Improving Heart Health for Cancer Patients with Myocarditis
NCT05335928 · RecruitingThis trial is studying abatacept, a medicine, for people who have heart issues called myocarditis after taking immune checkpoint inhibitors for cancer. The goal is to see if abatacept can reduce serious heart problems compared to a placebo, which looks like the real medicine but has no active ingredients. Myocarditis is a rare side effect of using these cancer treatments, and current treatments may not always work well.
Locations and contact
This trial is running at 31 locations in 2 countries. 30 of them are currently recruiting.
United States29 locations · 28 recruiting
- Allegheny-Singer Research InstitutionPittsburgh, PennsylvaniaRecruiting
- Aurora St Luke's Medical CenterMilwaukee, WisconsinRecruiting
- Beth Israel Deaconess Medical CenterBoston, MassachusettsRecruiting
- Boston Medical CenterBoston, MassachusettsRecruiting
- Brigham and Women's HospitalBoston, MassachusettsRecruiting
- Cedars-Sinai Medical CenterLos Angeles, CaliforniaRecruiting
- Cleveland ClinicCleveland, OhioRecruiting
- Columbia University Irving Medical CenterNew York, New YorkRecruiting
- Franciscan HealthIndianapolis, IndianaRecruiting
- Johns HopkinsBaltimore, MarylandRecruiting
- Lehigh Valley Health NetworkBethlehem, PennsylvaniaRecruiting
- Maine HealthPortland, MaineRecruiting
- Massachusetts General HospitalBoston, MassachusettsRecruiting
- Mayo ClinicRochester, MinnesotaRecruiting
- MedStar Health Research Institute, Georgetown UniversityWashington D.C., District of ColumbiaRecruiting
- Memorial Sloan Kettering Cancer CenterNew York, New YorkRecruiting
- Moffitt Cancer CenterTampa, FloridaRecruiting
- Robert Wood Johnson University HospitalNew Brunswick, New JerseyRecruiting
- University of California Los AngelesLos Angeles, CaliforniaRecruiting
- University of ChicagoChicago, IllinoisRecruiting
- University of Kansas Medical CenterKansas City, KansasRecruiting
- University of KentuckyLexington, KentuckyRecruiting
- University of MichiganAnn Arbor, MichiganRecruiting
- University of North Carolina Chapel HillChapel Hill, North CarolinaRecruiting
- University of PennsylvaniaPhiladelphia, PennsylvaniaRecruiting
- University of Texas SouthwesternDallas, TexasRecruiting
- University of UtahSalt Lake City, UtahRecruiting
- University of West VirginiaMorgantown, West VirginiaRecruiting
- MD Anderson Cancer CenterHouston, TexasNot Yet Recruiting
Canada2 locations · 2 recruiting
- McMaster UniversityHamilton, OntarioRecruiting
- University of British ColombiaVancouver, British ColombiaRecruiting
Who can join
Adults aged 18 and older can join this trial. Participation requires that individuals have recently used an approved immune checkpoint inhibitor and are hospitalized with myocarditis. They must also be receiving high doses of corticosteroids. Participants need to meet certain health criteria, and everyone will be checked by the trial team to confirm eligibility.
What happens during the trial
Participants will be randomly assigned to one of two groups. One group will receive abatacept along with standard care, while the other group will get a placebo with standard care. Everyone will receive the treatment through intravenous infusions over several weeks. This means some will get the real medicine, and others will get the placebo, without knowing which one they are receiving.
The trial team
This trial is led by Massachusetts General Hospital, with support from Bristol-Myers Squibb. The principal investigator is responsible for the trial management.
Important dates
This trial started on July 2, 2022, and is currently enrolling new participants. It is expected to finish by April 20, 2027, with primary results available by November 20, 2026.
Additional information
The trial's ID number is NCT05335928. It is a Phase 3 trial, meaning it is looking at how well the treatment works and how safe it is. The trial is FDA-regulated and aims to include 390 participants.
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