Investigating the Benefits of Adding a New Drug to Osteosarcoma Treatment
NCT05691478 · RecruitingAbout this trial
This study looks at how well cabozantinib works when added to standard chemotherapy for patients with newly diagnosed osteosarcoma. The goal is to see if this combination is safe and if it helps patients do better than just chemotherapy alone. Cabozantinib is a medicine that may help stop tumor growth by blocking signals that allow cancer cells to grow and form new blood vessels. The standard chemotherapy includes medicines like methotrexate, doxorubicin, and cisplatin.
Locations and contact
This trial is running at 198 locations in 4 countries. All of them are currently recruiting.
United States177 locations · 177 recruiting
- AdventHealth OrlandoOrlando, FloridaRecruiting
- Albany Medical CenterAlbany, New YorkRecruiting
- Alfred I duPont Hospital for ChildrenWilmington, DelawareRecruiting
- Allegiance HealthJackson, MichiganRecruiting
- Alliance for Childhood Diseases/Cure 4 the Kids FoundationLas Vegas, NevadaRecruiting
- Arkansas Children's HospitalLittle Rock, ArkansasRecruiting
- Arnold Palmer Hospital for ChildrenOrlando, FloridaRecruiting
- Atrium Health Pineville/LCI-PinevilleCharlotte, North CarolinaRecruiting
- Augusta University Medical CenterAugusta, GeorgiaRecruiting
- Banner Children's at DesertMesa, ArizonaRecruiting
- Banner University Medical Center - TucsonTucson, ArizonaRecruiting
- Baylor College of Medicine/Dan L Duncan Comprehensive Cancer CenterHouston, TexasRecruiting
- BI-LO Charities Children's Cancer CenterGreenville, South CarolinaRecruiting
- Blank Children's HospitalDes Moines, IowaRecruiting
- Bronson Methodist HospitalKalamazoo, MichiganRecruiting
- C S Mott Children's HospitalAnn Arbor, MichiganRecruiting
- Cardinal Glennon Children's Medical CenterSt Louis, MissouriRecruiting
- Carolinas Medical Center/Levine Cancer InstituteCharlotte, North CarolinaRecruiting
- Cedars-Sinai Medical CenterLos Angeles, CaliforniaRecruiting
- Children's Healthcare of Atlanta - Arthur M Blank HospitalAtlanta, GeorgiaRecruiting
- Children's Hospital and Medical Center of OmahaOmaha, NebraskaRecruiting
- Children's Hospital ColoradoAurora, ColoradoRecruiting
- Children's Hospital Los AngelesLos Angeles, CaliforniaRecruiting
- Children's Hospital Medical Center of AkronAkron, OhioRecruiting
- Children's Hospital New OrleansNew Orleans, LouisianaRecruiting
- Children's Hospital of AlabamaBirmingham, AlabamaRecruiting
- Children's Hospital of MichiganDetroit, MichiganRecruiting
- Children's Hospital of Orange CountyOrange, CaliforniaRecruiting
- Children's Hospital of PhiladelphiaPhiladelphia, PennsylvaniaRecruiting
- Children's Hospital of Pittsburgh of UPMCPittsburgh, PennsylvaniaRecruiting
- Children's Hospital of San AntonioSan Antonio, TexasRecruiting
- Children's Hospital of The King's DaughtersNorfolk, VirginiaRecruiting
- Children's Hospital of WisconsinMilwaukee, WisconsinRecruiting
- Children's Hospitals and Clinics of Minnesota - MinneapolisMinneapolis, MinnesotaRecruiting
- Children's Mercy Hospitals and ClinicsKansas City, MissouriRecruiting
- Children's National Medical CenterWashington D.C., District of ColumbiaRecruiting
- Cincinnati Children's Hospital Medical CenterCincinnati, OhioRecruiting
- City of Hope Comprehensive Cancer CenterDuarte, CaliforniaRecruiting
- Cleveland Clinic FoundationCleveland, OhioRecruiting
- Connecticut Children's Medical CenterHartford, ConnecticutRecruiting
- Cook Children's Medical CenterFort Worth, TexasRecruiting
- Corewell Health Children'sRoyal Oak, MichiganRecruiting
- Corewell Health Grand Rapids Hospitals - Helen DeVos Children's HospitalGrand Rapids, MichiganRecruiting
- Covenant Children's HospitalLubbock, TexasRecruiting
- Dana-Farber Cancer InstituteBoston, MassachusettsRecruiting
- Dartmouth Hitchcock Medical Center/Dartmouth Cancer CenterLebanon, New HampshireRecruiting
- Dayton Children's HospitalDayton, OhioRecruiting
- Dell Children's Medical Center of Central TexasAustin, TexasRecruiting
- Driscoll Children's HospitalCorpus Christi, TexasRecruiting
- Duke University Medical CenterDurham, North CarolinaRecruiting
- East Carolina UniversityGreenville, North CarolinaRecruiting
- East Tennessee Childrens HospitalKnoxville, TennesseeRecruiting
- Eastern Maine Medical CenterBangor, MaineRecruiting
- El Paso Children's HospitalEl Paso, TexasRecruiting
- Geisinger Medical CenterDanville, PennsylvaniaRecruiting
- Golisano Children's Hospital of Southwest FloridaFort Myers, FloridaRecruiting
- Hackensack University Medical CenterHackensack, New JerseyRecruiting
- Henry Ford Cancer Institute-DownriverBrownstown, MichiganRecruiting
- Henry Ford HospitalDetroit, MichiganRecruiting
- Henry Ford Macomb Hospital-Clinton TownshipClinton Township, MichiganRecruiting
- Henry Ford Medical Center-ColumbusNovi, MichiganRecruiting
- Henry Ford Medical Center-FairlaneDearborn, MichiganRecruiting
- Henry Ford West Bloomfield HospitalWest Bloomfield, MichiganRecruiting
- Henry Ford Wyandotte HospitalWyandotte, MichiganRecruiting
- Johns Hopkins All Children's HospitalSt. Petersburg, FloridaRecruiting
- Johns Hopkins University/Sidney Kimmel Cancer CenterBaltimore, MarylandRecruiting
- Kaiser Permanente Downey Medical CenterDowney, CaliforniaRecruiting
- Kaiser Permanente-OaklandOakland, CaliforniaRecruiting
- Kapiolani Medical Center for Women and ChildrenHonolulu, HawaiiRecruiting
- Laura and Isaac Perlmutter Cancer Center at NYU LangoneNew York, New YorkRecruiting
- Legacy Emanuel Children's HospitalPortland, OregonRecruiting
- Loma Linda University Medical CenterLoma Linda, CaliforniaRecruiting
- Lucile Packard Children's Hospital Stanford UniversityPalo Alto, CaliforniaRecruiting
- Lurie Children's Hospital-ChicagoChicago, IllinoisRecruiting
- Madigan Army Medical CenterTacoma, WashingtonRecruiting
- Maine Children's Cancer ProgramScarborough, MaineRecruiting
- Marshfield Medical Center-MarshfieldMarshfield, WisconsinRecruiting
- Mary Bridge Children's Hospital and Health CenterTacoma, WashingtonRecruiting
- Massachusetts General Hospital Cancer CenterBoston, MassachusettsRecruiting
- Mattel Children's Hospital UCLALos Angeles, CaliforniaRecruiting
- Mayo Clinic Hospital in ArizonaPhoenix, ArizonaRecruiting
- Mayo Clinic in RochesterRochester, MinnesotaRecruiting
- Medical City Dallas HospitalDallas, TexasRecruiting
- Medical University of South CarolinaCharleston, South CarolinaRecruiting
- MedStar Georgetown University HospitalWashington D.C., District of ColumbiaRecruiting
- Memorial Health University Medical CenterSavannah, GeorgiaRecruiting
- Memorial Regional Hospital/Joe DiMaggio Children's HospitalHollywood, FloridaRecruiting
- Memorial Sloan Kettering Cancer CenterNew York, New YorkRecruiting
- Mercy Hospital Saint LouisSt Louis, MissouriRecruiting
- Methodist Children's Hospital of South TexasSan Antonio, TexasRecruiting
- Miami Cancer InstituteMiami, FloridaRecruiting
- Miller Children's and Women's Hospital Long BeachLong Beach, CaliforniaRecruiting
- Montefiore Medical Center - Moses CampusThe Bronx, New YorkRecruiting
- Morristown Medical CenterMorristown, New JerseyRecruiting
- Nationwide Children's HospitalColumbus, OhioRecruiting
- Nemours Children's Clinic - PensacolaPensacola, FloridaRecruiting
- Nemours Children's Clinic-JacksonvilleJacksonville, FloridaRecruiting
- Nemours Children's HospitalOrlando, FloridaRecruiting
- New York Medical CollegeValhalla, New YorkRecruiting
- Newark Beth Israel Medical CenterNewark, New JerseyRecruiting
- Nicklaus Children's HospitalMiami, FloridaRecruiting
- Northwestern UniversityChicago, IllinoisRecruiting
- Norton Children's HospitalLouisville, KentuckyRecruiting
- Novant Health Presbyterian Medical CenterCharlotte, North CarolinaRecruiting
- NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer CenterNew York, New YorkRecruiting
- NYP/Weill Cornell Medical CenterNew York, New YorkRecruiting
- NYU Langone Hospital - Long IslandMineola, New YorkRecruiting
- Ochsner Medical Center JeffersonNew Orleans, LouisianaRecruiting
- Ohio State University Comprehensive Cancer CenterColumbus, OhioRecruiting
- Oregon Health and Science UniversityPortland, OregonRecruiting
- OSF Children's Hospital of IllinoisPeoria, IllinoisRecruiting
- Penn State Children's HospitalHershey, PennsylvaniaRecruiting
- Phoenix Childrens HospitalPhoenix, ArizonaRecruiting
- Primary Children's HospitalSalt Lake City, UtahRecruiting
- Prisma Health Richland HospitalColumbia, South CarolinaRecruiting
- ProMedica Toledo Hospital/Russell J Ebeid Children's HospitalToledo, OhioRecruiting
- Providence Sacred Heart Medical Center and Children's HospitalSpokane, WashingtonRecruiting
- Rady Children's Hospital - San DiegoSan Diego, CaliforniaRecruiting
- Rainbow Babies and Childrens HospitalCleveland, OhioRecruiting
- Riley Hospital for ChildrenIndianapolis, IndianaRecruiting
- Rocky Mountain Hospital for Children-Presbyterian Saint Luke's Medical CenterDenver, ColoradoRecruiting
- Roswell Park Cancer InstituteBuffalo, New YorkRecruiting
- Rutgers Cancer Institute of New Jersey-Robert Wood Johnson University HospitalNew Brunswick, New JerseyRecruiting
- Saint Christopher's Hospital for ChildrenPhiladelphia, PennsylvaniaRecruiting
- Saint Francis Cancer CenterGreenville, South CarolinaRecruiting
- Saint Francis HospitalGreenville, South CarolinaRecruiting
- Saint Joseph's Hospital/Children's Hospital-TampaTampa, FloridaRecruiting
- Saint Joseph's Regional Medical CenterPaterson, New JerseyRecruiting
- Saint Jude Children's Research HospitalMemphis, TennesseeRecruiting
- Saint Luke's Cancer Institute - BoiseBoise, IdahoRecruiting
- Saint Vincent Hospital Cancer Center Green BayGreen Bay, WisconsinRecruiting
- Sanford Broadway Medical CenterFargo, North DakotaRecruiting
- Sanford USD Medical Center - Sioux FallsSioux Falls, South DakotaRecruiting
- Scott and White Memorial HospitalTemple, TexasRecruiting
- Seattle Children's HospitalSeattle, WashingtonRecruiting
- Sinai Hospital of BaltimoreBaltimore, MarylandRecruiting
- State University of New York Upstate Medical UniversitySyracuse, New YorkRecruiting
- Stony Brook University Medical CenterStony Brook, New YorkRecruiting
- Summerlin Hospital Medical CenterLas Vegas, NevadaRecruiting
- The Children's Hospital at TriStar CentennialNashville, TennesseeRecruiting
- The Steven and Alexandra Cohen Children's Medical Center of New YorkNew Hyde Park, New YorkRecruiting
- Thomas Jefferson University HospitalPhiladelphia, PennsylvaniaRecruiting
- UCSF Benioff Children's Hospital OaklandOakland, CaliforniaRecruiting
- UCSF Medical Center-Mission BaySan Francisco, CaliforniaRecruiting
- UF Health Cancer Institute - GainesvilleGainesville, FloridaRecruiting
- UMass Memorial Medical Center - University CampusWorcester, MassachusettsRecruiting
- UMC Cancer Center / UMC Health SystemLubbock, TexasRecruiting
- UNC Lineberger Comprehensive Cancer CenterChapel Hill, North CarolinaRecruiting
- University of California Davis Comprehensive Cancer CenterSacramento, CaliforniaRecruiting
- University of Chicago Comprehensive Cancer CenterChicago, IllinoisRecruiting
- University of IllinoisChicago, IllinoisRecruiting
- University of Iowa/Holden Comprehensive Cancer CenterIowa City, IowaRecruiting
- University of Kentucky/Markey Cancer CenterLexington, KentuckyRecruiting
- University of Maryland/Greenebaum Cancer CenterBaltimore, MarylandRecruiting
- University of Miami Miller School of Medicine-Sylvester Cancer CenterMiami, FloridaRecruiting
- University of Michigan Rogel Cancer CenterAnn Arbor, MichiganRecruiting
- University of Minnesota/Masonic Cancer CenterMinneapolis, MinnesotaRecruiting
- University of Mississippi Medical CenterJackson, MississippiRecruiting
- University of Missouri Children's HospitalColumbia, MissouriRecruiting
- University of Nebraska Medical CenterOmaha, NebraskaRecruiting
- University of Oklahoma Health Sciences CenterOklahoma City, OklahomaRecruiting
- University of Pittsburgh Cancer Institute (UPCI)Pittsburgh, PennsylvaniaRecruiting
- University of RochesterRochester, New YorkRecruiting
- University of Texas Health Science Center at San AntonioSan Antonio, TexasRecruiting
- University of Virginia Cancer CenterCharlottesville, VirginiaRecruiting
- University of Wisconsin Carbone Cancer Center - University HospitalMadison, WisconsinRecruiting
- UT MD Anderson Cancer CenterHouston, TexasRecruiting
- UT Southwestern/Simmons Cancer Center-DallasDallas, TexasRecruiting
- Valley Children's HospitalMadera, CaliforniaRecruiting
- Vanderbilt University/Ingram Cancer CenterNashville, TennesseeRecruiting
- VCU Massey Cancer Center at Stony PointRichmond, VirginiaRecruiting
- VCU Massey Comprehensive Cancer CenterRichmond, VirginiaRecruiting
- Wake Forest University Health SciencesWinston-Salem, North CarolinaRecruiting
- Walter Reed National Military Medical CenterBethesda, MarylandRecruiting
- Washington University School of MedicineSt Louis, MissouriRecruiting
- West Virginia University Charleston DivisionCharleston, West VirginiaRecruiting
- Yale UniversityNew Haven, ConnecticutRecruiting
Canada12 locations · 12 recruiting
- Alberta Children's HospitalCalgary, AlbertaRecruiting
- CancerCare ManitobaWinnipeg, ManitobaRecruiting
- Centre Hospitalier Universitaire de Sherbrooke-FleurimontSherbrooke, QuebecRecruiting
- Centre Hospitalier Universitaire Sainte-JustineMontreal, QuebecRecruiting
- Children's HospitalLondon, OntarioRecruiting
- Children's Hospital of Eastern OntarioOttawa, OntarioRecruiting
- CHU de Quebec-Centre Hospitalier de l'Universite Laval (CHUL)QuébecRecruiting
- Hospital for Sick ChildrenToronto, OntarioRecruiting
- IWK Health CentreHalifax, Nova ScotiaRecruiting
- Jim Pattison Children's HospitalSaskatoon, SaskatchewanRecruiting
- The Montreal Children's Hospital of the MUHCMontreal, QuebecRecruiting
- University of Alberta HospitalEdmonton, AlbertaRecruiting
Australia7 locations · 7 recruiting
- Monash Medical Center-Clayton CampusClayton, VictoriaRecruiting
- Perth Children's HospitalPerth, Western AustraliaRecruiting
- Queensland Children's HospitalSouth Brisbane, QueenslandRecruiting
- Royal Children's HospitalParkville, VictoriaRecruiting
- Sydney Children's HospitalRandwick, New South WalesRecruiting
- The Children's Hospital at WestmeadWestmead, New South WalesRecruiting
- Women's and Children's Hospital-AdelaideNorth Adelaide, South AustraliaRecruiting
New Zealand2 locations · 2 recruiting
- Christchurch HospitalChristchurchRecruiting
- Starship Children's HospitalGrafton, AucklandRecruiting
Who to ask about joining
Site Public Contact205-638-9285oncologyresearch@peds.uab.edu
Site Public Contact480-412-3100
Site Public Contact602-546-0920
Who can join
This trial is open to men and women under 40 years old. Participants must have a confirmed diagnosis of high-grade osteosarcoma and meet certain health criteria. Those with both localized and metastatic disease are eligible. The trial team will confirm if you qualify to join.
What happens during the trial
Participants will be placed in one of several groups by chance. Some will receive standard chemotherapy, while others will receive chemotherapy along with cabozantinib. The study includes different phases for both standard risk and high-risk patients, with various treatment plans involving cycles of chemotherapy and evaluations throughout the trial.
The trial team
The trial is sponsored by the National Cancer Institute (NCI), with Dr. Michael W. Bishop as the principal investigator from the Children's Oncology Group.
Important dates
The trial started on March 3, 2023, and is expected to finish by March 20, 2030. It is currently enrolling new participants.
Additional information
The trial's ID number is NCT05691478. It is a Phase 2/3 study, which means it is looking at how well the treatment works and how safe it is. The trial is FDA-regulated, and it aims to include about 1,122 participants.
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