Finding a Vaccine to Protect Patients After Stem Cell Transplant
NCT06059391 · RecruitingThis clinical trial is looking at a vaccine called CMV-MVA Triplex. It is given to stem cell donors to help protect patients from a virus called cytomegalovirus (CMV) after they receive a stem cell transplant. The goal is to see if this vaccine can help prevent CMV infection in patients. The study will also check if the vaccine is safe and effective.
Locations and contact
This trial is running at 3 locations in the United States. All of them are currently recruiting.
United States3 locations · 3 recruiting
- City of Hope Medical CenterDuarte, CaliforniaRecruiting
- DFCI/BWH Brigham and Women's HospitalBoston, MassachusettsRecruiting
- Northside HospitalAtlanta, GeorgiaRecruiting
Who can join
Adults aged 18 to 75 can participate. Both donors and recipients must agree to the study. Recipients should be getting a stem cell transplant for certain types of blood cancers. Some health conditions may prevent participation, but the trial team will confirm eligibility.
What happens during the trial
Participants will be placed into two groups by chance. One group of donors will receive the CMV-MVA Triplex vaccine, while the other group will receive a placebo (a dummy treatment). Both groups will have similar follow-up care after the stem cell transplant.
The trial team
The trial is led by the City of Hope Medical Center, with support from the National Cancer Institute. Dr. Vaibhav Agrawal is the principal investigator overseeing the study.
Important dates
This trial began on July 12, 2024, and is expected to finish by January 1, 2029. It is currently recruiting new participants.
Additional information
The trial's ID number is NCT06059391. It is a Phase 2 trial, meaning it is looking at how well the treatment works and how safe it is. The trial is FDA-regulated and aims to include about 216 participants.
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