Looking at the Benefits of Lovastatin and Pembrolizumab for Head and Neck Cancer
NCT06636734 · RecruitingThis trial looks at how well lovastatin and pembrolizumab work together for patients with head and neck cancer that has come back or spread. Lovastatin is a drug that lowers cholesterol and may help kill cancer cells. Pembrolizumab is a type of treatment that helps the immune system fight cancer. The goal is to see if these two medicines can help keep cancer under control better than either one alone.
Locations and contact
This trial is running at 2 locations in the United States. All of them are currently recruiting.
United States2 locations · 2 recruiting
- Emory University Hospital MidtownAtlanta, GeorgiaRecruiting
- Emory University Hospital/Winship Cancer InstituteAtlanta, GeorgiaRecruiting
Who can join
Adults aged 18 and older can join. Both men and women are welcome. Participants must have a type of head and neck cancer that has come back or spread. Those who are pregnant, breastfeeding, or have certain other health issues cannot join. The trial team will confirm who is eligible.
What happens during the trial
Participants will take lovastatin by mouth every day and receive pembrolizumab through an IV once every three weeks. This treatment will last for up to a year as long as the cancer does not progress and there are no serious side effects. Patients will also have blood samples taken and imaging tests like CT or MRI during the study.
The trial team
Emory University is leading the trial with support from the National Cancer Institute. Dr. Nicole C Schmitt is the principal investigator overseeing the study.
Important dates
The trial started on December 9, 2024, and is expected to finish by December 31, 2028. It is currently open for new participants.
Additional information
This trial is listed under NCT06636734. It is a Phase 2 study, meaning it is looking at how well the treatments work and their safety. It is regulated by the FDA, and the trial hopes to include about 28 participants.
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