Giving Hope: A Study to Improve Treatment for Children with Hard-to-Treat Leukemia
NCT04726241 · RecruitingAbout this trial
This study looks at children, teens, and young adults with leukemia that has come back after treatment or is hard to treat. The goal is to use tests on blood and bone marrow to find the best ways to treat these patients. Researchers want to gather important information from these samples to improve how leukemia is diagnosed and treated.
Locations and contact
This trial is running at 183 locations in 5 countries. 173 of them are currently recruiting.
United States164 locations · 155 recruiting
- Advocate Children's Hospital-Oak LawnOak Lawn, IllinoisRecruiting
- Advocate Children's Hospital-Park RidgePark Ridge, IllinoisRecruiting
- Albany Medical CenterAlbany, New YorkRecruiting
- Alfred I duPont Hospital for ChildrenWilmington, DelawareRecruiting
- Alliance for Childhood Diseases/Cure 4 the Kids FoundationLas Vegas, NevadaRecruiting
- Arkansas Children's HospitalLittle Rock, ArkansasRecruiting
- Arnold Palmer Hospital for ChildrenOrlando, FloridaRecruiting
- Ascension Saint Vincent Indianapolis HospitalIndianapolis, IndianaRecruiting
- Banner Children's at DesertMesa, ArizonaRecruiting
- Banner University Medical Center - TucsonTucson, ArizonaRecruiting
- Baylor College of Medicine/Dan L Duncan Comprehensive Cancer CenterHouston, TexasRecruiting
- BI-LO Charities Children's Cancer CenterGreenville, South CarolinaRecruiting
- Blank Children's HospitalDes Moines, IowaRecruiting
- Bronson Methodist HospitalKalamazoo, MichiganRecruiting
- Broward Health Medical CenterFort Lauderdale, FloridaRecruiting
- C S Mott Children's HospitalAnn Arbor, MichiganRecruiting
- Cardinal Glennon Children's Medical CenterSt Louis, MissouriRecruiting
- Carilion Children'sRoanoke, VirginiaRecruiting
- Carolinas Medical Center/Levine Cancer InstituteCharlotte, North CarolinaRecruiting
- Children's Healthcare of Atlanta - Arthur M Blank HospitalAtlanta, GeorgiaRecruiting
- Children's Hospital and Medical Center of OmahaOmaha, NebraskaRecruiting
- Children's Hospital ColoradoAurora, ColoradoRecruiting
- Children's Hospital Los AngelesLos Angeles, CaliforniaRecruiting
- Children's Hospital Medical Center of AkronAkron, OhioRecruiting
- Children's Hospital New OrleansNew Orleans, LouisianaRecruiting
- Children's Hospital of AlabamaBirmingham, AlabamaRecruiting
- Children's Hospital of MichiganDetroit, MichiganRecruiting
- Children's Hospital of Orange CountyOrange, CaliforniaRecruiting
- Children's Hospital of PhiladelphiaPhiladelphia, PennsylvaniaRecruiting
- Children's Hospital of Pittsburgh of UPMCPittsburgh, PennsylvaniaRecruiting
- Children's Hospital of San AntonioSan Antonio, TexasRecruiting
- Children's Hospital of The King's DaughtersNorfolk, VirginiaRecruiting
- Children's Hospitals and Clinics of Minnesota - MinneapolisMinneapolis, MinnesotaRecruiting
- Children's Mercy Hospitals and ClinicsKansas City, MissouriRecruiting
- Children's National Medical CenterWashington D.C., District of ColumbiaRecruiting
- Cincinnati Children's Hospital Medical CenterCincinnati, OhioRecruiting
- Connecticut Children's Medical CenterHartford, ConnecticutRecruiting
- Cook Children's Medical CenterFort Worth, TexasRecruiting
- Corewell Health Children'sRoyal Oak, MichiganRecruiting
- Corewell Health Grand Rapids Hospitals - Helen DeVos Children's HospitalGrand Rapids, MichiganRecruiting
- Covenant Children's HospitalLubbock, TexasRecruiting
- Dana-Farber Cancer InstituteBoston, MassachusettsRecruiting
- Dartmouth Hitchcock Medical Center/Dartmouth Cancer CenterLebanon, New HampshireRecruiting
- Dayton Children's HospitalDayton, OhioRecruiting
- Dell Children's Medical Center of Central TexasAustin, TexasRecruiting
- Driscoll Children's HospitalCorpus Christi, TexasRecruiting
- Duke University Medical CenterDurham, North CarolinaRecruiting
- East Carolina UniversityGreenville, North CarolinaRecruiting
- East Tennessee Childrens HospitalKnoxville, TennesseeRecruiting
- Eastern Maine Medical CenterBangor, MaineRecruiting
- El Paso Children's HospitalEl Paso, TexasRecruiting
- Geisinger Medical CenterDanville, PennsylvaniaRecruiting
- Golisano Children's Hospital of Southwest FloridaFort Myers, FloridaRecruiting
- Hackensack University Medical CenterHackensack, New JerseyRecruiting
- Inova Fairfax HospitalFalls Church, VirginiaRecruiting
- Jersey Shore Medical CenterNeptune City, New JerseyRecruiting
- Johns Hopkins All Children's HospitalSt. Petersburg, FloridaRecruiting
- Johns Hopkins University/Sidney Kimmel Cancer CenterBaltimore, MarylandRecruiting
- Kaiser Permanente Downey Medical CenterDowney, CaliforniaRecruiting
- Kaiser Permanente-OaklandOakland, CaliforniaRecruiting
- Kapiolani Medical Center for Women and ChildrenHonolulu, HawaiiRecruiting
- Laura and Isaac Perlmutter Cancer Center at NYU LangoneNew York, New YorkRecruiting
- Legacy Emanuel Children's HospitalPortland, OregonRecruiting
- Lehigh Valley Hospital-Cedar CrestAllentown, PennsylvaniaRecruiting
- Loma Linda University Medical CenterLoma Linda, CaliforniaRecruiting
- Loyola University Medical CenterMaywood, IllinoisRecruiting
- Lucile Packard Children's Hospital Stanford UniversityPalo Alto, CaliforniaRecruiting
- Lurie Children's Hospital-ChicagoChicago, IllinoisRecruiting
- M D Anderson Cancer CenterHouston, TexasRecruiting
- Madigan Army Medical CenterTacoma, WashingtonRecruiting
- Maimonides Medical CenterBrooklyn, New YorkRecruiting
- Maine Children's Cancer ProgramScarborough, MaineRecruiting
- Marshfield Medical Center-MarshfieldMarshfield, WisconsinRecruiting
- Mary Bridge Children's Hospital and Health CenterTacoma, WashingtonRecruiting
- Mayo Clinic in RochesterRochester, MinnesotaRecruiting
- Medical City Dallas HospitalDallas, TexasRecruiting
- Medical University of South CarolinaCharleston, South CarolinaRecruiting
- Memorial Health University Medical CenterSavannah, GeorgiaRecruiting
- Memorial Regional Hospital/Joe DiMaggio Children's HospitalHollywood, FloridaRecruiting
- Memorial Sloan Kettering Cancer CenterNew York, New YorkRecruiting
- Mercy Hospital Saint LouisSt Louis, MissouriRecruiting
- Methodist Children's Hospital of South TexasSan Antonio, TexasRecruiting
- Miller Children's and Women's Hospital Long BeachLong Beach, CaliforniaRecruiting
- Mission HospitalAsheville, North CarolinaRecruiting
- Morristown Medical CenterMorristown, New JerseyRecruiting
- Nationwide Children's HospitalColumbus, OhioRecruiting
- Nemours Children's Clinic - PensacolaPensacola, FloridaRecruiting
- Nemours Children's Clinic-JacksonvilleJacksonville, FloridaRecruiting
- Nemours Children's HospitalOrlando, FloridaRecruiting
- New York Medical CollegeValhalla, New YorkRecruiting
- Nicklaus Children's HospitalMiami, FloridaRecruiting
- Northwestern Medicine Central DuPage HospitalWinfield, IllinoisRecruiting
- Norton Children's HospitalLouisville, KentuckyRecruiting
- Novant Health Presbyterian Medical CenterCharlotte, North CarolinaRecruiting
- NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer CenterNew York, New YorkRecruiting
- NYU Langone Hospital - Long IslandMineola, New YorkRecruiting
- Ochsner Medical Center JeffersonNew Orleans, LouisianaRecruiting
- Oregon Health and Science UniversityPortland, OregonRecruiting
- Penn State Children's HospitalHershey, PennsylvaniaRecruiting
- Phoenix Childrens HospitalPhoenix, ArizonaRecruiting
- Primary Children's HospitalSalt Lake City, UtahRecruiting
- Prisma Health Richland HospitalColumbia, South CarolinaRecruiting
- ProMedica Toledo Hospital/Russell J Ebeid Children's HospitalToledo, OhioRecruiting
- Providence Alaska Medical CenterAnchorage, AlaskaRecruiting
- Providence Sacred Heart Medical Center and Children's HospitalSpokane, WashingtonRecruiting
- Rainbow Babies and Childrens HospitalCleveland, OhioRecruiting
- Renown Regional Medical CenterReno, NevadaRecruiting
- Rhode Island HospitalProvidence, Rhode IslandRecruiting
- Riley Hospital for ChildrenIndianapolis, IndianaRecruiting
- Rocky Mountain Hospital for Children-Presbyterian Saint Luke's Medical CenterDenver, ColoradoRecruiting
- Rutgers Cancer Institute of New Jersey-Robert Wood Johnson University HospitalNew Brunswick, New JerseyRecruiting
- Saint Christopher's Hospital for ChildrenPhiladelphia, PennsylvaniaRecruiting
- Saint Joseph's Hospital/Children's Hospital-TampaTampa, FloridaRecruiting
- Saint Joseph's Regional Medical CenterPaterson, New JerseyRecruiting
- Saint Jude Children's Research HospitalMemphis, TennesseeRecruiting
- Saint Jude Midwest AffiliatePeoria, IllinoisRecruiting
- Saint Luke's Cancer Institute - BoiseBoise, IdahoRecruiting
- Saint Mary's Medical CenterWest Palm Beach, FloridaRecruiting
- Saint Peter's University HospitalNew Brunswick, New JerseyRecruiting
- Sanford Broadway Medical CenterFargo, North DakotaRecruiting
- Sanford USD Medical Center - Sioux FallsSioux Falls, South DakotaRecruiting
- Seattle Children's HospitalSeattle, WashingtonRecruiting
- Sinai Hospital of BaltimoreBaltimore, MarylandRecruiting
- Southern Illinois University School of MedicineSpringfield, IllinoisRecruiting
- State University of New York Upstate Medical UniversitySyracuse, New YorkRecruiting
- Stony Brook University Medical CenterStony Brook, New YorkRecruiting
- Summerlin Hospital Medical CenterLas Vegas, NevadaRecruiting
- The Children's Hospital at TriStar CentennialNashville, TennesseeRecruiting
- The Steven and Alexandra Cohen Children's Medical Center of New YorkNew Hyde Park, New YorkRecruiting
- UCSF Benioff Children's Hospital OaklandOakland, CaliforniaRecruiting
- UCSF Medical Center-Mission BaySan Francisco, CaliforniaRecruiting
- UF Health Cancer Institute - GainesvilleGainesville, FloridaRecruiting
- UMC Cancer Center / UMC Health SystemLubbock, TexasRecruiting
- UNC Lineberger Comprehensive Cancer CenterChapel Hill, North CarolinaRecruiting
- University of Chicago Comprehensive Cancer CenterChicago, IllinoisRecruiting
- University of IllinoisChicago, IllinoisRecruiting
- University of Iowa/Holden Comprehensive Cancer CenterIowa City, IowaRecruiting
- University of Kentucky/Markey Cancer CenterLexington, KentuckyRecruiting
- University of Minnesota/Masonic Cancer CenterMinneapolis, MinnesotaRecruiting
- University of Missouri Children's HospitalColumbia, MissouriRecruiting
- University of Nebraska Medical CenterOmaha, NebraskaRecruiting
- University of New Mexico Cancer CenterAlbuquerque, New MexicoRecruiting
- University of Oklahoma Health Sciences CenterOklahoma City, OklahomaRecruiting
- University of Texas Health Science Center at San AntonioSan Antonio, TexasRecruiting
- University of Virginia Cancer CenterCharlottesville, VirginiaRecruiting
- University of Wisconsin Carbone Cancer Center - University HospitalMadison, WisconsinRecruiting
- USA Health Strada Patient Care CenterMobile, AlabamaRecruiting
- UT Southwestern/Simmons Cancer Center-DallasDallas, TexasRecruiting
- Valley Children's HospitalMadera, CaliforniaRecruiting
- Vanderbilt University/Ingram Cancer CenterNashville, TennesseeRecruiting
- VCU Massey Comprehensive Cancer CenterRichmond, VirginiaRecruiting
- Wake Forest University Health SciencesWinston-Salem, North CarolinaRecruiting
- Washington University School of MedicineSt Louis, MissouriRecruiting
- West Virginia University HealthcareMorgantown, West VirginiaRecruiting
- Yale UniversityNew Haven, ConnecticutRecruiting
- Rady Children's Hospital - San DiegoSan Diego, CaliforniaNot Yet Recruiting
- Cleveland Clinic FoundationCleveland, OhioActive Not Recruiting
- MedStar Georgetown University HospitalWashington D.C., District of ColumbiaActive Not Recruiting
- Michigan State UniversityEast Lansing, MichiganActive Not Recruiting
- Montefiore Medical Center - Moses CampusThe Bronx, New YorkSuspended
- Sacred Heart HospitalPensacola, FloridaActive Not Recruiting
- University of Mississippi Medical CenterJackson, MississippiSuspended
- University of RochesterRochester, New YorkActive Not Recruiting
- Walter Reed National Military Medical CenterBethesda, MarylandSuspended
Canada12 locations · 12 recruiting
- Alberta Children's HospitalCalgary, AlbertaRecruiting
- British Columbia Children's HospitalVancouver, British ColumbiaRecruiting
- CancerCare ManitobaWinnipeg, ManitobaRecruiting
- Centre Hospitalier Universitaire de Sherbrooke-FleurimontSherbrooke, QuebecRecruiting
- Centre Hospitalier Universitaire Sainte-JustineMontreal, QuebecRecruiting
- Children's HospitalLondon, OntarioRecruiting
- Children's Hospital of Eastern OntarioOttawa, OntarioRecruiting
- CHU de Quebec-Centre Hospitalier de l'Universite Laval (CHUL)QuébecRecruiting
- Hospital for Sick ChildrenToronto, OntarioRecruiting
- IWK Health CentreHalifax, Nova ScotiaRecruiting
- The Montreal Children's Hospital of the MUHCMontreal, QuebecRecruiting
- University of Alberta HospitalEdmonton, AlbertaRecruiting
Australia4 locations · 4 recruiting
- Perth Children's HospitalPerth, Western AustraliaRecruiting
- Queensland Children's HospitalSouth Brisbane, QueenslandRecruiting
- Royal Children's HospitalParkville, VictoriaRecruiting
- The Children's Hospital at WestmeadWestmead, New South WalesRecruiting
New Zealand2 locations · 2 recruiting
- Christchurch HospitalChristchurchRecruiting
- Starship Children's HospitalGrafton, AucklandRecruiting
Puerto Rico1 location
- HIMA San Pablo Oncologic HospitalCaguasActive Not Recruiting
Who to ask about joining
Site Public Contact205-638-9285oncologyresearch@peds.uab.edu
Site Public Contact800-388-8721
Site Public Contact907-212-6871AKPAMC.OncologyResearchSupport@providence.org
Who can join
Children and young adults under 22 years old can join this study. They must have specific types of leukemia that have returned after treatment or are not responding to treatment. Parents or guardians must give permission for their child to participate. The trial team will confirm eligibility.
What happens during the trial
Participants will provide blood and/or bone marrow samples at different times: when they start the study, after treatment cycles, and if their leukemia does not get better. Everyone in the study will take part in this sample collection process.
The trial team
The study is sponsored by PedAL BCU, LLC, in collaboration with the Children's Oncology Group and the National Cancer Institute. Dr. Michele S Redell from the Children's Oncology Group is the principal investigator.
Important dates
The trial started on April 18, 2022, and is expected to be completed by December 31, 2030. It is currently enrolling new participants.
Additional information
The trial's ID number is NCT04726241. It is in Phase 1 and Phase 2, which means it is looking at the safety and effectiveness of treatments. This study is not regulated by the FDA, and it hopes to include around 960 participants.
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