Tracking the Effects of Gemcitabine with BCG in Bladder Cancer Treatment
NCT07000084 · RecruitingThis study looks at how adding a drug called gemcitabine to the usual treatment with BCG helps people with non-muscle invasive bladder cancer when it comes back after previous treatment. Gemcitabine is a chemotherapy drug that may help kill cancer cells. The goal is to see if this combination works better than BCG alone in keeping the cancer from returning.
Locations and contact
This trial is running at 58 locations in the United States. All of them are currently recruiting.
United States58 locations · 58 recruiting
- Banner MD Anderson Cancer CenterGilbert, ArizonaRecruiting
- Benefis Helena Specialty CenterHelena, MontanaRecruiting
- Benefis Sletten Cancer InstituteGreat Falls, MontanaRecruiting
- Billings Clinic Cancer CenterBillings, MontanaRecruiting
- Billings Clinic-CodyCody, WyomingRecruiting
- Bozeman Health Deaconess HospitalBozeman, MontanaRecruiting
- Brigham and Women's HospitalBoston, MassachusettsRecruiting
- Community Hospital of AnacondaAnaconda, MontanaRecruiting
- Community Medical CenterMissoula, MontanaRecruiting
- Fairbanks Memorial HospitalFairbanks, AlaskaRecruiting
- FMH James M Stockman Cancer InstituteFrederick, MarylandRecruiting
- Fox Chase Cancer CenterPhiladelphia, PennsylvaniaRecruiting
- Fox Chase Cancer Center-RockledgeRockledge, PennsylvaniaRecruiting
- Geisinger Cancer Center Dickson CityDickson City, PennsylvaniaRecruiting
- Geisinger Medical CenterDanville, PennsylvaniaRecruiting
- Geisinger Medical Oncology-LewisburgLewisburg, PennsylvaniaRecruiting
- Geisinger Wyoming Valley/Henry Cancer CenterWilkes-Barre, PennsylvaniaRecruiting
- Great Falls ClinicGreat Falls, MontanaRecruiting
- Hackensack University Medical CenterHackensack, New JerseyRecruiting
- Hi-Line Sletten Cancer CenterHavre, MontanaRecruiting
- Indiana University/Melvin and Bren Simon Cancer CenterIndianapolis, IndianaRecruiting
- IU Health Methodist HospitalIndianapolis, IndianaRecruiting
- IU Health North HospitalCarmel, IndianaRecruiting
- IU Health West HospitalAvon, IndianaRecruiting
- Johns Hopkins University/Sidney Kimmel Cancer CenterBaltimore, MarylandRecruiting
- Kootenai Clinic Cancer Services - Post FallsPost Falls, IdahoRecruiting
- Kootenai Clinic Cancer Services - SandpointSandpoint, IdahoRecruiting
- Kootenai Health - Coeur d'AleneCoeur d'Alene, IdahoRecruiting
- Lahey ClinicBurlington, MassachusettsRecruiting
- Lahey Clinic PeabodyPeabody, MassachusettsRecruiting
- Logan Health Medical CenterKalispell, MontanaRecruiting
- Loyola University Medical CenterMaywood, IllinoisRecruiting
- Marjorie Weinberg Cancer Center at Loyola-GottliebMelrose Park, IllinoisRecruiting
- Mary Bird Perkins Cancer Center - MetairieMetairie, LouisianaRecruiting
- Mayo Clinic Hospital in ArizonaPhoenix, ArizonaRecruiting
- Mayo Clinic in FloridaJacksonville, FloridaRecruiting
- Mayo Clinic in RochesterRochester, MinnesotaRecruiting
- Medical University of South CarolinaCharleston, South CarolinaRecruiting
- Memorial Hospital of Laramie CountyCheyenne, WyomingRecruiting
- Memorial Sloan Kettering Basking RidgeBasking Ridge, New JerseyRecruiting
- Memorial Sloan Kettering BergenMontvale, New JerseyRecruiting
- Memorial Sloan Kettering Cancer CenterNew York, New YorkRecruiting
- Memorial Sloan Kettering CommackCommack, New YorkRecruiting
- Memorial Sloan Kettering MonmouthMiddletown, New JerseyRecruiting
- Memorial Sloan Kettering NassauUniondale, New YorkRecruiting
- Memorial Sloan Kettering WestchesterHarrison, New YorkRecruiting
- Northwestern UniversityChicago, IllinoisRecruiting
- Ohio State University Comprehensive Cancer CenterColumbus, OhioRecruiting
- Ralph H Johnson VA Medical CenterCharleston, South CarolinaRecruiting
- Roswell Park Cancer InstituteBuffalo, New YorkRecruiting
- Sibley Memorial HospitalWashington D.C., District of ColumbiaRecruiting
- UC Irvine Health/Chao Family Comprehensive Cancer CenterOrange, CaliforniaRecruiting
- UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory CareIrvine, CaliforniaRecruiting
- UF Health Cancer Institute - GainesvilleGainesville, FloridaRecruiting
- University of Alabama at Birmingham Cancer CenterBirmingham, AlabamaRecruiting
- University of IllinoisChicago, IllinoisRecruiting
- University of Oklahoma Health Sciences CenterOklahoma City, OklahomaRecruiting
- VCU Massey Comprehensive Cancer CenterRichmond, VirginiaRecruiting
Who can join
Adults aged 18 and older can join the trial. It is open to both men and women who have certain types of bladder cancer that has come back after treatment with BCG. Some specific health conditions may prevent someone from joining. The trial team will confirm who is eligible.
What happens during the trial
Participants are randomly assigned to one of two groups. In Arm A, patients receive BCG treatment once a week for six weeks. In Arm B, patients receive both gemcitabine and BCG in a specific schedule over several weeks. Everyone will have tests like bladder biopsies and scans throughout the study to monitor their health.
The trial team
The trial is sponsored by the Alliance for Clinical Trials in Oncology, with collaboration from the National Cancer Institute. Dr. Eugene Pietzak is the study chair leading the trial.
Important dates
The trial started on July 17, 2025, and is expected to finish by December 5, 2028. It is currently enrolling new participants.
Additional information
This is a Phase 3 trial, which means it is looking at how well the treatment works and how safe it is. The trial hopes to include about 330 participants. The trial is not testing a drug regulated by the FDA.
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