Improving Treatment Options for Advanced Breast Cancer with New Combination Therapy
NCT04862663 · RecruitingAbout this trial
This study looks at a new treatment plan for advanced hormone receptor-positive and HER2-negative breast cancer. It combines capivasertib with CDK4/6 inhibitors and fulvestrant. The goal is to see how well this combination works and if it is safe. The study will also confirm the best doses for this treatment.
Locations and contact
This trial is running at 284 locations in 23 countries. 82 of them are currently recruiting.
United States54 locations · 32 recruiting
- Annapolis, MarylandRecruiting
- Aurora, ColoradoRecruiting
- Camden, New JerseyRecruiting
- Chattanooga, TennesseeRecruiting
- Dallas, TexasRecruiting
- Detroit, MichiganRecruiting
- Fairfax, VirginiaRecruiting
- Fountain Valley, CaliforniaRecruiting
- Glendale, CaliforniaRecruiting
- Grand Rapids, MichiganRecruiting
- Gresham, OregonRecruiting
- Hannibal, MissouriRecruiting
- Houston, TexasRecruiting
- Los Angeles, CaliforniaRecruiting
- Louisville, KentuckyRecruiting
- Midlothian, VirginiaRecruiting
- Napa, CaliforniaRecruiting
- Nashville, TennesseeRecruiting
- New Haven, ConnecticutRecruiting
- New York, New YorkRecruiting
- Newark, DelawareRecruiting
- Newport Beach, CaliforniaRecruiting
- Omaha, NebraskaRecruiting
- Pittsburgh, PennsylvaniaRecruiting
- Salt Lake City, UtahRecruiting
- San Antonio, TexasRecruiting
- San Antonio, TexasRecruiting
- San Francisco, CaliforniaRecruiting
- Santa Rosa, CaliforniaRecruiting
- St Louis, MissouriRecruiting
- Tacoma, WashingtonRecruiting
- Tucson, ArizonaRecruiting
- Baltimore, MarylandWithdrawn
- Baltimore, MarylandWithdrawn
- Baton Rouge, LouisianaWithdrawn
- Boston, MassachusettsActive Not Recruiting
- Brooklyn, New YorkWithdrawn
- Covington, LouisianaWithdrawn
- Durham, North CarolinaWithdrawn
- Falls Church, VirginiaActive Not Recruiting
- Fort Wayne, IndianaWithdrawn
- Fort Worth, TexasWithdrawn
- Greenville, South CarolinaTerminated
- Irving, TexasWithdrawn
- Los Angeles, CaliforniaWithdrawn
- Louisville, KentuckyWithdrawn
- Mineola, New YorkActive Not Recruiting
- New York, New YorkActive Not Recruiting
- Norfolk, VirginiaSuspended
- Philadelphia, PennsylvaniaTerminated
- Providence, Rhode IslandWithdrawn
- Quincy, IllinoisSuspended
- Santa Barbara, CaliforniaWithdrawn
- York, PennsylvaniaTerminated
Germany22 locations · 16 recruiting
- AugsburgRecruiting
- BerlinRecruiting
- DresdenRecruiting
- ErlangenRecruiting
- EssenRecruiting
- Frankfurt am MainRecruiting
- Freiburg im BreisgauRecruiting
- GeorgsmarienhütteRecruiting
- HanoverRecruiting
- HeilbronnRecruiting
- KielRecruiting
- LeipzigRecruiting
- MannheimRecruiting
- MönchengladbachRecruiting
- RegensburgRecruiting
- UlmRecruiting
- BerlinWithdrawn
- BottropWithdrawn
- HamburgWithdrawn
- MünsterWithdrawn
- StadeWithdrawn
- TrierWithdrawn
Canada12 locations · 9 recruiting
- Abbotsford British Columbia, British ColumbiaRecruiting
- Brampton, OntarioRecruiting
- ChicoutimiRecruiting
- Halifax, Nova ScotiaRecruiting
- Kelowna, British ColumbiaRecruiting
- MontrealRecruiting
- Ottawa, OntarioRecruiting
- Sherbrooke, QuebecRecruiting
- Toronto, OntarioRecruiting
- Moncton, New BrunswickWithdrawn
- Sault Ste. Marie, OntarioWithdrawn
- Winnipeg, ManitobaWithdrawn
France8 locations · 8 recruiting
- BobignyRecruiting
- Clermont-FerrandRecruiting
- LimogesRecruiting
- LyonRecruiting
- PlérinRecruiting
- RouenRecruiting
- Saint-HerblainRecruiting
- VillejuifRecruiting
Taiwan8 locations · 8 recruiting
- Kaohsiung CityRecruiting
- Kaohsiung CityRecruiting
- TaichungRecruiting
- TaichungRecruiting
- TainanRecruiting
- TaipeiRecruiting
- TaipeiRecruiting
- TaoyuanRecruiting
Malaysia7 locations · 6 recruiting
- George TownRecruiting
- Kuala LumpurRecruiting
- Kuala LumpurRecruiting
- Kuala SelangorRecruiting
- KuchingRecruiting
- Pulau PinangRecruiting
- Kuala SelangorCompleted
Japan25 locations · 2 recruiting
- Hirakata-shiRecruiting
- OkayamaRecruiting
- NagoyaNot Yet Recruiting
- ChibaActive Not Recruiting
- ChūōkuActive Not Recruiting
- ChūōkuActive Not Recruiting
- Hidaka-shiActive Not Recruiting
- HiroshimaActive Not Recruiting
- Isehara-shiActive Not Recruiting
- KagoshimaActive Not Recruiting
- KōtokuActive Not Recruiting
- KyotoActive Not Recruiting
- MatsuyamaActive Not Recruiting
- NahaActive Not Recruiting
- OsakaActive Not Recruiting
- Ota-shiActive Not Recruiting
- SapporoActive Not Recruiting
- SendaiActive Not Recruiting
- Shimotsuke-shiActive Not Recruiting
- Shinagawa-kuActive Not Recruiting
- Shinjuku-kuActive Not Recruiting
- Suita-shiActive Not Recruiting
- Takasaki-shiActive Not Recruiting
- TsuActive Not Recruiting
- YokohamaActive Not Recruiting
China34 locations · 1 recruiting
- ShanghaiRecruiting
- BeijingActive Not Recruiting
- BeijingActive Not Recruiting
- BeijingActive Not Recruiting
- BeijingActive Not Recruiting
- BengbuActive Not Recruiting
- ChangchunActive Not Recruiting
- ChangshaActive Not Recruiting
- ChengduActive Not Recruiting
- ChongqingActive Not Recruiting
- GuangzhouActive Not Recruiting
- GuangzhouActive Not Recruiting
- GuangzhouWithdrawn
- HangzhouActive Not Recruiting
- HangzhouWithdrawn
- HangzhouActive Not Recruiting
- HefeiActive Not Recruiting
- JinanWithdrawn
- NanchangActive Not Recruiting
- NanchangActive Not Recruiting
- NanjingActive Not Recruiting
- NanningActive Not Recruiting
- ShandongActive Not Recruiting
- ShanghaiActive Not Recruiting
- ShenyangActive Not Recruiting
- ShenyangActive Not Recruiting
- ÜrümqiWithdrawn
- ÜrümqiActive Not Recruiting
- WuhanActive Not Recruiting
- Xi'anActive Not Recruiting
- Xi'anWithdrawn
- XiangyangWithdrawn
- XuzhouActive Not Recruiting
- ZhengzhouActive Not Recruiting
Italy13 locations
- AvianoWithdrawn
- BolognaActive Not Recruiting
- CatanzaroWithdrawn
- FlorenceActive Not Recruiting
- MilanWithdrawn
- MilanWithdrawn
- MisterbiancoActive Not Recruiting
- NaplesActive Not Recruiting
- PadovaActive Not Recruiting
- PratoActive Not Recruiting
- Reggio EmiliaWithdrawn
- RomaActive Not Recruiting
- RozzanoWithdrawn
India11 locations
- BangaloreActive Not Recruiting
- JaipurWithdrawn
- JaipurWithdrawn
- MohaliActive Not Recruiting
- MysuruActive Not Recruiting
- NagpurActive Not Recruiting
- New DelhiActive Not Recruiting
- New DelhiActive Not Recruiting
- PuducherryWithdrawn
- VadodaraActive Not Recruiting
- VaranasiActive Not Recruiting
Poland11 locations
- BialystokWithdrawn
- BydgoszczActive Not Recruiting
- GdanskWithdrawn
- KoszalinWithdrawn
- KrakowActive Not Recruiting
- LodzWithdrawn
- LodzWithdrawn
- LublinWithdrawn
- RzeszówWithdrawn
- WarsawCompleted
- WarsawActive Not Recruiting
Thailand11 locations
- BangkokActive Not Recruiting
- BangkokActive Not Recruiting
- BangkokWithdrawn
- BangkokActive Not Recruiting
- BangkokActive Not Recruiting
- Chiang MaiActive Not Recruiting
- DusitActive Not Recruiting
- Hat YaiActive Not Recruiting
- Khon KaenActive Not Recruiting
- LampangActive Not Recruiting
- RatchathewiActive Not Recruiting
Brazil9 locations
- AlfenasActive Not Recruiting
- BlumenauActive Not Recruiting
- NatalActive Not Recruiting
- Porto AlegreActive Not Recruiting
- Porto VelhoActive Not Recruiting
- São PauloActive Not Recruiting
- TaubatéActive Not Recruiting
- TeresinaActive Not Recruiting
- VitóriaActive Not Recruiting
Spain9 locations
- BarcelonaActive Not Recruiting
- GranadaActive Not Recruiting
- LleidaActive Not Recruiting
- MadridActive Not Recruiting
- MadridActive Not Recruiting
- MadridWithdrawn
- MálagaActive Not Recruiting
- PamplonaActive Not Recruiting
- Santiago de CompostelaActive Not Recruiting
Argentina8 locations
- Buenos AiresActive Not Recruiting
- CABAActive Not Recruiting
- CABAActive Not Recruiting
- CABAActive Not Recruiting
- CABASuspended
- ChivilcoyActive Not Recruiting
- RosarioActive Not Recruiting
- Santa FeWithdrawn
South Korea7 locations
- Goyang-siActive Not Recruiting
- SeoulActive Not Recruiting
- SeoulActive Not Recruiting
- SeoulActive Not Recruiting
- SeoulActive Not Recruiting
- SeoulActive Not Recruiting
- SeoulActive Not Recruiting
Turkey (Türkiye)7 locations
- AnkaraActive Not Recruiting
- AntalyaActive Not Recruiting
- CordaleoActive Not Recruiting
- Goztepe IstanbulActive Not Recruiting
- KayseriWithdrawn
- MalatyaActive Not Recruiting
- SamsunActive Not Recruiting
Vietnam6 locations
- Can ThoActive Not Recruiting
- HanoiActive Not Recruiting
- Hồ Chí MinhActive Not Recruiting
- Ho Chi Minh CityActive Not Recruiting
- Ho Chi Minh CityActive Not Recruiting
- VinhActive Not Recruiting
Australia5 locations
- DarlinghurstActive Not Recruiting
- MirandaWithdrawn
- NedlandsActive Not Recruiting
- WahroongaWithdrawn
- WaratahActive Not Recruiting
Belgium5 locations
- BrasschaatActive Not Recruiting
- BrusselsActive Not Recruiting
- EdegemActive Not Recruiting
- Haine-Saint-PaulActive Not Recruiting
- LeuvenActive Not Recruiting
United Kingdom5 locations
- GuildfordActive Not Recruiting
- LondonActive Not Recruiting
- LondonderryActive Not Recruiting
- TauntonActive Not Recruiting
- YorkActive Not Recruiting
Denmark4 locations
- AalborgActive Not Recruiting
- Aarhus NActive Not Recruiting
- HillerødActive Not Recruiting
- OdenseCompleted
Sweden3 locations
- LundActive Not Recruiting
- SolnaActive Not Recruiting
- VaxjoWithdrawn
Who to ask about joining
AstraZeneca Clinical Study Information Center1-877-240-9479information.center@astrazeneca.com
AstraZeneca Breast Cancer Study Locator Service1-877-400-4655az-bcsl@careboxhealth.com
Who can join
Adults aged 18 years and older can join. This includes both women and men. Participants must have confirmed HR+/HER2- breast cancer. They also need to be eligible for fulvestrant therapy and have had certain previous treatments. The trial team will check if you qualify.
What happens during the trial
Participants will be placed in different groups by chance. Some will receive capivasertib with either palbociclib, ribociclib, or abemaciclib alongside fulvestrant. Others will receive fulvestrant with their choice of CDK4/6 inhibitor. Everyone will be closely monitored during the study.
The trial team
AstraZeneca is the sponsor running this trial. They lead the research team and are responsible for its progress.
Important dates
The trial started on May 10, 2021. It is currently enrolling new participants. The main part of the trial is expected to finish by November 1, 2027, and the entire study by August 14, 2029.
Additional information
The trial ID is NCT04862663. This is a Phase 3 trial, which means it's looking at how well the treatment works and its safety. It is regulated by the FDA. The goal is to enroll 895 participants.
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