Comparing Treatments for Children with Favorable Wilms Tumors Based on Risk Factors

Recruiting · Phase 3 · Stage I Mixed Cell Type Kidney Wilms Tumor and related conditions · 45 states

Check if I qualify View on ClinicalTrials.gov

About this trial

This study looks at how doctors use risk factors to choose treatments for children with Wilms tumors. Wilms tumor is a type of kidney cancer that commonly affects kids. The goal is to improve treatment plans based on specific tumor features and how well kids respond to therapy. Researchers hope this will help more children with favorable histology Wilms tumors stay healthy after treatment.

The trial's ID number is NCT06401330. This is a Phase 3 study, which means it is looking closely at how well the treatments work and their safety. The study is FDA-regulated and aims to include about 1,656 participants.

Who can join

Children and young adults under 30 years old can join the study. They must have a newly diagnosed Wilms tumor and meet certain criteria related to their initial treatment and tumor characteristics. The trial team will confirm who can participate.

Conditions

Stage I Mixed Cell Type Kidney Wilms Tumor, Stage II Mixed Cell Type Kidney Wilms Tumor, Stage III Mixed Cell Type Kidney Wilms Tumor, Stage IV Mixed Cell Type Kidney Wilms Tumor

Age group

Child, Adult

Sex

All sexes

The study team makes the final call on eligibility.

What happens in the study

Participants will be randomly assigned to different treatment groups. Some will receive chemotherapy, while others may only be observed for a time. Specific treatment plans depend on the stage of the tumor and other factors. Everyone will have regular check-ups and imaging tests throughout the study.