Targeting Better Chemotherapy for Men with Germ Cell Tumors
NCT02582697 · RecruitingThis trial is looking at two ways to give chemotherapy for men with intermediate and poor-risk metastatic germ cell tumors. The goal is to see if a faster method, called accelerated BEP, works better than the standard method. Both methods use the same medicines but are given on different schedules. Researchers hope to find a more effective treatment for these patients.
Locations and contact
This trial is running at 28 locations in 3 countries. 24 of them are currently recruiting.
United States1 location · 1 recruiting
- Memorial Sloan Kettering Cancer CentreNew York, New YorkRecruiting
Australia22 locations · 19 recruiting
- Austin HealthHeidelberg, VictoriaRecruiting
- Border Medical OncologyWodonga, VictoriaRecruiting
- Box Hill HospitalBox Hill, VictoriaRecruiting
- Calvary Mater NewcastleNewcastle, New South WalesRecruiting
- Chris O'Brien LifehouseSydney, New South WalesRecruiting
- Concord Repatriation General HospitalSydney, New South WalesRecruiting
- Fiona Stanley HospitalMurdoch, Western AustraliaRecruiting
- Macquarie Cancer Clinical TrialsSydney, New South WalesRecruiting
- Nepean HospitalSydney, New South WalesRecruiting
- Peter MacCallum Cancer CentreEast Melbourne, VictoriaRecruiting
- Prince of Wales HospitalSydney, New South WalesRecruiting
- Princess AlexandraWoolloongabba, QueenslandRecruiting
- Queensland Children's HospitalSouth Brisbane, QueenslandRecruiting
- Royal Adelaide HospitalAdelaide, South AustraliaRecruiting
- Royal Brisbane & Women's HospitalBrisbane, QueenslandRecruiting
- Royal Hobart HospitalHobart, TasmaniaRecruiting
- Royal North Shore HospitalSt Leonards, New South WalesRecruiting
- SAN Clinical Trials UnitWahroonga, New South WalesRecruiting
- Tweed HospitalTweed Heads, New South WalesRecruiting
- Flinders Medical CentreBedford Park, South AustraliaActive Not Recruiting
- Sunshine HospitalSt Albans, VictoriaWithdrawn
- Westmead HospitalSydney, New South WalesWithdrawn
New Zealand5 locations · 4 recruiting
- Auckland HospitalGrafton, AucklandRecruiting
- Christchurch HospitalChristchurchRecruiting
- Palmerston North HospitalRoslyn, Palmerston NorthRecruiting
- Starship Children's HospitalGrafton, AucklandRecruiting
- Dunedin HospitalDunedinWithdrawn
Who can join
This study is open to males aged 11 to 50 years who have been diagnosed with a germ cell tumor. They should be willing to start treatment within 14 days after joining the trial. The trial team will check to see if each person is eligible based on specific health criteria.
What happens during the trial
Participants will be randomly placed in one of two groups. One group will receive the standard chemotherapy, while the other group will get the accelerated version. Everyone will receive similar medicines, including Bleomycin, Etoposide, and Cisplatin, but on different schedules. The study will last for several cycles, and participants will be monitored closely.
The trial team
The trial is sponsored by the University of Sydney, with help from multiple organizations including the Australian and New Zealand Urogenital and Prostate Cancer Trials Group. The lead doctor is Peter Grimison from Chris O'Brien Lifehouse.
Important dates
The trial started in February 2014 and is expected to finish by December 2029. It is currently enrolling new participants.
Additional information
This is a Phase 3 trial, which means it is looking closely at how well the treatments work and their safety. About 500 participants are expected to join.
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