Solid Tumor Study for Long Term Treatment of Cancer Patients Who Have Participated in BMS Parent Studies Investigating Adagrasib (BMS-986503)
Summary
This is an open-label, solid tumor, continuation, rollover trial which enrolls participants from ongoing BMS parent studies that evaluated adagrasib (MRTX849, BMS-986503) either as monotherapy or in combination with other cancer therapies in patients with non-small cell lung cancer (NSCLC), colorectal cancer (CRC) and other advanced solid tumors.
Arms & interventions
- DrugAdagrasib
Specified dose on specified days
- DrugPembrolizumab
Specified dose on specified days
- DrugCetuximab
Specified dose on specified days
- DrugPemetrexed
Specified dose on specified days
- DrugDocetaxel
Specified dose on specified days
- DrugIrinotecan
Specified dose on specified days
- DrugLeucovorin
Specified dose on specified days
- DrugOxaliplatin
Specified dose on specified days
- DrugFluorouracil
Specified dose on specified days
Outcome measures
Primary
Number of Participants With Adverse Events (AEs)
Time frame: Up to 90 days from last dose or study discontinuation
Number of Participants With AEs Leading to Treatment Discontinuation
Time frame: Up to 90 days from last dose or study discontinuation
Number of Participants With Serious Adverse Events (SAEs)
Time frame: Up to 90 days from last dose or study discontinuation
Number of Participants With AEs Leading to Death
Time frame: Up to 90 days from last dose or study discontinuation
Eligibility criteria
Study locations (17)
Local Institution - 0005
Phoenix, Arizona, 85054
Local Institution - 0016
Bellflower, California, 90706
Local Institution - 0082
Long Beach, California, 90806
Local Institution - 0003
Newark, Delaware, 19713
Local Institution - 0001
St. Petersburg, Florida, 33701
Local Institution - 0064
Chicago, Illinois, 60637
Local Institution - 0112
Wichita, Kansas, 67208
Local Institution - 0092
Boston, Massachusetts, 00215
Local Institution - 0080
Boston, Massachusetts, 02215
Mayo Clinic in Rochester, Minnesota
Rochester, Minnesota, 55905
Local Institution - 0073
Saint Paul, Minnesota, 55101
Local Institution - 0036
Omaha, Nebraska, 68114
Local Institution - 0116
New York, New York, 10065 6800
Local Institution - 0004
Eugene, Oregon, 97401
Local Institution - 0023
Germantown, Tennessee, 38138
Local Institution - 0002
Grapevine, Texas, 76051
Local Institution - 0013
Bellingham, Washington, 98225