and listen to music twice a week, then independently fill out quality of life questionnaires. Arm B will listen to music independently twice a week, then independently fill out quality of life questionnaires.

Arms & interventions

  • OtherMusic intervention

    Each GBM study participant in Arm A will receive two 30-minute live synchronous virtual music therapy sessions per week for a period of 8 weeks to be curated by a board-certified music therapist. Arm B participants will receive curated playlists of music created by a music therapist. Participants will then listen to the curated music playlists on the participant's own device twice per week. All participants will complete a total of 16 music therapy sessions, scheduled twice per week over 8 weeks. Each session will last approximately 30 minutes.

Outcome measures

Primary

  • Success rate of Music Therapy intervention for GBM patients

    Determine success rate of the delivery of individualized virtual music therapy (MT) in participants undergoing standard of care treatment for newly diagnosed glioblastoma.

    Time frame: 6 months

Secondary

  • Rate of survey completion

    Time frame: 2 years

Eligibility criteria

Sex: AllAge: 18 Years and olderHealthy volunteers: No
Inclusion Criteria: * Glioblastoma (Newly Diagnosed) * Cognitive capacity to respond to surveys * Access to computer and web access * Ability to attend virtual music therapy sessions * Audibly process music * Proficient in English Exclusion Criteria: * Not planning to undergo standard of care radiation therapy and concurrent and adjuvant temozolomide. * A life expectancy of less than 6 months. * Concurrent use of any other standard or investigational agents (excepting tumor treating fields). * Uncontrolled intercurrent illness including, but not limited to, ongoing or active infection or psychiatric illness/social situations that would limit adherence with study requirements.

Study locations (1)

Oncology- Broadway

Baltimore, Maryland, 21287

Recruiting
Matthias Holdhoff, MD. PhD. · Contact
410-955-8837bcp-iis@jh.edu
Music Therapy in Newly Diagnosed Glioblastoma After Chemoradiation Therapy (MELODY-GBM) | Cancerify