Dr. Susan M. Domchek

Dr. Susan M. Domchek, MD, is a renowned medical oncologist and a global authority in cancer genetics, recognized for her leadership in the management of hereditary breast and ovarian cancer syndromes. She serves as Executive Director of the Basser Center for BRCA at the Abramson Cancer Center of the University of Pennsylvania and holds the Basser Professorship in Oncology. Dr. Domchek earned her medical degree from Harvard Medical School, completed her residency in Internal Medicine at Massachusetts General Hospital, and pursued fellowship training in Medical Oncology at the Dana-Farber Cancer Institute. She is board-certified in Internal Medicine and Medical Oncology and is widely acknowledged for her contributions to advancing the understanding and clinical management of BRCA-related cancers.

A trailblazer in integrating genetic risk assessment with precision oncology, Dr. Domchek has led pivotal clinical trials that established PARP inhibitors as effective treatments for BRCA-associated breast and ovarian cancers. Her research has elucidated the molecular underpinnings of hereditary cancer susceptibility and informed best practices in genetic testing, risk-reducing strategies, and targeted therapy. Dr. Domchek has authored over 300 peer-reviewed publications and plays a central role in national and international efforts to advance translational research in hereditary cancer syndromes.

Beyond her scientific contributions, Dr. Domchek is a passionate mentor and advocate for patient-centered research. She has guided numerous physician-scientists in cancer genetics and oncology, fostering the next generation of leaders in precision medicine. Her work continues to influence global strategies in hereditary cancer care, bridging discovery science with impactful clinical innovation to improve outcomes for high-risk patients.