Tracking the Effect of Immunotherapy with Radiation for Bladder Cancer Treatment
NCT06770582 · RecruitingAbout this trial
This clinical trial is looking at how well pembrolizumab, an immunotherapy drug, works with radiation therapy compared to standard chemotherapy combined with radiation for treating bladder cancer. The goal is to see if using pembrolizumab helps the immune system fight the cancer better than chemotherapy does. Participants will be monitored for their response to treatment and overall health during the study.
Locations and contact
This trial is running at 134 locations in 2 countries. 131 of them are currently recruiting.
United States132 locations · 129 recruiting
- AIS Cancer Center at San Joaquin Community HospitalBakersfield, CaliforniaRecruiting
- BJC Outpatient Center at Sunset HillsSunset Hills, MissouriRecruiting
- Bon Secours Cancer Institute at Reynolds CrossingRichmond, VirginiaRecruiting
- Bon Secours Memorial Regional Medical CenterMechanicsville, VirginiaRecruiting
- Bon Secours Saint Francis Medical CenterMidlothian, VirginiaRecruiting
- Bon Secours Saint Mary's HospitalRichmond, VirginiaRecruiting
- Broadlawns Medical CenterDes Moines, IowaRecruiting
- Cancer Care Specialists of Illinois - DecaturDecatur, IllinoisRecruiting
- Carle at The RiverfrontDanville, IllinoisRecruiting
- Carle BroMenn Medical CenterNormal, IllinoisRecruiting
- Carle Cancer CenterUrbana, IllinoisRecruiting
- Carle Cancer Institute NormalNormal, IllinoisRecruiting
- Carle Physician Group-EffinghamEffingham, IllinoisRecruiting
- Carle Physician Group-Mattoon/CharlestonMattoon, IllinoisRecruiting
- Central Vermont Medical Center/National Life Cancer TreatmentBerlin Corners, VermontRecruiting
- Chelsea HospitalChelsea, MichiganRecruiting
- Christiana Care Health System-Concord Health CenterChadds Ford, PennsylvaniaRecruiting
- Crossroads Cancer CenterEffingham, IllinoisRecruiting
- Decatur Memorial HospitalDecatur, IllinoisRecruiting
- Doctors HospitalColumbus, OhioRecruiting
- Dublin Methodist HospitalDublin, OhioRecruiting
- Duluth Clinic AshlandAshland, WisconsinRecruiting
- Emory Proton Therapy CenterAtlanta, GeorgiaRecruiting
- Emory Saint Joseph's HospitalAtlanta, GeorgiaRecruiting
- Emory University Hospital MidtownAtlanta, GeorgiaRecruiting
- Emory University Hospital/Winship Cancer InstituteAtlanta, GeorgiaRecruiting
- Essentia Health - Deer River ClinicDeer River, MinnesotaRecruiting
- Essentia Health Cancer CenterDuluth, MinnesotaRecruiting
- Essentia Health Hibbing ClinicHibbing, MinnesotaRecruiting
- Essentia Health Saint Joseph's Medical CenterBrainerd, MinnesotaRecruiting
- Essentia Health Saint Mary's Medical CenterDuluth, MinnesotaRecruiting
- Essentia Health SandstoneSandstone, MinnesotaRecruiting
- Essentia Health Virginia ClinicVirginia, MinnesotaRecruiting
- Geisinger Cancer Center Dickson CityDickson City, PennsylvaniaRecruiting
- Geisinger Medical CenterDanville, PennsylvaniaRecruiting
- Geisinger Medical Oncology-LewisburgLewisburg, PennsylvaniaRecruiting
- Geisinger Wyoming Valley/Henry Cancer CenterWilkes-Barre, PennsylvaniaRecruiting
- Grady Health SystemAtlanta, GeorgiaRecruiting
- Grant Medical CenterColumbus, OhioRecruiting
- Helen F Graham Cancer CenterNewark, DelawareRecruiting
- Highlands Oncology GroupSpringdale, ArkansasRecruiting
- Highlands Oncology Group - FayettevilleFayetteville, ArkansasRecruiting
- Highlands Oncology Group - RogersRogers, ArkansasRecruiting
- HSHS Saint Elizabeth's HospitalO'Fallon, IllinoisRecruiting
- Iowa Methodist Medical CenterDes Moines, IowaRecruiting
- Lake Regional HospitalOsage Beach, MissouriRecruiting
- Los Angeles General Medical CenterLos Angeles, CaliforniaRecruiting
- Louisiana Hematology Oncology Associates LLCBaton Rouge, LouisianaRecruiting
- Marshfield Medical Center - WestonWeston, WisconsinRecruiting
- Mary Bird Perkins Cancer CenterBaton Rouge, LouisianaRecruiting
- Mary Bird Perkins Cancer Center - GonzalesGonzales, LouisianaRecruiting
- Mary Bird Perkins Cancer Center - MetairieMetairie, LouisianaRecruiting
- Mary Greeley Medical CenterAmes, IowaRecruiting
- Massachusetts General Hospital Cancer CenterBoston, MassachusettsRecruiting
- McFarland Clinic - AmesAmes, IowaRecruiting
- Medical Oncology Hematology Consultants PANewark, DelawareRecruiting
- Memorial Sloan Kettering Basking RidgeBasking Ridge, New JerseyRecruiting
- Memorial Sloan Kettering BergenMontvale, New JerseyRecruiting
- Memorial Sloan Kettering Cancer CenterNew York, New YorkRecruiting
- Memorial Sloan Kettering CommackCommack, New YorkRecruiting
- Memorial Sloan Kettering MonmouthMiddletown, New JerseyRecruiting
- Memorial Sloan Kettering NassauUniondale, New YorkRecruiting
- Memorial Sloan Kettering WestchesterHarrison, New YorkRecruiting
- Mercy Cancer Center-West LakesClive, IowaRecruiting
- Mercy Hospital Saint LouisSt Louis, MissouriRecruiting
- Mercy Hospital SouthSt Louis, MissouriRecruiting
- Mercy Medical Center - Des MoinesDes Moines, IowaRecruiting
- Michigan Healthcare Professionals PontiacPontiac, MichiganRecruiting
- Miller-Dwan HospitalDuluth, MinnesotaRecruiting
- Missouri Baptist Medical CenterSt Louis, MissouriRecruiting
- Missouri Baptist Sullivan HospitalSullivan, MissouriRecruiting
- Mount Sinai Medical CenterMiami Beach, FloridaRecruiting
- Northwest Wisconsin Cancer CenterAshland, WisconsinRecruiting
- OhioHealth Mansfield HospitalMansfield, OhioRecruiting
- OhioHealth Marion General HospitalMarion, OhioRecruiting
- Parkland Health Center - FarmingtonFarmington, MissouriRecruiting
- Penn State Milton S Hershey Medical CenterHershey, PennsylvaniaRecruiting
- Riverside Methodist HospitalColumbus, OhioRecruiting
- Rush MD Anderson Cancer CenterChicago, IllinoisRecruiting
- Saint Francis Medical CenterCape Girardeau, MissouriRecruiting
- Sainte Genevieve County Memorial HospitalSainte Genevieve, MissouriRecruiting
- Shaw Cancer CenterEdwards, ColoradoRecruiting
- Southern Illinois University School of MedicineSpringfield, IllinoisRecruiting
- Springfield ClinicSpringfield, IllinoisRecruiting
- Springfield Memorial HospitalSpringfield, IllinoisRecruiting
- The Iowa Clinic PCWest Des Moines, IowaRecruiting
- Trinity Health Medical Center - BrightonBrighton, MichiganRecruiting
- Trinity Health Medical Center - CantonCanton, MichiganRecruiting
- Trinity Health Saint Joseph Mercy Hospital Ann ArborAnn Arbor, MichiganRecruiting
- Trinity Health Saint Joseph Mercy Oakland HospitalPontiac, MichiganRecruiting
- Trinity Health Saint Mary Mercy Livonia HospitalLivonia, MichiganRecruiting
- UF Health Cancer Institute - GainesvilleGainesville, FloridaRecruiting
- UI Health Care Mission Cancer and Blood - Ankeny ClinicAnkeny, IowaRecruiting
- UI Health Care Mission Cancer and Blood - Des Moines ClinicDes Moines, IowaRecruiting
- UI Health Care Mission Cancer and Blood - Laurel ClinicDes Moines, IowaRecruiting
- UI Health Care Mission Cancer and Blood - Waukee ClinicWaukee, IowaRecruiting
- UI Health Care Mission Cancer and Blood - West Des Moines ClinicClive, IowaRecruiting
- UI Healthcare Mission Cancer and Blood - PellaPella, IowaRecruiting
- UNC Lineberger Comprehensive Cancer CenterChapel Hill, North CarolinaRecruiting
- University of Kansas Cancer CenterKansas City, KansasRecruiting
- University of Kansas Cancer Center - BriarcliffKansas City, MissouriRecruiting
- University of Kansas Cancer Center - Lee's SummitLee's Summit, MissouriRecruiting
- University of Kansas Cancer Center - NorthKansas City, MissouriRecruiting
- University of Kansas Cancer Center-Overland ParkOverland Park, KansasRecruiting
- University of Kansas Hospital-Indian Creek CampusOverland Park, KansasRecruiting
- University of Kansas Hospital-Westwood Cancer CenterWestwood, KansasRecruiting
- University of Michigan Health - Sparrow LansingLansing, MichiganRecruiting
- University of Oklahoma Health Sciences CenterOklahoma City, OklahomaRecruiting
- University of Pittsburgh Cancer Institute (UPCI)Pittsburgh, PennsylvaniaRecruiting
- University of Vermont and State Agricultural CollegeBurlington, VermontRecruiting
- University of Vermont Medical CenterBurlington, VermontRecruiting
- University of Virginia Cancer CenterCharlottesville, VirginiaRecruiting
- UPMC Cancer Center - MonroevilleMonroeville, PennsylvaniaRecruiting
- UPMC Cancer Center at UPMC HorizonFarrell, PennsylvaniaRecruiting
- UPMC Cancer Center at UPMC NorthwestSeneca, PennsylvaniaRecruiting
- UPMC Cancer Center-WashingtonWashington, PennsylvaniaRecruiting
- UPMC Cancer Centers - Arnold Palmer PavilionGreensburg, PennsylvaniaRecruiting
- UPMC Hillman Cancer Center - MonroevilleMonroeville, PennsylvaniaRecruiting
- UPMC Hillman Cancer Center - New CastleNew Castle, PennsylvaniaRecruiting
- UPMC Hillman Cancer Center ErieErie, PennsylvaniaRecruiting
- UPMC Washington Hospital Radiation OncologyWashington, PennsylvaniaRecruiting
- UPMC-Magee Womens HospitalPittsburgh, PennsylvaniaRecruiting
- UPMC-Passavant HospitalPittsburgh, PennsylvaniaRecruiting
- UPMC-Saint MargaretPittsburgh, PennsylvaniaRecruiting
- UPMC-Shadyside HospitalPittsburgh, PennsylvaniaRecruiting
- USC / Norris Comprehensive Cancer CenterLos Angeles, CaliforniaRecruiting
- VCU Community Memorial Health CenterSouth Hill, VirginiaRecruiting
- VCU Massey Comprehensive Cancer CenterRichmond, VirginiaRecruiting
- West Virginia University HealthcareMorgantown, West VirginiaRecruiting
- Sanford Broadway Medical CenterFargo, North DakotaActive Not Recruiting
- Sanford Joe Lueken Cancer CenterBemidji, MinnesotaActive Not Recruiting
- Sanford Roger Maris Cancer CenterFargo, North DakotaActive Not Recruiting
Canada2 locations · 2 recruiting
- CHU de Quebec-L'Hotel-Dieu de Quebec (HDQ)Québec, QuebecRecruiting
- The Research Institute of the McGill University Health Centre (MUHC)Montreal, QuebecRecruiting
Who to ask about joining
Site Public Contact479-872-8100research@hogonc.com
Site Public Contact479-872-8130research@hogonc.com
Site Public Contact661-323-4673
Site Public Contact323-865-0451uscnorrisinfo@med.usc.edu
Who can join
This trial is open to adults aged 18 and older. Men and women who have a specific type of bladder cancer that is high-grade and non-muscle invasive can join. There are some health requirements, and the trial team will check if each person is eligible before they can participate.
What happens during the trial
Participants will be placed into one of two groups by chance. One group will receive standard chemotherapy along with radiation. The other group will receive pembrolizumab with radiation. Everyone will also have tests like CT scans and blood samples during the study. Treatments are given as long as there are no major health issues or disease progression.
The trial team
The trial is sponsored by the National Cancer Institute (NCI). The principal investigator is Brian C Baumann from NRG Oncology.
Important dates
The trial started on June 3, 2025, and is expected to finish by February 1, 2032. It is currently recruiting new participants.
Additional information
The trial's ID number is NCT06770582. It is a Phase 2 trial, which means the team is looking at how well the treatment works and how safe it is. The trial is regulated by the FDA and plans to include about 160 participants.
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