Boosting Treatment Options for Chronic Lymphocytic Leukemia with Two Medicines
NCT05254743 · RecruitingAbout this trial
This study compares two medicines, pirtobrutinib and ibrutinib, for treating chronic lymphocytic leukemia (CLL) and small lymphocytic lymphoma (SLL). In the first part, it looks at how well these treatments work and their safety for patients who may have had previous treatments or not. The second part focuses on patients who have not yet been treated and have a specific genetic change. Participants could be involved for up to six years in Part 1 and two years in Part 2.
Locations and contact
This trial is running at 143 locations in 23 countries. 91 of them are currently recruiting.
United States19 locations · 12 recruiting
- American Oncology Partners of Maryland, PABethesda, MarylandRecruiting
- Cancer Specialists of North Florida -St AugustineSaint Augustine, FloridaRecruiting
- Florida Cancer SpecialistsFort Myers, FloridaRecruiting
- Florida Cancer Specialists EastWest Palm Beach, FloridaRecruiting
- Lumi ResearchKingwood, TexasRecruiting
- Medical Oncology Associates, PSSpokane, WashingtonRecruiting
- Pacific Cancer Medical Center, IncAnaheim, CaliforniaRecruiting
- Sarah Cannon Research Institute SCRINashville, TennesseeRecruiting
- St. Vincent Frontier Cancer CenterBillings, MontanaRecruiting
- Stanford School of Medicine-Cancer Clinical Trials OfficePalo Alto, CaliforniaRecruiting
- TOI Clinical ResearchCerritos, CaliforniaRecruiting
- Virginia Cancer InstituteRichmond, VirginiaRecruiting
- California Cancer Associates for Research and ExcellenceSan Marcos, CaliforniaActive Not Recruiting
- Cancer Care Associates of YorkYork, PennsylvaniaActive Not Recruiting
- Hematology Oncology ClinicBaton Rouge, LouisianaActive Not Recruiting
- Kelsey Research FoundationHouston, TexasActive Not Recruiting
- MultiCare Health System Institute for Research and InnovationSpokane, WashingtonActive Not Recruiting
- Prisma Health Cancer InstituteGreenville, South CarolinaActive Not Recruiting
- Tulane Cancer Center Office of Clinical ResearchNew Orleans, LouisianaActive Not Recruiting
Brazil14 locations · 13 recruiting
- Centro Gaucho Integrado - Mae de Deus CenterPorto AlegreRecruiting
- Centro Integrado de Pesquisa ClinicaSão José do Rio PretoRecruiting
- CEPHO - Centro de Estudos e Pesquisas de Hematologia e OncologiaSanto AndréRecruiting
- Fundação Pio XII - Hospital de Câncer de BarretosBarretosRecruiting
- Hemocentro UnicampCampinasRecruiting
- Hospital BPSão PauloRecruiting
- Hospital da Clinicas da Faculdade de Medicina da USPSão PauloRecruiting
- Hospital de Clínicas de Ribeirão PretoRibeirão PretoRecruiting
- Hospital Erasto Gaertner - Liga Paranaense de Combate ao CâncerCuritibaRecruiting
- Hospital Santa MarcelinaSão PauloRecruiting
- Hospital Uopeccan - Centro de Pesquisa ClinicaCascavelRecruiting
- Instituto do Câncer - Hospital São Vicente de PauloPasso FundoRecruiting
- Upeclin - Unidade de Pesquisa Clínica da Faculdade de Medicina de Botucatu - UNESPBotucatuRecruiting
- Centro Integrado de Oncologia de CuritibaCuritibaActive Not Recruiting
Spain13 locations · 10 recruiting
- Clinica Universitaria De NavarraPamplonaRecruiting
- Hospital Costa Del SolMarbellaRecruiting
- Hospital de la Santa Creu i Sant PauBarcelonaRecruiting
- Hospital De NavarraPamplonaRecruiting
- Hospital Universitari Vall d'HebronBarcelonaRecruiting
- Hospital Universitario Infanta Leonor-INTERNAL MEDMadridRecruiting
- Hospital Universitario Marqués de ValdecillaSantanderRecruiting
- Hospital Universitario Puerta de Hierro MajadahondaMajadahondaRecruiting
- Hospital Universitario Ramón y CajalMadridRecruiting
- Hospital Universitario Virgen MacarenaSevilleRecruiting
- Hospital Clinic de BarcelonaBarcelonaActive Not Recruiting
- Hospital Duran i ReynalsL'Hospitalet de LlobregatActive Not Recruiting
- Hospital Universitario Virgen Del RocioSevilleActive Not Recruiting
France10 locations · 10 recruiting
- Centre Antoine LacassagneNiceRecruiting
- Centre de Lutte Contre le Cancer - Centre Henri Becquerel Normandie RouenRouenRecruiting
- Centre Hospitalier du MansLe MansRecruiting
- Centre Hospitalier Lyon SudPierre-BéniteRecruiting
- Centre Hospitalier Universitaire (Limoges) (CHU DUPUYTREN 1)LimogesRecruiting
- CHD VendeeLa Roche-sur-YonRecruiting
- CHRU De ToursToursRecruiting
- CHU de Nantes - Hotel DieuNantesRecruiting
- Hopital de la Pitie SalpetriereParisRecruiting
- Hôpital de PontchaillouRennesRecruiting
China18 locations · 7 recruiting
- Anhui Provincial HospitalHefeiRecruiting
- First Affiliated Hosp of College of Med, Zhejiang UniversityHangzhouRecruiting
- Fudan University Shanghai Cancer CenterShanghaiRecruiting
- Guangxi Medical University Affiliated Tumor HospitalNanningRecruiting
- Southern Medical University Nanfang HospitalGuangzhouRecruiting
- Sun Yat-sen University Cancer CenterGuangzhouRecruiting
- The Second Hospital of Anhui Medical UniversityHefeiRecruiting
- Affiliated Cancer Hospital of Xinjiang Medical UniversityÜrümqiActive Not Recruiting
- Blood Institute of the Chinese Academy of Medical scienceTianjinActive Not Recruiting
- Hainan General HospitalHaikouActive Not Recruiting
- Hunan Cancer HospitalChangshaActive Not Recruiting
- Jiangxi Provincial Cancer HospitalNanchangActive Not Recruiting
- The Fourth Affiliated Hospital Zhejiang University School of MedicineYiwuActive Not Recruiting
- The Second Affiliated Hospital of Zhejiang University School of MedicineHangzhouActive Not Recruiting
- The Second Xiangya Hospital of Central South UniversityChangshaActive Not Recruiting
- Tianjin Medical University General HospitalTianjinActive Not Recruiting
- Union Hospital Tongji Medical College Huazhong University of Science and TechnologyWuhanActive Not Recruiting
- Wu Han Tongji HospitalWuhanActive Not Recruiting
Poland8 locations · 6 recruiting
- AIDPORT Sp. z o.o.SkórzewoRecruiting
- Pratia MCM KrakowKrakowRecruiting
- Pratia Onkologia KatowiceKatowiceRecruiting
- Szpital Uniwersytecki nr 1 im. Antoniego JuraszaBydgoszczRecruiting
- Uniwersytecki Szpital Kliniczny KlinikaWroclawRecruiting
- Uniwersyteckie Centrum KliniczneGdanskRecruiting
- Klinika Hematoonkologii i Transplantacji Szpiku,Samodzielny Publiczny Szpital Kliniczny Nr 1LublinActive Not Recruiting
- KO-MED Centra KliniczneBiała PodlaskaActive Not Recruiting
Czechia6 locations · 6 recruiting
- Fakultni nemocnice BrnoBrnoRecruiting
- Fakultni nemocnice Hradec KraloveHradec KrálovéRecruiting
- Fakultni nemocnice Kralovske VinohradyPragueRecruiting
- Fakultni Nemocnice OstravaOstravaRecruiting
- Fakultni Nemocnice PlzenPilsenRecruiting
- Vseobecna fakultni nemocnice v PrazePragueRecruiting
Italy6 locations · 4 recruiting
- Azienda Ospedaliera Nazionale Santi Antonio e Biagio e Cesare ArrigoAlessandriaRecruiting
- IRCCS Ospedale San RaffaeleMilanRecruiting
- Istituto Europeo di OncologiaMilanRecruiting
- Istituto Scientifico Romagnolo per lo Studio e la Cura dei TumoriMeldolaRecruiting
- Azienda Unita Sanitaria Locale di Reggio EmiliaReggio EmiliaActive Not Recruiting
- Policlinico Sant'Orsola MalpighiBolognaActive Not Recruiting
South Korea4 locations · 3 recruiting
- Inje Univ Busan Paik HospitalBusanRecruiting
- Seoul National University HospitalSeoulRecruiting
- The Catholic University of Korea-Seoul St. Mary's HospitalSeocho-GuRecruiting
- Samsung Medical CenterSeoulActive Not Recruiting
Taiwan4 locations · 3 recruiting
- Chang Bing Show Chwan Memorial HospitalChanghuaRecruiting
- Chang Gung Memorial Hospital - ChiayiChiayi CountyRecruiting
- Koo Foundation Sun Yan-Sen Cancer CenterTaipeiRecruiting
- National Cheng-Kung Uni. Hosp.TainanActive Not Recruiting
Turkey (Türkiye)7 locations · 2 recruiting
- Ankara University Medicine HospitalMamakRecruiting
- Istanbul University Istanbul Medicine FacultyFaithRecruiting
- 9 Eylul University HospitalBalçovaActive Not Recruiting
- Acıbadem Maslak HastanesiIstanbulCompleted
- American HospitalIstanbulActive Not Recruiting
- Ege ÜniversitesiBornovaActive Not Recruiting
- Gazi University Faculty of MedicineAnkaraActive Not Recruiting
New Zealand4 locations · 2 recruiting
- Middlemore Clinical TrialsPapatoetoeRecruiting
- Momentum Clinical ResearchNewtownRecruiting
- Dunedin HospitalDunedinActive Not Recruiting
- Waikato HospitalHamiltonActive Not Recruiting
United Kingdom4 locations · 2 recruiting
- Bristol Haematology and Oncology CentreBristolRecruiting
- Singleton HospitalSwanseaRecruiting
- HOPE CentreLeicesterActive Not Recruiting
- St Bartholomew's HospitalLondonActive Not Recruiting
Argentina3 locations · 2 recruiting
- Alexander FlemingCiudad Autónoma de Buenos AireRecruiting
- Clínica de Nefrología, Urología y Enfermedades CardiovascularesSanta FeRecruiting
- Hospital Privado De ComunidadMar del PlataActive Not Recruiting
Belgium2 locations · 2 recruiting
- Universitaire Ziekenhuizen Leuven - Campus GasthuisbergLeuvenRecruiting
- VITAZSint-NiklaasRecruiting
Chile4 locations · 1 recruiting
- Sociedad de Investigaciones Médicas LimitadaTemucoRecruiting
- CeCim BiocineticSantiagoActive Not Recruiting
- Centro de Investigaciones Clínicas Viña del Mar (CIC)Viña del MarActive Not Recruiting
- InmunocelSantiagoActive Not Recruiting
Germany4 locations · 1 recruiting
- Onkologische Gemeinschaftspraxis / BAGDresdenRecruiting
- Gemeinschaftspraxis für Hämatologie und Onkologie (Gefos)DortmundActive Not Recruiting
- Universitaetsklinikum Carl Gustav Carus an der TU Dresden, Medizinische Klinik und Poliklinik 1DresdenActive Not Recruiting
- Universitätsklinikum UlmUlmActive Not Recruiting
Australia3 locations · 1 recruiting
- The Perth Blood InstituteWest PerthRecruiting
- One Clinical ResearchNedlandsActive Not Recruiting
- Western Health, Sunshine HospitalSt AlbansActive Not Recruiting
Canada3 locations · 1 recruiting
- Hopital de L'Enfant JesusQuébecRecruiting
- Cancer Care ManitobaWinnipegActive Not Recruiting
- Royal Victoria Hospital-MontrealMontrealTerminated
Hungary2 locations · 1 recruiting
- Debreceni Egyetem Orvos-es Egészsegtudomanyi CentrumDebrecenRecruiting
- Markusovszky Egyetemi OktatokorhazSzombathelyActive Not Recruiting
Israel2 locations · 1 recruiting
- Hadassah Medical CenterJerusalemRecruiting
- Tel Aviv Sourasky Medical CenterTel AvivActive Not Recruiting
Japan2 locations · 1 recruiting
- Yamagata University HospitalYamagataRecruiting
- Kumamoto University HospitalKumamotoActive Not Recruiting
Austria1 location
- Hanusch KrankenhausViennaActive Not Recruiting
Who to ask about joining
Trial questions or participation questions: 1-877-CTLILLY (1-877-285-4559) or1-317-615-4559LillyTrials@Lilly.com
Physicians interested in becoming principal investigators please contactclinical_inquiry_hub@lilly.com
Who can join
Adults aged 18 and older can join this trial. It is open to anyone with a confirmed diagnosis of CLL or SLL who needs treatment. Some health conditions may prevent participation. The trial team will check to confirm who can join.
What happens during the trial
Participants will be randomly assigned to one of three groups. One group will take pirtobrutinib, another group will take ibrutinib, and the last group will also receive pirtobrutinib. All medicines will be taken by mouth. Everyone will be closely monitored to see how well the treatments work.
The trial team
The trial is sponsored by Loxo Oncology, Inc. Eli Lilly and Company is involved as a study director.
Important dates
This trial started on July 22, 2022, and is currently recruiting new participants. It is expected to finish by January 2028.
Additional information
The trial ID is NCT05254743. It is a Phase 3 trial, which means it is looking at how well the treatments work and their safety. It is regulated by the FDA and hopes to include about 737 participants.
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