Observing the Benefits of Radiation Therapy for Patients After Meningioma Surgery
NCT03180268 · RecruitingAbout this trial
This trial looks at how well radiation therapy works compared to just watching patients after they have surgery for grade II meningioma. Meningioma is a type of brain tumor. The main goal is to see if adding radiation therapy helps improve outcomes for these patients after their tumor has been completely removed.
Locations and contact
This trial is running at 215 locations in 5 countries. 120 of them are currently recruiting.
United States198 locations · 112 recruiting
- Abbott-Northwestern HospitalMinneapolis, MinnesotaRecruiting
- American Fork Hospital / Huntsman Intermountain Cancer CenterAmerican Fork, UtahRecruiting
- Aspirus Cancer Care - Stevens PointStevens Point, WisconsinRecruiting
- Aspirus Cancer Care - Wisconsin RapidsWisconsin Rapids, WisconsinRecruiting
- Aspirus Regional Cancer CenterWausau, WisconsinRecruiting
- Benefis Sletten Cancer InstituteGreat Falls, MontanaRecruiting
- California Pacific Medical Center-Pacific CampusSan Francisco, CaliforniaRecruiting
- Capital Health Medical Center-HopewellPennington, New JerseyRecruiting
- Case Western Reserve UniversityCleveland, OhioRecruiting
- Cleveland Clinic FoundationCleveland, OhioRecruiting
- Dartmouth Cancer Center - NorthSaint Johnsbury, VermontRecruiting
- Dartmouth Hitchcock Medical Center/Dartmouth Cancer CenterLebanon, New HampshireRecruiting
- Drexel Town Square Health CenterOak Creek, WisconsinRecruiting
- Emory Proton Therapy CenterAtlanta, GeorgiaRecruiting
- Emory Saint Joseph's HospitalAtlanta, GeorgiaRecruiting
- Emory University Hospital/Winship Cancer InstituteAtlanta, GeorgiaRecruiting
- Englewood Hospital and Medical CenterEnglewood, New JerseyRecruiting
- Essentia Health Cancer CenterDuluth, MinnesotaRecruiting
- Froedtert Menomonee Falls HospitalMenomonee Falls, WisconsinRecruiting
- Geisinger Cancer Services-PottsvillePottsville, PennsylvaniaRecruiting
- Geisinger Medical CenterDanville, PennsylvaniaRecruiting
- Geisinger Medical Oncology-LewisburgLewisburg, PennsylvaniaRecruiting
- Geisinger Wyoming Valley/Henry Cancer CenterWilkes-Barre, PennsylvaniaRecruiting
- Grady Health SystemAtlanta, GeorgiaRecruiting
- Hartford HospitalHartford, ConnecticutRecruiting
- Henry Ford HospitalDetroit, MichiganRecruiting
- Henry Ford Macomb Hospital-Clinton TownshipClinton Township, MichiganRecruiting
- Henry Ford West Bloomfield HospitalWest Bloomfield, MichiganRecruiting
- Intermountain Medical CenterMurray, UtahRecruiting
- Iowa Methodist Medical CenterDes Moines, IowaRecruiting
- Jersey Shore Medical CenterNeptune City, New JerseyRecruiting
- Kaiser Permanente Cancer Treatment CenterSouth San Francisco, CaliforniaRecruiting
- Kaiser Permanente DublinDublin, CaliforniaRecruiting
- Kaiser Permanente Los Angeles Medical CenterLos Angeles, CaliforniaRecruiting
- Kaiser Permanente Medical Center - Santa ClaraSanta Clara, CaliforniaRecruiting
- Kaiser Permanente Oakland-BroadwayOakland, CaliforniaRecruiting
- Kaiser Permanente-AnaheimAnaheim, CaliforniaRecruiting
- Kaiser Permanente-BellflowerBellflower, CaliforniaRecruiting
- Kaiser Permanente-OntarioOntario, CaliforniaRecruiting
- Kaiser Permanente-Rancho Cordova Cancer CenterRancho Cordova, CaliforniaRecruiting
- Langlade Hospital and Cancer CenterAntigo, WisconsinRecruiting
- LDS HospitalSalt Lake City, UtahRecruiting
- Lewistown HospitalLewistown, PennsylvaniaRecruiting
- Logan Regional HospitalLogan, UtahRecruiting
- Loyola University Medical CenterMaywood, IllinoisRecruiting
- MaineHealth Cancer Care Center of York CountySanford, MaineRecruiting
- MaineHealth Coastal Cancer Treatment CenterBath, MaineRecruiting
- MaineHealth Maine Medical Center - PortlandPortland, MaineRecruiting
- MaineHealth Maine Medical Center- ScarboroughScarborough, MaineRecruiting
- Marshfield Medical Center - MinocquaMinocqua, WisconsinRecruiting
- Marshfield Medical Center - WestonWeston, WisconsinRecruiting
- Marshfield Medical Center-EC Cancer CenterEau Claire, WisconsinRecruiting
- Marshfield Medical Center-MarshfieldMarshfield, WisconsinRecruiting
- Marshfield Medical Center-Rice LakeRice Lake, WisconsinRecruiting
- Marshfield Medical Center-River Region at Stevens PointStevens Point, WisconsinRecruiting
- Mayo Clinic in RochesterRochester, MinnesotaRecruiting
- McKay-Dee Hospital CenterOgden, UtahRecruiting
- Medical College of WisconsinMilwaukee, WisconsinRecruiting
- Memorial Hospital WestPembroke Pines, FloridaRecruiting
- Memorial Medical CenterModesto, CaliforniaRecruiting
- Memorial Regional Hospital/Joe DiMaggio Children's HospitalHollywood, FloridaRecruiting
- Miller-Dwan HospitalDuluth, MinnesotaRecruiting
- New York-Presbyterian/Brooklyn Methodist HospitalBrooklyn, New YorkRecruiting
- NorthShore University HealthSystem-Evanston HospitalEvanston, IllinoisRecruiting
- NorthShore University HealthSystem-Glenbrook HospitalGlenview, IllinoisRecruiting
- NorthShore University HealthSystem-Highland Park HospitalHighland Park, IllinoisRecruiting
- Northwestern Medicine Cancer Center DelnorGeneva, IllinoisRecruiting
- Northwestern Medicine Cancer Center WarrenvilleWarrenville, IllinoisRecruiting
- Northwestern UniversityChicago, IllinoisRecruiting
- Ohio State University Comprehensive Cancer CenterColumbus, OhioRecruiting
- Park Nicollet Clinic - Saint Louis ParkSaint Louis Park, MinnesotaRecruiting
- Piedmont Fayette HospitalFayetteville, GeorgiaRecruiting
- Piedmont Henry HospitalStockbridge, GeorgiaRecruiting
- Piedmont HospitalAtlanta, GeorgiaRecruiting
- Piedmont Newnan HospitalNewnan, GeorgiaRecruiting
- ProMedica Flower HospitalSylvania, OhioRecruiting
- Queen's Medical CenterHonolulu, HawaiiRecruiting
- Regions HospitalSaint Paul, MinnesotaRecruiting
- Riverton HospitalRiverton, UtahRecruiting
- Rohnert Park Cancer CenterRohnert Park, CaliforniaRecruiting
- Rush MD Anderson Cancer CenterChicago, IllinoisRecruiting
- Rutgers Cancer Institute of New JerseyNew Brunswick, New JerseyRecruiting
- Siteman Cancer Center at Saint Peters HospitalCity of Saint Peters, MissouriRecruiting
- Siteman Cancer Center at West County HospitalCreve Coeur, MissouriRecruiting
- Siteman Cancer Center-South CountySt Louis, MissouriRecruiting
- Smilow Cancer Hospital Care Center-TrumbullTrumbull, ConnecticutRecruiting
- South Sacramento Cancer CenterSacramento, CaliforniaRecruiting
- Sutter Cancer Centers Radiation Oncology Services-AuburnAuburn, CaliforniaRecruiting
- Sutter Cancer Centers Radiation Oncology Services-RosevilleRoseville, CaliforniaRecruiting
- Sutter Medical Center SacramentoSacramento, CaliforniaRecruiting
- Sutter Solano Medical Center/Cancer CenterVallejo, CaliforniaRecruiting
- The James Graham Brown Cancer Center at University of LouisvilleLouisville, KentuckyRecruiting
- The Permanente Medical Group-Roseville Radiation OncologyRoseville, CaliforniaRecruiting
- Trinity Health Grand Rapids HospitalGrand Rapids, MichiganRecruiting
- Tufts Medical CenterBoston, MassachusettsRecruiting
- UC Irvine Health/Chao Family Comprehensive Cancer CenterOrange, CaliforniaRecruiting
- UH Seidman Cancer Center at Lake Health Mentor CampusMentor, OhioRecruiting
- UM Sylvester Comprehensive Cancer Center at Coral GablesCoral Gables, FloridaRecruiting
- UM Sylvester Comprehensive Cancer Center at Deerfield BeachDeerfield Beach, FloridaRecruiting
- UM Sylvester Comprehensive Cancer Center at DoralDoral, FloridaRecruiting
- UM Sylvester Comprehensive Cancer Center at PlantationPlantation, FloridaRecruiting
- University of IllinoisChicago, IllinoisRecruiting
- University of Miami Miller School of Medicine-Sylvester Cancer CenterMiami, FloridaRecruiting
- University of Michigan Health - WestWyoming, MichiganRecruiting
- University of New Mexico Cancer CenterAlbuquerque, New MexicoRecruiting
- University of Wisconsin Carbone Cancer Center - Eastpark Medical CenterMadison, WisconsinRecruiting
- University of Wisconsin Carbone Cancer Center - University HospitalMadison, WisconsinRecruiting
- UofL Health Medical Center NortheastLouisville, KentuckyRecruiting
- UT Southwestern/Simmons Cancer Center-DallasDallas, TexasRecruiting
- Utah Valley Regional Medical CenterProvo, UtahRecruiting
- UW Cancer Center at ProHealth CareWaukesha, WisconsinRecruiting
- Washington University School of MedicineSt Louis, MissouriRecruiting
- AdventHealth East OrlandoOrlando, FloridaSuspended
- AdventHealth OrlandoOrlando, FloridaSuspended
- Banner University Medical Center - TucsonTucson, ArizonaSuspended
- Baptist MD Anderson Cancer CenterJacksonville, FloridaActive Not Recruiting
- Beebe Health CampusRehoboth Beach, DelawareActive Not Recruiting
- Billings Clinic Cancer CenterBillings, MontanaSuspended
- Boca Raton Regional HospitalBoca Raton, FloridaActive Not Recruiting
- Chelsea HospitalChelsea, MichiganSuspended
- Christiana Care Health System-Christiana HospitalNewark, DelawareActive Not Recruiting
- Christiana Care Health System-Concord Health CenterChadds Ford, PennsylvaniaActive Not Recruiting
- Decatur Memorial HospitalDecatur, IllinoisActive Not Recruiting
- Fox Chase Cancer CenterPhiladelphia, PennsylvaniaActive Not Recruiting
- Helen F Graham Cancer CenterNewark, DelawareActive Not Recruiting
- Henry Ford Health Saint John HospitalDetroit, MichiganSuspended
- Henry Ford Health Warren HospitalWarren, MichiganSuspended
- Indiana University/Melvin and Bren Simon Cancer CenterIndianapolis, IndianaActive Not Recruiting
- IU Health Methodist HospitalIndianapolis, IndianaActive Not Recruiting
- Kettering Medical CenterKettering, OhioActive Not Recruiting
- Lankenau Medical CenterWynnewood, PennsylvaniaSuspended
- Legacy Good Samaritan Hospital and Medical CenterPortland, OregonActive Not Recruiting
- Legacy Mount Hood Medical CenterGresham, OregonActive Not Recruiting
- Legacy Salmon Creek HospitalVancouver, WashingtonActive Not Recruiting
- Logan Health Medical CenterKalispell, MontanaSuspended
- Los Angeles General Medical CenterLos Angeles, CaliforniaActive Not Recruiting
- LSU Health Sciences Center at ShreveportShreveport, LouisianaActive Not Recruiting
- Maryland Proton Treatment CenterBaltimore, MarylandActive Not Recruiting
- Mayo Clinic Hospital in ArizonaPhoenix, ArizonaActive Not Recruiting
- Mayo Clinic in ArizonaScottsdale, ArizonaActive Not Recruiting
- Medical University of South CarolinaCharleston, South CarolinaActive Not Recruiting
- Memorial Sloan Kettering Basking RidgeBasking Ridge, New JerseyActive Not Recruiting
- Memorial Sloan Kettering BergenMontvale, New JerseyActive Not Recruiting
- Memorial Sloan Kettering Cancer CenterNew York, New YorkActive Not Recruiting
- Memorial Sloan Kettering CommackCommack, New YorkActive Not Recruiting
- Memorial Sloan Kettering MonmouthMiddletown, New JerseyActive Not Recruiting
- Memorial Sloan Kettering NassauUniondale, New YorkActive Not Recruiting
- Memorial Sloan Kettering WestchesterHarrison, New YorkActive Not Recruiting
- Mercy Cancer Center-ElyriaElyria, OhioSuspended
- Miami Cancer InstituteMiami, FloridaActive Not Recruiting
- Moffitt Cancer CenterTampa, FloridaSuspended
- MU Health - University Hospital/Ellis Fischel Cancer CenterColumbia, MissouriActive Not Recruiting
- MyMichigan Medical Center SaginawSaginaw, MichiganSuspended
- Northside HospitalAtlanta, GeorgiaActive Not Recruiting
- Northside Hospital-ForsythCumming, GeorgiaActive Not Recruiting
- NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer CenterNew York, New YorkActive Not Recruiting
- NYP/Weill Cornell Medical CenterNew York, New YorkSuspended
- Prisma Health Cancer Institute - EastsideGreenville, South CarolinaActive Not Recruiting
- Prisma Health Cancer Institute - FarisGreenville, South CarolinaActive Not Recruiting
- Prisma Health Cancer Institute - GreerGreer, South CarolinaActive Not Recruiting
- Prisma Health Cancer Institute - SenecaSeneca, South CarolinaActive Not Recruiting
- Prisma Health Cancer Institute - SpartanburgBoiling Springs, South CarolinaActive Not Recruiting
- ProCure Proton Therapy Center-SomersetSomerset, New JerseyActive Not Recruiting
- Robert Wood Johnson University Hospital SomersetSomerville, New JerseyActive Not Recruiting
- Rutgers New Jersey Medical SchoolNewark, New JerseySuspended
- Saint Joseph's Hospital and Medical CenterPhoenix, ArizonaSuspended
- Saint Luke's University Hospital-Bethlehem CampusBethlehem, PennsylvaniaActive Not Recruiting
- Stanford Cancer Institute Palo AltoPalo Alto, CaliforniaActive Not Recruiting
- Temple University HospitalPhiladelphia, PennsylvaniaSuspended
- The Cancer Center of Hawaii-LilihaHonolulu, HawaiiSuspended
- The New York Hospital Medical Center of QueensFlushing, New YorkActive Not Recruiting
- Thomas Jefferson University HospitalPhiladelphia, PennsylvaniaActive Not Recruiting
- TidalHealth Nanticoke / Allen Cancer CenterSeaford, DelawareActive Not Recruiting
- Trinity Health Saint Joseph Mercy Hospital Ann ArborAnn Arbor, MichiganSuspended
- Trinity Health Saint Mary Mercy Livonia HospitalLivonia, MichiganSuspended
- UHHS-Westlake Medical CenterWestlake, OhioActive Not Recruiting
- UNC Lineberger Comprehensive Cancer CenterChapel Hill, North CarolinaActive Not Recruiting
- University of Alabama at Birmingham Cancer CenterBirmingham, AlabamaActive Not Recruiting
- University of Arizona Cancer Center-North CampusTucson, ArizonaSuspended
- University of Arizona Cancer Center-Orange Grove CampusTucson, ArizonaSuspended
- University of Iowa/Holden Comprehensive Cancer CenterIowa City, IowaActive Not Recruiting
- University of Kansas Cancer CenterKansas City, KansasActive Not Recruiting
- University of Kansas Cancer Center-Overland ParkOverland Park, KansasActive Not Recruiting
- University of Kentucky/Markey Cancer CenterLexington, KentuckyActive Not Recruiting
- University of Maryland/Greenebaum Cancer CenterBaltimore, MarylandActive Not Recruiting
- University of Michigan Rogel Cancer CenterAnn Arbor, MichiganActive Not Recruiting
- University of Mississippi Medical CenterJackson, MississippiActive Not Recruiting
- University of Nebraska Medical CenterOmaha, NebraskaActive Not Recruiting
- University of Oklahoma Health Sciences CenterOklahoma City, OklahomaSuspended
- University of RochesterRochester, New YorkActive Not Recruiting
- University of Texas Health Science Center at San AntonioSan Antonio, TexasActive Not Recruiting
- University of Washington Medical Center - MontlakeSeattle, WashingtonActive Not Recruiting
- USC / Norris Comprehensive Cancer CenterLos Angeles, CaliforniaActive Not Recruiting
- UT MD Anderson Cancer CenterHouston, TexasActive Not Recruiting
- Vanderbilt University/Ingram Cancer CenterNashville, TennesseeActive Not Recruiting
- VCU Massey Comprehensive Cancer CenterRichmond, VirginiaActive Not Recruiting
- Westchester Medical CenterValhalla, New YorkSuspended
- Yale UniversityNew Haven, ConnecticutActive Not Recruiting
Japan7 locations · 6 recruiting
- Hiroshima University HospitalHiroshimaRecruiting
- Hokkaido University HospitalSapporo, HokkaidoRecruiting
- Keio UniversityShinjuku-ku, TokyoRecruiting
- Kyorin University HospitalMitaka-shi, TokyoRecruiting
- National Cancer Center HospitalTokyoRecruiting
- Saitama Medical University International Medical CenterSaitamaRecruiting
- Iwate Medical University HospitalShiwa-gun, IwateSuspended
Canada8 locations · 2 recruiting
- Juravinski Cancer Centre at Hamilton Health SciencesHamilton, OntarioRecruiting
- University Health Network-Princess Margaret HospitalToronto, OntarioRecruiting
- Allan Blair Cancer CentreRegina, SaskatchewanActive Not Recruiting
- Arthur J E Child Comprehensive Cancer CentreCalgary, AlbertaSuspended
- CHUM - Centre Hospitalier de l'Universite de MontrealMontreal, QuebecSuspended
- Cross Cancer InstituteEdmonton, AlbertaActive Not Recruiting
- London Regional Cancer ProgramLondon, OntarioSuspended
- The Research Institute of the McGill University Health Centre (MUHC)Montreal, QuebecSuspended
India1 location
- Tata Memorial HospitalMumbaiSuspended
Saudi Arabia1 location
- King Faisal Specialist Hospital and Research CentreRiyadhSuspended
Who to ask about joining
Site Public Contact877-602-4111
Site Public Contact800-398-3996clinical.trials@kp.org
Site Public Contactclinicalresearch@sutterhealth.org
Who can join
Adults aged 18 and older can join this study. It is open to both men and women who have a newly diagnosed, completely removed grade II meningioma. Some health conditions may prevent participation, and the trial team will confirm eligibility before enrollment.
What happens during the trial
Participants are randomly placed into one of two groups. One group will be watched closely with regular imaging and blood tests. The other group will receive radiation therapy five days a week for about 6.5 to 7 weeks, along with imaging and blood tests. Everyone will be followed up for several years after treatment.
The trial team
This trial is sponsored by NRG Oncology, and it involves collaboration with the National Cancer Institute. Dr. Michael A Vogelbaum is the principal investigator leading the study.
Important dates
The trial started on September 12, 2017. It is currently recruiting new participants and is expected to finish on June 15, 2027.
Additional information
The trial ID is NCT03180268. This is a Phase 3 trial, which means it is looking at how well the treatment works and how safe it is. The study is not regulated by the FDA as a drug or device. It hopes to include around 163 participants.
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