Examining Two Treatment Options for Colorectal Cancer with a Specific Mutation
NCT06252649 · RecruitingAbout this trial
This study looks at two different treatments for people with metastatic colorectal cancer that has a specific mutation called KRAS p.G12C. The goal is to compare how well these treatments work in keeping the cancer from getting worse. One treatment includes a combination of three medicines: sotorasib, panitumumab, and FOLFIRI. The other treatment is FOLFIRI alone or with another medicine called bevacizumab-awwb.
Locations and contact
This trial is running at 292 locations in 35 countries. 262 of them are currently recruiting.
United States26 locations · 14 recruiting
- California Research InstituteLos Angeles, CaliforniaRecruiting
- Cancer and Blood Research Center, LLCLos Alamitos, CaliforniaRecruiting
- Cancer and Hematology Centers of Western MichiganGrand Rapids, MichiganRecruiting
- Cancer Specialists of North Florida - SouthpointJacksonville, FloridaRecruiting
- City of Hope National Medical CenterLong Beach, CaliforniaRecruiting
- Duke Cancer CenterDurham, North CarolinaRecruiting
- FirstHealth Cancer CenterPinehurst, North CarolinaRecruiting
- Henry Ford Health SystemDetroit, MichiganRecruiting
- Insight Research InstituteChicago, IllinoisRecruiting
- Ironwood Cancer and Research Centers ScottsdaleChandler, ArizonaRecruiting
- Pikeville Medical CenterPikeville, KentuckyRecruiting
- Tennessee Oncology PLLC - ChattanoogaNashville, TennesseeRecruiting
- Tennessee Oncology, PLLCNashville, TennesseeRecruiting
- Vanderbilt University Medical CenterNashville, TennesseeRecruiting
- Boca Raton Clinical Research Medical Center IncPlantation, FloridaTerminated
- Carolina Blood and Cancer CareRock Hill, South CarolinaTerminated
- D and H Cancer Research CenterMargate, FloridaTerminated
- Georgia Cancer SpecialistsAtlanta, GeorgiaTerminated
- Hope and Healing Cancer ServicesHinsdale, IllinoisTerminated
- Mid Florida Hematology and Oncology Centers PAOrange City, FloridaTerminated
- Minniti Center for Medical Oncology and HematologyMickleton, New JerseyTerminated
- Norwalk HospitalNorwalk, ConnecticutTerminated
- Orchard Healthcare Research IncSkokie, IllinoisTerminated
- Providence Saint Jude Medical CenterFullerton, CaliforniaTerminated
- Saint Louis Cancer Care West CountyBridgeton, MissouriTerminated
- Thomas Jefferson UniversityPhiladelphia, PennsylvaniaTerminated
Japan21 locations · 21 recruiting
- Aichi Cancer CenterNagoya, Aichi-kenRecruiting
- Chiba Cancer CenterChiba, ChibaRecruiting
- Hokkaido University HospitalSapporo, HokkaidoRecruiting
- Hyogo Cancer CenterAkashi-shi, HyōgoRecruiting
- Kanagawa Prefectural Hospital Organization Kanagawa Cancer CenterYokohama, KanagawaRecruiting
- Kansai Medical University HospitalHirakata-shi, OsakaRecruiting
- National Cancer Center HospitalChuo-ku, TokyoRecruiting
- National Cancer Center Hospital EastKashiwa-shi, ChibaRecruiting
- National Hospital Organization Kyushu Cancer CenterFukuoka, FukuokaRecruiting
- National Hospital Organization Osaka National HospitalOsaka, OsakaRecruiting
- National Hospital Organization Shikoku Cancer CenterMatsuyama, EhimeRecruiting
- Niigata Cancer Center HospitalNiigata, NiigataRecruiting
- Nippon Medical School HospitalBunkyo-ku, TokyoRecruiting
- Saitama Cancer CenterKitaadachi-gun, SaitamaRecruiting
- Shizuoka Cancer CenterSunto-gun, ShizuokaRecruiting
- St Marianna University HospitalKawasaki-shi, KanagawaRecruiting
- The Cancer Institute Hospital of Japanese Foundation for Cancer ResearchKoto-ku, TokyoRecruiting
- The University of Osaka HospitalSuita-shi, OsakaRecruiting
- Tokushima University HospitalTokushima, TokushimaRecruiting
- Tokyo Metropolitan Komagome HospitalBunkyo-ku, TokyoRecruiting
- Yokohama City University Medical CenterYokohama, KanagawaRecruiting
Spain20 locations · 20 recruiting
- Complexo Hospitalario Universitario de OurenseOurense, GaliciaRecruiting
- Hospital Clinico Universitario de ValenciaValencia, ValenciaRecruiting
- Hospital de la Santa Creu i Sant PauBarcelona, CataloniaRecruiting
- Hospital General Universitario de ElcheElche, ValenciaRecruiting
- Hospital General Universitario de ValenciaValencia, ValenciaRecruiting
- Hospital General Universitario Gregorio MaranonMadridRecruiting
- Hospital Regional Universitario de MalagaMálaga, AndalusiaRecruiting
- Hospital Universitari Vall d HebronBarcelona, CataloniaRecruiting
- Hospital Universitario 12 de OctubreMadridRecruiting
- Hospital Universitario Central de AsturiasOviedo, Principality of AsturiasRecruiting
- Hospital Universitario de BurgosBurgos, Castille and LeónRecruiting
- Hospital Universitario de NavarraPamplona, NavarreRecruiting
- Hospital Universitario La PazMadridRecruiting
- Hospital Universitario Marques de ValdecillaSantander, CantabriaRecruiting
- Hospital Universitario Miguel ServetZaragoza, AragonRecruiting
- Hospital Universitario Reina SofiaCórdoba, AndalusiaRecruiting
- Hospital Universitario Virgen de las NievesGranada, AndalusiaRecruiting
- Hospital Universitario Virgen del RocioSeville, AndalusiaRecruiting
- Institut Catala d Oncologia Badalona Hospital Universitari Germans Trias i PujolBadalona, CataloniaRecruiting
- Institut Catala d Oncologia Hospitalet Hospital Duran i ReynalsL'Hospitalet de Llobregat, CataloniaRecruiting
Italy19 locations · 19 recruiting
- Azienda di Rilievo Nazionale e Alta Specializzazione Civico Di Cristina BenfratelliPalermoRecruiting
- Azienda Ospedaliera di Rilievo Nazionale Specialistica dei Colli MonaldiNaplesRecruiting
- Azienda Ospedaliera Universitaria Integrata di Verona Ospedale Civile Maggiore Borgo TrentoVeronaRecruiting
- Azienda Ospedaliero Universitaria CareggiFlorenceRecruiting
- Azienda Ospedaliero Universitaria Ospedali Riuniti di FoggiaFoggiaRecruiting
- Azienda Ospedaliero Universitaria PisanaPisaRecruiting
- Azienda Sanitaria Territoriale Pesaro Urbino - Presidio San Salvatore MuragliaPesaroRecruiting
- Azienda Sanitaria Universitaria Friuli Centrale Presidio Ospedaliero Santa Maria della MisericordiaUdineRecruiting
- Azienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano NiguardaMilanRecruiting
- Azienda Unità Sanitaria Locale della Romagna Presidio ospedaliero di RavennaRavennaRecruiting
- Ente Ospedaliero IRCCS Saverio De BellisCastellana GrotteRecruiting
- Fondazione IRCCS Istituto Nazionale dei TumoriMilanRecruiting
- Fondazione IRCCS Ospedale Casa Sollievo della SofferenzaSan Giovanni RotondoRecruiting
- IRCCS Istituto Clinico HumanitasRozzano MIRecruiting
- Istituto Nazionale dei Tumori IRCCS Fondazione Giovanni PascaleNaplesRecruiting
- Istituto Oncologico Veneto IRCCSPadovaRecruiting
- Istituto Ospedaliero Fondazione PoliambulanzaBresciaRecruiting
- Istituto Romagnolo per lo Studio dei Tumori Dino AmadoriMeldola FCRecruiting
- Ospedale Policlinico San Martino IRCCSGenovaRecruiting
France16 locations · 16 recruiting
- Centre Antoine LacassagneNiceRecruiting
- Centre Hospitalier Universitaire de Bordeaux - Hopital Haut LevequePessacRecruiting
- Centre Hospitalier Universitaire de Clermont Ferrand - Hopital EstaingClermont-FerrandRecruiting
- Centre Hospitalier Universitaire de Dijon - Hopital du BocageDijonRecruiting
- Centre Hospitalier Universitaire de PoitiersPoitiersRecruiting
- Centre Hospitalier Universitaire de Rennes - Hopital PontchaillouRennesRecruiting
- Centre Hospitalier Universitaire Nord de Saint Etienne - Hopital NordSaint-Priest-en-JarezRecruiting
- Hopital Europeen Georges PompidouParisRecruiting
- Hopital Henri MondorCréteilRecruiting
- Hopital Pitie-SalpetriereParisRecruiting
- Hopital Prive Jean MermozLyonRecruiting
- Hopital Robert DebreReimsRecruiting
- Hopital Saint LouisParisRecruiting
- Institut de Cancerologie de l Ouest Rene GauducheauSaint-HerblainRecruiting
- Institut de Cancerologie de LorraineVandœuvre-lès-NancyRecruiting
- Institut regional du Cancer MontpellierMontpellierRecruiting
Brazil16 locations · 15 recruiting
- Associação Hospitalar Moinhos de VentoPorto Alegre, Rio Grande do SulRecruiting
- Clinica de Neoplasias LitoralItajaí, Santa CatarinaRecruiting
- Fundacao pio xII BarretosBarretos, São PauloRecruiting
- Hospital de Base de Sao Jose do Rio PretoSão José do Rio Preto, São PauloRecruiting
- Hospital Evangelico de Cachoeiro de ItapemirimCachoeiro de Itapemirim, Espírito SantoRecruiting
- Hospital Sirio Libanes BrasiliaBrasília, Federal DistrictRecruiting
- Instituto Brasileiro de Controle do Cancer IbccSão PauloRecruiting
- Instituto Cancer Sao Paulo IcespSão PauloRecruiting
- Irmandade da Santa Casa de Misericordia de Porto AlegrePorto Alegre, Rio Grande do SulRecruiting
- Liga Norte-Riograndense Contra O CancerNatal, Rio Grande do NorteRecruiting
- Oncoclinicas Belo HorizonteBarretos, São PauloRecruiting
- Oncoclinicas Rio de Janeiro S ARio de JaneiroRecruiting
- Oncologia Rede D OrSão PauloRecruiting
- Oncosite Centro de Pesquisa Clinica Em Oncologia LtdaIjuí, Rio Grande do SulRecruiting
- Vencer e OncoclinicaTeresina, PiauíRecruiting
- Fundacao Antonio Prudente AC Camargo Cancer CenterSão Paulo, São PauloTerminated
Argentina13 locations · 13 recruiting
- CemicCiudad Autonoma de Buenos Aires, Buenos AiresRecruiting
- Centro Oncologico Riojano IntegralLa RiojaRecruiting
- Clinica Universitaria Privada Reina FabiolaCórdoba, Córdoba ProvinceRecruiting
- Clinica ViedmaViedma, Río Negro ProvinceRecruiting
- Exelsus Oncologia ClinicaSan Miguel de Tucumán, Tucumán ProvinceRecruiting
- Hospital Britanico de Buenos AiresBuenos AiresRecruiting
- Hospital Italiano de CórdobaCórdoba, Córdoba ProvinceRecruiting
- Hospital Universitario Fundacion FavaloroCABA, Buenos AiresRecruiting
- Instituto Argentino de Diagnóstico y TratamientoCABA, Buenos AiresRecruiting
- Instituto de Investigaciones clinicas de Mar del PlataMar del Plata, Buenos AiresRecruiting
- Investigaciones Clinicas Moleculares - Centro de Endocrinologia y Diabetes Dr Raul Gutman SRLCABA, Buenos AiresRecruiting
- Sanatorio AllendeCórdoba, Córdoba ProvinceRecruiting
- Sanatorio Británico de RosarioLa Plata, Buenos AiresRecruiting
Turkey (Türkiye)13 locations · 11 recruiting
- Adana Sehir Egitim ve Arastirma HastanesiAdanaRecruiting
- Ankara Bilkent Sehir HastanesiAnkaraRecruiting
- Ankara Universitesi Tip Fakultesi HastanesiAnkaraRecruiting
- Bezmialem Vakif Universitesi HastanesiIstanbulRecruiting
- Ege Universitesi Tip Fakultesi HastanesiIzmirRecruiting
- Gazi Universitesi Saglik Arastirma ve Uygulama Merkezi Gazi HastanesiAnkaraRecruiting
- Hacettepe Universitesi Tip Fakultesi HastanesiAnkaraRecruiting
- Inonu Universitesi Turgut Ozal Tip MerkeziMalatyaRecruiting
- Kartal Dr Lutfi Kirdar Sehir HastanesiIstanbulRecruiting
- Necmettin Erbakan Universitesi Tip Fakultesi HastanesiKonyaRecruiting
- Trakya Universitesi Saglik Arastirma ve Uygulama MerkeziEdirneRecruiting
- Acibadem Altunizade HastanesiIstanbulTerminated
- Bagcilar Medipol Mega Universite HastanesiIstanbulTerminated
Germany10 locations · 10 recruiting
- Charite - Universitaetsmedizin Berlin, Campus VirchowBerlinRecruiting
- Haematologisch Onkologische Praxis EppendorfHamburgRecruiting
- Klinikum Chemnitz gGmbHChemnitzRecruiting
- Klinikum der LMU MuenchenMünchenRecruiting
- Klinikum der Stadt WolfsburgWolfsburgRecruiting
- Regional Kliniken Holding Klinikum LudwigsburgLudwigsburgRecruiting
- UCT Universitaeres Zentrum fuer Tumorerkrankungen FrankfurtFrankfurt am MainRecruiting
- Universitaetsklinikum DresdenDresdenRecruiting
- Universitaetsklinikum EssenEssenRecruiting
- Universitaetsklinikum UlmUlmRecruiting
Greece12 locations · 9 recruiting
- Aretaieio HospitalAthensRecruiting
- Athens Medical Center S.A - PsychikonAthensRecruiting
- Bioclinic of ThessalonikiThessalonikiRecruiting
- European Interbalkan Medical CenterThessalonikiRecruiting
- General Hospital EvangelismosAthensRecruiting
- Hygeia HospitalAthensRecruiting
- Metaxa Anticancer HospitalPiraeusRecruiting
- Saint Luke HospitalThessalonikiRecruiting
- University Hospital of LarissaLarissaRecruiting
- Agios Savvas Anticancer HospitalAthensTerminated
- Metropolitan HospitalAthensTerminated
- Saint Lukes Hospital SAThessalonikiTerminated
United Kingdom10 locations · 9 recruiting
- Beatson West of Scotland Cancer CentreGlasgowRecruiting
- Guys HospitalLondonRecruiting
- Maidstone HospitalMaidstoneRecruiting
- Mount Vernon Cancer CentreNorthwoodRecruiting
- Queen Elizabeth Hospital BirminghamBirminghamRecruiting
- Royal Free HospitalLondonRecruiting
- Royal Marsden HospitalLondonRecruiting
- Royal Marsden Hospital - SuttonSuttonRecruiting
- Weston Park HospitalSheffieldRecruiting
- Sarah Cannon Research Institute UKLondonTerminated
Portugal9 locations · 9 recruiting
- Fundacao ChampalimaudLisbonRecruiting
- Hospital Cuf TejoLisbonRecruiting
- Hospital da Luz, SALisbonRecruiting
- Instituto Portugues de Oncologia de Coimbra Francisco Gentil, EPECoimbraRecruiting
- Unidade Local de Saude de Almada-Seixal, EPE - Hospital Garcia de OrtaAlmadaRecruiting
- Unidade Local de Saude de Coimbra, EPECoimbraRecruiting
- Unidade Local de Saude de Entre Douro e Vouga, EPE - Hospital de Sao SebastiaoSanta Maria da FeiraRecruiting
- Unidade Local de Saude de Matosinhos, EPE - Hospital Pedro HispanoMatosinhos MunicipalityRecruiting
- Unidade Local de Saude de Santa Maria, EPE - Hospital de Santa MariaLisbonRecruiting
Belgium8 locations · 8 recruiting
- Algemeen Ziekenhuis Sint Maarten-Emmaus vzwMechelenRecruiting
- AZ Delta Campus RumbekeRoeselareRecruiting
- Grand Hôpital de Charleroi - Site des ViviersCharleroiRecruiting
- Institut Jules BordetBrusselsRecruiting
- Universitair Ziekenhuis GentGhentRecruiting
- Universitair Ziekenhuis Leuven - Campus GasthuisbergLeuvenRecruiting
- Universite Catholique de Louvain Cliniques Universitaires Saint LucBrusselsRecruiting
- Vitaz campus Sint-Niklaas MoerlandSint-NiklaasRecruiting
Poland8 locations · 8 recruiting
- Narodowy Instytut Onkologii im Marii Sklodowskiej-Curie - Panstwowy Instytut BadawczyWarsawRecruiting
- Panstwowy Instytut Medyczny Ministerstwa Spraw Wewnetrznych i AdministracjiWarsawRecruiting
- SPZOZ Opolskie Centrum Onkologii imienia prof Tadeusza Koszarowskiego w OpoluOpoleRecruiting
- Swietokrzyskie Centrum Onkologii Samodzielny Publiczny Zaklad Opieki Zdrowotnej w KielcachKielceRecruiting
- Szpitale Pomorskie spolka z ograniczona odpowiedzialnosciaGdyniaRecruiting
- Wielkopolskie Centrum Onkologii imienia Marii Sklodowskiej-CuriePoznanRecruiting
- Wojewodzkie Wielospecjalistyczne Centrum Onkologii i Traumatologii im M Kopernika w LodziLodzRecruiting
- Wojskowy Instytut Medyczny - Panstwowy Instytut BadawczyWarsawRecruiting
Chile8 locations · 7 recruiting
- Biocinetic servicios medicos limitadaSantiagoRecruiting
- Centro de investigacion y desarrollo oncolgico SpaTemuco, CautínRecruiting
- Centro de oncologia de precision SpaSantiagoRecruiting
- Clinica Redsalud Vitacura, Instituto del CancerVitacura, Santiago MetropolitanRecruiting
- Enroll SpAProvidencia, Santiago MetropolitanRecruiting
- Fundacion Arturo Lopez PerezSantiagoRecruiting
- James Lind Centro de Investigacion del CancerTemuco, CautínRecruiting
- Clinical Research Chile SpAValdiviaTerminated
Romania7 locations · 7 recruiting
- Centrul de Oncologie Sf Nectarie SRLCraiovaRecruiting
- Institutul Clinic FundeniBucharestRecruiting
- Institutul Oncologic Prof Dr Alexandru Trestioreanu BucurestiBucharestRecruiting
- Institutul Oncologic Prof Dr Ion Chiricuta Cluj-NapocaCluj-NapocaRecruiting
- Institutul Regional de Oncologie IasiIașiRecruiting
- SC Oncomed SRLTimișoaraRecruiting
- Spitalul Municipal PloiestiPloieştiRecruiting
Hungary7 locations · 6 recruiting
- Bekes Varmegyei Kozponti Korhaz Pandy Kalman TagkorhazGyulaRecruiting
- Debreceni Egyetem Klinikai KozpontDebrecenRecruiting
- Jasz-Nagykun-Szolnok Varmegyei Hetenyi Geza Korhaz-RendelointezetSzolnokRecruiting
- Orszagos Onkologiai IntezetBudapestRecruiting
- Semmelweis EgyetemBudapestRecruiting
- Somogy Varmegyei Kaposi Mor Oktato KorhazKaposvárRecruiting
- Szabolcs-Szatmar-Bereg Varmegyei Oktatokorhaz Nyiregyhazi Josa Andras TagkorhazNyíregyházaTerminated
Australia6 locations · 6 recruiting
- Austin Health, Austin HospitalHeidelberg, VictoriaRecruiting
- Chris OBrien LifehouseCamperdown, New South WalesRecruiting
- Flinders Medical CentreBedford Park, South AustraliaRecruiting
- Princess Alexandra HospitalWoolloongabba, QueenslandRecruiting
- The Queen Elizabeth HospitalWoodville South, South AustraliaRecruiting
- Toowoomba HospitalToowoomba, QueenslandRecruiting
Canada6 locations · 6 recruiting
- Allan Blair Cancer CentreRegina, SaskatchewanRecruiting
- Arthur J E Child Comprehensive Cancer CentreCalgary, AlbertaRecruiting
- Mount Sinai HospitalToronto, OntarioRecruiting
- Saskatoon Cancer CentreSaskatoon, SaskatchewanRecruiting
- Sunnybrook Research Institute Sunnybrook Health Sciences CentreToronto, OntarioRecruiting
- William Osler Health System - Brampton Civic HospitalBrampton, OntarioRecruiting
Czechia6 locations · 6 recruiting
- Fakultni nemocnice BulovkaPragueRecruiting
- Fakultni nemocnice Hradec KraloveHradec KrálovéRecruiting
- Fakultni nemocnice Kralovske VinohradyPragueRecruiting
- Fakultni nemocnice OlomoucOlomoucRecruiting
- Fakultni nemocnice v MotolePragueRecruiting
- Masarykuv onkologicky ustavBrnoRecruiting
Netherlands6 locations · 6 recruiting
- Albert Schweitzer Ziekenhuis, Locatie DordwijkDordrechtRecruiting
- Maastricht Universitair Medisch CentrumMaastrichtRecruiting
- Martini ZiekenhuisGroningenRecruiting
- Medisch Spectrum TwenteEnschedeRecruiting
- Nederlands Kanker Instituut - Antoni van LeeuwenhoekAmsterdamRecruiting
- Universitair Medisch Centrum UtrechtUtrechtRecruiting
Colombia6 locations · 5 recruiting
- Centro de Tratamiento e Investigación sobre Cancer Luis Carlos Sarmiento Angulo CticBogotá, CundinamarcaRecruiting
- Institucion Prestadora de Servicios de Salud Sociedad Médica Rionegro SA Somer SARionegro, AntioquiaRecruiting
- Instituto Medico de Alta Tecnologia sas - Imat sasMontería, Departamento de CórdobaRecruiting
- Instituto Nacional de CancerologiaBogota, CundinamarcaRecruiting
- Servicios de Salud Ips Suramericana Sas - Ips Sura IndustrialesMedellín, AntioquiaRecruiting
- Fundacion Oftalmologica de Santander - FoscalFloridablanca, Santander DepartmentTerminated
South Korea8 locations · 4 recruiting
- Asan Medical CenterSeoulRecruiting
- National Cancer CenterGoyang-si, Gyeonggi-doRecruiting
- Samsung Medical CenterSeoulRecruiting
- Severance Hospital Yonsei University Health SystemSeoulRecruiting
- Korea University Anam HospitalSeoulTerminated
- Korea University Guro HospitalSeoulTerminated
- Seoul National University HospitalSeoulTerminated
- The Catholic University of Korea Seoul St Marys HospitalSeoulTerminated
Austria5 locations · 4 recruiting
- Krankenhaus Wiener NeustadtWiener NeustadtRecruiting
- Medizinische Universitaet GrazGrazRecruiting
- Ordensklinikum Linz Barmherzige SchwesternLinzRecruiting
- Universitaetsklinikum Allgemeines Krankenhaus WienViennaRecruiting
- Landeskrankenhaus FeldkirchRankweilCompleted
Bulgaria5 locations · 4 recruiting
- Military Medical Academy Multiprofile Hospital for Active Treatment - SofiaSofiaRecruiting
- Multiprofile Hospital for Active Treatment Central Onco Hospital OODPlovdivRecruiting
- Multiprofile Hospital for Active Treatment Serdikamed EOODSofiaRecruiting
- Specialized Hospital for Active Treatment of Oncology - Haskovo EOODHaskovoRecruiting
- Complex Oncology Center Plovdiv EOODPlovdivTerminated
Denmark4 locations · 4 recruiting
- Aalborg SygehusAalborgRecruiting
- Aarhus University HospitalAarhus NRecruiting
- Odense University HospitalOdense CRecruiting
- RigshospitaletCopenhagenRecruiting
Mexico4 locations · 4 recruiting
- Centro Especializado en Investigacion y Tratamiento Oncologicos SCBenito Juárez, Mexico CityRecruiting
- Health Pharma Professional Research SA de CVMexico City, Mexico CityRecruiting
- Hospital Universitario Dr Jose Eleuterio GonzalezMonterrey, Nuevo LeónRecruiting
- Instituto Nacional de Ciencias Medicas y Nutricion Salvador ZubiranMexico CityRecruiting
Taiwan4 locations · 4 recruiting
- China Medical University HospitalTaichungRecruiting
- Linkou Chang Gung Memorial Hospital of Chang Gung Medical FoundationTaoyuanRecruiting
- Taichung Veterans General HospitalTaichungRecruiting
- Taipei Veterans General HospitalTaipeiRecruiting
Hong Kong3 locations · 2 recruiting
- Queen Mary Hospital, The University of Hong KongHong KongRecruiting
- Tuen Mun HospitalNew TerritoriesRecruiting
- Princess Margaret HospitalKowloonTerminated
Estonia1 location · 1 recruiting
- North Estonia Medical Centre FoundationTallinnRecruiting
Puerto Rico1 location · 1 recruiting
- Pan American Center for Oncology Trials LLCRio PiedrasRecruiting
Slovakia1 location · 1 recruiting
- Vychodoslovensky onkologicky ustav, asKošiceRecruiting
Sweden1 location · 1 recruiting
- SoedersjukhusetStockholmRecruiting
Thailand1 location · 1 recruiting
- Siriraj HospitalBangkokRecruiting
Switzerland1 location
- Universitaetsspital ZuerichZurichTerminated
Who to ask about joining
Amgen Call Center866-572-6436medinfo@amgen.com
Who can join
Anyone aged 18 or older can join. This trial is open to both men and women with a certain type of metastatic colorectal cancer. Participants must have a confirmed KRAS p.G12C mutation. Some people may not be able to join if they have untreated brain metastases or have received certain previous treatments. The trial team will confirm eligibility for everyone.
What happens during the trial
Participants will be placed into two groups by chance. One group will receive sotorasib, panitumumab, and FOLFIRI. This will include daily pills and infusions every two weeks. The second group will receive FOLFIRI, with or without bevacizumab-awwb, also every two weeks. Everyone will be monitored closely throughout the study.
The trial team
The trial is sponsored by Amgen, with a study director from Amgen leading the research. They are responsible for ensuring the trial runs smoothly and safely.
Important dates
The trial started on July 17, 2024, and is expected to finish around April 25, 2032. It is currently recruiting new participants.
Additional information
This is a Phase 3 trial, which means it is looking at how well the new treatment works and its safety. The trial aims to include about 450 participants and is regulated by the FDA.
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