Evaluating the Benefit of Adding Cetuximab to Standard Treatment for Head and Neck Cancer
NCT06589804 · RecruitingAbout this trial
This trial looks at how well adding a drug called cetuximab to standard treatment with pembrolizumab helps patients with head and neck cancer. This type of cancer may come back after treatment or spread to other parts of the body. The goal is to see if the combination works better than pembrolizumab alone in helping patients live longer and respond to treatment.
Locations and contact
This trial is running at 177 locations in the United States. 172 of them are currently recruiting.
United States177 locations · 172 recruiting
- Abbott-Northwestern HospitalMinneapolis, MinnesotaRecruiting
- Advocate Christ Medical CenterOak Lawn, IllinoisRecruiting
- Advocate Good Samaritan HospitalDowners Grove, IllinoisRecruiting
- Advocate Good Shepherd HospitalBarrington, IllinoisRecruiting
- Advocate High Tech Medical ParkPalos Heights, IllinoisRecruiting
- Advocate Illinois Masonic Medical CenterChicago, IllinoisRecruiting
- Advocate Lutheran General HospitalPark Ridge, IllinoisRecruiting
- Advocate Outpatient Center - Oak LawnOak Lawn, IllinoisRecruiting
- Advocate Sherman HospitalElgin, IllinoisRecruiting
- Advocate South Suburban HospitalHazel Crest, IllinoisRecruiting
- AMG Crystal Lake - OncologyCrystal Lake, IllinoisRecruiting
- AMG Libertyville - OncologyLibertyville, IllinoisRecruiting
- Atrium Medical Center-Middletown Regional HospitalFranklin, OhioRecruiting
- Aurora Bay Area Medical Group-MarinetteMarinette, WisconsinRecruiting
- Aurora BayCare Medical CenterGreen Bay, WisconsinRecruiting
- Aurora Cancer Care-GraftonGrafton, WisconsinRecruiting
- Aurora Cancer Care-Kenosha SouthKenosha, WisconsinRecruiting
- Aurora Cancer Care-MilwaukeeMilwaukee, WisconsinRecruiting
- Aurora Cancer Care-Milwaukee WestWauwatosa, WisconsinRecruiting
- Aurora Cancer Care-RacineRacine, WisconsinRecruiting
- Aurora Cancer Care-Southern Lakes VLCCBurlington, WisconsinRecruiting
- Aurora Health Care Germantown Health CenterGermantown, WisconsinRecruiting
- Aurora Medical Center in SummitSummit, WisconsinRecruiting
- Aurora Saint Luke's Medical CenterMilwaukee, WisconsinRecruiting
- Aurora Saint Luke's South ShoreCudahy, WisconsinRecruiting
- Aurora Sinai Medical CenterMilwaukee, WisconsinRecruiting
- Aurora West Allis Medical CenterWest Allis, WisconsinRecruiting
- Avera Cancer InstituteSioux Falls, South DakotaRecruiting
- Avera Cancer Institute - MitchellMitchell, South DakotaRecruiting
- Avera Cancer Institute at PierrePierre, South DakotaRecruiting
- Avera Cancer Institute at YanktonYankton, South DakotaRecruiting
- Benefis Sletten Cancer InstituteGreat Falls, MontanaRecruiting
- Billings Clinic Cancer CenterBillings, MontanaRecruiting
- Boston Medical CenterBoston, MassachusettsRecruiting
- Bozeman Health Deaconess HospitalBozeman, MontanaRecruiting
- Cancer Care and Hematology-Fort CollinsFort Collins, ColoradoRecruiting
- Cancer Care Center of O'FallonO'Fallon, IllinoisRecruiting
- Cancer Care Specialists of Illinois - DecaturDecatur, IllinoisRecruiting
- Cancer Centers of Southwest Oklahoma ResearchLawton, OklahomaRecruiting
- Cancer Hematology Centers - FlintFlint, MichiganRecruiting
- Community Hospital of AnacondaAnaconda, MontanaRecruiting
- Community Medical CenterMissoula, MontanaRecruiting
- Condell Memorial HospitalLibertyville, IllinoisRecruiting
- Crossroads Cancer CenterEffingham, IllinoisRecruiting
- Dartmouth Cancer Center - NorthSaint Johnsbury, VermontRecruiting
- Dartmouth Hitchcock Medical Center/Dartmouth Cancer CenterLebanon, New HampshireRecruiting
- Decatur Memorial HospitalDecatur, IllinoisRecruiting
- Fairview Southdale HospitalEdina, MinnesotaRecruiting
- FirstHealth of the Carolinas-Moore Regional HospitalPinehurst, North CarolinaRecruiting
- Genesys Hurley Cancer InstituteFlint, MichiganRecruiting
- Glens Falls HospitalGlens Falls, New YorkRecruiting
- Gundersen Lutheran Medical CenterLa Crosse, WisconsinRecruiting
- HaysMedHays, KansasRecruiting
- Hennepin County Medical CenterMinneapolis, MinnesotaRecruiting
- Hurley Medical CenterFlint, MichiganRecruiting
- Illinois CancerCare-MacombMacomb, IllinoisRecruiting
- Illinois CancerCare-PeoriaPeoria, IllinoisRecruiting
- Jefferson Cherry Hill HospitalCherry Hill, New JerseyRecruiting
- Jefferson Torresdale HospitalPhiladelphia, PennsylvaniaRecruiting
- Kootenai Clinic Cancer Services - Post FallsPost Falls, IdahoRecruiting
- Kootenai Clinic Cancer Services - SandpointSandpoint, IdahoRecruiting
- Kootenai Health - Coeur d'AleneCoeur d'Alene, IdahoRecruiting
- Lake Regional HospitalOsage Beach, MissouriRecruiting
- Lawrence Memorial HospitalLawrence, KansasRecruiting
- Lehigh Valley Hospital - MuhlenbergBethlehem, PennsylvaniaRecruiting
- Lehigh Valley Hospital-Cedar CrestAllentown, PennsylvaniaRecruiting
- Logan Health Medical CenterKalispell, MontanaRecruiting
- Lutheran Hospital - Cancer Centers of ColoradoGolden, ColoradoRecruiting
- Margaret R Pardee Memorial HospitalHendersonville, North CarolinaRecruiting
- Marshfield Medical Center - WestonWeston, WisconsinRecruiting
- Marshfield Medical Center-EC Cancer CenterEau Claire, WisconsinRecruiting
- Marshfield Medical Center-MarshfieldMarshfield, WisconsinRecruiting
- Marshfield Medical Center-River Region at Stevens PointStevens Point, WisconsinRecruiting
- Mary Greeley Medical CenterAmes, IowaRecruiting
- McFarland Clinic - AmesAmes, IowaRecruiting
- McFarland Clinic - MarshalltownMarshalltown, IowaRecruiting
- McFarland Clinic - Trinity Cancer CenterFort Dodge, IowaRecruiting
- Medical Center of the RockiesLoveland, ColoradoRecruiting
- Medical University of South CarolinaCharleston, South CarolinaRecruiting
- Memorial Hospital EastShiloh, IllinoisRecruiting
- Memorial Hospital NorthColorado Springs, ColoradoRecruiting
- Memorial Sloan Kettering Basking RidgeBasking Ridge, New JerseyRecruiting
- Memorial Sloan Kettering BergenMontvale, New JerseyRecruiting
- Memorial Sloan Kettering Cancer CenterNew York, New YorkRecruiting
- Memorial Sloan Kettering CommackCommack, New YorkRecruiting
- Memorial Sloan Kettering MonmouthMiddletown, New JerseyRecruiting
- Memorial Sloan Kettering NassauUniondale, New YorkRecruiting
- Memorial Sloan Kettering WestchesterHarrison, New YorkRecruiting
- Mercy HospitalCedar Rapids, IowaRecruiting
- Mercy HospitalCoon Rapids, MinnesotaRecruiting
- Mercy Hospital SouthSt Louis, MissouriRecruiting
- Miami Valley Cancer Care and InfusionGreenville, OhioRecruiting
- Miami Valley HospitalDayton, OhioRecruiting
- Miami Valley Hospital NorthDayton, OhioRecruiting
- Miami Valley Hospital SouthCenterville, OhioRecruiting
- Minnesota Oncology - BurnsvilleBurnsville, MinnesotaRecruiting
- Mount Sinai Medical CenterMiami Beach, FloridaRecruiting
- Oncology Associates at Mercy Medical CenterCedar Rapids, IowaRecruiting
- Park Nicollet Clinic - Saint Louis ParkSaint Louis Park, MinnesotaRecruiting
- Pocono Medical CenterEast Stroudsburg, PennsylvaniaRecruiting
- Poudre Valley HospitalFort Collins, ColoradoRecruiting
- ProHealth D N Greenwald CenterMukwonago, WisconsinRecruiting
- ProHealth Oconomowoc Memorial HospitalOconomowoc, WisconsinRecruiting
- ProHealth Waukesha Memorial HospitalWaukesha, WisconsinRecruiting
- ProMedica Flower HospitalSylvania, OhioRecruiting
- Providence Portland Medical CenterPortland, OregonRecruiting
- Providence Saint Vincent Medical CenterPortland, OregonRecruiting
- Providence Willamette Falls Medical CenterOregon City, OregonRecruiting
- Regions HospitalSaint Paul, MinnesotaRecruiting
- Saint Alphonsus Cancer Care Center-BoiseBoise, IdahoRecruiting
- Saint Alphonsus Cancer Care Center-CaldwellCaldwell, IdahoRecruiting
- Saint Alphonsus Cancer Care Center-NampaNampa, IdahoRecruiting
- Saint Alphonsus Cancer Care Center-OntarioOntario, OregonRecruiting
- Saint Francis Medical CenterCape Girardeau, MissouriRecruiting
- Saint John's Hospital - HealtheastMaplewood, MinnesotaRecruiting
- Salina Regional Health CenterSalina, KansasRecruiting
- Sanford Bismarck Medical CenterBismarck, North DakotaRecruiting
- Sanford Broadway Medical CenterFargo, North DakotaRecruiting
- Sanford Cancer Center Oncology ClinicSioux Falls, South DakotaRecruiting
- Sanford Joe Lueken Cancer CenterBemidji, MinnesotaRecruiting
- Sanford Roger Maris Cancer CenterFargo, North DakotaRecruiting
- Sanford USD Medical Center - Sioux FallsSioux Falls, South DakotaRecruiting
- Sidney Kimmel Cancer Center Washington TownshipSewell, New JerseyRecruiting
- Siteman Cancer Center at Christian HospitalSt Louis, MissouriRecruiting
- Siteman Cancer Center at Saint Peters HospitalCity of Saint Peters, MissouriRecruiting
- Siteman Cancer Center at West County HospitalCreve Coeur, MissouriRecruiting
- Siteman Cancer Center-South CountySt Louis, MissouriRecruiting
- Southern Illinois University School of MedicineSpringfield, IllinoisRecruiting
- Springfield ClinicSpringfield, IllinoisRecruiting
- Springfield Memorial HospitalSpringfield, IllinoisRecruiting
- State University of New York Upstate Medical UniversitySyracuse, New YorkRecruiting
- SUNY Upstate Medical Center-Community CampusSyracuse, New YorkRecruiting
- The University of Kansas Cancer Center - OlatheOlathe, KansasRecruiting
- Trinity Health IHA Medical Group Hematology Oncology - BrightonBrighton, MichiganRecruiting
- Trinity Health IHA Medical Group Hematology Oncology - CantonCanton, MichiganRecruiting
- Trinity Health IHA Medical Group Hematology Oncology - Chelsea HospitalChelsea, MichiganRecruiting
- Trinity Health IHA Medical Group Hematology Oncology Ann Arbor CampusYpsilanti, MichiganRecruiting
- Trinity Health Saint Joseph Mercy Hospital Ann ArborAnn Arbor, MichiganRecruiting
- Trinity Health Saint Joseph Mercy Oakland HospitalPontiac, MichiganRecruiting
- Trinity Health Saint Mary Mercy Livonia HospitalLivonia, MichiganRecruiting
- UC Comprehensive Cancer Center at Silver CrossNew Lenox, IllinoisRecruiting
- UCHealth Greeley HospitalGreeley, ColoradoRecruiting
- UCHealth Memorial Hospital CentralColorado Springs, ColoradoRecruiting
- UChicago Medicine Northwest IndianaCrown Point, IndianaRecruiting
- UNC Lineberger Comprehensive Cancer CenterChapel Hill, North CarolinaRecruiting
- United HospitalSaint Paul, MinnesotaRecruiting
- University Health Truman Medical CenterKansas City, MissouriRecruiting
- University of Arkansas for Medical SciencesLittle Rock, ArkansasRecruiting
- University of Chicago Comprehensive Cancer CenterChicago, IllinoisRecruiting
- University of Chicago Medicine-Orland ParkOrland Park, IllinoisRecruiting
- University of Kansas Cancer CenterKansas City, KansasRecruiting
- University of Kansas Cancer Center - BriarcliffKansas City, MissouriRecruiting
- University of Kansas Cancer Center - Lee's SummitLee's Summit, MissouriRecruiting
- University of Kansas Cancer Center - NorthKansas City, MissouriRecruiting
- University of Kansas Cancer Center-Overland ParkOverland Park, KansasRecruiting
- University of Kansas Health System Saint Francis CampusTopeka, KansasRecruiting
- University of Kansas Hospital-Indian Creek CampusOverland Park, KansasRecruiting
- University of Kansas Hospital-Westwood Cancer CenterWestwood, KansasRecruiting
- University of Maryland/Greenebaum Cancer CenterBaltimore, MarylandRecruiting
- University of Michigan Health - Sparrow LansingLansing, MichiganRecruiting
- University of Oklahoma Health Sciences CenterOklahoma City, OklahomaRecruiting
- Upper Valley Medical CenterTroy, OhioRecruiting
- Upstate Cancer Center at VeronaVerona, New YorkRecruiting
- UW Cancer Center at ProHealth CareWaukesha, WisconsinRecruiting
- UW Health Carbone Cancer Center RockfordRockford, IllinoisRecruiting
- VCU Massey Cancer Center at Stony PointRichmond, VirginiaRecruiting
- VCU Massey Comprehensive Cancer CenterRichmond, VirginiaRecruiting
- Vince Lombardi Cancer Clinic - OshkoshOshkosh, WisconsinRecruiting
- Vince Lombardi Cancer Clinic-SheboyganSheboygan, WisconsinRecruiting
- Vince Lombardi Cancer Clinic-Two RiversTwo Rivers, WisconsinRecruiting
- Washington University School of MedicineSt Louis, MissouriRecruiting
- West Virginia University Charleston DivisionCharleston, West VirginiaRecruiting
- Fremont - Rideout Cancer CenterMarysville, CaliforniaTerminated
- Genesee Hematology Oncology PCFlint, MichiganSuspended
- McFarland Clinic - BooneBoone, IowaSuspended
- McFarland Clinic - JeffersonJefferson, IowaSuspended
- VA Palo Alto Health Care SystemPalo Alto, CaliforniaSuspended
Who to ask about joining
Site Public Contact501-686-8274
Site Public Contact719-365-2406
Site Public Contact719-364-6700
Site Public Contact970-297-6150
Who can join
Adults aged 18 and older, both men and women, with a confirmed diagnosis of head and neck squamous cell carcinoma can join. They should not have had prior treatment for their recurrent or metastatic disease. Some specific health conditions may prevent participation, but the trial team will confirm eligibility.
What happens during the trial
Participants are randomly placed in one of two groups. In one group, patients receive pembrolizumab alone. In the other group, patients receive both cetuximab and pembrolizumab. Treatments are given through an IV, and patients will have scans and blood tests during the trial to monitor their health.
The trial team
The trial is sponsored by the National Cancer Institute (NCI). Siddharth Sheth from the Alliance for Clinical Trials in Oncology is the principal investigator overseeing the study.
Important dates
The trial started on March 27, 2025, and is expected to finish by November 30, 2029. It is currently recruiting new participants.
Additional information
The trial's ID number is NCT06589804. It is a Phase 3 trial, which means it is studying how well the treatments work and their safety. This study is regulated by the FDA, and it aims to include around 158 participants.
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