Finding out if Opevesostat helps men with advanced prostate cancer
NCT06136624 · RecruitingAbout this trial
This study looks at how well a new medicine called opevesostat works compared to other treatments for men with advanced prostate cancer that has not responded to hormone therapy. The goal is to see if opevesostat can help people live longer. Participants must have already been treated with certain other therapies before joining the study.
Locations and contact
This trial is running at 282 locations in 36 countries. 224 of them are currently recruiting.
United States44 locations · 31 recruiting
- Anschutz Cancer Pavilion ( Site 0046)Aurora, ColoradoRecruiting
- Atlantic Health System Morristown Medical Center ( Site 0115)Morristown, New JerseyRecruiting
- Avera Cancer Institute - Pierre ( Site 0118)Pierre, South DakotaRecruiting
- Avera Cancer Institute - Yankton ( Site 0117)Yankton, South DakotaRecruiting
- Avera Cancer Institute- Research ( Site 0094)Sioux Falls, South DakotaRecruiting
- Baltimore Veterans Affairs Medical Center ( Site 0069)Baltimore, MarylandRecruiting
- Blue Ridge Cancer Care ( Site 0004)Roanoke, VirginiaRecruiting
- Comprehensive Cancer Centers of Nevada ( Site 0010)Las Vegas, NevadaRecruiting
- Florida Cancer Specialists - South ( Site 7003)Fort Myers, FloridaRecruiting
- Fred Hutchinson Cancer Center ( Site 0013)Seattle, WashingtonRecruiting
- Greenebaum Comprehensive Cancer Center ( Site 0049)Baltimore, MarylandRecruiting
- James J. Peters VA Medical Center ( Site 0088)The Bronx, New YorkRecruiting
- Kaiser Permanente Riverside Medical Center ( Site 0099)Riverside, CaliforniaRecruiting
- M Health Fairview Clinics and Surgery Center ( Site 0019)Minneapolis, MinnesotaRecruiting
- MEDICAL COLLEGE OF WISCONSIN ( Site 0020)Milwaukee, WisconsinRecruiting
- Metro-Minnesota Community Clinical Oncology ( Site 0014)Saint Louis Park, MinnesotaRecruiting
- SCRI Oncology Partners ( Site 7000)Nashville, TennesseeRecruiting
- Stanford Cancer Center ( Site 0036)Palo Alto, CaliforniaRecruiting
- Texas Oncology - Central/South Texas ( Site 8003)Austin, TexasRecruiting
- Texas Oncology - Gulf Coast ( Site 8002)The Woodlands, TexasRecruiting
- University Hospitals Cleveland Medical Center ( Site 0043)Cleveland, OhioRecruiting
- University of Chicago Medical Center ( Site 0045)Chicago, IllinoisRecruiting
- University of Colorado Health - Highlands Ranch Hospital ( Site 0111)Highlands Ranch, ColoradoRecruiting
- University of Colorado Health - Lone Tree Medical Center ( Site 0112)Lone Tree, ColoradoRecruiting
- University of Illinois at Chicago ( Site 0105)Chicago, IllinoisRecruiting
- University of Iowa ( Site 0047)Iowa City, IowaRecruiting
- University of Miami Hospital and Clinics, Sylvester Cancer Center ( Site 0051)Miami, FloridaRecruiting
- University Of Nebraska Medical Center-Oncology/Hematology ( Site 0095)Omaha, NebraskaRecruiting
- University of Virginia Health System ( Site 0054)Charlottesville, VirginiaRecruiting
- VA Portland Health Care System ( Site 0058)Portland, OregonRecruiting
- Yale-New Haven Hospital-Yale Cancer Center ( Site 0064)New Haven, ConnecticutRecruiting
- AHN Allegheny General Hospital ( Site 0001)Pittsburgh, PennsylvaniaActive Not Recruiting
- Bruce W. Carter Veterans Affairs Medical Center ( Site 0082)Miami, FloridaActive Not Recruiting
- Colorado Clinical Research ( Site 0067)Lakewood, ColoradoActive Not Recruiting
- Henry Ford Hospital ( Site 0015)Detroit, MichiganActive Not Recruiting
- Ochsner Clinic Foundation ( Site 0108)New Orleans, LouisianaActive Not Recruiting
- Oregon Health and Science University ( Site 0028)Portland, OregonActive Not Recruiting
- Ralph H. Johnson VA Health Care System (RHJVAHCS)-Urology ( Site 0083)Charleston, South CarolinaActive Not Recruiting
- Rutgers Cancer Institute of New Jersey ( Site 0033)New Brunswick, New JerseyActive Not Recruiting
- Texas Oncology - DFW ( Site 8001)Dallas, TexasActive Not Recruiting
- University of California, Irvine (UCI) Health - UC Irvine Medical Center ( Site 0040)Orange, CaliforniaActive Not Recruiting
- University of Kentucky Chandler Medical Center ( Site 0048)Lexington, KentuckyActive Not Recruiting
- VCU Health Adult Outpatient Pavillion ( Site 0061)Richmond, VirginiaActive Not Recruiting
- Washington University School of Medicine-Internal Medicine/Oncology ( Site 0062)St Louis, MissouriActive Not Recruiting
China39 locations · 39 recruiting
- Affiliated hospital of Jiangnan university ( Site 0434)Wuxi, JiangsuRecruiting
- Beijing Cancer hospital-Urinary Surgery ( Site 0395)Beijing, Beijing MunicipalityRecruiting
- Beijing Friendship Hospital Affiliate of Capital University ( Site 0396)Beijing, Beijing MunicipalityRecruiting
- Chongqing Three Gorges Central Hospital's ( Site 0426)Chongqing, Chongqing MunicipalityRecruiting
- Chongqing University Cancer Hospital ( Site 0416)Chongqing, Chongqing MunicipalityRecruiting
- First Huai'an Hospital Affiliated to Nanjing Medical University ( Site 0436)Huaian, JiangsuRecruiting
- Fudan University Shanghai Cancer Center-Urology department ( Site 0376)Shanghai, Shanghai MunicipalityRecruiting
- Huadong Hospital Affiliated to Fudan University-Urology ( Site 0388)Shanghai, Shanghai MunicipalityRecruiting
- Hubei Cancer Hospital-Urinary surgery ( Site 0406)Wuhan, HubeiRecruiting
- Hunan Cancer Hospital ( Site 0405)Changsha, HunanRecruiting
- Jiangxi Cancer Hospital ( Site 0386)Nanchang, JiangxiRecruiting
- Nanchong Central Hospital-urology ( Site 0422)Nanchong, SichuanRecruiting
- Nanjing Drum Tower Hospital The Affiliated Hospital of Nanjing University Medical School-Urology ( Site 0377)Nanjing, JiangsuRecruiting
- Peking University First Hospital-Urology ( Site 0390)Beijing, Beijing MunicipalityRecruiting
- Second Affiliated hospital of Anhui Medical University-Urology ( Site 0408)Hefei, AnhuiRecruiting
- Southwest Hospital of Third Military Medical University ( Site 0420)Chongqing, Chongqing MunicipalityRecruiting
- Suining Central Hospital ( Site 0437)Suining, SichuanRecruiting
- Sun Yat-sen University Cancer Center-Internal medicine ( Site 0413)Guangzhou, GuangdongRecruiting
- The First Affiliated Hospital of Chongqing Medical University ( Site 0427)Chongqing, Chongqing MunicipalityRecruiting
- The First Affiliated Hospital Of Fujian Medical University-Urology ( Site 0414)Fuzhou, FujianRecruiting
- The First Affiliated Hospital of Guangzhou Medical University ( Site 0412)Guangzhou, GuangdongRecruiting
- The First Affiliated Hospital of Ningbo University ( Site 0383)Ningbo, ZhejiangRecruiting
- The First Affiliated Hospital of Wenzhou Medical University-Urology Surgery ( Site 0379)Wenzhou, ZhejiangRecruiting
- The First Affiliated Hospital of Xi'an Jiaotong University-Oncology ( Site 0393)Xi'an, ShaanxiRecruiting
- The First Affiliated hospital of Xiamen University-Urology ( Site 0415)Xiamen, FujianRecruiting
- The First Hospital of Jiaxing-urology ( Site 0380)Jiaxing, ZhejiangRecruiting
- The Second Affiliated Hospital Of Kunming Medical University ( Site 0429)Kunming, YunnanRecruiting
- The Second Affiliated Hospital of Xi'an Jiaotong University ( Site 0394)Xi'an, ShaanxiRecruiting
- The Second Hospital of Tianjin Medical University ( Site 0391)Tianjin, Tianjin MunicipalityRecruiting
- The Third People's Hospital of Chengdu (CDTPH) ( Site 0428)Chengdu, SichuanRecruiting
- Tianjin Medical University Cancer Institute & Hospital ( Site 0392)Tianjin, Tianjin MunicipalityRecruiting
- Tongji Hospital Tongji Medical,Science & Technology ( Site 0407)Wuhan, HubeiRecruiting
- West China Hospital, Sichuan University-Urology Surgery ( Site 0417)Chengdu, SichuanRecruiting
- Xinjiang Medical University Cancer Hospital - Urumqi-Urology ( Site 0419)Ürümqi, XinjiangRecruiting
- Yantai Yuhuangding Hospital ( Site 0397)Yantai, ShandongRecruiting
- Yunnan Province Cancer Hospital ( Site 0418)Kunming, YunnanRecruiting
- Zhejiang Cancer Hospital ( Site 0435)Hangzhou, ZhejiangRecruiting
- Zhejiang Provincial People's Hospital-Urology ( Site 0378)Hangzhou, ZhejiangRecruiting
- Zhongshan Hospital of Fudan University (0430)Shanghai, ShangaiRecruiting
Japan30 locations · 25 recruiting
- Akita University Hospital ( Site 0904)AkitaRecruiting
- Asahikawa Medical University Hospital ( Site 0901)Asahikawa, HokkaidoRecruiting
- Bell Land General Hospital ( Site 0913)Sakai, OsakaRecruiting
- Ehime University Hospital ( Site 0918)Tōon, EhimeRecruiting
- Fukushima Medical University Hospital ( Site 0933)FukushimaRecruiting
- Gifu University Hospital ( Site 0910)GifuRecruiting
- Hiroshima University Hospital ( Site 0916)HiroshimaRecruiting
- Hokkaido University Hospital ( Site 0931)Sapporo, HokkaidoRecruiting
- Kagawa University Hospital ( Site 0917)Kita, Kagawa-kenRecruiting
- Kagoshima University Hospital ( Site 0929)KagoshimaRecruiting
- Kanazawa Medical University Hospital ( Site 0909)Mukai-awagasaki, Ishikawa-kenRecruiting
- Kansai Medical University Hospital ( Site 0912)Hirakata, OsakaRecruiting
- Kobe University Hospital ( Site 0914)Kobe, HyōgoRecruiting
- Kurume University Hospital ( Site 0920)Kurume, FukuokaRecruiting
- Kyushu University Hospital ( Site 0919)FukuokaRecruiting
- Miyazaki Prefectural Miyazaki Hospital ( Site 0927)MiyazakiRecruiting
- Nagano Municipal Hospital ( Site 0932)NaganoRecruiting
- Nanbu Tokushukai Hospital ( Site 0930)Shimajiri, OkinawaRecruiting
- National Hospital Organization Kumamoto Medical Center ( Site 0924)KumamotoRecruiting
- National Hospital Organization Nagasaki Medical Center ( Site 0923)Ōmura, NagasakiRecruiting
- Sapporo Medical University Hospital ( Site 0902)Sapporo, HokkaidoRecruiting
- The University of Osaka Hospital ( Site 0911)Suita, OsakaRecruiting
- Toho University Sakura Medical Center ( Site 0906)Sakura, ChibaRecruiting
- University of Miyazaki Hospital ( Site 0926)MiyazakiRecruiting
- Yokohama City University Medical Center ( Site 0908)Yokohama, KanagawaRecruiting
- Hospital of the University of Occupational and Environmental Health, Japan ( Site 0921)Kitakyushu, FukuokaActive Not Recruiting
- Nara Medical University Hospital ( Site 0915)Kashihara, NaraActive Not Recruiting
- National Hospital Organization Oita Medical Center ( Site 0925)ŌitaActive Not Recruiting
- Saga-Ken Medical Centre Koseikan ( Site 0922)Saga, Saga-kenActive Not Recruiting
- The Jikei University Hospital ( Site 0907)Minato, TokyoActive Not Recruiting
Netherlands11 locations · 8 recruiting
- ETZ Elisabeth-Internal Medicine ( Site 1160)Tilburg, North BrabantRecruiting
- Franciscus Gasthuis & Vlietland, Locatie Vlietland ( Site 1151)Schiedam, South HollandRecruiting
- Haga Ziekenhuis locatie Leyweg-Oncology ( Site 1164)The Hague, South HollandRecruiting
- Meander Medisch Centrum ( Site 1157)Amersfoort, UtrechtRecruiting
- Medische Centrum Leeuwarden ( Site 1172)Leeuwarden, Provincie FrieslandRecruiting
- Nederlands Kanker Instituut - Antoni van Leeuwenhoek - NKI-AVL ( Site 1153)Amsterdam, North HollandRecruiting
- Radboudumc-Medical Oncology ( Site 1152)Nijmegen, GelderlandRecruiting
- Spaarne Gasthuis - Hoofddorp-Oncology ( Site 1170)Hoofddorp, North HollandRecruiting
- Amsterdam UMC, locatie VUmc ( Site 1156)Amsterdam, North HollandActive Not Recruiting
- VieCuri Medisch Centrum ( Site 1173)Venlo, LimburgActive Not Recruiting
- Zuyderland Medical Centre-Trialbureau Interne Geneeskunde ( Site 1163)Sittard-Geleen, LimburgActive Not Recruiting
Turkey (Türkiye)8 locations · 8 recruiting
- Ankara Bilkent Şehir Hastanesi-Medical Oncology ( Site 1552)AnkaraRecruiting
- Baskent University Dr. Turgut Noyan Research and Training Center-ONCOLOGY ( Site 1554)AdanaRecruiting
- Gulhane Egitim Arastirma Hastanesi ( Site 1558)AnkaraRecruiting
- Hacettepe Universite Hastaneleri-oncology hospital ( Site 1551)AnkaraRecruiting
- Istanbul Universitesi Cerrahpasa-Medical Oncology ( Site 1555)IstanbulRecruiting
- Memorial Ankara Hastanesi-Medical Oncology ( Site 1557)AnkaraRecruiting
- Samsun Medical Park Hastanesi-medical oncology (1560)SamsunRecruiting
- TC Saglik Bakanligi Goztepe Prof. Dr. Suleyman Yalcin Sehir Hastanesi-oncology ( Site 1553)IstanbulRecruiting
France8 locations · 7 recruiting
- Centre Eugène Marquis Rennes - Centre de Lutte Contre le Cancer ( Site 0632)Rennes, Ille-et-VilaineRecruiting
- Centre Hospitalier de la Côte Basque ( Site 0633)Bayonne, Pyrenees-AtlantiquesRecruiting
- Centre Jean Perrin - Centre Régional de Lutte contre le Cancer d'Auvergne ( Site 0629)Clermont-Ferrand, Puy-de-DomeRecruiting
- Centre Oscar Lambret (Site 0634)Lille, AinRecruiting
- Gustave Roussy ( Site 0626)Villejuif, Val-de-MarneRecruiting
- Hôpital Européen Georges Pompidou ( Site 0628)ParisRecruiting
- Institut de cancérologie Strasbourg Europe (ICANS) ( Site 0627)Strasbourg, AlsaceRecruiting
- Centre Hospitalier Universitaire de Nîmes - Institut de Cancérologie du Gard - Hôpital Universitaire ( Site 0630)Nîmes, GardActive Not Recruiting
Germany8 locations · 7 recruiting
- Charité Universitaetsmedizin Berlin - Campus Mitte ( Site 0679)BerlinRecruiting
- HELIOS Kliniken Schwerin ( Site 0694)Schwerin, Mecklenburg-VorpommernRecruiting
- Universitaetsklinikum Hamburg-Eppendorf-Onkologisches Zentrum ( Site 0705)HamburgRecruiting
- Universitätsklinikum Bonn-Klinik und Poliklinik für Urologie und Kinderurologie ( Site 0680)Bonn, North Rhine-WestphaliaRecruiting
- Universitätsklinikum Jena-Klinik und Poliklinik für Urologie ( Site 0682)Jena, ThuringiaRecruiting
- Universitätsklinikum Münster - Albert Schweitzer Campus-Klinik für Urologie ( Site 0678)Münster, North Rhine-WestphaliaRecruiting
- Universitätsklinikum Schleswig-Holstein-Klinik für Urologie ( Site 0691)Lübeck, Schleswig-HolsteinRecruiting
- klinikum rechts der isar der technischen universität münchen-Urologische Klinik und Poliklinik ( Site 0696)Munich, BavariaActive Not Recruiting
Spain7 locations · 7 recruiting
- Complexo Hospitalario Universitario de Ourense ( Site 1426)Ourense, OrenseRecruiting
- Fundación Instituto Valenciano de Oncología-Oncologico ( Site 1430)Valencia, Valenciana, ComunitatRecruiting
- Hospital Jerez de la Frontera ( Site 1427)Jerez de la Frontera, CadizRecruiting
- Hospital Lucus Augusti-Oncology ( Site 1432)LugoRecruiting
- Hospital Universitario 12 de Octubre-Medical Oncology ( Site 1433)Madrid, Madrid, Comunidad deRecruiting
- Hospital Universitario Ramón y Cajal-Medical Oncology ( Site 1431)Madrid, Madrid, Comunidad deRecruiting
- HOSPITAL UNIVERSITARIO VIRGEN DEL ROCIO-Medical Oncology ( Site 1428)SevilleRecruiting
Canada8 locations · 6 recruiting
- Centre intégré de cancérologie du CHU de Québec Université Laval, Hôpital de l'Enfant-Jésus ( Site 0327)Québec, QuebecRecruiting
- Centre Intégré de Santé et de Services Sociaux de la Montérégie-Centre ( Site 0328)Greenfield Park, QuebecRecruiting
- Cross Cancer Institute ( Site 0332)Edmonton, AlbertaRecruiting
- Princess Margaret Cancer Centre ( Site 0330)Toronto, OntarioRecruiting
- Sunnybrook Research Institute ( Site 0331)Toronto, OntarioRecruiting
- The Ottawa Hospital - General Campus-The Ottawa Hospital Cancer Centre ( Site 0336)Ottawa, OntarioRecruiting
- Centre Hospitalier de l'Université de Montréal ( Site 0326)Montreal, QuebecActive Not Recruiting
- Centre intégré universitaire de santé et de services sociaux de l'Estrie - Centre Hospitalier Univer ( Site 0329)Sherbrooke, QuebecActive Not Recruiting
Argentina7 locations · 6 recruiting
- Asociación de Beneficencia Hospital Sirio Libanés ( Site 0205)Buenos Aires, Buenos Aires F.D.Recruiting
- Hospital Aleman-Oncology ( Site 0207)Buenos AiresRecruiting
- Hospital Británico de Buenos Aires-Oncology ( Site 0202)Ciudad Autónoma de Buenos Aires, Buenos AiresRecruiting
- Instituto Alexander Fleming-Alexander Fleming ( Site 0206)Buenos Aires, Buenos Aires F.D.Recruiting
- Instituto de Investigaciones Clínicas Mar del Plata ( Site 0201)Mar del Plata, Buenos AiresRecruiting
- Sanatorio Parque ( Site 0208)Rosario, Santa Fe ProvinceRecruiting
- Fundacion Centro Oncologico de Integración Regional-Medical Oncology ( Site 0204)MendozaActive Not Recruiting
Poland7 locations · 6 recruiting
- Centrum Onkologii im. Prof. Franciszka Lukaszczyka-Ambulatorium Chemioterapii ( Site 1302)Bydgoszcz, Kuyavian-Pomeranian VoivodeshipRecruiting
- Mazowiecki Szpital Wojewódzki w Siedlcach-Siedleckie Centrum Onkologii ( Site 1310)Siedlce, Masovian VoivodeshipRecruiting
- Regionalny Szpital Specjalistyczny im. dr. Władyslawa Biegańskiego ( Site 1316)Grudziądz, Kuyavian-Pomeranian VoivodeshipRecruiting
- Swietokrzyskie Centrum Onkologii, Samodzielny Publiczny Zakl-Klinika Onkologii Klinicznej, Dzial Ch ( Site 1318)Kielce, Świętokrzyskie VoivodeshipRecruiting
- Szpital Wojewódzki im. Mikoaja Kopernika w Koszalinie-Oddzial Dzienny Chemioterapii ( Site 1303)Koszalin, West Pomeranian VoivodeshipRecruiting
- Zachodniopomorskie Centrum Onkologii ( Site 1311)Szczecin, West Pomeranian VoivodeshipRecruiting
- Wojewodzki Szpital Zespolony im Ludwika Rydygiera w Toruniu ( Site 1304)Torun, Kuyavian-Pomeranian VoivodeshipActive Not Recruiting
Israel6 locations · 6 recruiting
- Emek Medical Center ( Site 0830)AfulaRecruiting
- Hadassah Medical Center ( Site 0833)JerusalemRecruiting
- Meir Medical Center. ( Site 0832)Kfar SabaRecruiting
- Rabin Medical Center ( Site 0828)Petah TikvaRecruiting
- Rambam Health Care Campus-Oncology Division ( Site 0826)HaifaRecruiting
- Sheba Medical Center ( Site 0827)Ramat GanRecruiting
Colombia6 locations · 5 recruiting
- Clinica Colsanitas S.A, Sede Clínica Universitaria Colombia-Center Investigator ( Site 0501)Bogotá, Bogota D.C.Recruiting
- Fundación Cardiovascular de Colombia ( Site 0503)Piedecuesta, Santander DepartmentRecruiting
- Fundación Valle del Lili ( Site 0505)Cali, Valle del Cauca DepartmentRecruiting
- IMAT S.A.S ( Site 0504)Montería, Departamento de CórdobaRecruiting
- Sociedad De Oncología y Hematología Del Cesar SAS-Oncology ( Site 0502)Valledupar, Cesar DepartmentRecruiting
- Clínica Imbanaco S.A.S ( Site 0509)Cali, Valle del Cauca DepartmentActive Not Recruiting
United Kingdom6 locations · 5 recruiting
- Addenbrooke's Hospital ( Site 1605)Cambridge, CambridgeshireRecruiting
- Charing Cross Hospital-Oncology Research ( Site 1606)London, Hammersmith and FulhamRecruiting
- The Beatson West of Scotland Cancer Centre ( Site 1603)Glasgow, Glasgow CityRecruiting
- The Christie NHS Foundation Trust ( Site 1608)ManchesterRecruiting
- The Royal Cornwall Hospital ( Site 1610)Truro, EnglandRecruiting
- University College London Hospital ( Site 1612)London, London, City ofActive Not Recruiting
Malaysia5 locations · 4 recruiting
- Hospital Kuala Lumpur-Radiotherapy and Oncology ( Site 1078)Kuala LumpurRecruiting
- Hospital Sultan Ismail ( Site 1081)Johor Bahru, JohorRecruiting
- National Cancer Institute ( Site 1079)Putrajaya, PutrajayaRecruiting
- Sarawak General Hospital-Radiotherapy Unit ( Site 1076)Kuching, SarawakRecruiting
- University Malaya Medical Centre ( Site 1077)Lembah Pantai, Kuala LumpurActive Not Recruiting
Taiwan5 locations · 4 recruiting
- Chang Gung Medical Foundation-Linkou Branch-Medical Oncology ( Site 1504)TaoyuanRecruiting
- China Medical University Hospital-Department of Urology ( Site 1503)TaichungRecruiting
- National Cheng Kung University Hospital-Urology ( Site 1502)TainanRecruiting
- Taipei Veterans General Hospital ( Site 1505)TaipeiRecruiting
- National Taiwan University Hospital-Urology ( Site 1506)TaipeiActive Not Recruiting
Hungary4 locations · 4 recruiting
- Bacs-Kiskun Varmegyei Oktatokorhaz-Onkoradiologiai Kozpont ( Site 0752)Kecskemét, Bács-Kiskun countyRecruiting
- Debreceni Egyetem Klinikai Kozpont-Onkológiai Klinika ( Site 0758)DebrecenRecruiting
- Nograd Varmegyei Szent Lazar Korhaz-Onkologia es Sugarterapias Osztaly ( Site 0761)Salgótarján, Nógrád megyeRecruiting
- Országos Onkológiai Intézet-Urogenitális Tumorok és Klinikai Farmakológiai Osztály ( Site 0756)Budapest, Pest CountyRecruiting
Thailand4 locations · 4 recruiting
- Chulalongkorn University ( Site 1530)Bangkok, BangkokRecruiting
- Faculty of Medicine - Khon Kaen University ( Site 1526)Muang, Changwat Khon KaenRecruiting
- Faculty of Medicine Siriraj Hospital ( Site 1531)Bangkok, BangkokRecruiting
- Songklanagarind hospital ( Site 1527)Hat Yai, Changwat SongkhlaRecruiting
Brazil8 locations · 3 recruiting
- Clínica de Neoplasias Litoral ( Site 0305)Itajaí, Santa CatarinaRecruiting
- Hospital Felicio Rocho ( Site 0317)Belo Horizonte, Minas GeraisRecruiting
- Hospital Santa Rita de Cassia-Centro de Pesquisa Clínica ( Site 0320)Vitória, Espírito SantoRecruiting
- A. C. Camargo Cancer Center ( Site 0310)São Paulo, São PauloActive Not Recruiting
- Hospital Mario Penna ( Site 0309)Belo Horizonte, Minas GeraisActive Not Recruiting
- Hospital Universitário Evangélico Mackenzie-Centro de Oncologia Mackenzie ( Site 0314)Curitiba, ParanáActive Not Recruiting
- Hospital Universitário São Francisco de Assis - Bragança Paulista ( Site 0308)Bragança Paulista, São PauloActive Not Recruiting
- Obras Sociais Irma Dulce ( Site 0302)Salvador, Estado de BahiaActive Not Recruiting
Chile7 locations · 3 recruiting
- Bradfordhill-Clinical Area ( Site 0351)Santiago, Region M. de SantiagoRecruiting
- Clinica Universidad Catolica del Maule-Oncology ( Site 0355)Talca, Maule RegionRecruiting
- Pontificia Universidad Catolica de Chile-Hemato-Oncology ( Site 0354)Santiago, Region M. de SantiagoRecruiting
- Bradford Hill Norte ( Site 0357)AntofagastaActive Not Recruiting
- Clinical Research Chile SpA ( Site 0358)Valdivia, Los Ríos RegionActive Not Recruiting
- FALP ( Site 0353)Santiago, Region M. de SantiagoActive Not Recruiting
- IC La Serena Research ( Site 0356)La Serena, Coquimbo RegionActive Not Recruiting
Peru6 locations · 3 recruiting
- Clínica Sánchez Ferrer ( Site 1261)Trujillo, La LibertadRecruiting
- INSTITUTO NACIONAL DE ENFERMEDADES NEOPLASICAS-Medical Oncology ( Site 1256)LimaRecruiting
- Instituto Regional de Enfermedades Neoplasicas del Centro (IREN CENTRO) ( Site 1258)Concepción, Departamento de JunínRecruiting
- Aliada-Oncologìa ( Site 1257)LimaActive Not Recruiting
- IPOR Instituto Peruano de Oncología & Radioterapia-Centro de Investigación ( Site 1254)LimaActive Not Recruiting
- Oncosalud-Clinical Research ( Site 1260)LimaActive Not Recruiting
Australia5 locations · 3 recruiting
- Dubbo Hospital ( Site 0235)Dubbo, New South WalesRecruiting
- Macquarie University-MQ Health Clinical Trials Unit ( Site 0234)Macquarie University, New South WalesRecruiting
- Princess Alexandra Hospital-Cancer Care Serices ( Site 0237)Brisbane, QueenslandRecruiting
- Peter MacCallum Cancer Centre-Parkville Cancer Clinical Trials Unit (PCCTU) ( Site 0230)Melbourne, VictoriaActive Not Recruiting
- Westmead Hospital ( Site 0232)Westmead, New South WalesActive Not Recruiting
Czechia4 locations · 3 recruiting
- Fakultni nemocnice Olomouc-Onkologicka klinika ( Site 0555)Olomouc, Olomouc RegionRecruiting
- Fakultni nemocnice Ostrava-Klinika onkologicka ( Site 0554)Ostrava, Moravian-Silesian RegionRecruiting
- Masarykuv onkologicky ustav-Klinika komplexni onkologicke pece ( Site 0553)Brno, Brno-mestoRecruiting
- Fakultni nemocnice v Motole-Onkologicka klinika 2. LF UK a FN Motol ( Site 0551)Prague, Praha 5Active Not Recruiting
South Korea4 locations · 3 recruiting
- Samsung Medical Center ( Site 1405)SeoulRecruiting
- Seoul National University Hospital-Oncology ( Site 1401)SeoulRecruiting
- Severance Hospital, Yonsei University Health System-Medical oncology ( Site 1404)SeoulRecruiting
- Asan Medical Center-Oncology ( Site 1402)Songpagu, SeoulActive Not Recruiting
Austria3 locations · 3 recruiting
- Klinikum Wels-Grieskirchen GmbH ( Site 0279)Wels, Upper AustriaRecruiting
- Medizinische Universität Graz-Innere Medizin Klin. Abt. Onkologie ( Site 0280)Graz, StyriaRecruiting
- Ordensklinikum Linz GmbH Elisabethinen-Urologie ( Site 0276)Linz, Upper AustriaRecruiting
Finland3 locations · 3 recruiting
- Kuopion Yliopistollinen Sairaala ( Site 0603)Kuopio, Northern SavoniaRecruiting
- Tampereen yliopistollinen sairaala ( Site 0604)Tampere, PirkanmaaRecruiting
- Turku University Hospital-Department of Oncology ( Site 0601)Turku, Southwest FinlandRecruiting
Italy3 locations · 3 recruiting
- Fondazione IRCCS Istituto Nazionale dei Tumori-Struttura Complessa Oncologia Medica 1 ( Site 0877)Milan, LombardyRecruiting
- IRCCS - Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori"-Oncologia Medica ( Site 0879)Meldola, Emilia-RomagnaRecruiting
- Ospedale San Raffaele-Oncologia Medica ( Site 0876)MilanRecruiting
Singapore3 locations · 3 recruiting
- National Cancer Centre Singapore ( Site 1377)Singapore, Central SingaporeRecruiting
- National University Hospital ( Site 1376)Singapore, Central SingaporeRecruiting
- Tan Tock Seng Hospital-Medical Oncology ( Site 1378)Singapore, Central SingaporeRecruiting
Denmark3 locations · 2 recruiting
- Rigshospitalet ( Site 0576)Copenhagen, Capital RegionRecruiting
- Vejle Sygehus ( Site 0578)Vejle, Region SyddanmarkRecruiting
- Odense Universitetshospital-Department of oncology ( Site 0579)Odense, Region SyddanmarkActive Not Recruiting
Sweden3 locations · 2 recruiting
- Akademiska sjukhuset-Blod- och tumörsjukdomar ( Site 1477)Uppsala, Uppsala CountyRecruiting
- Sahlgrenska Universitetssjukhuset ( Site 1479)Gothenburg, Västra Götaland CountyRecruiting
- Karolinska Universitetssjukhuset Solna ( Site 1478)Stockholm, Stockholm CountyActive Not Recruiting
Hong Kong2 locations · 2 recruiting
- Prince of Wales Hospital ( Site 0730)ShatinRecruiting
- Queen Mary Hospital ( Site 0727)Hong KongRecruiting
Ireland2 locations · 2 recruiting
- St. Vincent's University Hospital ( Site 0802)Dublin, DublinRecruiting
- Tallaght University Hospital ( Site 0801)DublinRecruiting
New Zealand2 locations · 2 recruiting
- Dunedin Hospital-Southern Blood and Cancers Service ( Site 1203)Dunedin, OtagoRecruiting
- Tauranga Hospital-Bay of Plenty Clinical Trials Unit ( Site 1201)Tauranga, Bay of PlentyRecruiting
Norway3 locations · 1 recruiting
- Akershus Universitetssykehus-Onkologisk avdeling ( Site 1227)Lørenskog, AkershusRecruiting
- St. Olavs Hospital-Kreftklinikken ( Site 1231)Trondheim, Sor-TrondelagActive Not Recruiting
- Sykehuset Østfold Kalnes ( Site 1228)Sarpsborg, Østfold fylkeActive Not Recruiting
Puerto Rico3 locations · 1 recruiting
- Ad-Vance Medical Research-Research ( Site 1353)PonceRecruiting
- Pan American Center for Oncology Trials - Ciudadela ( Site 1351)San JuanActive Not Recruiting
- Puerto Rico Medical Research Center LLC ( Site 1354)Hato ReyActive Not Recruiting
Mexico5 locations
- Centro de Investigacion Clinica de Oaxaca ( Site 1109)Oaxaca CityActive Not Recruiting
- CIO - Centro de Inmuno-Oncología de Occidente ( Site 1103)Guadalajara, JaliscoActive Not Recruiting
- Filios Alta Medicina ( Site 1106)Monterrey, Nuevo LeónActive Not Recruiting
- Medical Care and Research SA de CV ( Site 1108)Mérida, YucatánActive Not Recruiting
- Quemex Medical and Research ( Site 1112)Mexico City, Mexico CityActive Not Recruiting
Who to ask about joining
Toll Free Number1-888-577-8839Trialsites@msd.com
Who can join
Men and women can join if they are adults or older adults with a specific type of prostate cancer. They should have had previous treatments that have not worked well. The study team will check to make sure each person meets the criteria to join.
What happens during the trial
Participants will be divided into two groups by chance. One group will take opevesostat along with other medicines. The other group will receive one of the existing treatments, either abiraterone or enzalutamide. Everyone will take their assigned treatment until their condition progresses.
The trial team
The study is sponsored by Merck Sharp & Dohme LLC, with collaboration from Orion Corporation and Orion Pharma. The lead medical director from Merck is overseeing the trial.
Important dates
The trial began on December 31, 2023, and is expected to finish by February 15, 2030. It is currently enrolling new participants.
Additional information
This is a Phase 3 trial, meaning it is looking at how well the treatment works and how safe it is. The study is regulated by the FDA and aims to include about 1,310 participants.
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