Reviewing the Effectiveness of Opevesostat for Advanced Prostate Cancer Treatments
NCT06136650 · RecruitingAbout this trial
This study looks at how well opevesostat works compared to other treatments for men with metastatic castration-resistant prostate cancer (mCRPC) who have already tried one other hormonal treatment. The goal is to see if opevesostat, along with hormone replacement therapy, helps patients live longer without their cancer getting worse. The study will measure how long patients stay free of cancer progression on imaging tests.
Locations and contact
This trial is running at 329 locations in 39 countries. 276 of them are currently recruiting.
United States62 locations · 57 recruiting
- Associated Medical Professionals - Urology ( Site 0081)Syracuse, New YorkRecruiting
- Avera Cancer Institute - Aberdeen (Site 0123)Aberdeen, South DakotaRecruiting
- Avera Cancer Institute - Marshall (Site 0122)Marshall, MinnesotaRecruiting
- Avera Cancer Institute - Mitchell (Site 0121)Mitchell, South DakotaRecruiting
- Avera Cancer Institute - Yankton ( Site 0117)Yankton, South DakotaRecruiting
- Avera Cancer Institute- Research ( Site 0094)Sioux Falls, South DakotaRecruiting
- Baltimore Veterans Affairs Medical Center ( Site 0069)Baltimore, MarylandRecruiting
- Blue Ridge Cancer Care ( Site 0004)Roanoke, VirginiaRecruiting
- Cancer and Hematology Centers of Western Michigan ( Site 0005)Grand Rapids, MichiganRecruiting
- Chesapeake Urology ( Site 0009)Towson, MarylandRecruiting
- Colorado Clinical Research ( Site 0067)Lakewood, ColoradoRecruiting
- Comprehensive Cancer Centers of Nevada ( Site 0010)Las Vegas, NevadaRecruiting
- Edward-Elmhurst Healthcare, Edward Hospital-Edward Cancer Center ( Site 0075)Naperville, IllinoisRecruiting
- Edward-Elmhurst Healthcare, Elmhurst Hospital-Nancy W. Knowles Cancer Center ( Site 0074)Elmhurst, IllinoisRecruiting
- Fox Chase Cancer Center ( Site 0076)Philadelphia, PennsylvaniaRecruiting
- Genesis Healthcare System ( Site 0102)Zanesville, OhioRecruiting
- Greenebaum Comprehensive Cancer Center ( Site 0049)Baltimore, MarylandRecruiting
- HealthPartners Cancer Research Center-HealthPartners Cancer Center at Regions Hospital ( Site 0092)Saint Paul, MinnesotaRecruiting
- HealthPartners Cancer Research Center-HealthPartners Frauenshuh Cancer Center ( Site 0072)Saint Louis Park, MinnesotaRecruiting
- Henry Ford Hospital ( Site 0015)Detroit, MichiganRecruiting
- Illinois Cancer Care ( Site 0104)Peoria, IllinoisRecruiting
- Inova Schar Cancer Institute ( Site 0017)Fairfax, VirginiaRecruiting
- Kaiser Permanente Riverside Medical Center ( Site 0099)Riverside, CaliforniaRecruiting
- Kaiser Permanente-Kaiser Permanente, Vallejo Medical Center, Adult Oncology ( Site 0101)Vallejo, CaliforniaRecruiting
- MEDICAL COLLEGE OF WISCONSIN ( Site 0020)Milwaukee, WisconsinRecruiting
- MedStar Washington Hospital Center ( Site 0103)Washington D.C., District of ColumbiaRecruiting
- Memorial Hospital West-Memorial Cancer Institute ( Site 0109)Pembroke Pines, FloridaRecruiting
- MidLantic urology ( Site 0022)Bala-Cynwyd, PennsylvaniaRecruiting
- Mount Sinai Cancer Center ( Site 0107)Miami Beach, FloridaRecruiting
- Northside Hospital-Northside Hospital Oncology Network ( Site 0100)Atlanta, GeorgiaRecruiting
- Northwest Cancer Specialists (Compass Oncology) ( Site 8008)Vancouver, WashingtonRecruiting
- Oncology Hematology West P.C. dba Nebraska Cancer Specialists ( Site 0026)Omaha, NebraskaRecruiting
- OptumCare Cancer Care-Research Department ( Site 0078)Las Vegas, NevadaRecruiting
- Ralph H. Johnson VA Health Care System (RHJVAHCS)-Urology ( Site 0083)Charleston, South CarolinaRecruiting
- Rutgers Cancer Institute of New Jersey ( Site 0033)New Brunswick, New JerseyRecruiting
- San Francisco VA Health Care System ( Site 0093)San Francisco, CaliforniaRecruiting
- Spokane Urology ( Site 0035)Spokane, WashingtonRecruiting
- St. Vincent Frontier Cancer Center-Research ( Site 0037)Billings, MontanaRecruiting
- Stanford Cancer Center ( Site 0036)Palo Alto, CaliforniaRecruiting
- Texas Oncology - Central/South Texas ( Site 8003)Austin, TexasRecruiting
- Texas Oncology - DFW ( Site 8001)Dallas, TexasRecruiting
- Texas Oncology - Gulf Coast ( Site 8002)Houston, TexasRecruiting
- The University of Arizona Cancer Center - North Campus ( Site 0073)Tucson, ArizonaRecruiting
- The West Clinic, PLLC dba West Cancer Center ( Site 0063)Germantown, TennesseeRecruiting
- UCHealth Highlands Ranch Hospital ( Site 0111)Highlands Ranch, ColoradoRecruiting
- UCLA Hematology/Oncology - Santa Monica ( Site 0044)Los Angeles, CaliforniaRecruiting
- University Hospitals Cleveland Medical Center ( Site 0043)Cleveland, OhioRecruiting
- University of California Davis (UC Davis) Comprehensive Cancer Center ( Site 0114)Sacramento, CaliforniaRecruiting
- University of California, Irvine (UCI) Health - UC Irvine Medical Center ( Site 0040)Orange, CaliforniaRecruiting
- University of California, Irvine (UCI) Health - UC Irvine Medical Center (0120)Orange, CaliforniaRecruiting
- University of Colorado Anschutz Medical Campus ( Site 0046)Aurora, ColoradoRecruiting
- University of Colorado Health - Lone Tree Medical Center ( Site 0112)Lone Tree, ColoradoRecruiting
- University of Virginia Health System ( Site 0054)Charlottesville, VirginiaRecruiting
- Urology of Indiana - Carmel ( Site 0055)Carmel, IndianaRecruiting
- VCU Health Adult Outpatient Pavillion ( Site 0061)Richmond, VirginiaRecruiting
- Virginia Cancer Specialists (VCS) ( Site 8004)Fairfax, VirginiaRecruiting
- Yale-New Haven Hospital-Yale Cancer Center ( Site 0064)New Haven, ConnecticutRecruiting
- Avera Cancer Institute - Pierre ( Site 0118)Pierre, South DakotaActive Not Recruiting
- Central Ohio Urology Group - Gahanna ( Site 0098)Gahanna, OhioActive Not Recruiting
- Emad Ibrahim,MD,INC. ( Site 0012)Redlands, CaliforniaCompleted
- Florida Cancer Specialists - South ( Site 7003)Fort Myers, FloridaActive Not Recruiting
- University of Kentucky Chandler Medical Center ( Site 0048)Lexington, KentuckyActive Not Recruiting
China31 locations · 29 recruiting
- Beijing Cancer Hospital ( Site 1623)Beijing, Beijing MunicipalityRecruiting
- Beijing Cancer hospital-Urinary Surgery ( Site 1620)Beijing, Beijing MunicipalityRecruiting
- Chongqing University Cancer Hospital ( Site 1603)Chongqing, Chongqing MunicipalityRecruiting
- First Medical Center of Chinese PLA General Hospital ( Site 1601)Beijing, Beijing MunicipalityRecruiting
- Huadong Hospital Affiliated to Fudan University-Urology ( Site 1613)Shanghai, Shanghai MunicipalityRecruiting
- Hubei Cancer Hospital-Urinary surgery ( Site 1631)Wuhan, HubeiRecruiting
- Hunan Cancer Hospital ( Site 1630)Changsha, HunanRecruiting
- Nanchong Central Hospital-urology ( Site 1647)Nanchong, SichuanRecruiting
- Nanjing Drum Tower Hospital The Affiliated Hospital of Nanjing University Medical School-Urology ( Site 1615)Nanjing, JiangsuRecruiting
- Nantong Tumor Hospital-Urology ( Site 1609)Nantong, JiangsuRecruiting
- Ningbo First Hospital-Urology ( Site 1608)Ningbo, ZhejiangRecruiting
- Peking University First Hospital-Urology ( Site 1602)Beijing, Beijing MunicipalityRecruiting
- Sun Yat-sen University Cancer Center-Urology Surgery ( Site 1638)Guangzhou, GuangdongRecruiting
- The Central Hospital of Wuhan ( Site 1635)Wuhan, HubeiRecruiting
- The First Affiliated Hospital Of Fujian Medical University-Urology ( Site 1639)Fuzhou, FujianRecruiting
- The first affiliated hospital of Guangzhou medical university ( Site 1637)Guangzhou, GuangdongRecruiting
- The First Affiliated Hospital of Wenzhou Medical University ( Site 1604)Wenzhou, ZhejiangRecruiting
- The First Affiliated Hospital of Xi'an Jiaotong University-Oncology department ( Site 1618)Xi'an, ShaanxiRecruiting
- The First Hospital of Jiaxing-urology ( Site 1605)Jiaxing, ZhejiangRecruiting
- The Second Affiliated Hospital of Xi'an Jiaotong University-Oncology Department ( Site 1619)Xi'an, ShaanxiRecruiting
- The Second Hospital Of Anhui Medical University ( Site 1633)Hefei, AnhuiRecruiting
- The Second Hospital of Tianjin Medical University ( Site 1616)Tianjin, Tianjin MunicipalityRecruiting
- Tongji Hospital Tongji Medical,Science & Technology ( Site 1632)Wuhan, HubeiRecruiting
- West China Hospital, Sichuan University-Urology Surgery ( Site 1642)Chengdu, SichuanRecruiting
- Wuxi People's Hospital ( Site 1612)Wuxi, JiangsuRecruiting
- Xinjiang Medical University Cancer Hospital - Urumqi-Urology ( Site 1644)Ürümqi, XinjiangRecruiting
- Yantai Yuhuangding Hospital ( Site 1622)Yantai, ShandongRecruiting
- Yunnan Province Cancer Hospital ( Site 1643)Kunming, YunnanRecruiting
- Zhejiang Provincial People's Hospital-Urology ( Site 1641)Hangzhou, ZhejiangRecruiting
- Renji Hosp Shanghai Jiaotong U School of Med ( Site 1624)Shanghai, Shanghai MunicipalityActive Not Recruiting
- Southwest Hospital of Third Military Medical University ( Site 1645)Chongqing, Chongqing MunicipalityActive Not Recruiting
Japan30 locations · 22 recruiting
- Akita University Hospital ( Site 0728)AkitaRecruiting
- Fukushima Medical University Hospital ( Site 0758)FukushimaRecruiting
- Gifu University Hospital ( Site 0736)GifuRecruiting
- Hokkaido University Hospital ( Site 0756)Sapporo, HokkaidoRecruiting
- Hospital of the University of Occupational and Environmental Health, Japan ( Site 0746)Kitakyushu, FukuokaRecruiting
- Kagawa University Hospital ( Site 0744)Kita, Kagawa-kenRecruiting
- Kanazawa Medical University Hospital ( Site 0734)Mukai-awagasaki, Ishikawa-kenRecruiting
- Kansai Medical University Hospital ( Site 0739)Hirakata, OsakaRecruiting
- Kobe University Hospital ( Site 0741)Kobe, HyōgoRecruiting
- Miyazaki Prefectural Miyazaki Hospital ( Site 0752)MiyazakiRecruiting
- Nagano Municipal Hospital ( Site 0757)NaganoRecruiting
- Nara Medical University Hospital ( Site 0742)Kashihara, NaraRecruiting
- National Hospital Organization Kumamoto Medical Center ( Site 0749)KumamotoRecruiting
- National Hospital Organization Nagasaki Medical Center ( Site 0748)Ōmura, NagasakiRecruiting
- Saga-Ken Medical Centre Koseikan ( Site 0747)Saga, Saga-kenRecruiting
- Sapporo Medical University Hospital ( Site 0726)Sapporo, HokkaidoRecruiting
- The Jikei University Hospital ( Site 0731)Minato, TokyoRecruiting
- The University of Osaka Hospital ( Site 0738)Suita, OsakaRecruiting
- Toho University Sakura Medical Center ( Site 0730)Sakura, ChibaRecruiting
- University of Fukui Hospital ( Site 0735)Eiheiji-cho,Yoshida-gun, FukuiRecruiting
- University of Miyazaki Hospital ( Site 0751)MiyazakiRecruiting
- Yokohama City University Medical Center ( Site 0733)Yokohama, KanagawaRecruiting
- Bell Land General Hospital ( Site 0740)Sakai, OsakaActive Not Recruiting
- Hiroshima University Hospital ( Site 0743)HiroshimaActive Not Recruiting
- Kagoshima University Hospital ( Site 0754)KagoshimaActive Not Recruiting
- Kyushu University Hospital ( Site 0745)FukuokaActive Not Recruiting
- Mie University Hospital ( Site 0737)Tsu, Mie-kenActive Not Recruiting
- Nanbu Tokushukai Hospital ( Site 0755)Shimajiri, OkinawaActive Not Recruiting
- National Hospital Organization Oita Medical Center ( Site 0750)ŌitaCompleted
- Nihon University Itabashi Hospital ( Site 0732)Itabashiku, TokyoCompleted
Germany13 locations · 9 recruiting
- Caritas-Krankenhaus St. Josef-Klinik fuer Urologie ( Site 0523)Regensburg, BavariaRecruiting
- Charité Universitaetsmedizin Berlin - Campus Mitte ( Site 0504)BerlinRecruiting
- Marien-Krankenhaus ( Site 0515)Bergisch Gladbach, North Rhine-WestphaliaRecruiting
- Studienpraxis Urologie ( Site 0529)Nürtingen, Baden-WurttembergRecruiting
- Universitaetsklinikum Freiburg-Klinik für Urologie ( Site 0506)Freiburg im Breisgau, Baden-WurttembergRecruiting
- Universitaetsklinikum Heidelberg ( Site 0531)Heidelberg, Baden-WurttembergRecruiting
- Universitätsmedizin Göttingen - Georg-August-Universität-Klinik für Urologie ( Site 0527)Göttingen, Lower SaxonyRecruiting
- Urologicum Duisburg (Site 00538)Duisburg, North Rhine-WestphaliaRecruiting
- Vivantes Klinikum Am Urban ( Site 0512)BerlinRecruiting
- klinikum rechts der isar der technischen universität münchen-Urologische Klinik und Poliklinik ( Site 0521)Munich, BavariaActive Not Recruiting
- Universitaetsklinikum Carl Gustav Carus Dresden-Klinik und Poliklinik für Urologie ( Site 0528)Dresden, SaxonyCompleted
- Universitaetsklinikum Koeln ( Site 0518)Cologne, North Rhine-WestphaliaActive Not Recruiting
- Universitätsklinikum Marburg-Comprehensive Cancer Center ( Site 0510)Marburg, HesseCompleted
United Kingdom13 locations · 9 recruiting
- Addenbrooke's Hospital ( Site 1426)Cambridge, CambridgeshireRecruiting
- Charing Cross Hospital-Oncology Research ( Site 1434)London, Hammersmith and FulhamRecruiting
- Mount Vernon Cancer Centre ( Site 1440)Northwood, EnglandRecruiting
- Royal Derby Hospital ( Site 1431)Derby, DerbyshireRecruiting
- The Beatson West of Scotland Cancer Centre ( Site 1428)Glasgow, Glasgow CityRecruiting
- The Christie NHS Foundation Trust ( Site 1436)ManchesterRecruiting
- The Royal Cornwall Hospital ( Site 1430)Truro, EnglandRecruiting
- Torbay Hospital ( Site 1429)Torquay, DevonRecruiting
- University College London Hospital ( Site 1437)London, London, City ofRecruiting
- GenesisCare - Oxford ( Site 1442)Oxford, OxfordshireActive Not Recruiting
- GenesisCare - Windsor ( Site 1443)Windsor, Windsor And MaidenheadActive Not Recruiting
- Guy's & St Thomas' NHS Foundation Trust-Oncology & Haematology Clinical Trials ( Site 1435)London, London, City ofActive Not Recruiting
- St. George's Hospital-Oncology ( Site 1441)London, London, City ofCompleted
Turkey (Türkiye)9 locations · 9 recruiting
- Ankara Bilkent Şehir Hastanesi-Medical Oncology ( Site 1377)AnkaraRecruiting
- Baskent University Dr. Turgut Noyan Research and Training Center-ONCOLOGY ( Site 1379)AdanaRecruiting
- Ege Universitesi Hastanesi-Medical Oncology ( Site 1380)IzmirRecruiting
- Hacettepe Universite Hastaneleri-oncology hospital ( Site 1376)AnkaraRecruiting
- Istanbul Universitesi Cerrahpasa-Medical Oncology ( Site 1383)IstanbulRecruiting
- Koc Universitesi Hastanesi ( Site 1384)IstanbulRecruiting
- Samsun Medical Park Hastanesi-medical oncology ( Site 1382)SamsunRecruiting
- T.C. Saglik Bakanligi Turkiye Kamu Hastaneleri Kurumu - Baki-Istanbul Bakirkoy Sadi Konuk Training ( Site 1381)IstanbulRecruiting
- TC Saglik Bakanligi Goztepe Prof. Dr. Suleyman Yalcin Sehir Hastanesi-oncology ( Site 1378)IstanbulRecruiting
Brazil14 locations · 8 recruiting
- Clínica de Neoplasias Litoral ( Site 0269)Itajaí, Santa CatarinaRecruiting
- Hospital de Base de São José do Rio Preto ( Site 0275)São José do Rio Preto, São PauloRecruiting
- Hospital Santa Rita de Cassia ( Site 0271)Vitória, Espírito SantoRecruiting
- Hospital São Lucas da PUCRS ( Site 0270)Porto Alegre, Rio Grande do SulRecruiting
- Hospital Universitário Evangélico Mackenzie ( Site 0252)Curitiba, ParanáRecruiting
- Hospital Universitário São Francisco de Assis - Bragança Paulista ( Site 0251)Bragança Paulista, São PauloRecruiting
- ICTRIALS Pesquisa e Desenvolvimento ( Site 0274)Curitiba, ParanáRecruiting
- Universidade Federal do Triangulo Mineiro - Hospital de Clinicas ( Site 0262)Uberaba, Minas GeraisRecruiting
- CRIO - CENTRO REGIONAL INTEGRADO DE ONCOLOGIA ( Site 0256)Fortaleza, CearáActive Not Recruiting
- Hospital Mario Penna ( Site 0264)Belo Horizonte, Minas GeraisActive Not Recruiting
- Hospital Paulistano ( Site 0259)São PauloActive Not Recruiting
- Hospital São Domingos ( Site 0258)São Luís, MaranhãoActive Not Recruiting
- Instituto do Câncer Brasil - Unidade Taubaté ( Site 0263)Taubaté, São PauloActive Not Recruiting
- Obras Sociais Irma Dulce ( Site 0255)Salvador, Estado de BahiaActive Not Recruiting
Israel8 locations · 8 recruiting
- Emek Medical Center ( Site 0680)AfulaRecruiting
- Hadassah Medical Center ( Site 0683)JerusalemRecruiting
- Meir Medical Center. ( Site 0682)Kfar SabaRecruiting
- Rabin Medical Center ( Site 0678)Petah TikvaRecruiting
- Rambam Health Care Campus-Oncology Division ( Site 0676)HaifaRecruiting
- Shaare Zedek Medical Center ( Site 0679)JerusalemRecruiting
- Sheba Medical Center ( Site 0677)Ramat GanRecruiting
- Sourasky Medical Center ( Site 0681)Tel AvivRecruiting
Mexico8 locations · 8 recruiting
- Centro de Investigacion Clinica de Oaxaca ( Site 0934)Oaxaca City, OaxacaRecruiting
- CIO - Centro de Inmuno-Oncología de Occidente ( Site 0928)Guadalajara, JaliscoRecruiting
- Eukarya Pharmasite S.C. ( Site 0939)Monterrey, Nuevo LeónRecruiting
- Filios Alta Medicina ( Site 0931)Monterrey, Nuevo LeónRecruiting
- Health Pharma Professional Research S.A. de C.V: ( Site 0929)Mexico City, Mexico CityRecruiting
- Higiea Oncologia ( Site 0938)Mexico City, Mexico CityRecruiting
- Hospital Universitario "Dr. Jose Eleuterio Gonzalez"-Servicio de Oncología ( Site 0932)Monterrey, Nuevo LeónRecruiting
- Quemex Medical and Research ( Site 0937)Tlalpan, Mexico CityRecruiting
Spain8 locations · 8 recruiting
- Complexo Hospitalario Universitario A Coruna ( Site 1288)A Coruña, La CorunaRecruiting
- HOSPITAL CLÍNIC DE BARCELONA-ICHMO- Clinic Institut of Haematological and Oncological diseases ( Site 1284)Barcelona, CataloniaRecruiting
- Hospital Insular de Gran Canaria-Oncology ( Site 1280)Las Palmas de Gran Canaria, Las PalmasRecruiting
- Hospital Quirón Málaga ( Site 1286)MálagaRecruiting
- Hospital Universitari Parc Tauli-oncologia ( Site 1282)Sabadell, BarcelonaRecruiting
- Hospital Universitario de Burgos-Oncología ( Site 1281)BurgosRecruiting
- HOSPITAL UNIVERSITARIO QUIRONSALUD MADRID-ONCOLOGIA MEDICA ( Site 1283)Pozuelo de Alarcón, MadridRecruiting
- Institut Català d'Oncologia (ICO) - Girona ( Site 1285)Girona, GeronaRecruiting
Taiwan7 locations · 7 recruiting
- Chang Gung Medical Foundation-Linkou Branch-Urology ( Site 1334)TaoyuanRecruiting
- Chang Gung Memorial Hospital at Kaohsiung-Oncology and Hematology ( Site 1331)Kaohsiung CityRecruiting
- Chi Mei Medical Center ( Site 1336)Tainan, TainanRecruiting
- China Medical University Hospital-Department of Urology ( Site 1335)TaichungRecruiting
- Kaohsiung Veterans General Hospital ( Site 1337)Kaohsiung CityRecruiting
- Taichung Veterans General Hospital ( Site 1338)TaichungRecruiting
- Taipei Veterans General Hospital ( Site 1332)TaipeiRecruiting
Chile6 locations · 6 recruiting
- Bradfordhill-Clinical Area ( Site 0301)Santiago, Region M. de SantiagoRecruiting
- CIDO SpA-Oncology ( Site 0302)Temuco, AraucaniaRecruiting
- Clinica Universidad Catolica del Maule-Oncology ( Site 0306)Talca, Maule RegionRecruiting
- FALP ( Site 0303)Santiago, Region M. de SantiagoRecruiting
- ONCOCENTRO APYS-ACEREY ( Site 0305)Viña del Mar, ValparaisoRecruiting
- Pontificia Universidad Catolica de Chile-Hemato-Oncology ( Site 0304)Santiago, Region M. de SantiagoRecruiting
Portugal6 locations · 6 recruiting
- Hospital CUF - Tejo ( Site 1157)LisbonRecruiting
- Hospital de Cascais Doutor José de Almeida ( Site 1158)Alcabideche, Lisbon DistrictRecruiting
- Unidade Local de Saude de Braga - Hospital de Braga ( Site 1151)BragaRecruiting
- Unidade Local de Saude de Santa Maria - Hospital de Santa Maria ( Site 1153)LisbonRecruiting
- Unidade Local de Saude de Santo António - Hospital Santo António ( Site 1152)PortoRecruiting
- Unidade Local de Saude Gaia/Espinho - Hospital Eduardo Santos Silva ( Site 1156)Vila Nova de Gaia, Porto DistrictRecruiting
South Korea6 locations · 6 recruiting
- Kyungpook National University Chilgok Hospital-Urology ( Site 1252)Buk-gu, Kyongsangbuk-doRecruiting
- National Cancer Center-Center for Urologic Cancer ( Site 1254)Goyang-si, Kyonggi-doRecruiting
- Pusan National University Yangsan Hospital ( Site 1256)Pusan, Kyongsangnam-doRecruiting
- Seoul National University Bundang Hospital-Urology ( Site 1253)Seongnam, Kyonggi-doRecruiting
- Seoul National University Hospital-Urology ( Site 1251)SeoulRecruiting
- The Catholic University of Korea. Seoul St. Mary s Hospital ( Site 1255)SeoulRecruiting
France11 locations · 5 recruiting
- Centre Bourgogne ( Site 0464)Lille, Hauts-de-FranceRecruiting
- Centre Jean Perrin - Centre Régional de Lutte contre le Cancer d'Auvergne ( Site 0454)Clermont-Ferrand, Puy-de-DomeRecruiting
- CENTRE LEON BERARD ( Site 0459)Lyon Cedex08, Auvergne-Rhône-AlpesRecruiting
- Institut Bergonié - Centre Régional de Lutte Contre Le Cancer de Bordeaux et Sud Ouest ( Site 0461)Bordeaux, AquitaineRecruiting
- Institut de cancérologie Strasbourg Europe (ICANS) ( Site 0451)Strasbourg, AlsaceRecruiting
- CHU-BREST Cavale Blanche ( Site 0456)Brest, FinistereActive Not Recruiting
- Groupe Hospitalier Paris Saint Joseph ( Site 0465)ParisActive Not Recruiting
- Gustave Roussy ( Site 0452)Villejuif, Val-de-MarneActive Not Recruiting
- Hôpital Foch ( Site 0455)Suresnes, Hauts-de-SeineActive Not Recruiting
- Ramsay Santé - Clinical La Croix Du Sud ( Site 0460)Quint-Fonsegrives, Haute-GaronneActive Not Recruiting
- Sainte Catherine Institut du Cancer Avignon Provence ( Site 0458)Avignon, VaucluseActive Not Recruiting
Canada7 locations · 5 recruiting
- BC Cancer Abbotsford-Clinical Trials Unit (Site 0287)Abbotsford British Columbia, British ColumbiaRecruiting
- Cross Cancer Institute (Site 0281)Edmonton, AlbertaRecruiting
- Sunnybrook Research Institute ( Site 0285)Toronto, OntarioRecruiting
- The Ottawa Hospital - General Campus ( Site 0286)Ottawa, OntarioRecruiting
- Trillium Health Partners - Credit Valley Hospital ( Site 0289)Mississauga, OntarioRecruiting
- Centre Hospitalier de l'Université de Montréal ( Site 0276)Montreal, QuebecActive Not Recruiting
- Centre intégré de cancérologie du CHU de Québec Université Laval, Hôpital de l'Enfant-Jésus ( Site 0277)Québec, QuebecActive Not Recruiting
Colombia7 locations · 5 recruiting
- Clinica Colsanitas S.A, Sede Clínica Universitaria Colombia-Center Investigator ( Site 0326)Bogotá, Bogota D.C.Recruiting
- Fundación Cardiovascular de Colombia ( Site 0328)Piedecuesta, Santander DepartmentRecruiting
- Fundación Valle del Lili ( Site 0330)Cali, Valle del Cauca DepartmentRecruiting
- IMAT S.A.S ( Site 0329)Montería, Departamento de CórdobaRecruiting
- Sociedad De Oncología y Hematología Del Cesar SAS-Oncology ( Site 0327)Valledupar, Cesar DepartmentRecruiting
- Clínica Imbanaco S.A.S ( Site 0334)Cali, Valle del Cauca DepartmentActive Not Recruiting
- Los Cobos Medical Center ( Site 0336)Bogotá, Bogota D.C.Active Not Recruiting
Czechia6 locations · 5 recruiting
- Fakultni nemocnice Olomouc-Onkologicka klinika ( Site 0405)OlomoucRecruiting
- Fakultni Nemocnice u sv. Anny v Brne-Onkologicko-chirurgicke oddeleni ( Site 0404)Brno, South MoravianRecruiting
- Fakultni nemocnice v Motole-Onkologicka klinika 2. LF UK a FN Motol ( Site 0401)Prague, Praha 5Recruiting
- Masarykuv onkologicky ustav-Klinika komplexni onkologicke pece ( Site 0403)Brno, Brno-mestoRecruiting
- Vseobecna fakultni nemocnice v Praze ( Site 0406)PragueRecruiting
- Krajská nemocnice Liberec-Department of Urology ( Site 0407)Liberec, Liberec RegionActive Not Recruiting
Italy6 locations · 5 recruiting
- Azienda Ospedaliera Santa Maria Terni ( Site 1458)TerniRecruiting
- Azienda Ospedaliero Universitaria Policlinico Riuniti di Foggia ( Site 1456)FoggiaRecruiting
- Fondazione IRCCS Istituto Nazionale dei Tumori-Struttura Complessa Oncologia Medica 1 ( Site 1452)Milan, LombardyRecruiting
- Ospedale Cannizzaro ( Site 1455)CataniaRecruiting
- Ospedale San Raffaele-Oncologia Medica ( Site 1451)MilanRecruiting
- IRCCS - Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori"-Oncologia Medica ( Site 1454)Meldola, Emilia-RomagnaActive Not Recruiting
South Africa6 locations · 5 recruiting
- CANCERCARE LANGENHOVEN DRIVE ONCOLOGY CENTRE-Clinical Trials Unit ( Site 1230)Port Elizabeth, Eastern CapeRecruiting
- Curo Oncology. ( Site 1237)Pretoria, GautengRecruiting
- LIFE GROENKLOOF-Mary Potter Cancer Centre ( Site 1236)Pretoria, GautengRecruiting
- Wilgers Oncology Centre ( Site 1232)Pretoria, GautengRecruiting
- Wits Clinical Research ( Site 1234)Johannesburg, GautengRecruiting
- Cape Town Oncology Trials ( Site 1233)Cape Town, Western CapeCompleted
Australia5 locations · 5 recruiting
- Macquarie University-MQ Health Clinical Trials Unit ( Site 0214)Macquarie University, New South WalesRecruiting
- Monash Health ( Site 0219)Clayton, VictoriaRecruiting
- Peter MacCallum Cancer Centre-Parkville Cancer Clinical Trials Unit (PCCTU) ( Site 0210)Melbourne, VictoriaRecruiting
- Royal Brisbane and Women's Hospital-Medical Oncology Clinical Trials Unit, Cancer Care Services ( Site 0211)Brisbane, QueenslandRecruiting
- Westmead Hospital ( Site 0212)Westmead, New South WalesRecruiting
Guatemala5 locations · 5 recruiting
- CELAN,S.A ( Site 0579)Guatemala CityRecruiting
- INTEGRA Cancer Institute-Oncology ( Site 0578)Guatemala CityRecruiting
- MEDI-K ( Site 0576)Guatemala CityRecruiting
- Private Practice- Dr. Rixci Augusto Lenin Ramírez ( Site 0577)Guatemala CityRecruiting
- Sanatorio Nuestra Senora del Pilar ( Site 0580)Guatemala CityRecruiting
Malaysia5 locations · 4 recruiting
- Hospital Kuala Lumpur-Radiotherapy and Oncology ( Site 0903)Kuala LumpurRecruiting
- Hospital Sultan Ismail ( Site 0905)Johor Bahru, JohorRecruiting
- Sarawak General Hospital-Radiotherapy Unit ( Site 0901)Kuching, SarawakRecruiting
- University Malaya Medical Centre ( Site 0902)Lembah Pantai, Kuala LumpurRecruiting
- National Cancer Institute ( Site 0904)Putrajaya, PutrajayaCompleted
Thailand5 locations · 4 recruiting
- Chulalongkorn University ( Site 1355)Bangkok, BangkokRecruiting
- Faculty of Medicine Siriraj Hospital ( Site 1356)Bangkok, BangkokRecruiting
- Maharaj Nakorn Chiang Mai Hospital ( Site 1353)Muang, Chiang MaiRecruiting
- Songklanagarind hospital ( Site 1352)Hat Yai, Changwat SongkhlaRecruiting
- Faculty of Medicine - Khon Kaen University ( Site 1351)Muang, Changwat Khon KaenActive Not Recruiting
Hungary4 locations · 4 recruiting
- Borsod-Abaúj-Zemplén Megyei Központi Kórház és Egyetemi Okta-Klinikai Onkológiai és Sugárterápiás C ( Site 0630)Miskolc, Borsod-Abauj Zemplen countyRecruiting
- Debreceni Egyetem Klinikai Kozpont-Onkológiai Klinika ( Site 0632)DebrecenRecruiting
- Nograd Varmegyei Szent Lazar Korhaz-Onkologia es Sugarterapias Osztaly ( Site 0636)Salgótarján, Nógrád megyeRecruiting
- Országos Onkológiai Intézet-Urogenitális Tumorok és Klinikai Farmakológiai Osztály ( Site 0631)Budapest, Pest CountyRecruiting
Singapore4 locations · 4 recruiting
- National Cancer Centre Singapore ( Site 1202)Singapore, Central SingaporeRecruiting
- National University Hospital ( Site 1201)Singapore, Central SingaporeRecruiting
- Singapore General Hospital ( Site 1204)Singapore, Central SingaporeRecruiting
- Tan Tock Seng Hospital-Medical Oncology ( Site 1203)Singapore, Central SingaporeRecruiting
Romania6 locations · 3 recruiting
- Delta Health Care SRL (Site 1507)BucharestRecruiting
- Spitalul Clinic ''Prof Dr. Theodor Burghele" (Site 1505)BucharestRecruiting
- Spitalul Universitar de Urgență Elias ( Site 1504)Bucharest, BucharestRecruiting
- Cardiomed SRL Cluj-Napoca ( Site 1503)Cluj-Napoca, ClujActive Not Recruiting
- Centrul de Oncologie "Sfântul Nectarie" ( Site 1501)Craiova, DoljActive Not Recruiting
- SC Radiotherapy Center Cluj SRL ( Site 1502)Florești, ClujActive Not Recruiting
Estonia4 locations · 3 recruiting
- North Estonia Medical Centre Foundation ( Site 1526)Tallinn, HarjuRecruiting
- Pärnu Haigla (Site 1550)Pärnu, PärnumaaRecruiting
- Tartu University Hospital-Radiotherapy and oncology ( Site 1527)Tartu, TartuRecruiting
- East-Tallinn Central Hospital ( Site 1528)Tallinn, HarjuActive Not Recruiting
Peru4 locations · 3 recruiting
- Aliada-Oncologìa ( Site 1055)LimaRecruiting
- IPOR Instituto Peruano de Oncología & Radioterapia-Centro de Investigación ( Site 1052)LimaRecruiting
- Oncosalud-Clinical Research ( Site 1057)LimaRecruiting
- INSTITUTO NACIONAL DE ENFERMEDADES NEOPLASICAS-Medical Oncology ( Site 1054)LimaActive Not Recruiting
Costa Rica3 locations · 3 recruiting
- CIMCA-Hemato-Oncology ( Site 0380)San José, Provincia de San JoséRecruiting
- Hospital Metropolitano - Sede Lindora-Metropolitano Research Institute Sede Lindora ( Site 0379)Santa Ana, Provincia de San JoséRecruiting
- Onco Tech, S.A. ( Site 0376)San JoséRecruiting
Greece3 locations · 2 recruiting
- Alexandra General Hospital of Athens-ONCOLOGY DEPT. ( Site 0551)Athens, AtticaRecruiting
- ATTIKON GENERAL UNIVERSITY HOSPITAL-2nd Dep. of Int. Medicine. Research Unit & Diabetes Center ( Site 0552)Chaïdári, AtticaRecruiting
- UNIVERSITY HOSPITAL OF PATRAS-DIVISION OF ONCOLOGY ( Site 0553)Pátrai, AchaiaActive Not Recruiting
Puerto Rico3 locations · 2 recruiting
- Ad-Vance Medical Research-Research ( Site 1177)PonceRecruiting
- Pan American Center for Oncology Trials - Ciudadela ( Site 1176)San JuanRecruiting
- Advance Urology and Laparoscopic Center ( Site 1178)PonceCompleted
Hong Kong2 locations · 2 recruiting
- Hong Kong Integrated Oncology Centre ( Site 0603)CentralRecruiting
- Queen Mary Hospital ( Site 0602)Hong KongRecruiting
Ireland2 locations · 2 recruiting
- St. Vincent's University Hospital ( Site 0652)Dublin, DublinRecruiting
- Tallaght University Hospital ( Site 0651)DublinRecruiting
Lithuania2 locations · 2 recruiting
- Hospital of Lithuanian University of Health Sciences Kauno klinikos ( Site 1576)Kaunas, Kaunas CountyRecruiting
- National Cancer Institute ( Site 1577)Vilnius, Vilniaus MiestasRecruiting
Slovakia2 locations · 2 recruiting
- Privatna Urologicka Ambulancia ( Site 1478)Trenčín, Trenčín RegionRecruiting
- UROEXAM ( Site 1479)Nitra, Nitra RegionRecruiting
Sweden2 locations · 2 recruiting
- Akademiska sjukhuset-Blod- och tumörsjukdomar ( Site 1301)Uppsala, Uppsala CountyRecruiting
- Karolinska Universitetssjukhuset Solna ( Site 1302)Stockholm, Stockholm CountyRecruiting
Latvia2 locations · 1 recruiting
- Pauls Stradins Clinical Univeristy Hospital-Urological department ( Site 1551)RigaRecruiting
- Liepaja Regional Hospital ( Site 1553)LiepājaActive Not Recruiting
New Zealand2 locations · 1 recruiting
- Auckland City Hospital ( Site 1033)AucklandRecruiting
- Dunedin Hospital ( Site 1032)Dunedin, OtagoCompleted
Who to ask about joining
Toll Free Number1-888-577-8839Trialsites@msd.com
Who can join
Men and women 18 years and older can join this study. Participants must have prostate cancer that has progressed after treatment with one hormonal agent. They should have good organ function and must not have certain health conditions, such as poorly controlled diabetes or a history of severe heart problems. The study team will check to see if you meet these requirements before you can join.
What happens during the trial
Participants will be randomly placed into two groups. One group will receive opevesostat along with hormone replacement therapy. The other group will receive either abiraterone or enzalutamide. Both groups will continue their treatment until their cancer progresses. The study will monitor how well each treatment works.
The trial team
The study is sponsored by Merck Sharp & Dohme LLC. Orion Corporation and Orion Pharma are partners in this research. A medical director from Merck Sharp & Dohme LLC oversees the study.
Important dates
The study started on December 18, 2023, and is currently recruiting new participants. It is expected to finish by December 2, 2030.
Additional information
The trial ID is NCT06136650. This is a Phase 3 trial, which means it is testing how well the treatment works and its safety. The trial is FDA-regulated and aims to include about 1,314 participants.
Similar trials
Other recruiting trials for the same condition, with the eligibility rules written in plain language.
Browse similar trials →Talk to a specialist
Find a top oncologist who can tell you whether a trial is a sensible option for you.
Find a doctor →Cancer hospitals
The cancer centers running studies like this one, and what each is known for.
Browse hospitals →