Pairing New Treatments to Fight Advanced Cervical Cancer Safely and Effectively
NCT07216703 · RecruitingAbout this trial
This study is looking for new ways to treat metastatic cervical cancer, which is cancer that has spread to other parts of the body. Researchers want to find out how safe it is to give sacituzumab tirumotecan along with pembrolizumab and possibly bevacizumab. They also want to see if this treatment helps people live longer or keeps their cancer from getting worse compared to standard treatments.
Locations and contact
This trial is running at 138 locations in 25 countries. All of them are currently recruiting.
United States16 locations · 16 recruiting
- Florida Cancer Specialists - East ( Site 7000)West Palm Beach, FloridaRecruiting
- Laura and Isaac Perlmutter Cancer Center at NYU Langone ( Site 6009)New York, New YorkRecruiting
- Minnesota Oncology Hematology, PA ( Site 8003)Edina, MinnesotaRecruiting
- Mount Sinai Comprehensive Cancer Center ( Site 6000)Miami Beach, FloridaRecruiting
- Nancy N. & J.C. Lewis Cancer and Research Pavillion - Research Department ( Site 6005)Savannah, GeorgiaRecruiting
- Oklahoma Cancer Specialists and Research Institute, LLC ( Site 6001)Tulsa, OklahomaRecruiting
- Oncology Associates of Oregon, P.C.(Willamette Valley Cancer Institute) (WVCI) ( Site 8007)Eugene, OregonRecruiting
- Texas Oncology - DFW ( Site 8005)Fort Worth, TexasRecruiting
- Texas Oncology - Northeast Texas ( Site 8002)Tyler, TexasRecruiting
- Texas Oncology-The Woodlands ( Site 8000)The Woodlands, TexasRecruiting
- TRIALS 365 ( Site 6008)Shreveport, LouisianaRecruiting
- University of Tennessee Medical Center ( Site 6012)Knoxville, TennesseeRecruiting
- University of Virginia Cancer Center ( Site 6014)Charlottesville, VirginiaRecruiting
- Winship Cancer Institute of Emory University ( Site 5005)Atlanta, GeorgiaRecruiting
- Women & Infants Hospital ( Site 6003)Providence, Rhode IslandRecruiting
- Women's Cancer Center of Nevada ( Site 6011)Las Vegas, NevadaRecruiting
Japan16 locations · 16 recruiting
- Aichi Cancer Center ( Site 2114)Nagoya, Aichi-kenRecruiting
- Cancer Institute Hospital of JFCR ( Site 2119)Koto, TokyoRecruiting
- Gunma Prefectural Cancer Center ( Site 2109)Ōta, GunmaRecruiting
- Hyogo Cancer Center ( Site 2118)Akashi, HyōgoRecruiting
- Iwate Medical University Hospital ( Site 2116)Shiwa-gun, IwateRecruiting
- Kanagawa Cancer Center ( Site 2121)Yokohama, KanagawaRecruiting
- Kurume University Hospital ( Site 2112)Kurume, FukuokaRecruiting
- National Hospital Organization Hokkaido Cancer Center ( Site 2108)Sapporo, HokkaidoRecruiting
- National Hospital Organization Kyushu Cancer Center ( Site 2102)FukuokaRecruiting
- Niigata Cancer Center Hospital ( Site 2110)NiigataRecruiting
- Okayama University Hospital ( Site 2101)OkayamaRecruiting
- Osaka Prefectural Hospital Organization Osaka International Cancer Institute ( Site 2111)OsakaRecruiting
- Saitama Medical University International Medical Center ( Site 2106)Hidaka, SaitamaRecruiting
- Shizuoka Cancer Center ( Site 2104)Sunto-gun,, ShizuokaRecruiting
- The Jikei University Hospital ( Site 2107)Minato, TokyoRecruiting
- University of the Ryukyus Hospital ( Site 2117)Ginowan, OkinawaRecruiting
Italy9 locations · 9 recruiting
- ASST Spedali Civili ( Site 2001)BresciaRecruiting
- Azienda Ospedaliera Ordine Mauriziano di Torino ( Site 2006)TorinoRecruiting
- CRO-IRCCS ( Site 2014)Aviano, Friuli Venezia GiuliaRecruiting
- Fondazione IRCCS Istituto Nazionale dei Tumori ( Site 2008)Milan, MilanoRecruiting
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS -Ginecologia Oncologica ( Site 2012)RomaRecruiting
- IRCCS - Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori" ( Site 2009)Meldola, Forli-CesenaRecruiting
- Istituto Europeo di Oncologia ( Site 2003)MilanRecruiting
- Ospedale Cannizzaro ( Site 2010)CataniaRecruiting
- Ospedale Humanitas San Pio X ( Site 2013)Milan, LombardyRecruiting
Brazil8 locations · 8 recruiting
- Fundacao Faculdade Regional de Medicina de Sao Jose do Rio Preto ( Site 0512)São José do Rio Preto, São PauloRecruiting
- Fundação Pio XII - Hospital de Câncer de Barretos ( Site 0511)Barretos, São PauloRecruiting
- Hospital Araújo Jorge ( Site 0518)Goiânia, GoiásRecruiting
- Hospital São Lucas da PUCRS ( Site 0516)Porto Alegre, Rio Grande do SulRecruiting
- IBCC - Instituto Brasileiro de Controle do Câncer ( Site 0517)São Paulo, São PauloRecruiting
- Instituto Nacional de Câncer - INCA ( Site 0515)Rio de JaneiroRecruiting
- Irmandade da Santa Casa de Misericordia de Porto Alegre ( Site 0514)Porto Alegre, Rio Grande do SulRecruiting
- Liga Norte Riograndense Contra o Câncer ( Site 0513)Natal, Rio Grande do NorteRecruiting
Argentina7 locations · 7 recruiting
- Centro de Oncología e Investigación de Buenos Aires ( Site 0107)Berazategui, Buenos AiresRecruiting
- Fundación CORI para la Investigación y Prevención del Cáncer ( Site 0111)La RiojaRecruiting
- Fundación Respirar ( Site 0101)Belgrano, Buenos Aires F.D.Recruiting
- Hospital Provincial del Centenario ( Site 0106)Rosario, Santa Fe ProvinceRecruiting
- Instituto de Investigaciones Clinicas Mar del Plata ( Site 0105)Mar del Plata, Buenos AiresRecruiting
- Instituto de Oncologia de Rosario ( Site 0104)Rosario, Santa Fe ProvinceRecruiting
- Instituto Misionero del Cancer ( Site 0112)Posadas, Misiones ProvinceRecruiting
Spain7 locations · 7 recruiting
- Hosp Clinico Universitario de Valencia ( Site 3001)Valencia, Valenciana, ComunitatRecruiting
- Hospital Ramon y Cajal ( Site 3005)MadridRecruiting
- Hospital Universitari Vall d Hebron ( Site 3003)BarcelonaRecruiting
- Hospital Universitario 12 de Octubre ( Site 3007)MadridRecruiting
- Hospital Universitario La Paz ( Site 3004)MadridRecruiting
- Hospital Universitario Reina Sofia ( Site 3006)CórdobaRecruiting
- Institut Català d'Oncologia (ICO) - Girona ( Site 3002)Girona, GeronaRecruiting
Canada6 locations · 6 recruiting
- Centre Hospitalier de l'Université de Montréal ( Site 0616)Montreal, QuebecRecruiting
- Centre intégré de cancérologie du CHU de Québec Université Laval, Hôpital de l'Enfant-Jésus ( Site 0611)Québec, QuebecRecruiting
- CIUSSS de l Estrie Centre Hospitalier Universitaire de Sherbrooke ( Site 0604)Sherbrooke, QuebecRecruiting
- McGill University Health Centre ( Site 0602)Montreal, QuebecRecruiting
- Princess Margaret Cancer Centre ( Site 0601)Toronto, OntarioRecruiting
- Sunnybrook Research Institute ( Site 0605)Toronto, OntarioRecruiting
Chile6 locations · 6 recruiting
- Bradfordhill ( Site 0702)Santiago, Region M. de SantiagoRecruiting
- CIDO SpA-Oncology ( Site 0708)Temuco, AraucaniaRecruiting
- FALP ( Site 0701)Santiago, Region M. de SantiagoRecruiting
- IC La Serena Research ( Site 0710)La Serena, Coquimbo RegionRecruiting
- ONCOCENTRO APYS-ACEREY ( Site 0703)Viña del Mar, ValparaisoRecruiting
- Pontificia Universidad Catolica de Chile-CICUC ( Site 0706)Santiago, Region M. de SantiagoRecruiting
Israel6 locations · 6 recruiting
- Carmel Hospital ( Site 1901)HaifaRecruiting
- Hillel Yaffe Medical Center ( Site 1903)HaderaRecruiting
- Rabin Medical Center ( Site 1904)Petah TikvaRecruiting
- Rambam Health Care Campus ( Site 1907)HaifaRecruiting
- Shaare Zedek Medical Center ( Site 1905)JerusalemRecruiting
- Sourasky Medical Center ( Site 1902)Tel AvivRecruiting
Mexico6 locations · 6 recruiting
- CANCER TREAMTENT CLINIC AND CLINICAL TRIALS SA DE CV ( Site 2204)Guadalajara, JaliscoRecruiting
- Centro de Investigacion Clinica de Oaxaca ( Site 2207)Oaxaca CityRecruiting
- Grupo Médico ASSET ( Site 2203)Mexico City, Mexico CityRecruiting
- Higiea Oncologia ( Site 2205)Mexico City, Mexico CityRecruiting
- Hospital Universitario "Dr. Jose Eleuterio Gonzalez" ( Site 2202)Monterrey, Nuevo LeónRecruiting
- Scientia Investigacion Clinica S.C. ( Site 2201)Chihuahua CityRecruiting
Belgium5 locations · 5 recruiting
- Antwerp University Hospital ( Site 0407)Edegem, AntwerpenRecruiting
- Cliniques Universitaires Saint-Luc ( Site 0402)Brussels, Bruxelles-Capitale, Region deRecruiting
- Grand Hopital de Charleroi ( Site 0404)Charleroi, HainautRecruiting
- UZ Gent ( Site 0406)Ghent, Oost-VlaanderenRecruiting
- UZ Leuven ( Site 0401)Leuven, Vlaams-BrabantRecruiting
Colombia5 locations · 5 recruiting
- Centro Cancerológico del Caribe (CECAC) ( Site 0906)Barranquilla, AtlánticoRecruiting
- Clinica Somer ( Site 0903)Rionegro, AntioquiaRecruiting
- Instituto Nacional De Cancerologia ( Site 0909)Bogotá, Bogota D.C.Recruiting
- Oncólogos del Occidente S.A.S. ( Site 0908)Pereira, Risaralda DepartmentRecruiting
- Oncomédica S.A.S ( Site 0905)Montería, Departamento de CórdobaRecruiting
Czechia5 locations · 5 recruiting
- Fakultní Nemocnice Brno ( Site 1003)Brno, Brno-mestoRecruiting
- Fakultni nemocnice Kralovske Vinohrady ( Site 1002)Prague, Praha 10Recruiting
- Fakultni nemocnice Ostrava ( Site 1005)Ostrava, Moravian-Silesian RegionRecruiting
- Nemocnice AGEL Novy Jicin a.s. ( Site 1004)Nový Jičín, Moravian-Silesian RegionRecruiting
- Vseobecna fakultni nemocnice v Praze-Gynekologicko-porodnicka klinika 1.LF a VFN ( Site 1001)PragueRecruiting
South Korea5 locations · 5 recruiting
- Asan Medical Center ( Site 2904)SeoulRecruiting
- National Cancer Center ( Site 2905)Goyang-si, Kyonggi-doRecruiting
- Samsung Medical Center ( Site 2903)SeoulRecruiting
- Seoul National University Hospital ( Site 2901)Jongno-gu, SeoulRecruiting
- Severance Hospital Yonsei University Health System ( Site 2902)Seodaemun-Gu, SeoulRecruiting
Taiwan5 locations · 5 recruiting
- Chang Gung Memorial Hospital ( Site 3302)TaoyuanRecruiting
- Mackay Memorial Hospital ( Site 3303)TaipeiRecruiting
- National Cheng Kung University Hospital ( Site 3308)TainanRecruiting
- National Taiwan University Hospital ( Site 3301)Taiwan, TaipeiRecruiting
- Taichung Veterans General Hospital ( Site 3304)TaichungRecruiting
Austria4 locations · 4 recruiting
- Medizinische Universitaet Innsbruck ( Site 0301)Innsbruck, TyrolRecruiting
- Medizinische Universitaet Wien ( Site 0302)Vienna, State of ViennaRecruiting
- Medizinische Universitat Graz ( Site 0303)Graz, StyriaRecruiting
- Uniklinikum Salzburg Landeskrankenhaus ( Site 0304)SalzburgRecruiting
Poland4 locations · 4 recruiting
- Mazowiecki Szpital Wojewódzki w Siedlcach ( Site 2601)Siedlce, Warmian-Masurian VoivodeshipRecruiting
- Narodowy Instytut Onkologii - Oddzial w Gliwicach-III Klinika Radioterapii i Chemioterapii ( Site 2604)Gliwice, Silesian VoivodeshipRecruiting
- Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie - Panstwowy Instytut Badawczy w Warszawie ( Site 2605)Warsaw, Masovian VoivodeshipRecruiting
- Swietokrzyskie Centrum Onkologii. ( Site 2602)Kielce, Świętokrzyskie VoivodeshipRecruiting
Thailand4 locations · 4 recruiting
- Chulalongkorn University ( Site 3403)Bangkok, BangkokRecruiting
- Faculty of Medicine Siriraj Hospital ( Site 3401)Bangkok, BangkokRecruiting
- Maharaj Nakorn Chiang Mai Hospital ( Site 3402)Chiang MaiRecruiting
- Ramathibodi Hospital ( Site 3404)Bangkok, BangkokRecruiting
France3 locations · 3 recruiting
- CHU Strasbourg-Hautepierre ( Site 1207)Strasbourg, AlsaceRecruiting
- Hopital Europeen Georges Pompidou ( Site 1210)ParisRecruiting
- Oncopole Claudius Regaud ( Site 1203)Toulouse, Haute-GaronneRecruiting
Greece3 locations · 3 recruiting
- Alexandra General Hospital of Athens-ONCOLOGY DEPT. ( Site 1401)Athens, AtticaRecruiting
- Aretaieio Hospital Oncology Unit ( Site 1402)Athens, AtticaRecruiting
- ATTIKON GENERAL UNIVERSITY HOSPITAL ( Site 1403)Chaïdári, AtticaRecruiting
Sweden3 locations · 3 recruiting
- Karolinska Universitetssjukhuset-Solna ( Site 3102)Stockholm, Stockholm CountyRecruiting
- Linköping University Hospital ( Site 3101)Linköping, Östergötland CountyRecruiting
- Skanes Universitetssjukhus Lund ( Site 3103)Lund, Skåne CountyRecruiting
Hungary2 locations · 2 recruiting
- Debreceni Egyetem Klinikai Kozpont ( Site 1601)DebrecenRecruiting
- Országos Onkológiai Intézet ( Site 1603)BudapestRecruiting
Ireland1 location · 1 recruiting
- Mater Misercordiae University Hospital ( Site 1804)DublinRecruiting
South Africa1 location · 1 recruiting
- Hopelands Cancer Centre ( Site 2816)Hilton, KwaZulu-NatalRecruiting
United Kingdom1 location · 1 recruiting
- The Christie Hospital NHS Foundation Trust ( Site 3602)Withington, ManchesterRecruiting
Who to ask about joining
Toll Free Number1-888-577-8839Trialsites@msd.com
Who can join
This study is for women age 18 and older who have certain types of cervical cancer that cannot be treated with surgery or radiation. Some health conditions may prevent participation, but the trial team will confirm who is eligible.
What happens during the trial
Participants will take part in two parts of the study. In the first part, they will receive a combination of sacituzumab tirumotecan, pembrolizumab, and bevacizumab. In the second part, all participants will receive standard care first. Those whose cancer does not progress will then be randomly assigned to continue with either pembrolizumab alone or the combination treatment. Everyone may also receive bevacizumab if the doctor thinks it's right for them.
The trial team
The trial is sponsored by Merck Sharp & Dohme LLC, with help from the European Network of Gynaecological Oncological Trial Groups and the GOG Foundation. The study director is the Medical Director at Merck Sharp & Dohme LLC.
Important dates
The study started on January 19, 2026, and is expected to finish by October 29, 2031. It is currently recruiting new participants.
Additional information
The trial's ID number is NCT07216703. This is a Phase 3 study, which means it is looking at how well the treatment works and how safe it is. The trial is regulated by the FDA and aims to include about 1,023 participants.
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