Investigating the Benefits of Total Ablative Therapy for Metastatic Colorectal Cancer
NCT05673148 · RecruitingAbout this trial
This clinical trial is looking at how well total ablative therapy works when added to the usual treatment for colorectal cancer that has spread to up to four places in the body. The usual treatment includes medications to help stop the cancer from growing. Total ablative therapy includes focused radiation or surgery to try to remove cancer from specific spots. The goal is to see if adding this therapy can help improve patient outcomes.
Locations and contact
This trial is running at 186 locations in 2 countries. 164 of them are currently recruiting.
United States185 locations · 164 recruiting
- Allegheny General HospitalPittsburgh, PennsylvaniaRecruiting
- Ascension All Saints Hospital-Spring Street-RacineRacine, WisconsinRecruiting
- Ascension Calumet Hospital-ChiltonChilton, WisconsinRecruiting
- Ascension Columbia Saint Mary's Hospital-Milwaukee CampusMilwaukee, WisconsinRecruiting
- Ascension Columbia Saint Mary's Hospital-Ozaukee Campus-MequonMequon, WisconsinRecruiting
- Ascension Northeast Wisconsin-Mercy Hospital-OshkoshOshkosh, WisconsinRecruiting
- Ascension Northeast Wisconsin-Saint Elizabeth Cancer Center-AppletonAppleton, WisconsinRecruiting
- Ascension Southeast Wisconsin Hospital - FranklinFranklin, WisconsinRecruiting
- Ascension Southeast Wisconsin Hospital-Elmbrook Campus-BrookfieldBrookfield, WisconsinRecruiting
- Ascension Southeast Wisconsin Hospital-Mayfair Road-WauwatosaWauwatosa, WisconsinRecruiting
- Ascension Southeast Wisconsin Hospital-Saint Joseph-MilwaukeeMilwaukee, WisconsinRecruiting
- Aspirus Cancer Care - Stevens PointStevens Point, WisconsinRecruiting
- Aspirus Cancer Care - Wisconsin RapidsWisconsin Rapids, WisconsinRecruiting
- Aspirus Cancer Care-Antigo-Volm Cancer CenterAntigo, WisconsinRecruiting
- Aspirus Cancer Care-Rhinelander-James Beck Cancer CenterRhinelander, WisconsinRecruiting
- Aspirus Cancer Care-WausauWausau, WisconsinRecruiting
- Atrium Health Cabarrus/LCI-ConcordConcord, North CarolinaRecruiting
- Atrium Medical Center-Middletown Regional HospitalFranklin, OhioRecruiting
- Baptist Cancer Center-GrenadaGrenada, MississippiRecruiting
- Baptist Health FloydNew Albany, IndianaRecruiting
- Baptist Health LouisvilleLouisville, KentuckyRecruiting
- Baptist Memorial Hospital and Cancer Center-DesotoSouthhaven, MississippiRecruiting
- Baptist Memorial Hospital and Cancer Center-Golden TriangleColumbus, MississippiRecruiting
- Baptist Memorial Hospital and Cancer Center-MemphisMemphis, TennesseeRecruiting
- Baptist Memorial Hospital and Cancer Center-OxfordOxford, MississippiRecruiting
- Baptist Memorial Hospital and Cancer Center-Union CountyNew Albany, MississippiRecruiting
- Beebe Health CampusRehoboth Beach, DelawareRecruiting
- Beebe Medical CenterLewes, DelawareRecruiting
- Beebe South Coastal Health CampusMillville, DelawareRecruiting
- Benefis Sletten Cancer InstituteGreat Falls, MontanaRecruiting
- Billings Clinic Cancer CenterBillings, MontanaRecruiting
- BJC Outpatient Center at Sunset HillsSunset Hills, MissouriRecruiting
- Bon Secours Cancer Institute at Reynolds CrossingRichmond, VirginiaRecruiting
- Bon Secours Memorial Regional Medical CenterMechanicsville, VirginiaRecruiting
- Bon Secours Saint Francis Medical CenterMidlothian, VirginiaRecruiting
- Bon Secours Saint Mary's HospitalRichmond, VirginiaRecruiting
- Boston Medical CenterBoston, MassachusettsRecruiting
- Carolinas Medical Center/Levine Cancer InstituteCharlotte, North CarolinaRecruiting
- Cedars-Sinai Medical CenterLos Angeles, CaliforniaRecruiting
- Chelsea HospitalChelsea, MichiganRecruiting
- Christiana Care Health System-Christiana HospitalNewark, DelawareRecruiting
- Christiana Care Health System-Concord Health CenterChadds Ford, PennsylvaniaRecruiting
- Christiana Care Health System-Wilmington HospitalWilmington, DelawareRecruiting
- Corewell Health Beaumont Troy HospitalTroy, MichiganRecruiting
- Corewell Health Dearborn HospitalDearborn, MichiganRecruiting
- Corewell Health Farmington Hills HospitalFarmington Hills, MichiganRecruiting
- Corewell Health William Beaumont University HospitalRoyal Oak, MichiganRecruiting
- Dartmouth Hitchcock Medical Center/Dartmouth Cancer CenterLebanon, New HampshireRecruiting
- East Carolina UniversityGreenville, North CarolinaRecruiting
- Edwards Comprehensive Cancer CenterHuntington, West VirginiaRecruiting
- Emory Proton Therapy CenterAtlanta, GeorgiaRecruiting
- Emory Saint Joseph's HospitalAtlanta, GeorgiaRecruiting
- Emory University Hospital MidtownAtlanta, GeorgiaRecruiting
- Emory University Hospital/Winship Cancer InstituteAtlanta, GeorgiaRecruiting
- Englewood Hospital and Medical CenterEnglewood, New JerseyRecruiting
- Geisinger Medical CenterDanville, PennsylvaniaRecruiting
- Geisinger Medical Oncology-LewisburgLewisburg, PennsylvaniaRecruiting
- Geisinger Wyoming Valley/Henry Cancer CenterWilkes-Barre, PennsylvaniaRecruiting
- Genesys Hurley Cancer InstituteFlint, MichiganRecruiting
- George Washington University Medical CenterWashington D.C., District of ColumbiaRecruiting
- Grady Health SystemAtlanta, GeorgiaRecruiting
- Greater Regional Medical CenterCreston, IowaRecruiting
- Heartland Regional Medical CenterSaint Joseph, MissouriRecruiting
- Helen F Graham Cancer CenterNewark, DelawareRecruiting
- Henry Ford HospitalDetroit, MichiganRecruiting
- Huntsman Cancer Institute/University of UtahSalt Lake City, UtahRecruiting
- Hurley Medical CenterFlint, MichiganRecruiting
- Iowa Methodist Medical CenterDes Moines, IowaRecruiting
- Kingman Regional Medical CenterKingman, ArizonaRecruiting
- Lenox Hill HospitalNew York, New YorkRecruiting
- Manhattan Eye Ear and Throat HospitalNew York, New YorkRecruiting
- Mayo Clinic Hospital in ArizonaPhoenix, ArizonaRecruiting
- Medical College of WisconsinMilwaukee, WisconsinRecruiting
- Medical Oncology Hematology Consultants PANewark, DelawareRecruiting
- Memorial Sloan Kettering Basking RidgeBasking Ridge, New JerseyRecruiting
- Memorial Sloan Kettering BergenMontvale, New JerseyRecruiting
- Memorial Sloan Kettering Cancer CenterNew York, New YorkRecruiting
- Memorial Sloan Kettering CommackCommack, New YorkRecruiting
- Memorial Sloan Kettering MonmouthMiddletown, New JerseyRecruiting
- Memorial Sloan Kettering NassauUniondale, New YorkRecruiting
- Memorial Sloan Kettering WestchesterHarrison, New YorkRecruiting
- Mercy Cancer Center-West LakesClive, IowaRecruiting
- Mercy Hospital Saint LouisSt Louis, MissouriRecruiting
- Mercy Hospital SouthSt Louis, MissouriRecruiting
- Mercy Hospital SpringfieldSpringfield, MissouriRecruiting
- Mercy Medical Center - Des MoinesDes Moines, IowaRecruiting
- Mercy Medical Center-West LakesWest Des Moines, IowaRecruiting
- Miami Valley Cancer Care and InfusionGreenville, OhioRecruiting
- Miami Valley HospitalDayton, OhioRecruiting
- Miami Valley Hospital NorthDayton, OhioRecruiting
- Miami Valley Hospital SouthCenterville, OhioRecruiting
- Missouri Baptist Medical CenterSt Louis, MissouriRecruiting
- Missouri Baptist Sullivan HospitalSullivan, MissouriRecruiting
- Mount Sinai HospitalNew York, New YorkRecruiting
- Mount Sinai WestNew York, New YorkRecruiting
- MU Health - University Hospital/Ellis Fischel Cancer CenterColumbia, MissouriRecruiting
- Nebraska Medicine-BellevueBellevue, NebraskaRecruiting
- Nebraska Medicine-Village PointeOmaha, NebraskaRecruiting
- New York-Presbyterian/Brooklyn Methodist HospitalBrooklyn, New YorkRecruiting
- Northern Westchester HospitalMount Kisco, New YorkRecruiting
- Northwell Health Cancer Institute at HuntingtonGreenlawn, New YorkRecruiting
- Northwell Health Physicians Partners Radiation Medicine at QueensForest Hills, New YorkRecruiting
- Northwell Health/Center for Advanced MedicineLake Success, New YorkRecruiting
- NYP/Weill Cornell Medical CenterNew York, New YorkRecruiting
- Ohio State University Comprehensive Cancer CenterColumbus, OhioRecruiting
- Oregon Health and Science UniversityPortland, OregonRecruiting
- Parkland Health Center - FarmingtonFarmington, MissouriRecruiting
- Penn State Milton S Hershey Medical CenterHershey, PennsylvaniaRecruiting
- Phelps Memorial Hospital CenterSleepy Hollow, New YorkRecruiting
- Premier Blood and Cancer CenterDayton, OhioRecruiting
- Queens Cancer CenterRego Park, New YorkRecruiting
- Regions HospitalSaint Paul, MinnesotaRecruiting
- Renown Regional Medical CenterReno, NevadaRecruiting
- Saint Luke's Cancer Institute - BoiseBoise, IdahoRecruiting
- Saint Luke's Cancer Institute - FruitlandFruitland, IdahoRecruiting
- Saint Luke's Cancer Institute - MeridianMeridian, IdahoRecruiting
- Saint Luke's Cancer Institute - NampaNampa, IdahoRecruiting
- Saint Luke's Cancer Institute - Twin FallsTwin Falls, IdahoRecruiting
- Sainte Genevieve County Memorial HospitalSainte Genevieve, MissouriRecruiting
- Sanford Bismarck Medical CenterBismarck, North DakotaRecruiting
- Sanford Broadway Medical CenterFargo, North DakotaRecruiting
- Sanford Cancer Center Oncology ClinicSioux Falls, South DakotaRecruiting
- Sanford Joe Lueken Cancer CenterBemidji, MinnesotaRecruiting
- Sanford Roger Maris Cancer CenterFargo, North DakotaRecruiting
- Sanford USD Medical Center - Sioux FallsSioux Falls, South DakotaRecruiting
- The New York Hospital Medical Center of QueensFlushing, New YorkRecruiting
- Tower Cancer Research FoundationBeverly Hills, CaliforniaRecruiting
- Trinity Health IHA Medical Group Hematology Oncology - BrightonBrighton, MichiganRecruiting
- Trinity Health IHA Medical Group Hematology Oncology - CantonCanton, MichiganRecruiting
- Trinity Health IHA Medical Group Hematology Oncology - Chelsea HospitalChelsea, MichiganRecruiting
- Trinity Health IHA Medical Group Hematology Oncology Ann Arbor CampusYpsilanti, MichiganRecruiting
- Trinity Health Medical Center - BrightonBrighton, MichiganRecruiting
- Trinity Health Medical Center - CantonCanton, MichiganRecruiting
- Trinity Health Saint Joseph Mercy Hospital Ann ArborAnn Arbor, MichiganRecruiting
- Trinity Health Saint Mary Mercy Livonia HospitalLivonia, MichiganRecruiting
- UC Irvine Health/Chao Family Comprehensive Cancer CenterOrange, CaliforniaRecruiting
- UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory CareIrvine, CaliforniaRecruiting
- UF Health Cancer Institute - GainesvilleGainesville, FloridaRecruiting
- UI Health Care Mission Cancer and Blood - Ankeny ClinicAnkeny, IowaRecruiting
- UI Health Care Mission Cancer and Blood - Des Moines ClinicDes Moines, IowaRecruiting
- UI Health Care Mission Cancer and Blood - Laurel ClinicDes Moines, IowaRecruiting
- UI Health Care Mission Cancer and Blood - Waukee ClinicWaukee, IowaRecruiting
- UI Health Care Mission Cancer and Blood - West Des Moines ClinicClive, IowaRecruiting
- UM Sylvester Comprehensive Cancer Center at Coral GablesCoral Gables, FloridaRecruiting
- UM Sylvester Comprehensive Cancer Center at Coral SpringsCoral Springs, FloridaRecruiting
- UM Sylvester Comprehensive Cancer Center at Deerfield BeachDeerfield Beach, FloridaRecruiting
- UM Sylvester Comprehensive Cancer Center at DoralDoral, FloridaRecruiting
- UM Sylvester Comprehensive Cancer Center at HollywoodHollywood, FloridaRecruiting
- UM Sylvester Comprehensive Cancer Center at KendallMiami, FloridaRecruiting
- UM Sylvester Comprehensive Cancer Center at PlantationPlantation, FloridaRecruiting
- University Medical Center New OrleansNew Orleans, LouisianaRecruiting
- University of IllinoisChicago, IllinoisRecruiting
- University of Iowa Healthcare Cancer Services Quad CitiesBettendorf, IowaRecruiting
- University of Iowa/Holden Comprehensive Cancer CenterIowa City, IowaRecruiting
- University of Miami Miller School of Medicine-Sylvester Cancer CenterMiami, FloridaRecruiting
- University of Michigan Health - Sparrow LansingLansing, MichiganRecruiting
- University of Nebraska Medical CenterOmaha, NebraskaRecruiting
- University of New Mexico Cancer CenterAlbuquerque, New MexicoRecruiting
- Upper Valley Medical CenterTroy, OhioRecruiting
- Valley Medical CenterRenton, WashingtonRecruiting
- Vanderbilt University/Ingram Cancer CenterNashville, TennesseeRecruiting
- Wake Forest University Health SciencesWinston-Salem, North CarolinaRecruiting
- West Penn HospitalPittsburgh, PennsylvaniaRecruiting
- Westchester Medical CenterValhalla, New YorkRecruiting
- Allegiance HealthJackson, MichiganActive Not Recruiting
- Dayton Physician LLC - EnglewoodDayton, OhioActive Not Recruiting
- Dayton Physicians LLC-AtriumFranklin, OhioActive Not Recruiting
- Dayton Physicians LLC-Miami Valley SouthCenterville, OhioActive Not Recruiting
- Henry Ford Health Providence Novi HospitalNovi, MichiganActive Not Recruiting
- Henry Ford Health Providence Southfield HospitalSouthfield, MichiganActive Not Recruiting
- Henry Ford Macomb Hospital-Clinton TownshipClinton Township, MichiganActive Not Recruiting
- Henry Ford West Bloomfield HospitalWest Bloomfield, MichiganActive Not Recruiting
- Johns Hopkins University/Sidney Kimmel Cancer CenterBaltimore, MarylandActive Not Recruiting
- Jupiter Medical CenterJupiter, FloridaActive Not Recruiting
- Lancaster General Ann B Barshinger Cancer InstituteLancaster, PennsylvaniaActive Not Recruiting
- MetroHealth Medical CenterCleveland, OhioActive Not Recruiting
- Miami Cancer InstituteMiami, FloridaActive Not Recruiting
- NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer CenterNew York, New YorkActive Not Recruiting
- Sibley Memorial HospitalWashington D.C., District of ColumbiaActive Not Recruiting
- University of California Davis Comprehensive Cancer CenterSacramento, CaliforniaActive Not Recruiting
- University of Kentucky/Markey Cancer CenterLexington, KentuckyActive Not Recruiting
- University of Oklahoma Health Sciences CenterOklahoma City, OklahomaActive Not Recruiting
- University of RochesterRochester, New YorkActive Not Recruiting
- University of Texas Health Science Center at San AntonioSan Antonio, TexasWithdrawn
- Wilmot Cancer Institute at WebsterWebster, New YorkActive Not Recruiting
Canada1 location
- Arthur J E Child Comprehensive Cancer CentreCalgary, AlbertaSuspended
Who to ask about joining
Eric D. Miller, MD, PhD614-685-4922eric.miller@osumc.edu
Who can join
This trial is open to adults aged 18 and older, both men and women. Participants must have colorectal cancer that has spread but not to more than four places in the body. Patients need to have a treatable primary tumor and must not have certain genetic mutations. The study team will confirm who is eligible during the screening process.
What happens during the trial
Participants will be placed into one of two groups by chance. One group will receive total ablative therapy along with standard chemotherapy. The second group will only receive standard chemotherapy. All participants will have regular scans to monitor their condition throughout the trial.
The trial team
The trial is sponsored by the Alliance for Clinical Trials in Oncology, with collaboration from the National Cancer Institute (NCI).
Important dates
This trial started on October 9, 2023, and is currently recruiting new participants. It is expected to be completed by August 12, 2032.
Additional information
The trial's ID number is NCT05673148. This is a Phase 3 trial, meaning it is testing how well the treatment works and how safe it is. About 364 people are expected to join this study.
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