Helping Children with High-Risk Neuroblastoma through New Treatment Options
NCT03126916 · RecruitingAbout this trial
This trial looks at how well adding either iobenguane I-131 or lorlatinib to standard treatment helps children with high-risk neuroblastoma. Iobenguane I-131 is a radioactive drug that may target tumor cells while sparing normal cells. Lorlatinib may stop tumor cell growth by blocking certain enzymes. The main goal is to see if these additions improve outcomes for young patients with this type of cancer.
Locations and contact
This trial is running at 162 locations in 3 countries. 145 of them are currently recruiting.
United States152 locations · 145 recruiting
- AdventHealth OrlandoOrlando, FloridaRecruiting
- Advocate Children's Hospital-Oak LawnOak Lawn, IllinoisRecruiting
- Advocate Children's Hospital-Park RidgePark Ridge, IllinoisRecruiting
- Albany Medical CenterAlbany, New YorkRecruiting
- Alfred I duPont Hospital for ChildrenWilmington, DelawareRecruiting
- Alliance for Childhood Diseases/Cure 4 the Kids FoundationLas Vegas, NevadaRecruiting
- Arkansas Children's HospitalLittle Rock, ArkansasRecruiting
- Baylor College of Medicine/Dan L Duncan Comprehensive Cancer CenterHouston, TexasRecruiting
- BI-LO Charities Children's Cancer CenterGreenville, South CarolinaRecruiting
- Blank Children's HospitalDes Moines, IowaRecruiting
- Bronson Methodist HospitalKalamazoo, MichiganRecruiting
- C S Mott Children's HospitalAnn Arbor, MichiganRecruiting
- Carolinas Medical Center/Levine Cancer InstituteCharlotte, North CarolinaRecruiting
- Children's Healthcare of Atlanta - Arthur M Blank HospitalAtlanta, GeorgiaRecruiting
- Children's Hospital and Medical Center of OmahaOmaha, NebraskaRecruiting
- Children's Hospital ColoradoAurora, ColoradoRecruiting
- Children's Hospital Los AngelesLos Angeles, CaliforniaRecruiting
- Children's Hospital New OrleansNew Orleans, LouisianaRecruiting
- Children's Hospital of AlabamaBirmingham, AlabamaRecruiting
- Children's Hospital of Orange CountyOrange, CaliforniaRecruiting
- Children's Hospital of PhiladelphiaPhiladelphia, PennsylvaniaRecruiting
- Children's Hospital of Pittsburgh of UPMCPittsburgh, PennsylvaniaRecruiting
- Children's Hospital of San AntonioSan Antonio, TexasRecruiting
- Children's Hospital of WisconsinMilwaukee, WisconsinRecruiting
- Children's Hospitals and Clinics of Minnesota - MinneapolisMinneapolis, MinnesotaRecruiting
- Children's Mercy Hospitals and ClinicsKansas City, MissouriRecruiting
- Children's National Medical CenterWashington D.C., District of ColumbiaRecruiting
- Cincinnati Children's Hospital Medical CenterCincinnati, OhioRecruiting
- Cleveland Clinic FoundationCleveland, OhioRecruiting
- Connecticut Children's Medical CenterHartford, ConnecticutRecruiting
- Cook Children's Medical CenterFort Worth, TexasRecruiting
- Corewell Health Children'sRoyal Oak, MichiganRecruiting
- Corewell Health Grand Rapids Hospitals - Helen DeVos Children's HospitalGrand Rapids, MichiganRecruiting
- Covenant Children's HospitalLubbock, TexasRecruiting
- Dana-Farber Cancer InstituteBoston, MassachusettsRecruiting
- Dartmouth Hitchcock Medical Center/Dartmouth Cancer CenterLebanon, New HampshireRecruiting
- Dayton Children's HospitalDayton, OhioRecruiting
- Dell Children's Medical Center of Central TexasAustin, TexasRecruiting
- Driscoll Children's HospitalCorpus Christi, TexasRecruiting
- Duke University Medical CenterDurham, North CarolinaRecruiting
- East Carolina UniversityGreenville, North CarolinaRecruiting
- East Tennessee Childrens HospitalKnoxville, TennesseeRecruiting
- Eastern Maine Medical CenterBangor, MaineRecruiting
- El Paso Children's HospitalEl Paso, TexasRecruiting
- Geisinger Medical CenterDanville, PennsylvaniaRecruiting
- Golisano Children's Hospital of Southwest FloridaFort Myers, FloridaRecruiting
- Hackensack University Medical CenterHackensack, New JerseyRecruiting
- Johns Hopkins All Children's HospitalSt. Petersburg, FloridaRecruiting
- Johns Hopkins University/Sidney Kimmel Cancer CenterBaltimore, MarylandRecruiting
- Kaiser Permanente Downey Medical CenterDowney, CaliforniaRecruiting
- Kaiser Permanente-OaklandOakland, CaliforniaRecruiting
- Kapiolani Medical Center for Women and ChildrenHonolulu, HawaiiRecruiting
- Laura and Isaac Perlmutter Cancer Center at NYU LangoneNew York, New YorkRecruiting
- Legacy Emanuel Children's HospitalPortland, OregonRecruiting
- Lehigh Valley Hospital-Cedar CrestAllentown, PennsylvaniaRecruiting
- Loma Linda University Medical CenterLoma Linda, CaliforniaRecruiting
- Lucile Packard Children's Hospital Stanford UniversityPalo Alto, CaliforniaRecruiting
- Lurie Children's Hospital-ChicagoChicago, IllinoisRecruiting
- Madigan Army Medical CenterTacoma, WashingtonRecruiting
- Maimonides Medical CenterBrooklyn, New YorkRecruiting
- Maine Children's Cancer ProgramScarborough, MaineRecruiting
- Marshfield Medical Center-MarshfieldMarshfield, WisconsinRecruiting
- Mary Bridge Children's Hospital and Health CenterTacoma, WashingtonRecruiting
- Massachusetts General Hospital Cancer CenterBoston, MassachusettsRecruiting
- Mattel Children's Hospital UCLALos Angeles, CaliforniaRecruiting
- Mayo Clinic in RochesterRochester, MinnesotaRecruiting
- Medical University of South CarolinaCharleston, South CarolinaRecruiting
- Memorial Health University Medical CenterSavannah, GeorgiaRecruiting
- Memorial Regional Hospital/Joe DiMaggio Children's HospitalHollywood, FloridaRecruiting
- Mercy Hospital Saint LouisSt Louis, MissouriRecruiting
- Methodist Children's Hospital of South TexasSan Antonio, TexasRecruiting
- Mission HospitalAsheville, North CarolinaRecruiting
- Montefiore Medical Center - Moses CampusThe Bronx, New YorkRecruiting
- Morristown Medical CenterMorristown, New JerseyRecruiting
- Nationwide Children's HospitalColumbus, OhioRecruiting
- Naval Medical Center -San DiegoSan Diego, CaliforniaRecruiting
- Nemours Children's Clinic-JacksonvilleJacksonville, FloridaRecruiting
- Nemours Children's HospitalOrlando, FloridaRecruiting
- New York Medical CollegeValhalla, New YorkRecruiting
- Newark Beth Israel Medical CenterNewark, New JerseyRecruiting
- Nicklaus Children's HospitalMiami, FloridaRecruiting
- NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer CenterNew York, New YorkRecruiting
- NYU Langone Hospital - Long IslandMineola, New YorkRecruiting
- Ochsner Medical Center JeffersonNew Orleans, LouisianaRecruiting
- Penn State Children's HospitalHershey, PennsylvaniaRecruiting
- Phoenix Childrens HospitalPhoenix, ArizonaRecruiting
- Primary Children's HospitalSalt Lake City, UtahRecruiting
- Prisma Health Richland HospitalColumbia, South CarolinaRecruiting
- ProMedica Toledo Hospital/Russell J Ebeid Children's HospitalToledo, OhioRecruiting
- Providence Sacred Heart Medical Center and Children's HospitalSpokane, WashingtonRecruiting
- Rady Children's Hospital - San DiegoSan Diego, CaliforniaRecruiting
- Rainbow Babies and Childrens HospitalCleveland, OhioRecruiting
- Rhode Island HospitalProvidence, Rhode IslandRecruiting
- Riley Hospital for ChildrenIndianapolis, IndianaRecruiting
- Rocky Mountain Hospital for Children-Presbyterian Saint Luke's Medical CenterDenver, ColoradoRecruiting
- Roswell Park Cancer InstituteBuffalo, New YorkRecruiting
- Rutgers Cancer Institute of New Jersey-Robert Wood Johnson University HospitalNew Brunswick, New JerseyRecruiting
- Saint Joseph's Regional Medical CenterPaterson, New JerseyRecruiting
- Saint Jude Children's Research HospitalMemphis, TennesseeRecruiting
- Saint Jude Midwest AffiliatePeoria, IllinoisRecruiting
- Saint Luke's Cancer Institute - BoiseBoise, IdahoRecruiting
- Saint Mary's Medical CenterWest Palm Beach, FloridaRecruiting
- Saint Peter's University HospitalNew Brunswick, New JerseyRecruiting
- Saint Vincent Hospital Cancer Center Green BayGreen Bay, WisconsinRecruiting
- Sanford Broadway Medical CenterFargo, North DakotaRecruiting
- Sanford USD Medical Center - Sioux FallsSioux Falls, South DakotaRecruiting
- Seattle Children's HospitalSeattle, WashingtonRecruiting
- Sinai Hospital of BaltimoreBaltimore, MarylandRecruiting
- Southern Illinois University School of MedicineSpringfield, IllinoisRecruiting
- State University of New York Upstate Medical UniversitySyracuse, New YorkRecruiting
- Stony Brook University Medical CenterStony Brook, New YorkRecruiting
- Summerlin Hospital Medical CenterLas Vegas, NevadaRecruiting
- Sunrise Hospital and Medical CenterLas Vegas, NevadaRecruiting
- The Children's Hospital at TriStar CentennialNashville, TennesseeRecruiting
- The Steven and Alexandra Cohen Children's Medical Center of New YorkNew Hyde Park, New YorkRecruiting
- UCSF Medical Center-Mission BaySan Francisco, CaliforniaRecruiting
- UF Health Cancer Institute - GainesvilleGainesville, FloridaRecruiting
- UMC Cancer Center / UMC Health SystemLubbock, TexasRecruiting
- UNC Lineberger Comprehensive Cancer CenterChapel Hill, North CarolinaRecruiting
- University Medical Center of Southern NevadaLas Vegas, NevadaRecruiting
- University of California Davis Comprehensive Cancer CenterSacramento, CaliforniaRecruiting
- University of Chicago Comprehensive Cancer CenterChicago, IllinoisRecruiting
- University of IllinoisChicago, IllinoisRecruiting
- University of Iowa/Holden Comprehensive Cancer CenterIowa City, IowaRecruiting
- University of Kentucky/Markey Cancer CenterLexington, KentuckyRecruiting
- University of Maryland/Greenebaum Cancer CenterBaltimore, MarylandRecruiting
- University of Miami Miller School of Medicine-Sylvester Cancer CenterMiami, FloridaRecruiting
- University of Minnesota/Masonic Cancer CenterMinneapolis, MinnesotaRecruiting
- University of Mississippi Medical CenterJackson, MississippiRecruiting
- University of Missouri Children's HospitalColumbia, MissouriRecruiting
- University of Nebraska Medical CenterOmaha, NebraskaRecruiting
- University of New Mexico Cancer CenterAlbuquerque, New MexicoRecruiting
- University of Oklahoma Health Sciences CenterOklahoma City, OklahomaRecruiting
- University of RochesterRochester, New YorkRecruiting
- University of Texas Health Science Center at San AntonioSan Antonio, TexasRecruiting
- University of Vermont and State Agricultural CollegeBurlington, VermontRecruiting
- University of Wisconsin Carbone Cancer Center - University HospitalMadison, WisconsinRecruiting
- UT Southwestern/Simmons Cancer Center-DallasDallas, TexasRecruiting
- Valley Children's HospitalMadera, CaliforniaRecruiting
- Vanderbilt University/Ingram Cancer CenterNashville, TennesseeRecruiting
- Wake Forest University Health SciencesWinston-Salem, North CarolinaRecruiting
- Walter Reed National Military Medical CenterBethesda, MarylandRecruiting
- Washington University School of MedicineSt Louis, MissouriRecruiting
- West Virginia University HealthcareMorgantown, West VirginiaRecruiting
- Yale UniversityNew Haven, ConnecticutRecruiting
- Children's Hospital of MichiganDetroit, MichiganSuspended
- Henry Ford Health Saint John HospitalDetroit, MichiganActive Not Recruiting
- Medical City Dallas HospitalDallas, TexasActive Not Recruiting
- Michigan State UniversityEast Lansing, MichiganSuspended
- Tufts Children's HospitalBoston, MassachusettsActive Not Recruiting
- VCU Massey Comprehensive Cancer CenterRichmond, VirginiaActive Not Recruiting
- Wayne State University/Karmanos Cancer InstituteDetroit, MichiganActive Not Recruiting
Canada9 locations
- British Columbia Children's HospitalVancouver, British ColumbiaSuspended
- CancerCare ManitobaWinnipeg, ManitobaSuspended
- Children's HospitalLondon, OntarioSuspended
- Children's Hospital of Eastern OntarioOttawa, OntarioSuspended
- Hospital for Sick ChildrenToronto, OntarioSuspended
- IWK Health CentreHalifax, Nova ScotiaSuspended
- Janeway Child Health CentreSt. John's, Newfoundland and LabradorSuspended
- Kingston Health Sciences CentreKingston, OntarioSuspended
- McMaster Children's Hospital at Hamilton Health SciencesHamilton, OntarioSuspended
Puerto Rico1 location
- HIMA San Pablo Oncologic HospitalCaguasActive Not Recruiting
Who to ask about joining
Site Public Contact205-638-9285oncologyresearch@peds.uab.edu
Site Public Contact602-546-0920
Site Public Contact501-364-7373
Who can join
Children aged 1 to 30 years with newly diagnosed high-risk neuroblastoma can join. They should have specific features in their tumor that make them eligible. The trial is open to both boys and girls. The trial team will confirm if a child can participate based on these criteria.
What happens during the trial
Participants will be randomly placed into different groups. Each group will receive a different combination of treatments which may include chemotherapy, radiation, stem cell transplantation, and either iobenguane I-131 or lorlatinib. Everyone will receive some form of intensive therapy, but the specific drugs or combinations will vary by group.
The trial team
The Children's Oncology Group is leading this trial, with support from the National Cancer Institute. Dr. Steven G DuBois is the principal investigator overseeing the study.
Important dates
The trial started on May 14, 2018, and is currently recruiting new participants. It is expected to finish by September 30, 2030.
Additional information
The trial's ID is NCT03126916. It is a Phase 3 trial, which means it is testing how well the treatments work and their safety. This trial is regulated by the FDA and aims to include about 750 participants.
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