Understanding the Benefits of Adding Panitumumab to Chemotherapy for Advanced Pancreatic Cancer

NCT06998940 · Recruiting

About this trial

This trial compares the effects of adding a drug called panitumumab to standard chemotherapy in patients with advanced pancreatic cancer. The goal is to see if this combination helps people live longer and have better outcomes. The study focuses on patients whose cancer cannot be removed by surgery and has not shown certain mutations in their tumors.

Locations and contact

This trial is running at 274 locations in the United States. 272 of them are currently recruiting.

United States274 locations · 272 recruiting

Alaska Breast Care and Surgery LLCAnchorage, AlaskaRecruiting
Alaska Oncology and Hematology LLCAnchorage, AlaskaRecruiting
Alaska Women's Cancer CareAnchorage, AlaskaRecruiting
Alegent Health Bergan Mercy Medical CenterOmaha, NebraskaRecruiting
Alegent Health Immanuel Medical CenterOmaha, NebraskaRecruiting
Alegent Health Lakeside HospitalOmaha, NebraskaRecruiting
Alta Bates Summit Medical Center-Herrick CampusBerkeley, CaliforniaRecruiting
Anchorage Associates in Radiation MedicineAnchorage, AlaskaRecruiting
Atrium Medical Center-Middletown Regional HospitalFranklin, OhioRecruiting
Baptist Cancer Center-GrenadaGrenada, MississippiRecruiting
Baptist Memorial Hospital and Cancer Center-ColliervilleCollierville, TennesseeRecruiting
Baptist Memorial Hospital and Cancer Center-DesotoSouthhaven, MississippiRecruiting
Baptist Memorial Hospital and Cancer Center-Golden TriangleColumbus, MississippiRecruiting
Baptist Memorial Hospital and Cancer Center-MemphisMemphis, TennesseeRecruiting
Baptist Memorial Hospital and Cancer Center-OxfordOxford, MississippiRecruiting
Baptist Memorial Hospital and Cancer Center-Union CountyNew Albany, MississippiRecruiting
Bay Area HospitalCoos Bay, OregonRecruiting
Beacon KalamazooKalamazoo, MichiganRecruiting
Beacon Kalamazoo Cancer CenterKalamazoo, MichiganRecruiting
Beebe Health CampusRehoboth Beach, DelawareRecruiting
Beebe Medical CenterLewes, DelawareRecruiting
Beebe South Coastal Health CampusMillville, DelawareRecruiting
Benefis Helena Specialty CenterHelena, MontanaRecruiting
Benefis Sletten Cancer InstituteGreat Falls, MontanaRecruiting
Bethesda North HospitalCincinnati, OhioRecruiting
Billings Clinic Cancer CenterBillings, MontanaRecruiting
Billings Clinic-CodyCody, WyomingRecruiting
BJC Outpatient Center at Sunset HillsSunset Hills, MissouriRecruiting
Bozeman Health Deaconess HospitalBozeman, MontanaRecruiting
Bronson Battle CreekBattle Creek, MichiganRecruiting
Bronson Methodist HospitalKalamazoo, MichiganRecruiting
California Pacific Medical Center-Pacific CampusSan Francisco, CaliforniaRecruiting
Cancer and Hematology Centers of Western Michigan - Norton ShoresNorton Shores, MichiganRecruiting
Cancer Care Center of O'FallonO'Fallon, IllinoisRecruiting
Cancer Care Northwest - Spokane SouthSpokane, WashingtonRecruiting
Cancer Care Northwest-North SpokaneSpokane, WashingtonRecruiting
Cancer Care Northwest-ValleySpokane, WashingtonRecruiting
Cancer Care Specialists of Illinois - DecaturDecatur, IllinoisRecruiting
Cancer Center at Saint Joseph'sPhoenix, ArizonaRecruiting
Carle at The RiverfrontDanville, IllinoisRecruiting
Carle BroMenn Medical CenterNormal, IllinoisRecruiting
Carle Cancer CenterUrbana, IllinoisRecruiting
Carle Cancer Institute NormalNormal, IllinoisRecruiting
Carle Physician Group-EffinghamEffingham, IllinoisRecruiting
Carle Physician Group-Mattoon/CharlestonMattoon, IllinoisRecruiting
Centralia Oncology ClinicCentralia, IllinoisRecruiting
CHI Health Good SamaritanKearney, NebraskaRecruiting
CHI Health Saint FrancisGrand Island, NebraskaRecruiting
Christiana Care - Union HospitalElkton, MarylandRecruiting
Christiana Care Health System-Christiana HospitalNewark, DelawareRecruiting
Christiana Care Health System-Concord Health CenterChadds Ford, PennsylvaniaRecruiting
Christiana Care Health System-Wilmington HospitalWilmington, DelawareRecruiting
Clackamas Radiation Oncology CenterClackamas, OregonRecruiting
CommonSpirit Cancer Center MercyDurango, ColoradoRecruiting
Commonwealth Cancer Center-CorbinCorbin, KentuckyRecruiting
Community Hospital of AnacondaAnaconda, MontanaRecruiting
Community Medical CenterMissoula, MontanaRecruiting
Corewell Health Grand Rapids Hospitals - Butterworth HospitalGrand Rapids, MichiganRecruiting
Corewell Health Grand Rapids Hospitals - Helen DeVos Children's HospitalGrand Rapids, MichiganRecruiting
Corewell Health Lakeland Hospitals - Marie Yeager Cancer CenterSaint Joseph, MichiganRecruiting
Corewell Health Lakeland Hospitals - Niles HospitalNiles, MichiganRecruiting
Corewell Health Lakeland Hospitals - Saint Joseph HospitalSaint Joseph, MichiganRecruiting
Corewell Health Reed City HospitalReed City, MichiganRecruiting
Creighton University Medical CenterOmaha, NebraskaRecruiting
Crossroads Cancer CenterEffingham, IllinoisRecruiting
Decatur Memorial HospitalDecatur, IllinoisRecruiting
Duluth Clinic AshlandAshland, WisconsinRecruiting
Eden Hospital Medical CenterCastro Valley, CaliforniaRecruiting
Emory Decatur HospitalDecatur, GeorgiaRecruiting
Emory Johns Creek HospitalJohns Creek, GeorgiaRecruiting
Emory Saint Joseph's HospitalAtlanta, GeorgiaRecruiting
Emory University Hospital MidtownAtlanta, GeorgiaRecruiting
Emory University Hospital/Winship Cancer InstituteAtlanta, GeorgiaRecruiting
Essentia Health - Baxter ClinicBaxter, MinnesotaRecruiting
Essentia Health - Deer River ClinicDeer River, MinnesotaRecruiting
Essentia Health - Ely ClinicEly, MinnesotaRecruiting
Essentia Health - FosstonFosston, MinnesotaRecruiting
Essentia Health - International Falls ClinicInternational Falls, MinnesotaRecruiting
Essentia Health - Jamestown ClinicJamestown, North DakotaRecruiting
Essentia Health - Moose Lake ClinicMoose Lake, MinnesotaRecruiting
Essentia Health - Park RapidsPark Rapids, MinnesotaRecruiting
Essentia Health - Saint Joseph's Crosslake ClinicCrosslake, MinnesotaRecruiting
Essentia Health - Saint Joseph's Pequot Lakes ClinicPequot Lakes, MinnesotaRecruiting
Essentia Health - Saint Joseph's Pine River ClinicPine River, MinnesotaRecruiting
Essentia Health - Saint Joseph's Staples ClinicStaples, MinnesotaRecruiting
Essentia Health Cancer CenterDuluth, MinnesotaRecruiting
Essentia Health Cancer Center-South University ClinicFargo, North DakotaRecruiting
Essentia Health Hibbing ClinicHibbing, MinnesotaRecruiting
Essentia Health Saint Joseph's Medical CenterBrainerd, MinnesotaRecruiting
Essentia Health Saint Mary's - Detroit Lakes ClinicDetroit Lakes, MinnesotaRecruiting
Essentia Health Saint Mary's Hospital - SuperiorSuperior, WisconsinRecruiting
Essentia Health Saint Mary's Medical CenterDuluth, MinnesotaRecruiting
Essentia Health SandstoneSandstone, MinnesotaRecruiting
Essentia Health Virginia ClinicVirginia, MinnesotaRecruiting
Essentia Health-Hayward ClinicHayward, WisconsinRecruiting
Essentia Health-Spooner ClinicSpooner, WisconsinRecruiting
FirstHealth of the Carolinas-Moore Regional HospitalPinehurst, North CarolinaRecruiting
Flaget Memorial HospitalBardstown, KentuckyRecruiting
Fred Hutchinson Cancer CenterSeattle, WashingtonRecruiting
Good Samaritan Hospital - CincinnatiCincinnati, OhioRecruiting
Great Falls ClinicGreat Falls, MontanaRecruiting
Greater Regional Medical CenterCreston, IowaRecruiting
Gundersen Lutheran Medical CenterLa Crosse, WisconsinRecruiting
Helen F Graham Cancer CenterNewark, DelawareRecruiting
Hi-Line Sletten Cancer CenterHavre, MontanaRecruiting
Highlands Oncology GroupSpringdale, ArkansasRecruiting
Highlands Oncology Group - FayettevilleFayetteville, ArkansasRecruiting
Highlands Oncology Group - RogersRogers, ArkansasRecruiting
HSHS Saint Elizabeth's HospitalO'Fallon, IllinoisRecruiting
Illinois CancerCare - WashingtonWashington, IllinoisRecruiting
Illinois CancerCare-BloomingtonBloomington, IllinoisRecruiting
Illinois CancerCare-CantonCanton, IllinoisRecruiting
Illinois CancerCare-CarthageCarthage, IllinoisRecruiting
Illinois CancerCare-DixonDixon, IllinoisRecruiting
Illinois CancerCare-EurekaEureka, IllinoisRecruiting
Illinois CancerCare-GalesburgGalesburg, IllinoisRecruiting
Illinois CancerCare-Kewanee ClinicKewanee, IllinoisRecruiting
Illinois CancerCare-MacombMacomb, IllinoisRecruiting
Illinois CancerCare-Ottawa ClinicOttawa, IllinoisRecruiting
Illinois CancerCare-PekinPekin, IllinoisRecruiting
Illinois CancerCare-PeoriaPeoria, IllinoisRecruiting
Illinois CancerCare-PeruPeru, IllinoisRecruiting
Illinois CancerCare-PrincetonPrinceton, IllinoisRecruiting
Inova Fair Oaks HospitalFairfax, VirginiaRecruiting
Inova Schar Cancer InstituteFairfax, VirginiaRecruiting
Kadlec Clinic Hematology and OncologyKennewick, WashingtonRecruiting
Katmai Oncology GroupAnchorage, AlaskaRecruiting
Kootenai Clinic Cancer Services - Post FallsPost Falls, IdahoRecruiting
Kootenai Clinic Cancer Services - SandpointSandpoint, IdahoRecruiting
Kootenai Health - Coeur d'AleneCoeur d'Alene, IdahoRecruiting
Logan Health Medical CenterKalispell, MontanaRecruiting
Longmont United HospitalLongmont, ColoradoRecruiting
LSU Health Baton Rouge-North ClinicBaton Rouge, LouisianaRecruiting
Mary Greeley Medical CenterAmes, IowaRecruiting
McFarland Clinic - AmesAmes, IowaRecruiting
McFarland Clinic - MarshalltownMarshalltown, IowaRecruiting
McFarland Clinic - Trinity Cancer CenterFort Dodge, IowaRecruiting
Medical Oncology Hematology Consultants PANewark, DelawareRecruiting
Memorial Hospital of CarbondaleCarbondale, IllinoisRecruiting
Memorial Hospital of Laramie CountyCheyenne, WyomingRecruiting
Memorial Medical CenterModesto, CaliforniaRecruiting
Mercy Cancer CenterMerced, CaliforniaRecruiting
Mercy Cancer Center - CarmichaelCarmichael, CaliforniaRecruiting
Mercy Cancer Center - Elk GroveElk Grove, CaliforniaRecruiting
Mercy Cancer Center - RocklinRocklin, CaliforniaRecruiting
Mercy Cancer Center - SacramentoSacramento, CaliforniaRecruiting
Mercy Cancer Center-West LakesClive, IowaRecruiting
Mercy HospitalCedar Rapids, IowaRecruiting
Mercy Medical CenterDurango, ColoradoRecruiting
Mercy Medical Center - Des MoinesDes Moines, IowaRecruiting
Mercy Medical Center-West LakesWest Des Moines, IowaRecruiting
Mercy San Juan Medical CenterCarmichael, CaliforniaRecruiting
Miami Valley Cancer Care and InfusionGreenville, OhioRecruiting
Miami Valley HospitalDayton, OhioRecruiting
Miami Valley Hospital NorthDayton, OhioRecruiting
Miami Valley Hospital SouthCenterville, OhioRecruiting
Miller-Dwan HospitalDuluth, MinnesotaRecruiting
Mills Health CenterSan Mateo, CaliforniaRecruiting
Mills-Peninsula Medical CenterBurlingame, CaliforniaRecruiting
Mission Hope Medical Oncology - Arroyo GrandeArroyo Grande, CaliforniaRecruiting
Mission Hope Medical Oncology - Santa MariaSanta Maria, CaliforniaRecruiting
Missouri Baptist Medical CenterSt Louis, MissouriRecruiting
Missouri Baptist Sullivan HospitalSullivan, MissouriRecruiting
Munson Medical CenterTraverse City, MichiganRecruiting
NEA Baptist Memorial Hospital and Fowler Family Cancer Center - JonesboroJonesboro, ArkansasRecruiting
Northwest Hospital CenterRandallstown, MarylandRecruiting
Northwest Wisconsin Cancer CenterAshland, WisconsinRecruiting
Oncology Associates at Mercy Medical CenterCedar Rapids, IowaRecruiting
OSF Saint Francis Hospital and Medical GroupEscanaba, MichiganRecruiting
Our Lady of The LakeBaton Rouge, LouisianaRecruiting
Our Lady of the Lake Physician GroupBaton Rouge, LouisianaRecruiting
Pacific Central Coast Health Center-San Luis ObispoSan Luis Obispo, CaliforniaRecruiting
Palo Alto Medical Foundation Health CarePalo Alto, CaliforniaRecruiting
Palo Alto Medical Foundation-Camino DivisionMountain View, CaliforniaRecruiting
Palo Alto Medical Foundation-FremontFremont, CaliforniaRecruiting
Palo Alto Medical Foundation-Gynecologic OncologyMountain View, CaliforniaRecruiting
Palo Alto Medical Foundation-Santa CruzSanta Cruz, CaliforniaRecruiting
Palo Alto Medical Foundation-SunnyvaleSunnyvale, CaliforniaRecruiting
Parkland Health Center - FarmingtonFarmington, MissouriRecruiting
PeaceHealth Saint John Medical CenterLongview, WashingtonRecruiting
PeaceHealth Saint Joseph Medical CenterBellingham, WashingtonRecruiting
PeaceHealth Southwest Medical CenterVancouver, WashingtonRecruiting
PeaceHealth United General Medical CenterSedro-Woolley, WashingtonRecruiting
Penrose-Saint Francis HealthcareColorado Springs, ColoradoRecruiting
Premier Blood and Cancer CenterDayton, OhioRecruiting
Providence Alaska Medical CenterAnchorage, AlaskaRecruiting
Providence Hood River Memorial HospitalHood River, OregonRecruiting
Providence Medical Foundation - Santa RosaSanta Rosa, CaliforniaRecruiting
Providence Newberg Medical CenterNewberg, OregonRecruiting
Providence Portland Medical CenterPortland, OregonRecruiting
Providence Queen of The ValleyNapa, CaliforniaRecruiting
Providence Regional Cancer PartnershipEverett, WashingtonRecruiting
Providence Regional Cancer System-AberdeenAberdeen, WashingtonRecruiting
Providence Regional Cancer System-CentraliaCentralia, WashingtonRecruiting
Providence Regional Cancer System-LaceyLacey, WashingtonRecruiting
Providence Saint Joseph Medical Center/Disney Family Cancer CenterBurbank, CaliforniaRecruiting
Providence Saint Mary Regional Cancer CenterWalla Walla, WashingtonRecruiting
Providence Saint Vincent Medical CenterPortland, OregonRecruiting
Providence Santa Rosa Memorial HospitalSanta Rosa, CaliforniaRecruiting
Providence Willamette Falls Medical CenterOregon City, OregonRecruiting
Rapid City Regional HospitalRapid City, South DakotaRecruiting
Ridley-Tree Cancer CenterSanta Barbara, CaliforniaRecruiting
Riverwood Healthcare CenterAitkin, MinnesotaRecruiting
Rocky Mountain Cancer Centers-PenroseColorado Springs, ColoradoRecruiting
Saint Anthony HospitalLakewood, ColoradoRecruiting
Saint Anthony North HospitalWestminster, ColoradoRecruiting
Saint Charles Health SystemBend, OregonRecruiting
Saint Charles Health System-RedmondRedmond, OregonRecruiting
Saint Francis Cancer CenterColorado Springs, ColoradoRecruiting
Saint Francis Medical CenterCape Girardeau, MissouriRecruiting
Saint Joseph HospitalLexington, KentuckyRecruiting
Saint Joseph Hospital EastLexington, KentuckyRecruiting
Saint Joseph LondonLondon, KentuckyRecruiting
Saint Joseph Mount SterlingMount Sterling, KentuckyRecruiting
Saint Joseph Radiation Oncology Resource CenterLexington, KentuckyRecruiting
Saint Joseph's Medical CenterStockton, CaliforniaRecruiting
Saint Luke's Cancer Institute - BoiseBoise, IdahoRecruiting
Saint Luke's Cancer Institute - FruitlandFruitland, IdahoRecruiting
Saint Luke's Cancer Institute - MeridianMeridian, IdahoRecruiting
Saint Luke's Cancer Institute - NampaNampa, IdahoRecruiting
Saint Luke's Cancer Institute - Twin FallsTwin Falls, IdahoRecruiting
Saint Mary Corwin Medical CenterPueblo, ColoradoRecruiting
Saint Michael Cancer CenterSilverdale, WashingtonRecruiting
Saint Patrick Hospital - Community HospitalMissoula, MontanaRecruiting
Saint Vincent Hospital Cancer Center at Oconto FallsOconto Falls, WisconsinRecruiting
Saint Vincent Hospital Cancer Center at Saint Mary'sGreen Bay, WisconsinRecruiting
Saint Vincent Hospital Cancer Center at SheboyganSheboygan, WisconsinRecruiting
Saint Vincent Hospital Cancer Center at Sturgeon BaySturgeon Bay, WisconsinRecruiting
Saint Vincent Hospital Cancer Center Green BayGreen Bay, WisconsinRecruiting
Sainte Genevieve County Memorial HospitalSainte Genevieve, MissouriRecruiting
Santa Cruz Radiation Oncology Medical GroupSanta Cruz, CaliforniaRecruiting
Sheboygan Physicians GroupSheboygan, WisconsinRecruiting
SIH Cancer InstituteCarterville, IllinoisRecruiting
Sinai Hospital of BaltimoreBaltimore, MarylandRecruiting
Skagit Regional Health Cancer Care CenterMount Vernon, WashingtonRecruiting
Southeastern Medical Oncology Center-ClintonClinton, North CarolinaRecruiting
Southeastern Medical Oncology Center-GoldsboroGoldsboro, North CarolinaRecruiting
Southeastern Medical Oncology Center-JacksonvilleJacksonville, North CarolinaRecruiting
Southern Illinois University School of MedicineSpringfield, IllinoisRecruiting
Springfield ClinicSpringfield, IllinoisRecruiting
Springfield Memorial HospitalSpringfield, IllinoisRecruiting
Stamford Hospital/Bennett Cancer CenterStamford, ConnecticutRecruiting
Sutter Auburn Faith HospitalAuburn, CaliforniaRecruiting
Sutter Cancer Centers Radiation Oncology Services-AuburnAuburn, CaliforniaRecruiting
Sutter Cancer Centers Radiation Oncology Services-Cameron ParkCameron Park, CaliforniaRecruiting
Sutter Cancer Centers Radiation Oncology Services-RosevilleRoseville, CaliforniaRecruiting
Sutter Cancer Research ConsortiumNovato, CaliforniaRecruiting
Sutter Davis HospitalDavis, CaliforniaRecruiting
Sutter Medical Center SacramentoSacramento, CaliforniaRecruiting
Sutter Pacific Medical FoundationSanta Rosa, CaliforniaRecruiting
Sutter Roseville Medical CenterRoseville, CaliforniaRecruiting
Sutter Solano Medical Center/Cancer CenterVallejo, CaliforniaRecruiting
Swedish Cancer Institute-EdmondsEdmonds, WashingtonRecruiting
Swedish Cancer Institute-IssaquahIssaquah, WashingtonRecruiting
Swedish Medical Center-Ballard CampusSeattle, WashingtonRecruiting
Swedish Medical Center-Cherry HillSeattle, WashingtonRecruiting
Swedish Medical Center-First HillSeattle, WashingtonRecruiting
Tamarack Health Hayward Medical CenterHayward, WisconsinRecruiting
The Watson ClinicLakeland, FloridaRecruiting
TriHealth Cancer Institute-AndersonCincinnati, OhioRecruiting
TriHealth Cancer Institute-WestsideCincinnati, OhioRecruiting
Trinity Health Grand Rapids HospitalGrand Rapids, MichiganRecruiting
Trinity Health Muskegon HospitalMuskegon, MichiganRecruiting
University of Cincinnati Cancer Center-UC Medical CenterCincinnati, OhioRecruiting
University of Cincinnati Cancer Center-West ChesterWest Chester, OhioRecruiting
University of Michigan Health - WestWyoming, MichiganRecruiting
University of Washington Medical Center - MontlakeSeattle, WashingtonRecruiting
Upper Valley Medical CenterTroy, OhioRecruiting
Valley Radiation OncologyPeru, IllinoisRecruiting
West Michigan Cancer CenterKalamazoo, MichiganRecruiting
William E Kahlert Regional Cancer Center/Sinai HospitalWestminster, MarylandRecruiting
Woodland Memorial HospitalWoodland, CaliforniaRecruiting
McFarland Clinic - BooneBoone, IowaSuspended
McFarland Clinic - JeffersonJefferson, IowaSuspended

Who to ask about joining

Site Public Contact907-212-6871 AKPAMC.OncologyResearchSupport@providence.org

Site Public Contact720-874-1881 ResearchInstituteInquiries@CommonSpirit.org

Site Public Contact479-872-8100 research@hogonc.com

Who can join

Men and women aged 18 and older can join. Participants must have pancreatic cancer that has not been treated with specific drugs before. They should also have certain test results showing their cancer type. The trial team will confirm who can participate based on these details.

What happens during the trial

Participants will be divided into two groups by chance. One group will receive chemotherapy plus panitumumab, while the other group will only receive chemotherapy. Both groups will have regular treatments every 28 days. Everyone will also undergo scans and provide blood samples to help with the study.

The trial team

The trial is run by the SWOG Cancer Research Network, with support from the National Cancer Institute. Dr. Rachael A Safyan is the principal investigator leading this study.

Important dates

The trial started on May 13, 2026, and is expected to finish by December 2030. It is currently recruiting new participants.

Additional information

The trial's ID number is NCT06998940. It is a Phase 3 study, which means it's looking at how well the treatment works and how safe it is. The trial does not involve FDA-regulated drugs. About 94 people are expected to join.

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