Reviewing Treatment Options for Colorectal Cancer with Chemotherapy
NCT07221357 · RecruitingAbout this trial
This study looks at how well pumitamig works with chemotherapy compared to bevacizumab with chemotherapy. It focuses on patients who have not been treated before and have colorectal cancer that cannot be removed by surgery. The goal is to find out which treatment is safer and more effective for these patients.
Locations and contact
This trial is running at 287 locations in 27 countries. 121 of them are currently recruiting.
United States49 locations · 25 recruiting
- Baylor College of Medicine Medical CenterHouston, TexasRecruiting
- Florida Cancer Specialists - EastCape Coral, FloridaRecruiting
- Florida Cancer Specialists - NorthSt. Petersburg, FloridaRecruiting
- Highlands Oncology GroupSpringdale, ArkansasRecruiting
- Laura and Isaac Perlmutter Cancer Center at NYU LangoneMineola, New YorkRecruiting
- Lehigh Valley Health NetworkAllentown, PennsylvaniaRecruiting
- Maryland Oncology Hematology - Silver SpringSilver Spring, MarylandRecruiting
- Minnesota OncologyMaple Grove, MinnesotaRecruiting
- Moffitt Cancer CenterTampa, FloridaRecruiting
- New York Cancer and Blood SpecialistsShirley, New YorkRecruiting
- Northside HospitalAtlanta, GeorgiaRecruiting
- Northwell Health/ RJ Zuckerberg Cancer CenterLake Success, New YorkRecruiting
- Northwest Cancer Specialists, P.C.Vancouver, WashingtonRecruiting
- Northwest Georgia Oncology Centers, a Service of Wellstar Cobb HospitalMarietta, GeorgiaRecruiting
- Sanford Cancer CenterSioux Falls, South DakotaRecruiting
- Sanford Fargo Medical CenterFargo, North DakotaRecruiting
- SCRI Oncology PartnersNashville, TennesseeRecruiting
- Texas Oncology - San AntonioSan Antonio, TexasRecruiting
- Texas Oncology Dallas Fort Worth West (DFWW) - Arlington Cancer Center NorthArlington, TexasRecruiting
- Texas Oncology, PAAustin, TexasRecruiting
- University of California, Irvine (UCI) Health - UC Irvine Medical CenterOrange, CaliforniaRecruiting
- University Of Nebraska Medical CenterOmaha, NebraskaRecruiting
- USC/Norris Comprehensive Cancer CenterLos Angeles, CaliforniaRecruiting
- Virginia Oncology AssociatesNorfolk, VirginiaRecruiting
- Washington University School OF Medicine-Siteman Cancer CenterSt Louis, MissouriRecruiting
- Ann Arbor, MichiganNot Yet Recruiting
- Baltimore, MarylandNot Yet Recruiting
- Charlotte, North CarolinaNot Yet Recruiting
- Chicago, IllinoisNot Yet Recruiting
- Chicago, IllinoisNot Yet Recruiting
- Columbus, OhioNot Yet Recruiting
- Edmonds, WashingtonNot Yet Recruiting
- Fairfax, VirginiaNot Yet Recruiting
- Fort Wayne, IndianaNot Yet Recruiting
- Grand Rapids, MichiganNot Yet Recruiting
- Iowa City, IowaNot Yet Recruiting
- Kansas City, MissouriNot Yet Recruiting
- La Jolla, CaliforniaNot Yet Recruiting
- Nashville, TennesseeNot Yet Recruiting
- Oklahoma City, OklahomaNot Yet Recruiting
- Pittsburgh, PennsylvaniaNot Yet Recruiting
- Salt Lake City, UtahNot Yet Recruiting
- San Francisco, CaliforniaNot Yet Recruiting
- Santa Monica, CaliforniaNot Yet Recruiting
- Seattle, WashingtonNot Yet Recruiting
- Spokane, WashingtonNot Yet Recruiting
- Stanford, CaliforniaNot Yet Recruiting
- Tucson, ArizonaNot Yet Recruiting
- Boston, MassachusettsWithdrawn
Australia15 locations · 12 recruiting
- Cabrini Hospital - MalvernMalvern, VictoriaRecruiting
- Flinders Medical CentreAdelaide, South AustraliaRecruiting
- Gallipoli Medical Research LtdBrisbane, QueenslandRecruiting
- GenesisCare St LeonardsSt Leonards, New South WalesRecruiting
- Goulburn Valley HealthShepparton, VictoriaRecruiting
- Grampians HealthBallarat Central, VictoriaRecruiting
- Lyell McEwin HospitalElizabeth Vale, South AustraliaRecruiting
- Royal Brisbane and Women's HospitalBrisbane, QueenslandRecruiting
- St. John of God Murdoch HospitalMurdoch, Western AustraliaRecruiting
- Sunshine Coast University HospitalBirtinya, QueenslandRecruiting
- Western Health-Sunshine & Footscray HospitalsSt Albans, VictoriaRecruiting
- Westmead HospitalWestmead, New South WalesRecruiting
- Camperdown, New South WalesNot Yet Recruiting
- Epping, VictoriaNot Yet Recruiting
- Liverpool, New South WalesNot Yet Recruiting
Japan20 locations · 10 recruiting
- Hokkaido University HospitalSapporo, HokkaidoRecruiting
- Kobe City Medical Center General HospitalKobe, HyōgoRecruiting
- National Cancer Center HospitalChuo-ku, TokyoRecruiting
- National Cancer Center Hospital EastKashiwa, ChibaRecruiting
- National Hospital Organization Kyushu Cancer CenterFukuokaRecruiting
- National Hospital Organization Shikoku Cancer CenterMatsuyama, EhimeRecruiting
- Osaka International Cancer InstituteOsakaRecruiting
- Osaka Medical and Pharmaceutical University HospitalTakatsuki, OsakaRecruiting
- The Cancer Institute Hospital of JFCRKoto-ku, TokyoRecruiting
- The University of Osaka HospitalSuita, OsakaRecruiting
- Chiba, ChibaNot Yet Recruiting
- Chikusa-kuNot Yet Recruiting
- Hidaka, SaitamaNot Yet Recruiting
- Kitaadachi-gunNot Yet Recruiting
- Kurashiki, Okayama-kenNot Yet Recruiting
- SendaiNot Yet Recruiting
- Sunto-gunNot Yet Recruiting
- Toyoake, Aichi-kenNot Yet Recruiting
- Yamagata, YamagataNot Yet Recruiting
- Yokohama, KanagawaNot Yet Recruiting
Germany16 locations · 9 recruiting
- Charité - Universitaetsmedizin Berlin - Campus Bejnamin FranklinBerlinRecruiting
- Facharztzentrum EppendorfHamburgRecruiting
- Klinikum NeuperlachMünchenRecruiting
- Krankenhaus Nordwest GmbHFrankfurtRecruiting
- Marien Hospital DüsseldorfDüsseldorfRecruiting
- Universitaetsklinikum Carl Gustav Carus DresdenDresden, SaxonyRecruiting
- Universitaetsmedizin der Johannes Gutenberg-Universitaet MainzMainzRecruiting
- Universitaetsmedizin GoettingenGöttingenRecruiting
- Universitatsklinikum LeipzigLeipzigRecruiting
- BochumNot Yet Recruiting
- ChemnitzNot Yet Recruiting
- Erlangen, BavariaNot Yet Recruiting
- HamburgNot Yet Recruiting
- Hanover, Lower SaxonyNot Yet Recruiting
- MannheimNot Yet Recruiting
- UlmNot Yet Recruiting
Italy16 locations · 7 recruiting
- ASST Grande Ospedale Metropolitano NiguardaMilan, MilanoRecruiting
- Azienda Ospedaliera GaribaldiCataniaRecruiting
- Azienda Ospedaliero Universitaria PisanaPisa, TuscanyRecruiting
- IRCCS Casa Sollievo della SofferenzaSan Giovanni Rotondo, FoggiaRecruiting
- Istituto Nazionale Tumori IRCCS Fondazione PascaleNaplesRecruiting
- Istituto Oncologico Veneto IRCCSPadova, VenetoRecruiting
- Ospedale San RaffaeleMilanRecruiting
- AvellinoNot Yet Recruiting
- Aviano, PordenoneNot Yet Recruiting
- BariNot Yet Recruiting
- Castellana Grotte, BariNot Yet Recruiting
- La SpeziaNot Yet Recruiting
- MilanNot Yet Recruiting
- RavennaNot Yet Recruiting
- Reggio EmiliaNot Yet Recruiting
- Tricase, LecceNot Yet Recruiting
France15 locations · 6 recruiting
- Assistance Publique Hôpitaux de Marseille - Hôpital de la TimoneMarseilleRecruiting
- Centre Hospitalier Universitaire Dijon Bourgogne - Hôpital François MitterrandDijonRecruiting
- CHU Bordeaux Haut-LevequePessac, AquitaineRecruiting
- CHU Charles NicolleRouen, Haute-NormandieRecruiting
- CHU RangueilToulouse, Haute-GaronneRecruiting
- Hôpital Saint AntoineParisRecruiting
- Besançon, DoubsNot Yet Recruiting
- Lille, NordNot Yet Recruiting
- LimogesNot Yet Recruiting
- Lorient, MorbihanNot Yet Recruiting
- Marseille, Provence-Alpes-Côte d'Azur RegionNot Yet Recruiting
- Nantes, Pays de la Loire RegionNot Yet Recruiting
- Saint-Herblain, Loire-AtlantiqueNot Yet Recruiting
- SuresnesNot Yet Recruiting
- VillejuifNot Yet Recruiting
South Korea9 locations · 6 recruiting
- Asan Medical CenterSeoul, Seoul-teukbyeolsi [Seoul]Recruiting
- Samsung Medical CenterSeoul, Seoul-teukbyeolsi [Seoul]Recruiting
- Seoul National University Bundang HospitalSeongnam, GyeonggidoRecruiting
- Seoul National University HospitalSeoul, Seoul-teukbyeolsi [Seoul]Recruiting
- Severance Hospital, Yonsei University Health SystemSeoul, Seoul-teukbyeolsi [Seoul]Recruiting
- The Catholic Univ. of Korea Seoul St. Mary's HospitalSeoul, Seoul-teukbyeolsi [Seoul]Recruiting
- Deagu, Taegu-KwangyǒkshiNot Yet Recruiting
- Goyang-si, Gyeonggi-doNot Yet Recruiting
- Seoul, Seoul-teukbyeolsi [Seoul]Not Yet Recruiting
Romania7 locations · 6 recruiting
- Centrul de Oncologie "Sfântul Nectarie"Craiova, DoljRecruiting
- Fundeni Clinical InstituteBucharest, BucharestRecruiting
- Institutul Oncologic ClujCluj-NapocaRecruiting
- Institutul Regional de Gastroenterologie și Hepatologie Prof. Dr. Octavian FodorCluj-Napoca, ClujRecruiting
- Institutul Regional de OncologieIașiRecruiting
- S.C. Centrul de Oncologie Euroclinic S.R.L.IașiRecruiting
- Floresti/ ClujNot Yet Recruiting
Spain11 locations · 5 recruiting
- Complejo Hospitalario de NavarraPamplona, NavarreRecruiting
- H.R.U Málaga - Hospital GeneralMálagaRecruiting
- Hospital General Universitario Gregorio MarañonMadridRecruiting
- Hospital Universitari Vall d'HebronBarcelona, Barcelona [Barcelona]Recruiting
- Hospital Universitario Virgen Del RocioSevilleRecruiting
- Badalona, Barcelona [Barcelona]Not Yet Recruiting
- Elche (alicante)Not Yet Recruiting
- Madrid, Madrid, Comunidad deNot Yet Recruiting
- Madrid, Madrid, Comunidad deNot Yet Recruiting
- SalamancaNot Yet Recruiting
- Santiago de CompostelaNot Yet Recruiting
Poland10 locations · 5 recruiting
- Luxmed Onkologia sp. z o. o.Warsaw, Masovian VoivodeshipRecruiting
- Mazowiecki Szpital OnkologicznyWieliszew, Masovian VoivodeshipRecruiting
- Państwowy Instytut Medyczny MSWiAWarsaw, Masovian VoivodeshipRecruiting
- SP ZOZ Opolskie Centrum Onkologii im. prof. Tadeusza Koszarowskiego w OpoluOpole, Opole VoivodeshipRecruiting
- Wojewódzkie Centrum Szpitalne Kotliny JeleniogórskiejJelenia GóraRecruiting
- Brzozów, Podkarpackie VoivodeshipNot Yet Recruiting
- Gdansk, Pomeranian VoivodeshipNot Yet Recruiting
- Koszalin, West Pomeranian VoivodeshipNot Yet Recruiting
- Krakow, Lesser Poland VoivodeshipNot Yet Recruiting
- Gliwice, Silesian VoivodeshipWithdrawn
Argentina7 locations · 5 recruiting
- Centro de Educación Médica e Investigaciones clínicas "Dr. Norberto Quirno" (CEMIC)Buenos AiresRecruiting
- Centro Médico FleischerCiudad Autónoma de Buenos Aires, Buenos AiresRecruiting
- Hospital Británico de Buenos AiresCABA, Buenos AiresRecruiting
- Hospital Italiano de Buenos AiresABB, Buenos Aires F.D.Recruiting
- Instituto Alexander FlemingCiudad Autónoma de Buenos Aires, Buenos AiresRecruiting
- CórdobaNot Yet Recruiting
- San Miguel de Tucumán, Tucumán ProvinceNot Yet Recruiting
Taiwan6 locations · 5 recruiting
- Chang Gung Medical Foundation-Linkou BranchTaoyuanRecruiting
- Kaohsiung Medical University Chung-Ho Memorial HospitalKaohsiung CityRecruiting
- National Cheng Kung University HospitalTainanRecruiting
- National Taiwan University HospitalTaipeiRecruiting
- Taipei Veterans General HospitalTaipeiRecruiting
- Kaohsiung Niao Sung Dist, KaohsiungNot Yet Recruiting
United Kingdom15 locations · 4 recruiting
- Maidstone and Tunbridge Wells NHS TrustMaidstoneRecruiting
- Royal Marsden HospitalLondonRecruiting
- Royal Marsden Hospital SuttonLondonRecruiting
- The Christie NHS Foundation TrustManchester, LancashireRecruiting
- Birmingham, West MidlandsNot Yet Recruiting
- CardiffNot Yet Recruiting
- DorchesterNot Yet Recruiting
- Enfield, LondonNot Yet Recruiting
- GlasgowNot Yet Recruiting
- Guildford, South EastNot Yet Recruiting
- LondonNot Yet Recruiting
- Metropolitan Borough of Wirral, MerseysideNot Yet Recruiting
- Newcastle upon TyneNot Yet Recruiting
- Norwich, EastNot Yet Recruiting
- Oxford, OxfordshireNot Yet Recruiting
Belgium7 locations · 4 recruiting
- Antwerp University HospitalEdegem, AntwerpenRecruiting
- AZ Delta vzwRoeselare, West-VlaanderenRecruiting
- Cliniques universitaires Saint-LucBrussels, Bruxelles-Capitale, Région deRecruiting
- UZ LeuvenLeuven, Vlaams-BrabantRecruiting
- Bonheiden, AntwerpenNot Yet Recruiting
- BrusselsNot Yet Recruiting
- Charleroi, HainautWithdrawn
Czechia6 locations · 4 recruiting
- Fakultni nemocnice Hradec KraloveHradec KrálovéRecruiting
- Fakultni nemocnice Motol a HomolkaPrague, Praha 5Recruiting
- Masarykuv onkologicky ustavBrno, Brno-městoRecruiting
- Vseobecna fakultni nemocnice v PrazePragueRecruiting
- OlomoucNot Yet Recruiting
- Prague, Praha 10Not Yet Recruiting
Canada8 locations · 3 recruiting
- Centre Hospitalier de l'Université de MontréalMontreal, QuebecRecruiting
- Centre intégré universitaire de santé et de services sociaux de l'Estrie - Centre Hospitalier Universitaire de Sherbrooke (CIUSSherbrooke, QuebecRecruiting
- Jewish General HospitalMontreal, QuebecRecruiting
- Calgary, AlbertaNot Yet Recruiting
- Halifax, Nova ScotiaNot Yet Recruiting
- Ottawa, OntarioNot Yet Recruiting
- Toronto, OntarioNot Yet Recruiting
- Toronto, OntarioNot Yet Recruiting
Singapore4 locations · 3 recruiting
- Curie Oncology - FarrerSingapore, Central SingaporeRecruiting
- National Cancer Centre SingaporeSingapore, Central SingaporeRecruiting
- National University HospitalSingaporeRecruiting
- SingaporeNot Yet Recruiting
Austria5 locations · 2 recruiting
- Krankenhaus Der Barmherzigen Schwestern LinzLinzRecruiting
- Universitaetsklinik SalzburgSalzburgRecruiting
- FeldkirchNot Yet Recruiting
- Sankt PöltenNot Yet Recruiting
- ViennaNot Yet Recruiting
China26 locations
- BeijingNot Yet Recruiting
- Changsha, HunanNot Yet Recruiting
- Changsha, HunanNot Yet Recruiting
- Chengdu, SichuanNot Yet Recruiting
- Chongqing, Chongqing MunicipalityNot Yet Recruiting
- Fuzhou Fujian, FujianNot Yet Recruiting
- Fuzhou, FujianNot Yet Recruiting
- Guangzhou, GuangdongNot Yet Recruiting
- Guangzhou, GuangdongNot Yet Recruiting
- HangzhouNot Yet Recruiting
- Hangzhou, ZhejiangNot Yet Recruiting
- Hangzhou, ZhejiangNot Yet Recruiting
- Harbin, HeilongjiangNot Yet Recruiting
- Hefei, AnhuiNot Yet Recruiting
- Jinan, ShandongNot Yet Recruiting
- Nanchang, JiangxiNot Yet Recruiting
- Nanjing, JiangsuNot Yet Recruiting
- Nanyang, HenanNot Yet Recruiting
- ShanghaiNot Yet Recruiting
- Shanghai, Shanghai MunicipalityNot Yet Recruiting
- Shenyang, LiaoningNot Yet Recruiting
- Shenyang, LiaoningNot Yet Recruiting
- Tianjin, HebeiNot Yet Recruiting
- Wuhan, HubeiNot Yet Recruiting
- Wuhan, HubeiNot Yet Recruiting
- Yangzhou, JiangsuNot Yet Recruiting
Brazil10 locations
- Barretos, São PauloNot Yet Recruiting
- Chapecó, Santa CatarinaNot Yet Recruiting
- Curitiba, ParanáNot Yet Recruiting
- Natal/RN, Rio Grande do NorteNot Yet Recruiting
- Porto Alegre, Rio Grande do SulNot Yet Recruiting
- Porto Alegre, Rio Grande do SulNot Yet Recruiting
- Santa Cruz do Sul, Rio Grande do SulNot Yet Recruiting
- São José do Rio PretoNot Yet Recruiting
- São PauloNot Yet Recruiting
- São PauloNot Yet Recruiting
India7 locations
- DelhiNot Yet Recruiting
- DelhiNot Yet Recruiting
- Mumbai, MaharashtraNot Yet Recruiting
- Nashik, Dādra and Nagar Haveli and Damān and DiuNot Yet Recruiting
- PuneNot Yet Recruiting
- Mumbai, MaharashtraWithdrawn
- PuducherryWithdrawn
Netherlands5 locations
- Amsterdam, North HollandNot Yet Recruiting
- Eindhoven, North BrabantNot Yet Recruiting
- GroningenNot Yet Recruiting
- TilburgNot Yet Recruiting
- UtrechtNot Yet Recruiting
Turkey (Türkiye)5 locations
- AdanaNot Yet Recruiting
- AnkaraNot Yet Recruiting
- ErzurumNot Yet Recruiting
- IstanbulNot Yet Recruiting
- Kadiköy/IstanbulNot Yet Recruiting
Chile3 locations
- Recoleta, Santiago MetropolitanNot Yet Recruiting
- Santiago, Santiago MetropolitanNot Yet Recruiting
- Santiago, Santiago MetropolitanNot Yet Recruiting
Sweden3 locations
- Gothenburg, Västra Götaland CountyNot Yet Recruiting
- LundNot Yet Recruiting
- Stockholm, Stockholm CountyNot Yet Recruiting
Hungary1 location
- VeszprémNot Yet Recruiting
Mexico1 location
- TlalpanNot Yet Recruiting
Who to ask about joining
BMS Clinical Trials Contact Center www.BMSClinicalTrials.com855-907-3286Clinical.Trials@bms.com
Who can join
Adults aged 18 and older can join the study. It is open to both men and women. Participants should have colorectal cancer that cannot be treated with surgery. They should not have certain genetic markers or other health issues that could affect their treatment. The trial team will confirm who is eligible.
What happens during the trial
Participants will be randomly placed into different groups. Some will receive pumitamig with chemotherapy, while others will receive bevacizumab with chemotherapy. Everyone will get treatment, but the specific medications will differ based on the group they are in.
The trial team
This trial is sponsored by Bristol-Myers Squibb. BioNTech SE is collaborating on this study. Bristol-Myers Squibb is also the main organization running the trial.
Important dates
The trial started on December 31, 2025, and is expected to finish by March 11, 2034. It is currently enrolling new participants.
Additional information
The trial ID is NCT07221357. It is in Phase 2 and Phase 3, which means it is looking at how well the treatments work and how safe they are. This study is regulated by the FDA and hopes to include about 990 participants.
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