Dr. Benjamin Samstein

Dr. Benjamin Samstein, MD, is a prominent medical oncologist at Weill Cornell Medicine, specializing in gastrointestinal and genitourinary cancers, with particular expertise in bladder and kidney malignancies. He earned his medical degree from Stanford University School of Medicine and completed his residency in Internal Medicine at NewYork–Presbyterian Hospital. He then pursued fellowship training in medical oncology at Memorial Sloan Kettering Cancer Center, where he gained extensive experience in advanced urologic and gastrointestinal cancers. Board-certified in Internal Medicine and Medical Oncology, Dr. Samstein provides expert care at Weill Cornell’s Manhattan campus, offering both in-person and telehealth consultations.

He is highly regarded for his translational research in bladder and kidney cancer, focusing on the development of biomarker-driven immunotherapy and targeted therapy approaches. He has been involved in numerous early- and late-phase clinical trials evaluating checkpoint inhibitors, antibody-drug conjugates, and novel targeted agents for advanced disease. His work aims to refine patient selection and optimize therapeutic outcomes by integrating tumor genomics and immune signatures. He also studies mechanisms of immunotherapy resistance and strategies to enhance efficacy and minimize toxicity. Through collaborations with pathologists, geneticists, and bioinformatics teams, he supports personalized treatment protocols rooted in molecular profiling.

In addition to his clinical and research roles, Dr. Samstein is an active contributor to education and multidisciplinary care. He presents regularly at national oncology conferences and contributes to institutional tumor boards, guiding treatment decisions and protocol development. He mentors fellows and residents in clinical oncology and participates in professional committees aimed at setting standards of care for genitourinary cancers. Through his combination of patient-centered treatment, pioneering research, and academic mentorship, Dr. Samstein is recognized as a leading expert in the management of bladder and kidney cancers.