Examining the Benefits of Ivonescimab with FOLFOX for Advanced Cancer
NCT07070466 · RecruitingThis trial is looking at how well ivonescimab works with standard FOLFOX chemotherapy for patients with advanced HER2 negative gastroesophageal adenocarcinomas. The study aims to see if this combination can improve treatment results and help patients live longer without their cancer getting worse. It is a phase II trial, which means it is testing the effectiveness and safety of this treatment.
Locations and contact
This trial is running at 2 locations in the United States. All of them are currently recruiting.
United States2 locations · 2 recruiting
- Massachusetts General HospitalBoston, MassachusettsRecruiting
- UCLASanta Monica, CaliforniaRecruiting
Who can join
Adults aged 18 and older can join this trial. It is open to both men and women who have been diagnosed with certain types of stomach or esophageal cancer. People who have received specific previous treatments or have certain medical conditions may not be eligible. The trial team will confirm who can join.
What happens during the trial
Participants will receive ivonescimab and FOLFOX. Ivonescimab will be given through an IV every two weeks. Initially, it will be given alone, followed by FOLFOX, which includes other chemotherapy medicines. Treatment will continue for up to two years, as long as it is safe and beneficial for the patient.
The trial team
The trial is run by Massachusetts General Hospital, with Dr. Samuel Klempner as the principal investigator. Summit Therapeutics is a partner organization.
Important dates
The trial started on October 10, 2025, and is currently recruiting new participants. It is expected to finish by September 1, 2028.
Additional information
This is a phase II trial, meaning it's looking at how well the treatment works and its safety. The trial is FDA-regulated and aims to include about 40 participants.
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