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RecruitingInterventionalPhase 2

Solid Tumor Study for Long Term Treatment of Cancer Patients Who Have Participated in BMS Parent Studies Investigating Adagrasib (BMS-986503)

NCT ID: NCT07415031Sponsor: Mirati Therapeutics Inc.Last updated: 2026-05-15

Summary

This is an open-label, solid tumor, continuation, rollover trial which enrolls participants from ongoing BMS parent studies that evaluated adagrasib (MRTX849, BMS-986503) either as monotherapy or in combination with other cancer therapies in patients with non-small cell lung cancer (NSCLC), colorectal cancer (CRC) and other advanced solid tumors.

Arms & interventions

  • DrugAdagrasib

    Specified dose on specified days

  • DrugPembrolizumab

    Specified dose on specified days

  • DrugCetuximab

    Specified dose on specified days

  • DrugPemetrexed

    Specified dose on specified days

  • DrugDocetaxel

    Specified dose on specified days

  • DrugIrinotecan

    Specified dose on specified days

  • DrugLeucovorin

    Specified dose on specified days

  • DrugOxaliplatin

    Specified dose on specified days

  • DrugFluorouracil

    Specified dose on specified days

Outcome measures

Primary

  • Number of Participants With Adverse Events (AEs)

    Time frame: Up to 90 days from last dose or study discontinuation

  • Number of Participants With AEs Leading to Treatment Discontinuation

    Time frame: Up to 90 days from last dose or study discontinuation

  • Number of Participants With Serious Adverse Events (SAEs)

    Time frame: Up to 90 days from last dose or study discontinuation

  • Number of Participants With AEs Leading to Death

    Time frame: Up to 90 days from last dose or study discontinuation

Eligibility criteria

Sex: AllAge: 18 Years and olderHealthy volunteers: No
Inclusion Criteria: * Participant is eligible to receive continued study treatment as per the parent study, and/or investigator assessed clinical benefit. * Individuals with assigned female sex at birth (AFSB) must have documented proof that they are not of childbearing potential. IOCBP participants who are sexually active must agree to follow the instructions for method(s) of contraception and included in the ICF. Exclusion Criteria: * Participant is not eligible for study treatment per the parent study eligibility criteria. * Participants who have completed treatment with the study drugs, progressed on prior study treatment, or discontinued study treatment due to toxicity in the parent study are not eligible to receive study drug in this study. * Participants not receiving clinical benefit from parent study drug as assessed by the investigator. Other protocol defined inclusion/exclusion criteria applies.

Study locations (17)

Local Institution - 0005

Phoenix, Arizona, 85054

Withdrawn

Local Institution - 0016

Bellflower, California, 90706

Not Yet Recruiting
Site 0016 · Contact

Local Institution - 0082

Long Beach, California, 90806

Not Yet Recruiting
Site 0082 · Contact

Local Institution - 0003

Newark, Delaware, 19713

Withdrawn

Local Institution - 0001

St. Petersburg, Florida, 33701

Not Yet Recruiting
Site 0001 · Contact

Local Institution - 0064

Chicago, Illinois, 60637

Not Yet Recruiting
Site 0064 · Contact

Local Institution - 0112

Wichita, Kansas, 67208

Not Yet Recruiting
Site 0112 · Contact

Local Institution - 0092

Boston, Massachusetts, 00215

Not Yet Recruiting
Site 0092 · Contact

Local Institution - 0080

Boston, Massachusetts, 02215

Not Yet Recruiting
Site 0080 · Contact

Mayo Clinic in Rochester, Minnesota

Rochester, Minnesota, 55905

Recruiting
Konstantinos Leventakos, Site 0017 · Contact

Local Institution - 0073

Saint Paul, Minnesota, 55101

Not Yet Recruiting
Site 0073 · Contact

Local Institution - 0036

Omaha, Nebraska, 68114

Not Yet Recruiting
Site 0036 · Contact

Local Institution - 0116

New York, New York, 10065 6800

Not Yet Recruiting
Site 0116 · Contact

Local Institution - 0004

Eugene, Oregon, 97401

Not Yet Recruiting
Site 0004 · Contact

Local Institution - 0023

Germantown, Tennessee, 38138

Not Yet Recruiting
Site 0023 · Contact

Local Institution - 0002

Grapevine, Texas, 76051

Not Yet Recruiting
Site 0002 · Contact

Local Institution - 0013

Bellingham, Washington, 98225

Not Yet Recruiting
Site 0013 · Contact