Finding Better Treatments for Advanced Head and Neck Cancer After Surgery
NCT07195734 · RecruitingThis trial looks at how adding chemotherapy or chemo-immunotherapy to standard surgery may help patients with advanced head and neck cancer. The goal is to see if these treatments can improve event-free survival, which means time without disease progression or complications after surgery. Patients in the study have locally recurrent or persistent squamous cell carcinoma, a type of cancer that affects the head and neck area.
Locations and contact
This trial is running at 87 locations in the United States. 86 of them are currently recruiting.
United States87 locations · 86 recruiting
- Allegheny General HospitalPittsburgh, PennsylvaniaRecruiting
- Asplundh Cancer PavilionWillow Grove, PennsylvaniaRecruiting
- Banner University Medical Center - TucsonTucson, ArizonaRecruiting
- Broadlawns Medical CenterDes Moines, IowaRecruiting
- Clackamas Radiation Oncology CenterClackamas, OregonRecruiting
- Community Medical CenterToms River, New JerseyRecruiting
- Cooper Hospital University Medical CenterCamden, New JerseyRecruiting
- Drexel Town Square Health CenterOak Creek, WisconsinRecruiting
- Emory Proton Therapy CenterAtlanta, GeorgiaRecruiting
- Emory University Hospital MidtownAtlanta, GeorgiaRecruiting
- Forbes HospitalMonroeville, PennsylvaniaRecruiting
- Froedtert and MCW Moorland Reserve Health CenterNew Berlin, WisconsinRecruiting
- Froedtert Menomonee Falls HospitalMenomonee Falls, WisconsinRecruiting
- Froedtert West Bend Hospital/Kraemer Cancer CenterWest Bend, WisconsinRecruiting
- Henry Ford HospitalDetroit, MichiganRecruiting
- Iowa Methodist Medical CenterDes Moines, IowaRecruiting
- IRMC Cancer CenterIndiana, PennsylvaniaRecruiting
- Jefferson HospitalJefferson Hills, PennsylvaniaRecruiting
- Jersey City Medical CenterJersey City, New JerseyRecruiting
- Legacy Cancer Institute Medical Oncology and Day TreatmentVancouver, WashingtonRecruiting
- Legacy Good Samaritan Hospital and Medical CenterPortland, OregonRecruiting
- Legacy Meridian Park HospitalTualatin, OregonRecruiting
- Legacy Mount Hood Medical CenterGresham, OregonRecruiting
- Legacy Salmon Creek HospitalVancouver, WashingtonRecruiting
- LSU Health Baton Rouge-North ClinicBaton Rouge, LouisianaRecruiting
- Medical College of WisconsinMilwaukee, WisconsinRecruiting
- Medical University of South CarolinaCharleston, South CarolinaRecruiting
- Memorial Hospital EastShiloh, IllinoisRecruiting
- Mercy Medical Center - Des MoinesDes Moines, IowaRecruiting
- Monmouth Medical CenterLong Branch, New JerseyRecruiting
- Nebraska Cancer Specialists/Oncology Hematology West PC - MECCOmaha, NebraskaRecruiting
- Nebraska Methodist HospitalOmaha, NebraskaRecruiting
- Our Lady of the Lake Physician GroupBaton Rouge, LouisianaRecruiting
- ProMedica Flower HospitalSylvania, OhioRecruiting
- Providence Newberg Medical CenterNewberg, OregonRecruiting
- Providence Portland Medical CenterPortland, OregonRecruiting
- Providence Saint Vincent Medical CenterPortland, OregonRecruiting
- Providence Willamette Falls Medical CenterOregon City, OregonRecruiting
- Rush MD Anderson Cancer CenterChicago, IllinoisRecruiting
- Rush MD Anderson Cancer Center at Rush LisleLisle, IllinoisRecruiting
- Rutgers Cancer Institute of New JerseyNew Brunswick, New JerseyRecruiting
- Rutgers New Jersey Medical SchoolNewark, New JerseyRecruiting
- Saint Vincent HospitalErie, PennsylvaniaRecruiting
- Siteman Cancer Center at Christian HospitalSt Louis, MissouriRecruiting
- Siteman Cancer Center at Saint Peters HospitalCity of Saint Peters, MissouriRecruiting
- Siteman Cancer Center at West County HospitalCreve Coeur, MissouriRecruiting
- Siteman Cancer Center-South CountySt Louis, MissouriRecruiting
- Stony Brook University Medical CenterStony Brook, New YorkRecruiting
- Sutter Medical Center SacramentoSacramento, CaliforniaRecruiting
- Thomas Jefferson University HospitalPhiladelphia, PennsylvaniaRecruiting
- UI Health Care Mission Cancer and Blood - Ankeny ClinicAnkeny, IowaRecruiting
- UI Health Care Mission Cancer and Blood - Des Moines ClinicDes Moines, IowaRecruiting
- UI Health Care Mission Cancer and Blood - Laurel ClinicDes Moines, IowaRecruiting
- UI Health Care Mission Cancer and Blood - Waukee ClinicWaukee, IowaRecruiting
- UI Health Care Mission Cancer and Blood - West Des Moines ClinicClive, IowaRecruiting
- UNC Lineberger Comprehensive Cancer CenterChapel Hill, North CarolinaRecruiting
- University of Arizona Cancer Center-North CampusTucson, ArizonaRecruiting
- University of California Davis Comprehensive Cancer CenterSacramento, CaliforniaRecruiting
- University of Kansas Cancer CenterKansas City, KansasRecruiting
- University of Kansas Cancer Center - BriarcliffKansas City, MissouriRecruiting
- University of Kansas Cancer Center - Lee's SummitLee's Summit, MissouriRecruiting
- University of Kansas Cancer Center - NorthKansas City, MissouriRecruiting
- University of Kansas Cancer Center-Overland ParkOverland Park, KansasRecruiting
- University of Kansas Hospital-Westwood Cancer CenterWestwood, KansasRecruiting
- University of Michigan - Brighton Center for Specialty CareBrighton, MichiganRecruiting
- University of Michigan Rogel Cancer CenterAnn Arbor, MichiganRecruiting
- University of Oklahoma Health Sciences CenterOklahoma City, OklahomaRecruiting
- University of Pittsburgh Cancer Institute (UPCI)Pittsburgh, PennsylvaniaRecruiting
- University of Wisconsin Carbone Cancer Center - Eastpark Medical CenterMadison, WisconsinRecruiting
- University of Wisconsin Carbone Cancer Center - Johnson CreekJohnson Creek, WisconsinRecruiting
- University of Wisconsin Carbone Cancer Center - University HospitalMadison, WisconsinRecruiting
- UPMC Cancer Center - MonroevilleMonroeville, PennsylvaniaRecruiting
- UPMC Cancer Center at UPMC HorizonFarrell, PennsylvaniaRecruiting
- UPMC Cancer Center at UPMC NorthwestSeneca, PennsylvaniaRecruiting
- UPMC Cancer Center-WashingtonWashington, PennsylvaniaRecruiting
- UPMC Hillman Cancer Center - MonroevilleMonroeville, PennsylvaniaRecruiting
- UPMC Hillman Cancer Center ErieErie, PennsylvaniaRecruiting
- UPMC Washington Hospital Radiation OncologyWashington, PennsylvaniaRecruiting
- UPMC-Johnstown/John P. Murtha Regional Cancer CenterJohnstown, PennsylvaniaRecruiting
- UPMC-Saint Clair Hospital Cancer CenterPittsburgh, PennsylvaniaRecruiting
- UPMC-Saint MargaretPittsburgh, PennsylvaniaRecruiting
- UPMC-Shadyside HospitalPittsburgh, PennsylvaniaRecruiting
- USC / Norris Comprehensive Cancer CenterLos Angeles, CaliforniaRecruiting
- Vanderbilt University/Ingram Cancer CenterNashville, TennesseeRecruiting
- Washington University School of MedicineSt Louis, MissouriRecruiting
- Wexford Health and Wellness PavilionWexford, PennsylvaniaRecruiting
- Methodist Jennie Edmundson HospitalCouncil Bluffs, IowaSuspended
Who can join
Men and women aged 18 and older can join. They must have a confirmed diagnosis of locally recurrent or persistent squamous cell carcinoma in the head and neck. Participants should also have measurable disease and meet certain health criteria. The trial team will check if interested patients meet the eligibility requirements.
What happens during the trial
Participants will be randomly placed into one of three groups. In the first group, patients will have standard salvage surgery. In the second group, patients will receive chemotherapy with carboplatin and paclitaxel before their surgery. The third group will get both chemotherapy and the immunotherapy drug cemiplimab before surgery. All groups will also receive follow-up treatments, including radiation therapy after surgery.
The trial team
The trial is sponsored by the National Cancer Institute (NCI). Dr. Nabil F Saba from NRG Oncology is the principal investigator leading the study.
Important dates
The trial started on April 24, 2026, and is expected to finish by February 1, 2033. It is currently recruiting new participants.
Additional information
The trial's ID number is NCT07195734. This is a Phase 2 trial, which means it is looking at how well the treatments work and how safe they are. The trial hopes to include about 180 participants. The trial uses medications that are regulated by the FDA.
Other recruiting trials for the same condition, with the eligibility rules written in plain language.
Browse similar trials →Find a top oncologist who can tell you whether a trial is a sensible option for you.
Find a doctor →The cancer centers running studies like this one, and what each is known for.
Browse hospitals →