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RecruitingObservational

Vanquish® Water Vapor Ablation for PrOstate CanceR: Long-Term Registry

NCT ID: NCT07455058Sponsor: Francis Medical Inc.Last updated: 2026-06-12

Summary

The purpose of the registry is to evaluate real-world safety, efficacy, and patient reported outcomes among participants receiving Vanquish Water Vapor Ablation System therapy (Vanquish Therapy). This includes longitudinal assessment of patients who have received or will receive the therapy one or multiple times as part of routine clinical care and encompasses those who completed a company-sponsored Vanquish therapy study (as applicable).

Arms & interventions

  • DeviceVanquish Therapy

    The Francis Medical, Inc. Vanquish Water Vapor Ablation Device ("Vanquish" or "Vanquish System") is a transurethral thermal water vapor ablation device. The Vanquish System is designed ablate prostate tissue, while minimizing side effects.

Outcome measures

Primary

  • Primary Efficacy Outcome

    Freedom from disease specific mortality.

    Time frame: Through study completion, or up to 15 years.

  • Primary Safety Outcome

    Rate of complications classified as Clavien-Dindo grades III-V and attributable to the Vanquish procedure and/or device over time. * Grade III: Complications requiring surgical intervention (IIIa: laparoscopic, IIIb: open). * Grade IV: Life-threatening complications (IVa: single organ failure, IVb: multi-organ failure). * Grade V: Death of a patient.

    Time frame: Through study completion, or up to 15 years

Eligibility criteria

Sex: MaleAge: All agesHealthy volunteers: No
Inclusion Criteria: * Candidate for Vanquish therapy per physician discretion or participant has completed a company-sponsored Vanquish therapy study. * Participant is willing and able to provide written informed consent. Exclusion Criteria: * Contraindications per the Vanquish IFU * Previously participated in VAPOR 2 study and is not planning to receive further Vanquish therapy.

Study locations (2)

The Urology Place, Inc.

San Antonio, Texas, 78240

Recruiting
Naveen Kella, MD · Contact
Naveen Kella, MD · Principal Investigator
Savannah Eggerss, PA · Sub Investigator

Urology of Virginia

Virginia Beach, Virginia, 23462

Recruiting
Robert Given, MD · Contact
Robert Given, MD · Principal Investigator