This study looks at how safe and effective sotorasib is for people with advanced non-small cell lung cancer (NSCLC) with a KRAS G12C mutation. These participants have not received any treatment for their cancer since it became advanced. The goal is to see if this medicine can help them.
The trial ID is NCT06582771. It is a Phase 2 study, which means it is looking at how well the treatment works and how safe it is. This trial is regulated by the FDA, and it aims to include about 39 participants.
Who can join
Adults aged 18 and older can join. Both men and women are welcome. Participants must have a certain type of lung cancer and a specific genetic change called KRAS G12C. They should not have received treatment for their cancer since it got worse. The trial team will confirm who is eligible before anyone joins.
Condition
Non Small Lung Cancer
Age group
Adult, Older adult
Sex
All sexes
The study team makes the final call on eligibility.
What happens in the study
Everyone in this study will take sotorasib, which is 8 pills each day for treatment. They will start this medicine within a week after having a tumor biopsy to check their cancer.
Where
This trial is enrolling at 7 locations. Recruiting sites are listed first.
Memorial Sloan Kettering Basking Ridge (Limited Protocol Activities)
Basking Ridge, New Jersey
Recruiting
Memorial Sloan Kettering Bergen (Limited Protocol Activities)
Montvale, New Jersey
Recruiting
Memorial Sloan Kettering Cancer Center
New York, New York
Recruiting
Memorial Sloan Kettering Monmouth (Limited Protocol Activities)
Middletown, New Jersey
Recruiting
Memorial Sloan Kettering Nassau
Uniondale, New York
Recruiting
Memorial Sloan Kettering Suffolk - Commack (Limited Protocol Activities)
SurgeonSurgeon · Morgantown, WV · West Virginia · WV
Chief of Thoracic Surgery and Director of the Lung Cancer Program at West Virginia University Cancer Institute. Treats lung cancer and esophageal cancer. Works as a thoracic surgeon. Based in Morgantown, West Virginia. Chosen on merit.
Medical OncologistMedical Oncologist · Durham, NC · North Carolina · NC
A medical oncologist who treats pancreatic cancer and lung cancer in Durham, NC. Treats pancreatic cancer, lung cancer and colorectal cancer. Based in Durham, North Carolina. Chosen on merit.
Other specialistOther specialist · Los Angeles, CA · California · CA
Led the National Lung Screening Trial. Treats lung cancer. Works as a diagnostic radiologist. Based in Los Angeles, California. Other doctors who help with cancer care, like gastroenterologists, dermatologists, and endocrinologists. Recognized at state, national or international level. Chosen on merit.