Investigating the Benefits of Combining Chemotherapy with Hormonal Therapy for Prostate Cancer
NCT06931340 · RecruitingAbout this trial
This trial studies whether adding docetaxel to hormonal therapy and apalutamide can improve treatment for men with prostate cancer that has spread to other parts of the body. Docetaxel is a type of chemotherapy that helps stop cancer cells from growing. Hormonal therapy reduces male hormones to slow prostate cancer growth. The goal is to see if this combination works better than hormonal therapy and apalutamide alone.
Locations and contact
This trial is running at 195 locations in the United States. 190 of them are currently recruiting.
United States195 locations · 190 recruiting
- Allegheny General HospitalPittsburgh, PennsylvaniaRecruiting
- Allegheny Valley HospitalNatrona Heights, PennsylvaniaRecruiting
- Ascension All Saints Hospital-Spring Street-RacineRacine, WisconsinRecruiting
- Ascension Calumet Hospital-ChiltonChilton, WisconsinRecruiting
- Ascension Columbia Saint Mary's Hospital-Milwaukee CampusMilwaukee, WisconsinRecruiting
- Ascension Columbia Saint Mary's Hospital-Ozaukee Campus-MequonMequon, WisconsinRecruiting
- Ascension Northeast Wisconsin-Mercy Hospital-OshkoshOshkosh, WisconsinRecruiting
- Ascension Northeast Wisconsin-Saint Elizabeth Cancer Center-AppletonAppleton, WisconsinRecruiting
- Ascension Southeast Wisconsin Hospital-Elmbrook Campus-BrookfieldBrookfield, WisconsinRecruiting
- Ascension Southeast Wisconsin Hospital-Mayfair Road-WauwatosaWauwatosa, WisconsinRecruiting
- Asplundh Cancer PavilionWillow Grove, PennsylvaniaRecruiting
- Banner University Medical Center - TucsonTucson, ArizonaRecruiting
- Benefis Sletten Cancer InstituteGreat Falls, MontanaRecruiting
- Billings Clinic Cancer CenterBillings, MontanaRecruiting
- Bozeman Health Deaconess HospitalBozeman, MontanaRecruiting
- Cancer Care Center of O'FallonO'Fallon, IllinoisRecruiting
- Cancer Care Specialists of Illinois - DecaturDecatur, IllinoisRecruiting
- Carle at The RiverfrontDanville, IllinoisRecruiting
- Carle BroMenn Medical CenterNormal, IllinoisRecruiting
- Carle Cancer CenterUrbana, IllinoisRecruiting
- Carle Cancer Institute NormalNormal, IllinoisRecruiting
- Carle Physician Group-EffinghamEffingham, IllinoisRecruiting
- Carle Physician Group-Mattoon/CharlestonMattoon, IllinoisRecruiting
- Central Vermont Medical Center/National Life Cancer TreatmentBerlin Corners, VermontRecruiting
- Centralia Oncology ClinicCentralia, IllinoisRecruiting
- Coborn Cancer Center at Saint Cloud HospitalSaint Cloud, MinnesotaRecruiting
- Community Hospital of AnacondaAnaconda, MontanaRecruiting
- Community Medical CenterMissoula, MontanaRecruiting
- Crossroads Cancer CenterEffingham, IllinoisRecruiting
- Decatur Memorial HospitalDecatur, IllinoisRecruiting
- Drexel Town Square Health CenterOak Creek, WisconsinRecruiting
- Duke University Medical CenterDurham, North CarolinaRecruiting
- Durham VA Medical CenterDurham, North CarolinaRecruiting
- Eisenhower Medical CenterRancho Mirage, CaliforniaRecruiting
- FirstHealth of the Carolinas-Moore Regional HospitalPinehurst, North CarolinaRecruiting
- Forbes HospitalMonroeville, PennsylvaniaRecruiting
- Froedtert and MCW Moorland Reserve Health CenterNew Berlin, WisconsinRecruiting
- Froedtert Menomonee Falls HospitalMenomonee Falls, WisconsinRecruiting
- Froedtert West Bend Hospital/Kraemer Cancer CenterWest Bend, WisconsinRecruiting
- Genesys Hurley Cancer InstituteFlint, MichiganRecruiting
- Guthrie Cortland Memorial HospitalCortland, New YorkRecruiting
- Guthrie Medical Group PC-Robert Packer HospitalSayre, PennsylvaniaRecruiting
- HaysMedHays, KansasRecruiting
- Hematology Oncology Associates of Fredericksburg IncFredericksburg, VirginiaRecruiting
- HSHS Saint Elizabeth's HospitalO'Fallon, IllinoisRecruiting
- Hurley Medical CenterFlint, MichiganRecruiting
- Illinois CancerCare - WashingtonWashington, IllinoisRecruiting
- Illinois CancerCare-BloomingtonBloomington, IllinoisRecruiting
- Illinois CancerCare-CantonCanton, IllinoisRecruiting
- Illinois CancerCare-CarthageCarthage, IllinoisRecruiting
- Illinois CancerCare-DixonDixon, IllinoisRecruiting
- Illinois CancerCare-EurekaEureka, IllinoisRecruiting
- Illinois CancerCare-GalesburgGalesburg, IllinoisRecruiting
- Illinois CancerCare-Kewanee ClinicKewanee, IllinoisRecruiting
- Illinois CancerCare-MacombMacomb, IllinoisRecruiting
- Illinois CancerCare-Ottawa ClinicOttawa, IllinoisRecruiting
- Illinois CancerCare-PekinPekin, IllinoisRecruiting
- Illinois CancerCare-PeoriaPeoria, IllinoisRecruiting
- Illinois CancerCare-PeruPeru, IllinoisRecruiting
- Illinois CancerCare-PrincetonPrinceton, IllinoisRecruiting
- Intermountain Medical CenterMurray, UtahRecruiting
- Jefferson Cherry Hill HospitalCherry Hill, New JerseyRecruiting
- Jefferson HospitalJefferson Hills, PennsylvaniaRecruiting
- Jefferson Torresdale HospitalPhiladelphia, PennsylvaniaRecruiting
- Kaiser Permanente Downtown CommonsSacramento, CaliforniaRecruiting
- Kaiser Permanente DublinDublin, CaliforniaRecruiting
- Kaiser Permanente Fresno Orchard PlazaFresno, CaliforniaRecruiting
- Kaiser Permanente Medical Center - Santa ClaraSanta Clara, CaliforniaRecruiting
- Kaiser Permanente Moanalua Medical CenterHonolulu, HawaiiRecruiting
- Kaiser Permanente San LeandroSan Leandro, CaliforniaRecruiting
- Kaiser Permanente- Modesto MOB IIModesto, CaliforniaRecruiting
- Kaiser Permanente-FranklinDenver, ColoradoRecruiting
- Kaiser Permanente-FremontFremont, CaliforniaRecruiting
- Kaiser Permanente-Lone TreeLone Tree, ColoradoRecruiting
- Kaiser Permanente-ModestoModesto, CaliforniaRecruiting
- Kaiser Permanente-OaklandOakland, CaliforniaRecruiting
- Kaiser Permanente-Rock CreekLafayette, ColoradoRecruiting
- Kaiser Permanente-RosevilleRoseville, CaliforniaRecruiting
- Kaiser Permanente-San FranciscoSan Francisco, CaliforniaRecruiting
- Kaiser Permanente-Santa RosaSanta Rosa, CaliforniaRecruiting
- Kaiser Permanente-Santa Teresa-San JoseSan Jose, CaliforniaRecruiting
- Kaiser Permanente-South SacramentoSacramento, CaliforniaRecruiting
- Kaiser Permanente-South San FranciscoSouth San Francisco, CaliforniaRecruiting
- Kaiser Permanente-VallejoVallejo, CaliforniaRecruiting
- Kaiser Permanente-Walnut CreekWalnut Creek, CaliforniaRecruiting
- Kaiser San Rafael-GallinasSan Rafael, CaliforniaRecruiting
- Kootenai Clinic Cancer Services - Post FallsPost Falls, IdahoRecruiting
- Kootenai Clinic Cancer Services - SandpointSandpoint, IdahoRecruiting
- Kootenai Health - Coeur d'AleneCoeur d'Alene, IdahoRecruiting
- Lawrence Memorial HospitalLawrence, KansasRecruiting
- LDS HospitalSalt Lake City, UtahRecruiting
- Logan Health Medical CenterKalispell, MontanaRecruiting
- Malcom Randall Veterans Administration Medical CenterGainesville, FloridaRecruiting
- Mary Greeley Medical CenterAmes, IowaRecruiting
- McFarland Clinic - AmesAmes, IowaRecruiting
- McFarland Clinic - MarshalltownMarshalltown, IowaRecruiting
- McFarland Clinic - Trinity Cancer CenterFort Dodge, IowaRecruiting
- Medical College of WisconsinMilwaukee, WisconsinRecruiting
- MedStar Georgetown University HospitalWashington D.C., District of ColumbiaRecruiting
- MedStar Washington Hospital CenterWashington D.C., District of ColumbiaRecruiting
- Memorial Hospital EastShiloh, IllinoisRecruiting
- Memorial Sloan Kettering Basking RidgeBasking Ridge, New JerseyRecruiting
- Memorial Sloan Kettering BergenMontvale, New JerseyRecruiting
- Memorial Sloan Kettering Cancer CenterNew York, New YorkRecruiting
- Memorial Sloan Kettering CommackCommack, New YorkRecruiting
- Memorial Sloan Kettering MonmouthMiddletown, New JerseyRecruiting
- Memorial Sloan Kettering NassauUniondale, New YorkRecruiting
- Memorial Sloan Kettering WestchesterHarrison, New YorkRecruiting
- Mercy HospitalCedar Rapids, IowaRecruiting
- Mercy Hospital Saint LouisSt Louis, MissouriRecruiting
- Mercy Hospital SouthSt Louis, MissouriRecruiting
- Mount Sinai HospitalNew York, New YorkRecruiting
- Ohio State University Comprehensive Cancer CenterColumbus, OhioRecruiting
- Oncology Associates at Mercy Medical CenterCedar Rapids, IowaRecruiting
- OSF Saint Francis Hospital and Medical GroupEscanaba, MichiganRecruiting
- ProMedica Flower HospitalSylvania, OhioRecruiting
- Rapid City Regional HospitalRapid City, South DakotaRecruiting
- Reiman Cancer Center-Ascension Wisconsin Health Center-RawsonFranklin, WisconsinRecruiting
- Roswell Park Cancer InstituteBuffalo, New YorkRecruiting
- Rush MD Anderson Cancer CenterChicago, IllinoisRecruiting
- Saint Francis Cancer CenterGreenville, South CarolinaRecruiting
- Saint Francis HospitalGreenville, South CarolinaRecruiting
- Saint Francis Medical CenterCape Girardeau, MissouriRecruiting
- Saint George Regional Medical CenterSt. George, UtahRecruiting
- Saint Luke's Cancer Institute - BoiseBoise, IdahoRecruiting
- Saint Luke's Cancer Institute - FruitlandFruitland, IdahoRecruiting
- Saint Luke's Cancer Institute - MeridianMeridian, IdahoRecruiting
- Saint Luke's Cancer Institute - NampaNampa, IdahoRecruiting
- Saint Mary's Hospital and Regional Medical CenterGrand Junction, ColoradoRecruiting
- Saint Vincent Frontier Cancer CenterBillings, MontanaRecruiting
- Saint Vincent HospitalErie, PennsylvaniaRecruiting
- Saint Vincent Hospital Cancer Center at Oconto FallsOconto Falls, WisconsinRecruiting
- Saint Vincent Hospital Cancer Center at Saint Mary'sGreen Bay, WisconsinRecruiting
- Saint Vincent Hospital Cancer Center at SheboyganSheboygan, WisconsinRecruiting
- Saint Vincent Hospital Cancer Center at Sturgeon BaySturgeon Bay, WisconsinRecruiting
- Saint Vincent Hospital Cancer Center Green BayGreen Bay, WisconsinRecruiting
- Salina Regional Health CenterSalina, KansasRecruiting
- Sanford Bismarck Medical CenterBismarck, North DakotaRecruiting
- Sanford Broadway Medical CenterFargo, North DakotaRecruiting
- Sanford Cancer Center Oncology ClinicSioux Falls, South DakotaRecruiting
- Sanford Joe Lueken Cancer CenterBemidji, MinnesotaRecruiting
- Sanford Roger Maris Cancer CenterFargo, North DakotaRecruiting
- Sanford USD Medical Center - Sioux FallsSioux Falls, South DakotaRecruiting
- Self Regional HealthcareGreenwood, South CarolinaRecruiting
- Sheboygan Physicians GroupSheboygan, WisconsinRecruiting
- Sidney Kimmel Cancer Center Washington TownshipSewell, New JerseyRecruiting
- Siteman Cancer Center at Christian HospitalSt Louis, MissouriRecruiting
- Siteman Cancer Center at Saint Peters HospitalCity of Saint Peters, MissouriRecruiting
- Siteman Cancer Center at West County HospitalCreve Coeur, MissouriRecruiting
- Siteman Cancer Center-South CountySt Louis, MissouriRecruiting
- Southern Illinois University School of MedicineSpringfield, IllinoisRecruiting
- Springfield ClinicSpringfield, IllinoisRecruiting
- Springfield Memorial HospitalSpringfield, IllinoisRecruiting
- Stony Brook University Medical CenterStony Brook, New YorkRecruiting
- The University of Kansas Cancer Center - OlatheOlathe, KansasRecruiting
- ThedaCare Regional Cancer CenterAppleton, WisconsinRecruiting
- Thomas Jefferson University HospitalPhiladelphia, PennsylvaniaRecruiting
- Trinity Health IHA Medical Group Hematology Oncology - BrightonBrighton, MichiganRecruiting
- Trinity Health IHA Medical Group Hematology Oncology - CantonCanton, MichiganRecruiting
- Trinity Health IHA Medical Group Hematology Oncology - Chelsea HospitalChelsea, MichiganRecruiting
- Trinity Health IHA Medical Group Hematology Oncology Ann Arbor CampusYpsilanti, MichiganRecruiting
- Trinity Health Saint Joseph Mercy Oakland HospitalPontiac, MichiganRecruiting
- Trinity Health Saint Mary Mercy Livonia HospitalLivonia, MichiganRecruiting
- UC San Diego Medical Center - HillcrestSan Diego, CaliforniaRecruiting
- UC San Diego Moores Cancer CenterLa Jolla, CaliforniaRecruiting
- University Health Truman Medical CenterKansas City, MissouriRecruiting
- University of Arizona Cancer Center-North CampusTucson, ArizonaRecruiting
- University of IllinoisChicago, IllinoisRecruiting
- University of Kansas Cancer Center - BriarcliffKansas City, MissouriRecruiting
- University of Kansas Cancer Center - Lee's SummitLee's Summit, MissouriRecruiting
- University of Kansas Cancer Center - NorthKansas City, MissouriRecruiting
- University of Kansas Cancer Center-Overland ParkOverland Park, KansasRecruiting
- University of Kansas Health System Saint Francis CampusTopeka, KansasRecruiting
- University of Kansas Hospital-Westwood Cancer CenterWestwood, KansasRecruiting
- University of Michigan Health - Sparrow LansingLansing, MichiganRecruiting
- University of Oklahoma Health Sciences CenterOklahoma City, OklahomaRecruiting
- University of Vermont and State Agricultural CollegeBurlington, VermontRecruiting
- University of Vermont Medical CenterBurlington, VermontRecruiting
- UT Southwestern Clinical Center at Richardson/PlanoRichardson, TexasRecruiting
- UT Southwestern Simmons Cancer Center - RedBirdDallas, TexasRecruiting
- UT Southwestern/Simmons Cancer Center-DallasDallas, TexasRecruiting
- UT Southwestern/Simmons Cancer Center-Fort WorthFort Worth, TexasRecruiting
- VCU Health Tappahannock HospitalTappahannock, VirginiaRecruiting
- VCU Massey Cancer Center at Stony PointRichmond, VirginiaRecruiting
- VCU Massey Comprehensive Cancer CenterRichmond, VirginiaRecruiting
- Washington University School of MedicineSt Louis, MissouriRecruiting
- West Penn HospitalPittsburgh, PennsylvaniaRecruiting
- West Virginia University Charleston DivisionCharleston, West VirginiaRecruiting
- Wexford Health and Wellness PavilionWexford, PennsylvaniaRecruiting
- William S Middleton VA Medical CenterMadison, WisconsinRecruiting
- Bayhealth Hospital Kent CampusDover, DelawareActive Not Recruiting
- Bayhealth Hospital Sussex CampusMilford, DelawareActive Not Recruiting
- Jefferson Methodist HospitalPhiladelphia, PennsylvaniaSuspended
- McFarland Clinic - BooneBoone, IowaSuspended
- McFarland Clinic - JeffersonJefferson, IowaSuspended
Who to ask about joining
Shiva Baghaie, MPH(773) 702-9171GUprotocols@alliancenctn.org
Who can join
Men aged 18 years or older with confirmed prostate cancer that has spread. They must not have had prior chemotherapy for prostate cancer and need to meet other health criteria. The trial team will confirm who is eligible to participate.
What happens during the trial
Participants will be placed into two groups by chance. One group will receive hormonal therapy and apalutamide, while the other group will receive the same treatment plus docetaxel. Everyone will have regular scans and may provide blood samples during the study.
The trial team
The trial is sponsored by the Alliance for Clinical Trials in Oncology, with collaboration from the National Cancer Institute.
Important dates
The trial started on December 1, 2025, and is expected to finish by May 8, 2039. It is currently recruiting new participants.
Additional information
The trial ID is NCT06931340. This is a Phase 3 trial, meaning it is looking at how well the treatment works and its safety. It is not regulated by the FDA for drugs or devices. The study aims to include about 1,260 participants.
Similar trials
Other recruiting trials for the same condition, with the eligibility rules written in plain language.
Browse similar trials →Talk to a specialist
Find a top oncologist who can tell you whether a trial is a sensible option for you.
Find a doctor →Cancer hospitals
The cancer centers running studies like this one, and what each is known for.
Browse hospitals →