Bringing New Hope with Combined Treatments for Advanced Brain Cancer
NCT07215910 · RecruitingThis trial is looking at how adding a drug called vorasidenib to the usual treatment of temozolomide can help patients with newly diagnosed grade 3 astrocytoma. The goal is to see if this combination works better than temozolomide alone after radiation therapy. Temozolomide is a medicine that can damage cancer cells and slow their growth. Vorasidenib targets specific changes in cancer cells to help stop their growth.
Locations and contact
This trial is running at 82 locations in the United States. All of them are currently recruiting.
United States82 locations · 82 recruiting
- Allegheny General HospitalPittsburgh, PennsylvaniaRecruiting
- Broadlawns Medical CenterDes Moines, IowaRecruiting
- Children's Hospital New OrleansNew Orleans, LouisianaRecruiting
- Christiana Care Health System-Concord Health CenterChadds Ford, PennsylvaniaRecruiting
- City of Hope Comprehensive Cancer CenterDuarte, CaliforniaRecruiting
- Drexel Town Square Health CenterOak Creek, WisconsinRecruiting
- East Jefferson General HospitalMetairie, LouisianaRecruiting
- Forbes HospitalMonroeville, PennsylvaniaRecruiting
- Froedtert and MCW Moorland Reserve Health CenterNew Berlin, WisconsinRecruiting
- Froedtert Menomonee Falls HospitalMenomonee Falls, WisconsinRecruiting
- Froedtert West Bend Hospital/Kraemer Cancer CenterWest Bend, WisconsinRecruiting
- Helen F Graham Cancer CenterNewark, DelawareRecruiting
- Illinois CancerCare - WashingtonWashington, IllinoisRecruiting
- Illinois CancerCare-BloomingtonBloomington, IllinoisRecruiting
- Illinois CancerCare-CantonCanton, IllinoisRecruiting
- Illinois CancerCare-CarthageCarthage, IllinoisRecruiting
- Illinois CancerCare-EurekaEureka, IllinoisRecruiting
- Illinois CancerCare-GalesburgGalesburg, IllinoisRecruiting
- Illinois CancerCare-Kewanee ClinicKewanee, IllinoisRecruiting
- Illinois CancerCare-MacombMacomb, IllinoisRecruiting
- Illinois CancerCare-Ottawa ClinicOttawa, IllinoisRecruiting
- Illinois CancerCare-PekinPekin, IllinoisRecruiting
- Illinois CancerCare-PeoriaPeoria, IllinoisRecruiting
- Illinois CancerCare-PeruPeru, IllinoisRecruiting
- Illinois CancerCare-PrincetonPrinceton, IllinoisRecruiting
- Iowa Methodist Medical CenterDes Moines, IowaRecruiting
- MaineHealth Cancer Care Center of York CountySanford, MaineRecruiting
- MaineHealth Coastal Cancer Treatment CenterBath, MaineRecruiting
- MaineHealth Maine Medical Center - PortlandPortland, MaineRecruiting
- MaineHealth Maine Medical Center- ScarboroughScarborough, MaineRecruiting
- Medical College of WisconsinMilwaukee, WisconsinRecruiting
- Medical Oncology Hematology Consultants PANewark, DelawareRecruiting
- Memorial Sloan Kettering Basking RidgeBasking Ridge, New JerseyRecruiting
- Memorial Sloan Kettering BergenMontvale, New JerseyRecruiting
- Memorial Sloan Kettering Cancer CenterNew York, New YorkRecruiting
- Memorial Sloan Kettering CommackCommack, New YorkRecruiting
- Memorial Sloan Kettering MonmouthMiddletown, New JerseyRecruiting
- Memorial Sloan Kettering NassauUniondale, New YorkRecruiting
- Memorial Sloan Kettering WestchesterHarrison, New YorkRecruiting
- Mercy Medical Center - Des MoinesDes Moines, IowaRecruiting
- Midwestern Regional Medical CenterZion, IllinoisRecruiting
- Northern Westchester HospitalMount Kisco, New YorkRecruiting
- NorthShore University HealthSystem-Evanston HospitalEvanston, IllinoisRecruiting
- NorthShore University HealthSystem-Glenbrook HospitalGlenview, IllinoisRecruiting
- NorthShore University HealthSystem-Highland Park HospitalHighland Park, IllinoisRecruiting
- Northwell Health Imbert Cancer CenterBay Shore, New YorkRecruiting
- Northwell Health/Center for Advanced MedicineLake Success, New YorkRecruiting
- Ohio State University Comprehensive Cancer CenterColumbus, OhioRecruiting
- OSF Saint Francis Medical CenterPeoria, IllinoisRecruiting
- OSF Saint Francis Radiation Oncology at Peoria Cancer CenterPeoria, IllinoisRecruiting
- OSF Saint Joseph Medical CenterBloomington, IllinoisRecruiting
- ProHealth D N Greenwald CenterMukwonago, WisconsinRecruiting
- ProHealth Oconomowoc Memorial HospitalOconomowoc, WisconsinRecruiting
- Smilow Cancer Hospital Care Center - WaterfordWaterford, ConnecticutRecruiting
- Smilow Cancer Hospital Care Center-TrumbullTrumbull, ConnecticutRecruiting
- Stony Brook University Medical CenterStony Brook, New YorkRecruiting
- Thomas Jefferson University HospitalPhiladelphia, PennsylvaniaRecruiting
- UC Irvine Health/Chao Family Comprehensive Cancer CenterOrange, CaliforniaRecruiting
- UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory CareIrvine, CaliforniaRecruiting
- UI Health Care Mission Cancer and Blood - Ankeny ClinicAnkeny, IowaRecruiting
- UI Health Care Mission Cancer and Blood - Des Moines ClinicDes Moines, IowaRecruiting
- UI Health Care Mission Cancer and Blood - Laurel ClinicDes Moines, IowaRecruiting
- UI Health Care Mission Cancer and Blood - Waukee ClinicWaukee, IowaRecruiting
- UI Health Care Mission Cancer and Blood - West Des Moines ClinicClive, IowaRecruiting
- UI Healthcare Mission Cancer and Blood - PellaPella, IowaRecruiting
- University Medical Center New OrleansNew Orleans, LouisianaRecruiting
- University of California Davis Comprehensive Cancer CenterSacramento, CaliforniaRecruiting
- University of Cincinnati Cancer Center-UC Medical CenterCincinnati, OhioRecruiting
- University of Cincinnati Cancer Center-West ChesterWest Chester, OhioRecruiting
- University of IllinoisChicago, IllinoisRecruiting
- University of Michigan - Brighton Center for Specialty CareBrighton, MichiganRecruiting
- University of Michigan Rogel Cancer CenterAnn Arbor, MichiganRecruiting
- University of Oklahoma Health Sciences CenterOklahoma City, OklahomaRecruiting
- University of Pittsburgh Cancer Institute (UPCI)Pittsburgh, PennsylvaniaRecruiting
- University of Vermont and State Agricultural CollegeBurlington, VermontRecruiting
- University of Vermont Medical CenterBurlington, VermontRecruiting
- UPMC Hillman Cancer Center ErieErie, PennsylvaniaRecruiting
- UPMC-Shadyside HospitalPittsburgh, PennsylvaniaRecruiting
- UW Cancer Center at ProHealth CareWaukesha, WisconsinRecruiting
- West Jefferson Medical CenterMarrero, LouisianaRecruiting
- Wexford Health and Wellness PavilionWexford, PennsylvaniaRecruiting
- Yale UniversityNew Haven, ConnecticutRecruiting
Who can join
People aged 12 and older can join this study. It is open to both men and women. To be eligible, participants must have a confirmed diagnosis of grade 3 astrocytoma with specific gene changes. They should not have had certain prior treatments or other serious health issues. The trial team will check who can join based on these criteria.
What happens during the trial
Participants will be randomly placed into one of two groups. One group will receive temozolomide and a placebo, while the other group will receive temozolomide and vorasidenib. Everyone will also get radiation therapy. Treatments will continue for up to 12 months. Throughout the study, blood samples will be taken and MRIs will be performed to monitor progress.
The trial team
The trial is sponsored by the Alliance for Clinical Trials in Oncology. Leading doctors include Dr. Ugonma N Chukwueke, Dr. Rifaquat M. Rahman, and Dr. Patrick Y Wen, who are all part of the Alliance for Clinical Trials in Oncology. The National Cancer Institute (NCI) is also collaborating on this study.
Important dates
This trial is estimated to begin on July 20, 2026, and is currently recruiting new participants. It is expected to be completed by January 2040, with the primary results anticipated by May 31, 2033.
Additional information
The trial ID is NCT07215910. It is a Phase 3 trial, which means it is looking at how well the treatment works and how safe it is. The study is not FDA regulated. The trial hopes to include about 408 participants.
Other recruiting trials for the same condition, with the eligibility rules written in plain language.
Browse similar trials →Find a top oncologist who can tell you whether a trial is a sensible option for you.
Find a doctor →The cancer centers running studies like this one, and what each is known for.
Browse hospitals →