This trial looks at how well new medicines work for different types of breast cancer. The goal is to find out which treatments help the most based on the unique characteristics of each tumor. Researchers will also study early signs that show if treatments are working, using MRI scans and samples from the patient.
The trial's ID number is NCT01042379. It is a Phase 2 study, meaning it is focused on understanding how well the treatments work and their safety. The trial aims to include about 5,000 participants.
Who can join
Adults aged 18 and older can participate. Both men and women are welcome. Eligible participants must have a confirmed diagnosis of invasive breast cancer. They should not have received prior chemotherapy or radiation for this cancer. The trial team will confirm if each person meets the eligibility requirements.
Conditions
Breast Neoplasms, Breast Cancer, Breast Tumors, Angiosarcoma, TNBC - Triple-Negative Breast Cancer, HER2-positive Breast Cancer, HER2-negative Breast Cancer, Hormone Receptor Positive Tumor, Hormone Receptor Negative Tumor, Early-stage Breast Cancer, Locally Advanced Breast Cancer
Age group
Adult, Older adult
Sex
All sexes
The study team makes the final call on eligibility.
What happens in the study
Participants will be placed into different groups by chance. Some will receive standard therapy, which includes medicines like Paclitaxel and Doxorubicin. Others may receive experimental treatments that are currently being tested. The trial includes many different treatment combinations, but some arms are currently closed to new participants.
Where
This trial is running at 42 locations in the United States. 32 of them are currently recruiting.
City of Hope
Duarte, California
Recruiting
Cleveland Clinic
Cleveland, Ohio
Recruiting
Columbia University Medical Center
New York, New York
Recruiting
Georgetown University Medical Center
Washington D.C., District of Columbia
Recruiting
H. Lee Moffitt Cancer Center and Research Institute
Tampa, Florida
Recruiting
Herbert-Herman Cancer Center, Sparrow Hospital
Lansing, Michigan
Recruiting
HOAG Memorial Hospital Presbyterian
Newport Beach, California
Recruiting
Huntsman Cancer Institute, University of Utah
Salt Lake City, Utah
Recruiting
The first 8 of 42 sites are listed here. The registry record has the full list.