Pairing Two Immunotherapies to Treat Advanced Melanoma and Head and Neck Cancer
NCT05136196 · RecruitingAbout this trial
This study looks at how effective and safe two medicines, cabozantinib and nivolumab, are for treating patients with advanced melanoma or squamous cell head and neck cancer. These cancers may have spread from their original site to other areas. Cabozantinib works by blocking certain enzymes that help tumors grow. Nivolumab helps the immune system fight cancer. The trial also aims to see if patients can be grouped based on specific markers in their tumors, which could help doctors understand treatment responses better.
Locations and contact
This trial is running at 223 locations in the United States. 206 of them are currently recruiting.
United States223 locations · 206 recruiting
- Abbott-Northwestern HospitalMinneapolis, MinnesotaRecruiting
- Atrium Medical Center-Middletown Regional HospitalFranklin, OhioRecruiting
- Baystate Medical CenterSpringfield, MassachusettsRecruiting
- Beacon Kalamazoo Cancer CenterKalamazoo, MichiganRecruiting
- Benefis Sletten Cancer InstituteGreat Falls, MontanaRecruiting
- Billings Clinic Cancer CenterBillings, MontanaRecruiting
- Bozeman Health Deaconess HospitalBozeman, MontanaRecruiting
- Bronson Battle CreekBattle Creek, MichiganRecruiting
- Bronson Methodist HospitalKalamazoo, MichiganRecruiting
- Cancer and Hematology Centers of Western Michigan - Norton ShoresNorton Shores, MichiganRecruiting
- Cancer Care and Hematology-Fort CollinsFort Collins, ColoradoRecruiting
- Cancer Care Center of O'FallonO'Fallon, IllinoisRecruiting
- Cancer Care Specialists of Illinois - DecaturDecatur, IllinoisRecruiting
- Cancer Center of Western WisconsinNew Richmond, WisconsinRecruiting
- Cancer Hematology Centers - FlintFlint, MichiganRecruiting
- Carle at The RiverfrontDanville, IllinoisRecruiting
- Carle Cancer CenterUrbana, IllinoisRecruiting
- Carle Physician Group-EffinghamEffingham, IllinoisRecruiting
- Carle Physician Group-Mattoon/CharlestonMattoon, IllinoisRecruiting
- Cedars-Sinai Medical CenterLos Angeles, CaliforniaRecruiting
- Centra Alan B Pearson Regional Cancer CenterLynchburg, VirginiaRecruiting
- Centralia Oncology ClinicCentralia, IllinoisRecruiting
- Chelsea HospitalChelsea, MichiganRecruiting
- Clackamas Radiation Oncology CenterClackamas, OregonRecruiting
- Community Hospital of AnacondaAnaconda, MontanaRecruiting
- Community Medical CenterMissoula, MontanaRecruiting
- Corewell Health Grand Rapids Hospitals - Butterworth HospitalGrand Rapids, MichiganRecruiting
- Corewell Health Lakeland Hospitals - Marie Yeager Cancer CenterSaint Joseph, MichiganRecruiting
- Corewell Health Lakeland Hospitals - Niles HospitalNiles, MichiganRecruiting
- Corewell Health Reed City HospitalReed City, MichiganRecruiting
- Crossroads Cancer CenterEffingham, IllinoisRecruiting
- Dartmouth Cancer Center - NorthSaint Johnsbury, VermontRecruiting
- Dartmouth Hitchcock Medical Center/Dartmouth Cancer CenterLebanon, New HampshireRecruiting
- Decatur Memorial HospitalDecatur, IllinoisRecruiting
- Duluth Clinic AshlandAshland, WisconsinRecruiting
- Essentia Health - Deer River ClinicDeer River, MinnesotaRecruiting
- Essentia Health - FosstonFosston, MinnesotaRecruiting
- Essentia Health - Jamestown ClinicJamestown, North DakotaRecruiting
- Essentia Health - Park RapidsPark Rapids, MinnesotaRecruiting
- Essentia Health Cancer CenterDuluth, MinnesotaRecruiting
- Essentia Health Cancer Center-South University ClinicFargo, North DakotaRecruiting
- Essentia Health Hibbing ClinicHibbing, MinnesotaRecruiting
- Essentia Health Saint Joseph's Medical CenterBrainerd, MinnesotaRecruiting
- Essentia Health Saint Mary's - Detroit Lakes ClinicDetroit Lakes, MinnesotaRecruiting
- Essentia Health Saint Mary's Hospital - SuperiorSuperior, WisconsinRecruiting
- Essentia Health SandstoneSandstone, MinnesotaRecruiting
- Essentia Health Virginia ClinicVirginia, MinnesotaRecruiting
- Fairview Southdale HospitalEdina, MinnesotaRecruiting
- Genesys Hurley Cancer InstituteFlint, MichiganRecruiting
- Gundersen Lutheran Medical CenterLa Crosse, WisconsinRecruiting
- Helen F Graham Cancer CenterNewark, DelawareRecruiting
- Huntsman Cancer Institute/University of UtahSalt Lake City, UtahRecruiting
- Hurley Medical CenterFlint, MichiganRecruiting
- Huron Gastroenterology PCYpsilanti, MichiganRecruiting
- Illinois CancerCare - WashingtonWashington, IllinoisRecruiting
- Illinois CancerCare-BloomingtonBloomington, IllinoisRecruiting
- Illinois CancerCare-CantonCanton, IllinoisRecruiting
- Illinois CancerCare-CarthageCarthage, IllinoisRecruiting
- Illinois CancerCare-DixonDixon, IllinoisRecruiting
- Illinois CancerCare-EurekaEureka, IllinoisRecruiting
- Illinois CancerCare-GalesburgGalesburg, IllinoisRecruiting
- Illinois CancerCare-Kewanee ClinicKewanee, IllinoisRecruiting
- Illinois CancerCare-MacombMacomb, IllinoisRecruiting
- Illinois CancerCare-Ottawa ClinicOttawa, IllinoisRecruiting
- Illinois CancerCare-PekinPekin, IllinoisRecruiting
- Illinois CancerCare-PeoriaPeoria, IllinoisRecruiting
- Illinois CancerCare-PeruPeru, IllinoisRecruiting
- Illinois CancerCare-PrincetonPrinceton, IllinoisRecruiting
- Inova Alexandria HospitalAlexandria, VirginiaRecruiting
- Inova Fair Oaks HospitalFairfax, VirginiaRecruiting
- Inova Fairfax HospitalFalls Church, VirginiaRecruiting
- Inova Schar Cancer InstituteFairfax, VirginiaRecruiting
- Kootenai Clinic Cancer Services - Post FallsPost Falls, IdahoRecruiting
- Kootenai Clinic Cancer Services - SandpointSandpoint, IdahoRecruiting
- Kootenai Health - Coeur d'AleneCoeur d'Alene, IdahoRecruiting
- Laura and Isaac Perlmutter Cancer Center at NYU LangoneNew York, New YorkRecruiting
- Logan Health Medical CenterKalispell, MontanaRecruiting
- Loyola University Medical CenterMaywood, IllinoisRecruiting
- Marshfield Medical Center - MinocquaMinocqua, WisconsinRecruiting
- Marshfield Medical Center - WestonWeston, WisconsinRecruiting
- Marshfield Medical Center-EC Cancer CenterEau Claire, WisconsinRecruiting
- Marshfield Medical Center-MarshfieldMarshfield, WisconsinRecruiting
- Marshfield Medical Center-Rice LakeRice Lake, WisconsinRecruiting
- Marshfield Medical Center-River Region at Stevens PointStevens Point, WisconsinRecruiting
- Mary Greeley Medical CenterAmes, IowaRecruiting
- Mayo Clinic Hospital in ArizonaPhoenix, ArizonaRecruiting
- Mayo Clinic in FloridaJacksonville, FloridaRecruiting
- Mayo Clinic in RochesterRochester, MinnesotaRecruiting
- McFarland Clinic - AmesAmes, IowaRecruiting
- McFarland Clinic - MarshalltownMarshalltown, IowaRecruiting
- McFarland Clinic - Trinity Cancer CenterFort Dodge, IowaRecruiting
- Medical Center of the RockiesLoveland, ColoradoRecruiting
- Medical College of WisconsinMilwaukee, WisconsinRecruiting
- Medical Oncology Hematology Consultants PANewark, DelawareRecruiting
- Memorial Hospital EastShiloh, IllinoisRecruiting
- Memorial Hospital NorthColorado Springs, ColoradoRecruiting
- Mercy Cancer Center-West LakesClive, IowaRecruiting
- Mercy HospitalCedar Rapids, IowaRecruiting
- Mercy HospitalCoon Rapids, MinnesotaRecruiting
- Mercy Hospital SouthSt Louis, MissouriRecruiting
- Mercy Medical Center - Des MoinesDes Moines, IowaRecruiting
- Miami Valley Cancer Care and InfusionGreenville, OhioRecruiting
- Miami Valley Hospital NorthDayton, OhioRecruiting
- Miami Valley Hospital SouthCenterville, OhioRecruiting
- Minnesota Oncology - BurnsvilleBurnsville, MinnesotaRecruiting
- Minnesota Oncology Hematology PA-WoodburyWoodbury, MinnesotaRecruiting
- Munson Medical CenterTraverse City, MichiganRecruiting
- Nebraska Medicine-BellevueBellevue, NebraskaRecruiting
- Nebraska Medicine-Village PointeOmaha, NebraskaRecruiting
- Northwestern Medicine Cancer Center DelnorGeneva, IllinoisRecruiting
- Northwestern Medicine Cancer Center KishwaukeeDeKalb, IllinoisRecruiting
- Northwestern Medicine Cancer Center WarrenvilleWarrenville, IllinoisRecruiting
- Northwestern Medicine Lake Forest HospitalLake Forest, IllinoisRecruiting
- Northwestern Medicine Orland ParkOrland Park, IllinoisRecruiting
- Northwestern UniversityChicago, IllinoisRecruiting
- NYU Langone Hospital - Long IslandMineola, New YorkRecruiting
- Oncology Associates at Mercy Medical CenterCedar Rapids, IowaRecruiting
- OSF Saint Francis Hospital and Medical GroupEscanaba, MichiganRecruiting
- Park Nicollet Clinic - Saint Louis ParkSaint Louis Park, MinnesotaRecruiting
- Poudre Valley HospitalFort Collins, ColoradoRecruiting
- Premier Blood and Cancer CenterDayton, OhioRecruiting
- ProHealth D N Greenwald CenterMukwonago, WisconsinRecruiting
- ProHealth Oconomowoc Memorial HospitalOconomowoc, WisconsinRecruiting
- ProHealth Waukesha Memorial HospitalWaukesha, WisconsinRecruiting
- Providence Newberg Medical CenterNewberg, OregonRecruiting
- Providence Portland Medical CenterPortland, OregonRecruiting
- Providence Saint Vincent Medical CenterPortland, OregonRecruiting
- Providence Willamette Falls Medical CenterOregon City, OregonRecruiting
- Rapid City Regional HospitalRapid City, South DakotaRecruiting
- Regions HospitalSaint Paul, MinnesotaRecruiting
- Ridgeview Medical CenterWaconia, MinnesotaRecruiting
- Rush-Copley Healthcare CenterYorkville, IllinoisRecruiting
- Rush-Copley Medical CenterAurora, IllinoisRecruiting
- Saint Alphonsus Cancer Care Center-BoiseBoise, IdahoRecruiting
- Saint Alphonsus Cancer Care Center-CaldwellCaldwell, IdahoRecruiting
- Saint Alphonsus Cancer Care Center-NampaNampa, IdahoRecruiting
- Saint Alphonsus Cancer Care Center-OntarioOntario, OregonRecruiting
- Saint Charles Health SystemBend, OregonRecruiting
- Saint Francis Medical CenterCape Girardeau, MissouriRecruiting
- Saint John's Hospital - HealtheastMaplewood, MinnesotaRecruiting
- Saint Luke's Cancer Institute - BoiseBoise, IdahoRecruiting
- Saint Luke's Cancer Institute - FruitlandFruitland, IdahoRecruiting
- Saint Luke's Cancer Institute - MeridianMeridian, IdahoRecruiting
- Saint Luke's Cancer Institute - NampaNampa, IdahoRecruiting
- Saint Luke's Cancer Institute - Twin FallsTwin Falls, IdahoRecruiting
- Saint Vincent Hospital Cancer Center at Oconto FallsOconto Falls, WisconsinRecruiting
- Saint Vincent Hospital Cancer Center at Saint Mary'sGreen Bay, WisconsinRecruiting
- Saint Vincent Hospital Cancer Center at SheboyganSheboygan, WisconsinRecruiting
- Saint Vincent Hospital Cancer Center at Sturgeon BaySturgeon Bay, WisconsinRecruiting
- Saint Vincent Hospital Cancer Center Green BayGreen Bay, WisconsinRecruiting
- Sanford Bismarck Medical CenterBismarck, North DakotaRecruiting
- Sanford Broadway Medical CenterFargo, North DakotaRecruiting
- Sanford Cancer Center Oncology ClinicSioux Falls, South DakotaRecruiting
- Sanford Joe Lueken Cancer CenterBemidji, MinnesotaRecruiting
- Sanford Roger Maris Cancer CenterFargo, North DakotaRecruiting
- Sanford USD Medical Center - Sioux FallsSioux Falls, South DakotaRecruiting
- Siteman Cancer Center at Christian HospitalSt Louis, MissouriRecruiting
- Siteman Cancer Center at Saint Peters HospitalCity of Saint Peters, MissouriRecruiting
- Siteman Cancer Center at West County HospitalCreve Coeur, MissouriRecruiting
- Siteman Cancer Center-South CountySt Louis, MissouriRecruiting
- Southeastern Medical Oncology Center-ClintonClinton, North CarolinaRecruiting
- Southeastern Medical Oncology Center-GoldsboroGoldsboro, North CarolinaRecruiting
- Southeastern Medical Oncology Center-JacksonvilleJacksonville, North CarolinaRecruiting
- Southern Illinois University School of MedicineSpringfield, IllinoisRecruiting
- Springfield ClinicSpringfield, IllinoisRecruiting
- Springfield Memorial HospitalSpringfield, IllinoisRecruiting
- The Angeles Clinic and Research Institute - West Los Angeles OfficeLos Angeles, CaliforniaRecruiting
- Thomas Jefferson University HospitalPhiladelphia, PennsylvaniaRecruiting
- Tower Cancer Research FoundationBeverly Hills, CaliforniaRecruiting
- Trinity Health Grand Rapids HospitalGrand Rapids, MichiganRecruiting
- Trinity Health IHA Medical Group Hematology Oncology - BrightonBrighton, MichiganRecruiting
- Trinity Health IHA Medical Group Hematology Oncology - CantonCanton, MichiganRecruiting
- Trinity Health IHA Medical Group Hematology Oncology - Chelsea HospitalChelsea, MichiganRecruiting
- Trinity Health IHA Medical Group Hematology Oncology Ann Arbor CampusYpsilanti, MichiganRecruiting
- Trinity Health Medical Center - BrightonBrighton, MichiganRecruiting
- Trinity Health Medical Center - CantonCanton, MichiganRecruiting
- Trinity Health Muskegon HospitalMuskegon, MichiganRecruiting
- Trinity Health Saint Joseph Mercy Hospital Ann ArborAnn Arbor, MichiganRecruiting
- Trinity Health Saint Joseph Mercy Oakland HospitalPontiac, MichiganRecruiting
- Trinity Health Saint Mary Mercy Livonia HospitalLivonia, MichiganRecruiting
- UC Irvine Health/Chao Family Comprehensive Cancer CenterOrange, CaliforniaRecruiting
- UCHealth Greeley HospitalGreeley, ColoradoRecruiting
- UCHealth Memorial Hospital CentralColorado Springs, ColoradoRecruiting
- UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory CareIrvine, CaliforniaRecruiting
- UI Health Care Mission Cancer and Blood - Ankeny ClinicAnkeny, IowaRecruiting
- UI Health Care Mission Cancer and Blood - Des Moines ClinicDes Moines, IowaRecruiting
- UI Health Care Mission Cancer and Blood - Laurel ClinicDes Moines, IowaRecruiting
- UI Health Care Mission Cancer and Blood - Waukee ClinicWaukee, IowaRecruiting
- UI Health Care Mission Cancer and Blood - West Des Moines ClinicClive, IowaRecruiting
- United HospitalSaint Paul, MinnesotaRecruiting
- University of Arkansas for Medical SciencesLittle Rock, ArkansasRecruiting
- University of IllinoisChicago, IllinoisRecruiting
- University of Michigan Health - Sparrow LansingLansing, MichiganRecruiting
- University of Michigan Health - WestWyoming, MichiganRecruiting
- University of Michigan Rogel Cancer CenterAnn Arbor, MichiganRecruiting
- University of Nebraska Medical CenterOmaha, NebraskaRecruiting
- University of New Mexico Cancer CenterAlbuquerque, New MexicoRecruiting
- University of Oklahoma Health Sciences CenterOklahoma City, OklahomaRecruiting
- Upper Valley Medical CenterTroy, OhioRecruiting
- UW Cancer Center at ProHealth CareWaukesha, WisconsinRecruiting
- VCU Health Tappahannock HospitalTappahannock, VirginiaRecruiting
- VCU Massey Cancer Center at Stony PointRichmond, VirginiaRecruiting
- VCU Massey Comprehensive Cancer CenterRichmond, VirginiaRecruiting
- Virginia Cancer InstituteRichmond, VirginiaRecruiting
- Washington University School of MedicineSt Louis, MissouriRecruiting
- West Michigan Cancer CenterKalamazoo, MichiganRecruiting
- Asplundh Cancer PavilionWillow Grove, PennsylvaniaActive Not Recruiting
- Genesee Hematology Oncology PCFlint, MichiganSuspended
- Hawaii Cancer Care - Westridge‘Aiea, HawaiiActive Not Recruiting
- Hawaii Cancer Care Inc - Waterfront PlazaHonolulu, HawaiiActive Not Recruiting
- Jefferson Torresdale HospitalPhiladelphia, PennsylvaniaActive Not Recruiting
- McFarland Clinic - BooneBoone, IowaSuspended
- McFarland Clinic - JeffersonJefferson, IowaSuspended
- Northwell Health/Center for Advanced MedicineLake Success, New YorkActive Not Recruiting
- Queen's Cancer Cenrer - POB IHonolulu, HawaiiActive Not Recruiting
- Queen's Cancer Center - KuakiniHonolulu, HawaiiActive Not Recruiting
- Queen's Medical CenterHonolulu, HawaiiActive Not Recruiting
- Rocky Mountain Regional VA Medical CenterAurora, ColoradoActive Not Recruiting
- Tufts Medical CenterBoston, MassachusettsActive Not Recruiting
- Tufts Medical Center Cancer Center StonehamStoneham, MassachusettsActive Not Recruiting
- Unity HospitalFridley, MinnesotaActive Not Recruiting
- Wayne State University/Karmanos Cancer InstituteDetroit, MichiganActive Not Recruiting
- Weisberg Cancer Treatment CenterFarmington Hills, MichiganActive Not Recruiting
Who to ask about joining
Site Public Contact855-776-0015
Site Public Contact501-686-8274
Site Public Contacttowercancerresearch@toweroncology.com
Who can join
This trial is open to adults aged 18 and older, including both men and women. Participants must have confirmed advanced melanoma or squamous cell head and neck cancer that is hard to treat with standard methods. Those with certain health conditions or who have recently had specific treatments may not be eligible. The trial team will check all potential participants to confirm who can join.
What happens during the trial
Everyone in the trial will receive both nivolumab and cabozantinib. Nivolumab is given through an IV over 30 minutes on the first day of each treatment cycle, while cabozantinib is taken by mouth every day. Each treatment cycle lasts 28 days and continues for up to 2 years if the disease does not get worse. Participants will also have imaging scans and blood tests throughout the study, and they may have tumor biopsies at different times.
The trial team
The trial is sponsored by the National Cancer Institute (NCI). The principal investigator is Dr. Siwen Hu-Lieskovan from the SWOG Cancer Research Network.
Important dates
The trial started on December 6, 2022, and is expected to finish on January 1, 2027. It is currently enrolling new participants.
Additional information
The trial's ID number is NCT05136196. This is a Phase 2 trial, meaning it is looking at how well the treatment works and how safe it is. The trial is FDA-regulated and aims to include about 150 participants.
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