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A Community-Engaged Approach to Culturally Adapting an Intervention to Increase Uptake of Genetic Testing Among African American Cancer Survivors

NCT ID: NCT07436078Sponsor: Barbara Ann Karmanos Cancer InstituteLast updated: 2026-02-27

Summary

The goal of this clinical trial is to culturally adapt an educational genetic counseling intervention to increase the uptake in genetic counseling and testing among African Americans at risk for heredity cancers. With the help of community stakeholders and clinical genetic professionals the investigators will: * adapt and refine a culturally relevant online educational genetic counseling program for at-risk African Americans * Test the effects of the educational program * collaborate with community leaders and clinical genetic professionals to translate study findings, develop a road map for dissemination to the community, and identify barriers to prepare for future trials. Participants from Detroit Research on Cancer Survivor group will be offered enrollment. Once consent is obtained, questionnaires will be completed before an online genetic counselling intervention immediately after, and at 3 months

Arms & interventions

  • BehavioralCulturally adapted Online Genetic Counseling and Testing Information

    Testing the effects of the educational intervention designed to increase the uptake of genetic counseling testing among at-risk African American survivors

Outcome measures

Primary

  • Uptake of genetic counseling and genetic testing

    One item question will ask whether participants have participated in genetic counseling and genetic testing (Yes or No)

    Time frame: 3 month follow Up

Secondary

  • Intention to undergo genetic counseling and testing

    Time frame: 1 day Pre Intervention to 1 day Post Intervention

  • Sharing Your Results

    Time frame: 3 month follow up

  • Major Experiences of Discrimination

    Time frame: 1 day prior to intervention

  • Everyday Experiences of Discrimination

    Time frame: 1 day prior to intervention

  • Interpersonal Processes of Care Survey

    Time frame: 1 day prior to intervention

  • Group-Based Medical Mistrust Scale

    Time frame: 1 day prior to intervention

  • Perceived Access to Health Care Services

    Time frame: 1 day prior to intervention

  • Perceived risk of carrying genetic mutation

    Time frame: 1 day Pre Intervention to 1 day Post Intervention

  • Attitudes about genetic counseling and testing

    Time frame: 1 day Pre Intervention to 1 day Post Intervention

  • Behavioral beliefs about genetic counseling

    Time frame: 1 day Pre Intervention to 1 day Post Intervention

  • Perceived norms

    Time frame: 1 day Pre Intervention to 1 day Post Intervention

  • Knowledge of Genetic Counseling

    Time frame: 1 day Pre Intervention to 1 day Post Intervention

  • Perceived self-Efficacy

    Time frame: 1 day Pre Intervention to 1 day Post Intervention

  • Multidimensional Impact of Cancer Risk Assessment

    Time frame: 3 month Follow Up

  • Cancer Family Impact

    Time frame: 3 Month Follow Up

Eligibility criteria

Sex: AllAge: 20 Years to 79 YearsHealthy volunteers: No
Inclusion Criteria: * Participants enrolled in Detroit Research on Cancer Survivors (Detroit ROCS) * Diagnosis of Primary Breast, prostate, or colorectal cancer on or after 1/1/2013 * have received or currently receiving care at Karmanos Cancer Institute * meet one or more of the National Comprehensive Cancer Network (NCCN) guidelines for cancer genetic testing as described below Female breast 1. personal diagnosis at age ≤50 2. personal history of the triple-negative subtype 3. at least 1 close (first- or second-degree) relative diagnosed with breast cancer at age \<50 4. at least 1 close relative diagnosed with ovarian cancer 5. 2+ close relatives diagnosed with breast or prostate cancer 6. age \<50 AND another primary breast cancer at any age 7. 2+ primary breast cancers at any age OR Prostate 1. personal history of high-risk or very high-risk prostate cancer 2. personal history of regional or metastatic prostate cancer 3. personal history of less than high-risk prostate cancer with a suggestive family history (i.e., father or brother or multiple relatives with prostate cancer diagnosed at age \<60; at least 1 relative with breast, ovarian, or pancreatic cancer; or at least 1 relative with colorectal, ovarian, pancreatic, or kidney cancer) OR Colorectal 1. personal diagnosis at age ≤50 2. at least 1 close relative diagnosed with HNPCC at age \<50 3. at least 2 close relatives diagnosed with an HNPCC cancer at any age 4. colorectal and \>=1 primary endometrial, ovarian, gastric, pancreatic, or prostate Exclusion Criteria: * Previous genetic counseling and/or testing

Study locations (1)

Karmanos Cancer Institute

Detroit, Michigan, 48201

Recruiting
Jasminder Phalore, MPH · Contact
Hayley Thompson, Ph.D · Sub Investigator
Felicity WK Harper, Ph.D · Principal Investigator