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Boosting Treatment for Head and Neck Cancer After Surgery

About This Trial

This trial studies how well radiation therapy works with or without a drug called cisplatin for patients who have stage III-IVA squamous cell carcinoma of the head and neck. The goal is to find out which approach helps patients more after they have had surgery. Radiation therapy uses high-energy rays to kill cancer cells, while cisplatin is a chemotherapy drug that helps stop the growth of these cells in different ways. Researchers want to see if combining these treatments is better than radiation alone.

NCT ID

NCT02734537

Study Details

RecruitingInterventionalPhase 2

Conditions

Head and Neck Squamous Cell CarcinomaHypopharyngeal Squamous Cell CarcinomaLaryngeal Squamous Cell CarcinomaLaryngeal Squamous Cell Carcinoma, Spindle Cell VariantLip and Oral Cavity Squamous Cell Carcinomap16INK4a Negative Oropharyngeal Squamous Cell CarcinomaStage III Hypopharyngeal Carcinoma AJCC v8Stage III Laryngeal Cancer AJCC v8Stage III Lip and Oral Cavity Cancer AJCC v8Stage III Oral Cavity Verrucous CarcinomaStage III Oropharyngeal (p16-Negative) Carcinoma AJCC v8Stage IVA Hypopharyngeal Carcinoma AJCC v8Stage IVA Laryngeal Cancer AJCC v8Stage IVA Lip and Oral Cavity Cancer AJCC v8Stage IVA Oral Cavity Verrucous CarcinomaStage IVA Oropharyngeal (p16-Negative) Carcinoma AJCC v8

Eligibility

All sexesAdultOlder adult

Locations

AlabamaAlaskaArizonaArkansasCaliforniaColoradoConnecticutDelawareDistrict of ColumbiaFloridaGeorgiaHawaiiIdahoIllinoisIndianaIowaKansasKentuckyLouisianaMarylandMassachusettsMichiganMinnesotaMississippiMissouriMontanaNebraskaNew JerseyNew MexicoNew YorkNorth CarolinaNorth DakotaOhioOklahomaOregonPennsylvaniaRhode IslandSouth CarolinaSouth DakotaTennesseeTexasUtahVirginiaWashingtonWest VirginiaWisconsinWyoming