Targeting Better Outcomes with Shorter Radiation Therapy for Bladder Cancer Patients
NCT07097142 · RecruitingAbout this trial
This trial looks at two types of radiation therapy for patients with muscle invasive bladder cancer who are also receiving standard chemotherapy. The goal is to see if a shorter type of radiation therapy works just as well as the usual length while patients receive chemotherapy with drugs like cisplatin, gemcitabine, or mitomycin. This study will help determine the best way to treat bladder cancer and improve outcomes for patients.
Locations and contact
This trial is running at 211 locations in the United States. 204 of them are currently recruiting.
United States211 locations · 204 recruiting
- Abbott-Northwestern HospitalMinneapolis, MinnesotaRecruiting
- Allegiance HealthJackson, MichiganRecruiting
- Ascension Via Christi Hospitals WichitaWichita, KansasRecruiting
- Aspirus Cancer Care - James Beck Cancer CenterRhinelander, WisconsinRecruiting
- Aspirus Cancer Care - Stevens PointStevens Point, WisconsinRecruiting
- Aspirus Cancer Care - Wisconsin RapidsWisconsin Rapids, WisconsinRecruiting
- Aspirus Regional Cancer CenterWausau, WisconsinRecruiting
- Beacon KalamazooKalamazoo, MichiganRecruiting
- Beebe Health CampusRehoboth Beach, DelawareRecruiting
- Beebe Medical CenterLewes, DelawareRecruiting
- Beebe South Coastal Health CampusMillville, DelawareRecruiting
- Benefis Sletten Cancer InstituteGreat Falls, MontanaRecruiting
- Billings Clinic Cancer CenterBillings, MontanaRecruiting
- BJC Outpatient Center at Sunset HillsSunset Hills, MissouriRecruiting
- Bon Secours Cancer Institute at Reynolds CrossingRichmond, VirginiaRecruiting
- Bon Secours Memorial Regional Medical CenterMechanicsville, VirginiaRecruiting
- Bon Secours Saint Francis Medical CenterMidlothian, VirginiaRecruiting
- Bon Secours Saint Mary's HospitalRichmond, VirginiaRecruiting
- Bozeman Health Deaconess HospitalBozeman, MontanaRecruiting
- Bronson Battle CreekBattle Creek, MichiganRecruiting
- Bronson Methodist HospitalKalamazoo, MichiganRecruiting
- Cancer and Hematology Centers of Western Michigan - Norton ShoresNorton Shores, MichiganRecruiting
- Cancer Care Center of O'FallonO'Fallon, IllinoisRecruiting
- Cancer Care Specialists of Illinois - DecaturDecatur, IllinoisRecruiting
- Cancer Center of Western WisconsinNew Richmond, WisconsinRecruiting
- Case Western Reserve UniversityCleveland, OhioRecruiting
- Central Care Cancer Center - BolivarBolivar, MissouriRecruiting
- Central Care Cancer Center - Garden CityGarden City, KansasRecruiting
- Centralia Oncology ClinicCentralia, IllinoisRecruiting
- Christiana Care Health System-Christiana HospitalNewark, DelawareRecruiting
- Christiana Care Health System-Concord Health CenterChadds Ford, PennsylvaniaRecruiting
- Christiana Care Health System-Wilmington HospitalWilmington, DelawareRecruiting
- Coborn Cancer Center at Saint Cloud HospitalSaint Cloud, MinnesotaRecruiting
- Community Medical CenterMissoula, MontanaRecruiting
- Corewell Health Grand Rapids Hospitals - Butterworth HospitalGrand Rapids, MichiganRecruiting
- Corewell Health Grand Rapids Hospitals - Helen DeVos Children's HospitalGrand Rapids, MichiganRecruiting
- Corewell Health Lakeland Hospitals - Marie Yeager Cancer CenterSaint Joseph, MichiganRecruiting
- Corewell Health Lakeland Hospitals - Niles HospitalNiles, MichiganRecruiting
- Corewell Health Lakeland Hospitals - Saint Joseph HospitalSaint Joseph, MichiganRecruiting
- Corewell Health Reed City HospitalReed City, MichiganRecruiting
- CoxHealth South HospitalSpringfield, MissouriRecruiting
- Crossroads Cancer CenterEffingham, IllinoisRecruiting
- Dartmouth Hitchcock Medical Center/Dartmouth Cancer CenterLebanon, New HampshireRecruiting
- Decatur Memorial HospitalDecatur, IllinoisRecruiting
- Duke University Medical CenterDurham, North CarolinaRecruiting
- Emory Saint Joseph's HospitalAtlanta, GeorgiaRecruiting
- Emory University Hospital MidtownAtlanta, GeorgiaRecruiting
- Emory University Hospital/Winship Cancer InstituteAtlanta, GeorgiaRecruiting
- Fairview Clinics and Surgery Center Maple GroveMaple Grove, MinnesotaRecruiting
- Fairview Southdale HospitalEdina, MinnesotaRecruiting
- Freeman Health SystemJoplin, MissouriRecruiting
- Gibbs Cancer Center-GaffneyGaffney, South CarolinaRecruiting
- Gibbs Cancer Center-PelhamGreer, South CarolinaRecruiting
- Grady Health SystemAtlanta, GeorgiaRecruiting
- Great Falls ClinicGreat Falls, MontanaRecruiting
- Greater Regional Medical CenterCreston, IowaRecruiting
- Heartland Regional Medical CenterSaint Joseph, MissouriRecruiting
- Helen F Graham Cancer CenterNewark, DelawareRecruiting
- Hennepin County Medical CenterMinneapolis, MinnesotaRecruiting
- Henry Ford Cancer Institute-DownriverBrownstown, MichiganRecruiting
- Henry Ford HospitalDetroit, MichiganRecruiting
- Henry Ford Macomb Hospital-Clinton TownshipClinton Township, MichiganRecruiting
- Henry Ford Medical Center-ColumbusNovi, MichiganRecruiting
- Henry Ford Medical Center-FairlaneDearborn, MichiganRecruiting
- Henry Ford West Bloomfield HospitalWest Bloomfield, MichiganRecruiting
- Henry Ford Wyandotte HospitalWyandotte, MichiganRecruiting
- Hi-Line Sletten Cancer CenterHavre, MontanaRecruiting
- HSHS Saint Elizabeth's HospitalO'Fallon, IllinoisRecruiting
- Illinois CancerCare - WashingtonWashington, IllinoisRecruiting
- Illinois CancerCare-BloomingtonBloomington, IllinoisRecruiting
- Illinois CancerCare-CantonCanton, IllinoisRecruiting
- Illinois CancerCare-CarthageCarthage, IllinoisRecruiting
- Illinois CancerCare-EurekaEureka, IllinoisRecruiting
- Illinois CancerCare-GalesburgGalesburg, IllinoisRecruiting
- Illinois CancerCare-Kewanee ClinicKewanee, IllinoisRecruiting
- Illinois CancerCare-MacombMacomb, IllinoisRecruiting
- Illinois CancerCare-Ottawa ClinicOttawa, IllinoisRecruiting
- Illinois CancerCare-PekinPekin, IllinoisRecruiting
- Illinois CancerCare-PeoriaPeoria, IllinoisRecruiting
- Illinois CancerCare-PeruPeru, IllinoisRecruiting
- Illinois CancerCare-PrincetonPrinceton, IllinoisRecruiting
- Iowa Methodist Medical CenterDes Moines, IowaRecruiting
- Kootenai Clinic Cancer Services - Post FallsPost Falls, IdahoRecruiting
- Kootenai Health - Coeur d'AleneCoeur d'Alene, IdahoRecruiting
- Lake Regional HospitalOsage Beach, MissouriRecruiting
- Lakeview HospitalStillwater, MinnesotaRecruiting
- Langlade Hospital and Cancer CenterAntigo, WisconsinRecruiting
- Logan Health Medical CenterKalispell, MontanaRecruiting
- Louisiana Hematology Oncology Associates LLCBaton Rouge, LouisianaRecruiting
- M D Anderson Cancer CenterHouston, TexasRecruiting
- Mary Bird Perkins Cancer CenterBaton Rouge, LouisianaRecruiting
- Mary Bird Perkins Cancer Center - MetairieMetairie, LouisianaRecruiting
- Massachusetts General Hospital Cancer CenterBoston, MassachusettsRecruiting
- MD Anderson in Sugar LandSugar Land, TexasRecruiting
- MD Anderson in The WoodlandsConroe, TexasRecruiting
- MD Anderson League CityLeague City, TexasRecruiting
- MD Anderson West HoustonHouston, TexasRecruiting
- Medical Oncology Hematology Consultants PANewark, DelawareRecruiting
- Medical University of South CarolinaCharleston, South CarolinaRecruiting
- Memorial Hospital of CarbondaleCarbondale, IllinoisRecruiting
- Memorial Hospital of Laramie CountyCheyenne, WyomingRecruiting
- Memorial Sloan Kettering Basking RidgeBasking Ridge, New JerseyRecruiting
- Memorial Sloan Kettering BergenMontvale, New JerseyRecruiting
- Memorial Sloan Kettering Cancer CenterNew York, New YorkRecruiting
- Memorial Sloan Kettering CommackCommack, New YorkRecruiting
- Memorial Sloan Kettering MonmouthMiddletown, New JerseyRecruiting
- Memorial Sloan Kettering NassauUniondale, New YorkRecruiting
- Memorial Sloan Kettering WestchesterEast White Plains, New YorkRecruiting
- Mercy Cancer Center - Cape GirardeauCape Girardeau, MissouriRecruiting
- Mercy Cancer Center-West LakesClive, IowaRecruiting
- Mercy Clinic-Rolla-Cancer and HematologyRolla, MissouriRecruiting
- Mercy HospitalCoon Rapids, MinnesotaRecruiting
- Mercy Hospital Fort SmithFort Smith, ArkansasRecruiting
- Mercy Hospital JoplinJoplin, MissouriRecruiting
- Mercy Hospital Oklahoma CityOklahoma City, OklahomaRecruiting
- Mercy Hospital PittsburgPittsburg, KansasRecruiting
- Mercy Hospital Saint LouisSt Louis, MissouriRecruiting
- Mercy Hospital SouthSt Louis, MissouriRecruiting
- Mercy Hospital SpringfieldSpringfield, MissouriRecruiting
- Mercy Medical Center - Des MoinesDes Moines, IowaRecruiting
- Mercy Medical Center-West LakesWest Des Moines, IowaRecruiting
- Methodist Medical Center of IllinoisPeoria, IllinoisRecruiting
- Miami Cancer InstituteMiami, FloridaRecruiting
- Minnesota Oncology - BurnsvilleBurnsville, MinnesotaRecruiting
- Minnesota Oncology Hematology PA-MaplewoodMaplewood, MinnesotaRecruiting
- Minnesota Oncology Hematology PA-WoodburyWoodbury, MinnesotaRecruiting
- Missouri Baptist Medical CenterSt Louis, MissouriRecruiting
- Missouri Baptist Sullivan HospitalSullivan, MissouriRecruiting
- Monticello Cancer CenterMonticello, MinnesotaRecruiting
- MU Health - University Hospital/Ellis Fischel Cancer CenterColumbia, MissouriRecruiting
- Munson Medical CenterTraverse City, MichiganRecruiting
- North Memorial Medical Health CenterRobbinsdale, MinnesotaRecruiting
- Northwestern Medicine Orland ParkOrland Park, IllinoisRecruiting
- Northwestern UniversityChicago, IllinoisRecruiting
- Ohio State University Comprehensive Cancer CenterColumbus, OhioRecruiting
- OSF Saint Anthony's Health CenterAlton, IllinoisRecruiting
- OSF Saint Francis Medical CenterPeoria, IllinoisRecruiting
- OSF Saint Francis Radiation Oncology at Peoria Cancer CenterPeoria, IllinoisRecruiting
- OSF Saint Joseph Medical CenterBloomington, IllinoisRecruiting
- Park Nicollet Clinic - Saint Louis ParkSaint Louis Park, MinnesotaRecruiting
- Parkland Health Center - FarmingtonFarmington, MissouriRecruiting
- Parkland Memorial HospitalDallas, TexasRecruiting
- Phelps Health Delbert Day Cancer InstituteRolla, MissouriRecruiting
- Regions HospitalSaint Paul, MinnesotaRecruiting
- Rice Memorial HospitalWillmar, MinnesotaRecruiting
- Ridgeview Medical CenterWaconia, MinnesotaRecruiting
- Rush MD Anderson Cancer CenterChicago, IllinoisRecruiting
- Rush MD Anderson Cancer Center at Rush Oak ParkOak Park, IllinoisRecruiting
- Saint Francis Medical CenterCape Girardeau, MissouriRecruiting
- Saint Francis Regional Medical CenterShakopee, MinnesotaRecruiting
- Saint John's Hospital - HealtheastMaplewood, MinnesotaRecruiting
- Sainte Genevieve County Memorial HospitalSainte Genevieve, MissouriRecruiting
- Self Regional HealthcareGreenwood, South CarolinaRecruiting
- SIH Cancer InstituteCarterville, IllinoisRecruiting
- SMC Center for Hematology Oncology UnionUnion, South CarolinaRecruiting
- Southern Illinois University School of MedicineSpringfield, IllinoisRecruiting
- Spartanburg Medical CenterSpartanburg, South CarolinaRecruiting
- Springfield ClinicSpringfield, IllinoisRecruiting
- Springfield Memorial HospitalSpringfield, IllinoisRecruiting
- SSM Health Good SamaritanMount Vernon, IllinoisRecruiting
- The Iowa Clinic PCWest Des Moines, IowaRecruiting
- Trinity Health Grand Rapids HospitalGrand Rapids, MichiganRecruiting
- Trinity Health Muskegon HospitalMuskegon, MichiganRecruiting
- UC Irvine Health/Chao Family Comprehensive Cancer CenterOrange, CaliforniaRecruiting
- UC San Diego Moores Cancer CenterLa Jolla, CaliforniaRecruiting
- UCHealth - Cherry CreekDenver, ColoradoRecruiting
- UCHealth Highlands Ranch HospitalHighlands Ranch, ColoradoRecruiting
- UCHealth Lone Tree Health CenterLone Tree, ColoradoRecruiting
- UCHealth University of Colorado HospitalAurora, ColoradoRecruiting
- UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory CareIrvine, CaliforniaRecruiting
- UH Seidman Cancer Center at Lake Health Mentor CampusMentor, OhioRecruiting
- UH Seidman Cancer Center at UH Avon Health CenterAvon, OhioRecruiting
- UHHS-Chagrin Highlands Medical CenterBeachwood, OhioRecruiting
- UI Health Care Mission Cancer and Blood - Ankeny ClinicAnkeny, IowaRecruiting
- UI Health Care Mission Cancer and Blood - Des Moines ClinicDes Moines, IowaRecruiting
- UI Health Care Mission Cancer and Blood - Laurel ClinicDes Moines, IowaRecruiting
- UI Health Care Mission Cancer and Blood - Waukee ClinicWaukee, IowaRecruiting
- UI Health Care Mission Cancer and Blood - West Des Moines ClinicClive, IowaRecruiting
- UM Sylvester Comprehensive Cancer Center at Coral GablesCoral Gables, FloridaRecruiting
- UM Sylvester Comprehensive Cancer Center at Deerfield BeachDeerfield Beach, FloridaRecruiting
- UM Sylvester Comprehensive Cancer Center at DoralDoral, FloridaRecruiting
- UM Sylvester Comprehensive Cancer Center at KendallMiami, FloridaRecruiting
- UM Sylvester Comprehensive Cancer Center at PlantationPlantation, FloridaRecruiting
- UNC Lineberger Comprehensive Cancer CenterChapel Hill, North CarolinaRecruiting
- United HospitalSaint Paul, MinnesotaRecruiting
- University of California Davis Comprehensive Cancer CenterSacramento, CaliforniaRecruiting
- University of IllinoisChicago, IllinoisRecruiting
- University of Kansas Cancer CenterKansas City, KansasRecruiting
- University of Kansas Cancer Center - BriarcliffKansas City, MissouriRecruiting
- University of Kansas Cancer Center - Lee's SummitLee's Summit, MissouriRecruiting
- University of Kansas Cancer Center - NorthKansas City, MissouriRecruiting
- University of Kansas Cancer Center-Overland ParkOverland Park, KansasRecruiting
- University of Kansas Health System Saint Francis CampusTopeka, KansasRecruiting
- University of Kansas Hospital-Westwood Cancer CenterWestwood, KansasRecruiting
- University of Miami Miller School of Medicine-Sylvester Cancer CenterMiami, FloridaRecruiting
- University of Miami Sylvester Comprehensive Cancer Center at Sole MiaNorth Miami, FloridaRecruiting
- University of Michigan - Brighton Center for Specialty CareBrighton, MichiganRecruiting
- University of Michigan Health - WestWyoming, MichiganRecruiting
- University of Michigan Rogel Cancer CenterAnn Arbor, MichiganRecruiting
- University of Oklahoma Health Sciences CenterOklahoma City, OklahomaRecruiting
- UT Southwestern/Simmons Cancer Center-DallasDallas, TexasRecruiting
- Vanderbilt Breast Center at One Hundred OaksNashville, TennesseeRecruiting
- Vanderbilt University/Ingram Cancer CenterNashville, TennesseeRecruiting
- West Michigan Cancer CenterKalamazoo, MichiganRecruiting
- Highland HospitalRochester, New YorkNot Yet Recruiting
- University of Kentucky/Markey Cancer CenterLexington, KentuckyNot Yet Recruiting
- University of RochesterRochester, New YorkNot Yet Recruiting
- Wilmot Cancer Institute at WebsterWebster, New YorkNot Yet Recruiting
- Central Care Cancer Center - Great BendGreat Bend, KansasSuspended
- Illinois CancerCare-DixonDixon, IllinoisSuspended
- Valley Radiation OncologyPeru, IllinoisSuspended
Who to ask about joining
Site Public Contact800-378-9373
Site Public Contact877-827-8839ucstudy@uci.edu
Site Public Contact858-822-5354cancercto@ucsd.edu
Who can join
Adults aged 18 and older can join this trial if they have a specific type of bladder cancer and have had surgery to remove their tumors. They should not have certain other health issues or previous bladder cancer treatments that could interfere. Both men and women are welcome, and the trial team will check who is eligible before enrollment.
What happens during the trial
Participants will be randomly assigned to one of two groups. In one group, patients will receive the usual radiation therapy with daily treatments for 20 days. In the other group, patients will receive the shorter radiation therapy with treatments for just 5 days. Both groups will also receive one of three chemotherapy options. Throughout the study, patients will have imaging tests and may provide blood and urine samples.
The trial team
The trial is sponsored by NRG Oncology. The principal investigator is Dr. Scott E Delacroix, who is affiliated with NRG Oncology.
Important dates
The trial started on October 7, 2025, and is expected to finish by May 31, 2030. It is currently recruiting new participants.
Additional information
This is a Phase 3 trial, which means it is testing how well the treatments work and their safety. The trial is not FDA-regulated for drugs or devices and hopes to include about 486 participants.
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