This study looks at a new medicine called BMS-986340. It aims to see how safe it is and how well it works alone or with other treatments like nivolumab or docetaxel. The study includes participants with different types of advanced solid tumors, like lung cancer and melanoma. This is a first-in-human study, which means it's one of the first times this treatment is being tested in people.
The trial's ID number is NCT04895709. It is a Phase 1/2 trial, which means it is looking at both safety and effectiveness. The study is regulated by the FDA, and about 1,109 people are expected to join.
Who can join
Adults aged 18 and older can join. Both men and women are welcome. Participants need to have measurable disease and a tumor sample for testing. Some people, like those with certain other cancers or health issues, may not be able to join. The trial team will confirm who is eligible.
Conditions
Cervical Cancer, Gastric/Gastroesophageal Junction Adenocarcinoma, Microsatellite Stable Colorectal Cancer, Non-Small-Cell Lung Cancer, Squamous Cell Carcinoma of Head and Neck, Carcinoma, Renal Cell, Urothelial Carcinoma, Pancreatic Adenocarcinoma, Melanoma, Ovarian Neoplasms, Triple Negative Breast Neoplasms
Age group
Adult, Older adult
Sex
All sexes
The study team makes the final call on eligibility.
What happens in the study
Everyone who joins will receive treatment. Participants will be placed into different groups by chance. Some will receive BMS-986340 on its own, while others will get it with nivolumab, docetaxel, or Pumitamig. The study will look at different doses in these groups to find the best ones.
Where
This trial is running at 11 locations in the United States. 8 of them are currently recruiting.
Community Cancer Institute
Clovis, California
Recruiting
Hoag Memorial Hospital Presbyterian
Newport Beach, California
Recruiting
Houston Methodist Hospital
Houston, Texas
Recruiting
John Theurer Cancer Center
Hackensack, New Jersey
Recruiting
Providence Cancer Center Oncology and Hematology Care- Eastside
Portland, Oregon
Recruiting
University of Iowa
Iowa City, Iowa
Recruiting
USC/Norris Comprehensive Cancer Center
Los Angeles, California
Recruiting
Vanderbilt University Medical Center
Nashville, Tennessee
Recruiting
The first 8 of 11 sites are listed here. The registry record has the full list.
Study contact
BMS Clinical Trials Contact Center www.BMSClinicalTrials.com