Observing Heart Health in Patients with Advanced HER-2 Positive Breast Cancer
NCT03418961 · RecruitingAbout this trial
This trial looks at two groups of patients with HER-2 positive breast cancer that has spread. All participants are receiving treatment with trastuzumab, a medicine that targets HER-2. The main goal is to see how common heart problems are in patients taking certain heart medications along with their cancer treatment. The larger group is observed without any new treatment, while a smaller group is given a heart medicine called carvedilol to see if it helps prevent heart issues from chemotherapy.
Locations and contact
This trial is running at 590 locations in 4 countries. 145 of them are currently recruiting.
United States577 locations · 144 recruiting
- Abbott-Northwestern HospitalMinneapolis, MinnesotaRecruiting
- Ascension Providence Hospitals - SouthfieldSouthfield, MichiganRecruiting
- Augusta Health Center for Cancer and Blood DisordersFishersville, VirginiaRecruiting
- Aultman Health FoundationCanton, OhioRecruiting
- Baptist Memorial Hospital and Cancer Center-Golden TriangleColumbus, MississippiRecruiting
- Baptist Memorial Hospital and Cancer Center-MemphisMemphis, TennesseeRecruiting
- Bayhealth Hospital Kent CampusDover, DelawareRecruiting
- Beebe Health CampusRehoboth Beach, DelawareRecruiting
- Beebe South Coastal Health CampusFrankford, DelawareRecruiting
- Benefis Healthcare- Sletten Cancer InstituteGreat Falls, MontanaRecruiting
- Camden Clark Medical CenterParkersburg, West VirginiaRecruiting
- Cancer Care Center of O'FallonO'Fallon, IllinoisRecruiting
- Capital Region Southwest CampusJefferson City, MissouriRecruiting
- Case Western Reserve UniversityCleveland, OhioRecruiting
- City of Hope Comprehensive Cancer CenterDuarte, CaliforniaRecruiting
- City of Hope Mission HillsMission Hills, CaliforniaRecruiting
- City of Hope Newport BeachNewport Beach, CaliforniaRecruiting
- City of Hope South BayTorrance, CaliforniaRecruiting
- City of Hope South PasadenaSouth Pasadena, CaliforniaRecruiting
- City of Hope UplandUpland, CaliforniaRecruiting
- Cleveland Clinic Akron GeneralAkron, OhioRecruiting
- Cleveland Clinic Cancer Center IndependenceIndependence, OhioRecruiting
- Cleveland Clinic Cancer Center MansfieldMansfield, OhioRecruiting
- Cleveland Clinic Cancer Center StrongsvilleStrongsville, OhioRecruiting
- Cleveland Clinic Cancer Center/Fairview HospitalCleveland, OhioRecruiting
- Cleveland Clinic FoundationCleveland, OhioRecruiting
- Cleveland Clinic Wooster Family Health and Surgery CenterWooster, OhioRecruiting
- Cleveland Clinic-WestonWeston, FloridaRecruiting
- Contra Costa Regional Medical CenterMartinez, CaliforniaRecruiting
- CoxHealth South HospitalSpringfield, MissouriRecruiting
- Decatur Memorial HospitalDecatur, IllinoisRecruiting
- Dickstein Cancer Treatment CenterWhite Plains, New YorkRecruiting
- Emory University Hospital/Winship Cancer InstituteAtlanta, GeorgiaRecruiting
- FHCC South Lake UnionSeattle, WashingtonRecruiting
- Franciscan Health IndianapolisIndianapolis, IndianaRecruiting
- Franciscan Health MooresvilleMooresville, IndianaRecruiting
- Franciscan Saint Elizabeth Health - Lafayette EastLafayette, IndianaRecruiting
- Geauga HospitalChardon, OhioRecruiting
- Guthrie Medical Group PC-Robert Packer HospitalSayre, PennsylvaniaRecruiting
- HaysMed University of Kansas Health SystemHays, KansasRecruiting
- Hennepin County Medical CenterMinneapolis, MinnesotaRecruiting
- Henry Ford Cancer Institute-DownriverBrownstown, MichiganRecruiting
- Henry Ford HospitalDetroit, MichiganRecruiting
- Henry Ford Macomb Hospital-Clinton TownshipClinton Township, MichiganRecruiting
- Henry Ford Medical Center-ColumbusNovi, MichiganRecruiting
- Henry Ford Medical Center-FairlaneDearborn, MichiganRecruiting
- Henry Ford West Bloomfield HospitalWest Bloomfield, MichiganRecruiting
- Hillcrest Hospital Cancer CenterMayfield Heights, OhioRecruiting
- Holy Name HospitalTeaneck, New JerseyRecruiting
- John H Stroger Jr Hospital of Cook CountyChicago, IllinoisRecruiting
- Kaiser Permanente NorthwestPortland, OregonRecruiting
- Karmanos Cancer Institute at McLaren Greater LansingLansing, MichiganRecruiting
- Lahey Hospital and Medical CenterBurlington, MassachusettsRecruiting
- Lehigh Valley Hospital - MuhlenbergBethlehem, PennsylvaniaRecruiting
- Lehigh Valley Hospital-Cedar CrestAllentown, PennsylvaniaRecruiting
- Lewis Cancer and Research Pavilion at Saint Joseph's/CandlerSavannah, GeorgiaRecruiting
- Lewis Hall Singletary Oncology CenterThomasville, GeorgiaRecruiting
- Louisiana Hematology Oncology AssociatesBaton Rouge, LouisianaRecruiting
- Louisiana Hematology Oncology Associates LLCBaton Rouge, LouisianaRecruiting
- Loyola University Medical CenterMaywood, IllinoisRecruiting
- LSU Health Baton Rouge-North ClinicBaton Rouge, LouisianaRecruiting
- Mary Bird Perkins Cancer CenterBaton Rouge, LouisianaRecruiting
- McLaren Cancer Institute-Bay CityBay City, MichiganRecruiting
- McLaren Cancer Institute-ClarkstonClarkston, MichiganRecruiting
- McLaren Cancer Institute-FlintFlint, MichiganRecruiting
- McLaren Cancer Institute-Lapeer RegionLapeer, MichiganRecruiting
- McLaren Cancer Institute-MacombMount Clemens, MichiganRecruiting
- Medical Oncology and Hematology Associates-West Des MoinesClive, IowaRecruiting
- Mercy Cancer Center-West LakesClive, IowaRecruiting
- Mercy HospitalCoon Rapids, MinnesotaRecruiting
- Mercy Hospital Saint LouisSt Louis, MissouriRecruiting
- Mercy Hospital SouthSt Louis, MissouriRecruiting
- Mercy Hospital SpringfieldSpringfield, MissouriRecruiting
- Mercy Medical Center - Des MoinesDes Moines, IowaRecruiting
- Mercy Medical Center-West LakesWest Des Moines, IowaRecruiting
- Minnesota Oncology Hematology PA-MaplewoodMaplewood, MinnesotaRecruiting
- Minnesota Oncology Hematology PA-WoodburyWoodbury, MinnesotaRecruiting
- Mission Cancer and Blood - LaurelDes Moines, IowaRecruiting
- Missouri Baptist Medical CenterSt Louis, MissouriRecruiting
- Moffitt Cancer CenterTampa, FloridaRecruiting
- Monticello Cancer CenterMonticello, MinnesotaRecruiting
- Morristown Medical CenterMorristown, New JerseyRecruiting
- North Coast Cancer CareSandusky, OhioRecruiting
- Northeast Georgia Medical Center-GainesvilleGainesville, GeorgiaRecruiting
- Northside HospitalAtlanta, GeorgiaRecruiting
- Nyack HospitalNyack, New YorkRecruiting
- Olathe Health Cancer CenterOlathe, KansasRecruiting
- Oregon Health and Science UniversityPortland, OregonRecruiting
- Our Lady of the Lake Medical OncologyBaton Rouge, LouisianaRecruiting
- Our Lady of the Lake Physicians Group - Medical OncologyBaton Rouge, LouisianaRecruiting
- Overlook HospitalSummit, New JerseyRecruiting
- Park Nicollet Clinic - Saint Louis ParkSaint Louis Park, MinnesotaRecruiting
- PeaceHealth Saint Joseph Medical CenterBellingham, WashingtonRecruiting
- Penn State Milton S Hershey Medical CenterHershey, PennsylvaniaRecruiting
- Prisma Health Cancer Institute - ButternutGreenville, South CarolinaRecruiting
- Prisma Health Cancer Institute - EastsideGreenville, South CarolinaRecruiting
- Prisma Health Cancer Institute - FarisGreenville, South CarolinaRecruiting
- Regions HospitalSaint Paul, MinnesotaRecruiting
- Saint Alphonsus Cancer Care Center-BoiseBoise, IdahoRecruiting
- Saint Alphonsus Cancer Care Center-NampaNampa, IdahoRecruiting
- Saint Francis Medical CenterCape Girardeau, MissouriRecruiting
- Saint Joseph Hospital EastLexington, KentuckyRecruiting
- Saint Joseph Mercy HospitalAnn Arbor, MichiganRecruiting
- Saint Louis Cancer and Breast Institute-BallwinBallwin, MissouriRecruiting
- Saint Louis Cancer and Breast Institute-South CitySt Louis, MissouriRecruiting
- Singh and Arora Hematology Oncology PCFlint, MichiganRecruiting
- South Pointe HospitalWarrensville Heights, OhioRecruiting
- Spectrum Health at Butterworth CampusGrand Rapids, MichiganRecruiting
- Swedish Cancer Institute-IssaquahIssaquah, WashingtonRecruiting
- Swedish Medical Center-First HillSeattle, WashingtonRecruiting
- The Christ HospitalCincinnati, OhioRecruiting
- Trinity Health IHA Medical Group Hematology Oncology Ann Arbor CampusYpsilanti, MichiganRecruiting
- Truman Medical CentersKansas City, MissouriRecruiting
- UH Seidman Cancer Center at Saint John Medical CenterWestlake, OhioRecruiting
- UHHS-Chagrin Highlands Medical CenterBeachwood, OhioRecruiting
- UHHS-Westlake Medical CenterWestlake, OhioRecruiting
- UM Upper Chesapeake Medical CenterBel Air, MarylandRecruiting
- United HospitalSaint Paul, MinnesotaRecruiting
- University Hospitals Sharon Health CenterWadsworth, OhioRecruiting
- University of Cincinnati Cancer Center-UC Medical CenterCincinnati, OhioRecruiting
- University of Cincinnati Cancer Center-West ChesterWest Chester, OhioRecruiting
- University of Kansas Cancer CenterKansas City, KansasRecruiting
- University of Kansas Cancer Center - Lee's SummitLee's Summit, MissouriRecruiting
- University of Kansas Cancer Center - NorthKansas City, MissouriRecruiting
- University of Kansas Cancer Center at North Kansas City HospitalNorth Kansas City, MissouriRecruiting
- University of Kansas Cancer Center-Overland ParkOverland Park, KansasRecruiting
- University of Kansas Cancer Center-WestKansas City, KansasRecruiting
- University of Kansas Health System Saint Francis CampusTopeka, KansasRecruiting
- University of Kansas Hospital-Indian Creek CampusOverland Park, KansasRecruiting
- University of Kansas Hospital-Westwood Cancer CenterWestwood, KansasRecruiting
- University of Michigan Comprehensive Cancer CenterAnn Arbor, MichiganRecruiting
- University of Mississippi Medical CenterJackson, MississippiRecruiting
- University of New Mexico Cancer CenterAlbuquerque, New MexicoRecruiting
- University of Washington Medical Center - MontlakeSeattle, WashingtonRecruiting
- USC / Norris Comprehensive Cancer CenterLos Angeles, CaliforniaRecruiting
- UT Southwestern Clinical Center at Richardson/PlanoRichardson, TexasRecruiting
- UT Southwestern/Simmons Cancer Center-DallasDallas, TexasRecruiting
- UT Southwestern/Simmons Cancer Center-Fort WorthFort Worth, TexasRecruiting
- Wayne State University/Karmanos Cancer InstituteDetroit, MichiganRecruiting
- West Virginia University HealthcareMorgantown, West VirginiaRecruiting
- Wheeling Hospital/Schiffler Cancer CenterWheeling, West VirginiaRecruiting
- Winchester HospitalWinchester, MassachusettsRecruiting
- Woman's HospitalBaton Rouge, LouisianaRecruiting
- WVUH-Berkely Medical CenterMartinsburg, West VirginiaRecruiting
- 21st Century Oncology-PontiacPontiac, MichiganSuspended
- Academic Hematology Oncology SpecialistsGrosse Pointe Woods, MichiganSuspended
- Advanced Breast Care Center PLLCWarren, MichiganSuspended
- Alaska Breast Care and Surgery LLCAnchorage, AlaskaSuspended
- Alaska Oncology and Hematology LLCAnchorage, AlaskaSuspended
- Alaska Women's Cancer CareAnchorage, AlaskaSuspended
- Alegent Health Bergan Mercy Medical CenterOmaha, NebraskaSuspended
- Alegent Health Immanuel Medical CenterOmaha, NebraskaSuspended
- Alegent Health Lakeside HospitalOmaha, NebraskaSuspended
- Alegent Health Mercy HospitalCouncil Bluffs, IowaSuspended
- Allegiance HealthJackson, MichiganSuspended
- Alta Bates Summit Medical Center - Summit CampusOakland, CaliforniaActive Not Recruiting
- Anchorage Associates in Radiation MedicineAnchorage, AlaskaSuspended
- Anchorage Oncology CentreAnchorage, AlaskaSuspended
- Armes Family Cancer CenterFindlay, OhioActive Not Recruiting
- Ascension Providence Hospitals - NoviNovi, MichiganSuspended
- Ascension Saint John HospitalDetroit, MichiganSuspended
- Ascension Saint Joseph HospitalTawas City, MichiganSuspended
- Ascension Saint Mary's HospitalSaginaw, MichiganSuspended
- Ascension Via Christi - PittsburgPittsburg, KansasSuspended
- Atrium Medical Center-Middletown Regional HospitalFranklin, OhioActive Not Recruiting
- Baptist Cancer Center-GrenadaGrenada, MississippiSuspended
- Baptist Memorial Hospital and Cancer Center-ColliervilleCollierville, TennesseeSuspended
- Baptist Memorial Hospital and Cancer Center-DesotoSouthhaven, MississippiSuspended
- Baptist Memorial Hospital and Cancer Center-OxfordOxford, MississippiSuspended
- Baptist Memorial Hospital and Cancer Center-Union CountyNew Albany, MississippiSuspended
- Baptist Memorial Hospital for WomenMemphis, TennesseeSuspended
- Bay Area Breast Surgeons IncEmeryville, CaliforniaSuspended
- Bay Area HospitalCoos Bay, OregonSuspended
- Bay Area Tumor InstituteOakland, CaliforniaSuspended
- Beebe Medical CenterLewes, DelawareSuspended
- Bellin Memorial HospitalGreen Bay, WisconsinSuspended
- Bethesda North HospitalCincinnati, OhioSuspended
- Bhadresh Nayak MD PC-Sterling HeightsSterling Heights, MichiganSuspended
- Billings Clinic Cancer CenterBillings, MontanaSuspended
- Billings Clinic-CodyCody, WyomingSuspended
- Blanchard Valley HospitalFindlay, OhioActive Not Recruiting
- Borgess Medical CenterKalamazoo, MichiganSuspended
- Bozeman Deaconess HospitalBozeman, MontanaSuspended
- Broadlawns Medical CenterDes Moines, IowaActive Not Recruiting
- Bronson Battle CreekBattle Creek, MichiganSuspended
- Bronson Methodist HospitalKalamazoo, MichiganSuspended
- Broward Health Medical CenterFort Lauderdale, FloridaActive Not Recruiting
- Bryn Mawr HospitalBryn Mawr, PennsylvaniaActive Not Recruiting
- Cancer Care Specialists of Illinois - DecaturDecatur, IllinoisSuspended
- Cancer Center of Western WisconsinNew Richmond, WisconsinSuspended
- Carle at The RiverfrontDanville, IllinoisSuspended
- Carle Cancer CenterUrbana, IllinoisSuspended
- Carle Physician Group-EffinghamEffingham, IllinoisSuspended
- Carle Physician Group-Mattoon/CharlestonMattoon, IllinoisSuspended
- Caro Cancer CenterCaro, MichiganSuspended
- Centerpoint Medical Center LLCIndependence, MissouriActive Not Recruiting
- Central Care Cancer Center - BolivarBolivar, MissouriSuspended
- Central Care Cancer Center - Garden CityGarden City, KansasSuspended
- Central Care Cancer Center - Great BendGreat Bend, KansasSuspended
- Centralia Oncology ClinicCentralia, IllinoisSuspended
- CHI Health Good SamaritanKearney, NebraskaSuspended
- CHI Health Saint FrancisGrand Island, NebraskaSuspended
- CHI Saint Vincent Cancer Center Hot SpringsHot Springs, ArkansasSuspended
- Christiana Care Health System-Christiana HospitalNewark, DelawareSuspended
- Christiana Care Health System-Concord Health CenterChadds Ford, PennsylvaniaSuspended
- Christiana Care Health System-Wilmington HospitalWilmington, DelawareSuspended
- Clackamas Radiation Oncology CenterClackamas, OregonSuspended
- Coffeyville Regional Medical CenterCoffeyville, KansasSuspended
- Commonwealth Cancer Center-CorbinCorbin, KentuckySuspended
- Community Hospital of AnacondaAnaconda, MontanaSuspended
- Community Medical HospitalMissoula, MontanaSuspended
- Cox Cancer Center BransonBranson, MissouriSuspended
- Creighton University Medical CenterOmaha, NebraskaSuspended
- Crossroads Cancer CenterEffingham, IllinoisSuspended
- Dayton Physician LLC-Miami Valley Hospital NorthDayton, OhioActive Not Recruiting
- Dayton Physicians LLC - TroyTroy, OhioActive Not Recruiting
- Dayton Physicians LLC-AtriumFranklin, OhioActive Not Recruiting
- Dayton Physicians LLC-Miami Valley SouthCenterville, OhioActive Not Recruiting
- Dayton Physicians LLC-WayneGreenville, OhioActive Not Recruiting
- Delaware Clinical and Laboratory Physicians PANewark, DelawareSuspended
- Delbert Day Cancer Institute at PCRMCRolla, MissouriSuspended
- Duluth Clinic AshlandAshland, WisconsinActive Not Recruiting
- Emory Saint Joseph's HospitalAtlanta, GeorgiaSuspended
- Emory University Hospital MidtownAtlanta, GeorgiaSuspended
- Enloe Medical CenterChico, CaliforniaActive Not Recruiting
- Epic Care Partners in Cancer CareEmeryville, CaliforniaSuspended
- Epic Care-DublinDublin, CaliforniaSuspended
- Essentia Health Cancer CenterDuluth, MinnesotaActive Not Recruiting
- Essentia Health Cancer Center-South University ClinicFargo, North DakotaActive Not Recruiting
- Essentia Health Hibbing ClinicHibbing, MinnesotaActive Not Recruiting
- Essentia Health Saint Joseph's Medical CenterBrainerd, MinnesotaActive Not Recruiting
- Essentia Health Saint Mary's Medical CenterDuluth, MinnesotaActive Not Recruiting
- Essentia Health Virginia ClinicVirginia, MinnesotaActive Not Recruiting
- Fairbanks Memorial HospitalFairbanks, AlaskaSuspended
- Fairview Clinics and Surgery Center Maple GroveMaple Grove, MinnesotaSuspended
- Fairview Lakes Medical CenterWyoming, MinnesotaSuspended
- Fairview Ridges HospitalBurnsville, MinnesotaSuspended
- Fairview Southdale HospitalEdina, MinnesotaSuspended
- First Dayton Cancer CareKettering, OhioActive Not Recruiting
- Flaget Memorial HospitalBardstown, KentuckySuspended
- Franciscan Research Center-Northwest Medical PlazaTacoma, WashingtonSuspended
- Freeman Health SystemJoplin, MissouriSuspended
- Fresno Cancer CenterFresno, CaliforniaActive Not Recruiting
- Genesee Cancer and Blood Disease Treatment CenterFlint, MichiganSuspended
- Genesee Hematology Oncology PCFlint, MichiganSuspended
- Genesys Hurley Cancer InstituteFlint, MichiganSuspended
- Good Samaritan Hospital - CincinnatiCincinnati, OhioSuspended
- Good Samaritan Hospital - DaytonDayton, OhioSuspended
- Good Samaritan Medical CenterLafayette, ColoradoSuspended
- Good Samaritan Regional Health CenterMount Vernon, IllinoisSuspended
- Great Falls ClinicGreat Falls, MontanaSuspended
- Great Lakes Cancer Management Specialists-Doctors ParkEast China Township, MichiganSuspended
- Great Lakes Cancer Management Specialists-Macomb Medical CampusMacomb, MichiganSuspended
- Great Lakes Cancer Management Specialists-Macomb Professional BuildingWarren, MichiganSuspended
- Great Lakes Cancer Management Specialists-Rochester HillsRochester Hills, MichiganSuspended
- Great Lakes Cancer Management Specialists-Van Elslander Cancer CenterGrosse Pointe Woods, MichiganSuspended
- Greater Dayton Cancer CenterKettering, OhioActive Not Recruiting
- Greater Regional Medical CenterCreston, IowaSuspended
- Harrison HealthPartners Hematology and Oncology-BremertonBremerton, WashingtonSuspended
- Harrison HealthPartners Hematology and Oncology-PoulsboPoulsbo, WashingtonActive Not Recruiting
- Harrison Medical CenterBremerton, WashingtonSuspended
- Hawaii Cancer Care Inc - Waterfront PlazaHonolulu, HawaiiSuspended
- Hawaii Cancer Care Inc-LilihaHonolulu, HawaiiSuspended
- Health Partners IncMinneapolis, MinnesotaSuspended
- Heartland Hematology and OncologyKearney, NebraskaSuspended
- Heartland Regional Medical CenterSaint Joseph, MissouriSuspended
- Helen F Graham Cancer CenterNewark, DelawareSuspended
- Hematology and Oncology Consultants PCOmaha, NebraskaSuspended
- Hematology Oncology Consultants-ClarkstonClarkston, MichiganSuspended
- Highline Medical Center-Main CampusBurien, WashingtonSuspended
- Hope Cancer CenterPontiac, MichiganSuspended
- Hope Cancer ClinicLivonia, MichiganSuspended
- Hurley Medical CenterFlint, MichiganSuspended
- Huron Gastroenterology PCYpsilanti, MichiganSuspended
- Idaho Urologic Institute-MeridianMeridian, IdahoSuspended
- Illinois CancerCare-BloomingtonBloomington, IllinoisSuspended
- Illinois CancerCare-CantonCanton, IllinoisSuspended
- Illinois CancerCare-CarthageCarthage, IllinoisSuspended
- Illinois CancerCare-EurekaEureka, IllinoisSuspended
- Illinois CancerCare-GalesburgGalesburg, IllinoisSuspended
- Illinois CancerCare-Kewanee ClinicKewanee, IllinoisSuspended
- Illinois CancerCare-MacombMacomb, IllinoisSuspended
- Illinois CancerCare-Ottawa ClinicOttawa, IllinoisSuspended
- Illinois CancerCare-PekinPekin, IllinoisSuspended
- Illinois CancerCare-PeoriaPeoria, IllinoisSuspended
- Illinois CancerCare-PeruPeru, IllinoisSuspended
- Illinois CancerCare-PrincetonPrinceton, IllinoisSuspended
- Indu and Raj Soin Medical CenterBeavercreek, OhioActive Not Recruiting
- Iowa Lutheran HospitalDes Moines, IowaActive Not Recruiting
- Iowa Methodist Medical CenterDes Moines, IowaActive Not Recruiting
- Island UrologyHonolulu, HawaiiSuspended
- Jefferson HealthcarePort Townsend, WashingtonSuspended
- Jewish HospitalLouisville, KentuckySuspended
- Jewish Hospital Medical Center SouthShepherdsville, KentuckySuspended
- John B Amos Cancer CenterColumbus, GeorgiaActive Not Recruiting
- Kadlec Clinic Hematology and OncologyKennewick, WashingtonSuspended
- Kaiser Permanente - SacramentoSacramento, CaliforniaActive Not Recruiting
- Kaiser Permanente Cancer Treatment CenterSouth San Francisco, CaliforniaActive Not Recruiting
- Kaiser Permanente Medical Center - Santa ClaraSanta Clara, CaliforniaActive Not Recruiting
- Kaiser Permanente Medical Center-VacavilleVacaville, CaliforniaActive Not Recruiting
- Kaiser Permanente Moanalua Medical CenterHonolulu, HawaiiActive Not Recruiting
- Kaiser Permanente Oakland-BroadwayOakland, CaliforniaActive Not Recruiting
- Kaiser Permanente San LeandroSan Leandro, CaliforniaActive Not Recruiting
- Kaiser Permanente WashingtonSeattle, WashingtonActive Not Recruiting
- Kaiser Permanente-Deer Valley Medical CenterAntioch, CaliforniaActive Not Recruiting
- Kaiser Permanente-FranklinDenver, ColoradoSuspended
- Kaiser Permanente-FremontFremont, CaliforniaActive Not Recruiting
- Kaiser Permanente-FresnoFresno, CaliforniaActive Not Recruiting
- Kaiser Permanente-Lone TreeLone Tree, ColoradoSuspended
- Kaiser Permanente-ModestoModesto, CaliforniaActive Not Recruiting
- Kaiser Permanente-OaklandOakland, CaliforniaActive Not Recruiting
- Kaiser Permanente-Rancho Cordova Cancer CenterRancho Cordova, CaliforniaActive Not Recruiting
- Kaiser Permanente-Redwood CityRedwood City, CaliforniaActive Not Recruiting
- Kaiser Permanente-RichmondRichmond, CaliforniaActive Not Recruiting
- Kaiser Permanente-Rock CreekLafayette, ColoradoSuspended
- Kaiser Permanente-RosevilleRoseville, CaliforniaActive Not Recruiting
- Kaiser Permanente-San FranciscoSan Francisco, CaliforniaActive Not Recruiting
- Kaiser Permanente-San RafaelSan Rafael, CaliforniaActive Not Recruiting
- Kaiser Permanente-Santa RosaSanta Rosa, CaliforniaActive Not Recruiting
- Kaiser Permanente-Santa Teresa-San JoseSan Jose, CaliforniaActive Not Recruiting
- Kaiser Permanente-South SacramentoSacramento, CaliforniaActive Not Recruiting
- Kaiser Permanente-South San FranciscoSouth San Francisco, CaliforniaActive Not Recruiting
- Kaiser Permanente-StocktonStockton, CaliforniaActive Not Recruiting
- Kaiser Permanente-VallejoVallejo, CaliforniaActive Not Recruiting
- Kaiser Permanente-Walnut CreekWalnut Creek, CaliforniaActive Not Recruiting
- Kaiser San Rafael-GallinasSan Rafael, CaliforniaActive Not Recruiting
- Kalispell Regional Medical CenterKalispell, MontanaSuspended
- Kansas Institute of Medicine Cancer and Blood CenterLenexa, KansasActive Not Recruiting
- Kapiolani Medical Center for Women and ChildrenHonolulu, HawaiiSuspended
- Katmai Oncology GroupAnchorage, AlaskaSuspended
- Kettering Medical CenterKettering, OhioActive Not Recruiting
- Kootenai Cancer ClinicSandpoint, IdahoSuspended
- Kootenai Clinic Cancer Services - Post FallsPost Falls, IdahoSuspended
- Kootenai Health - Coeur d'AleneCoeur d'Alene, IdahoSuspended
- Kuakini Medical CenterHonolulu, HawaiiSuspended
- Lake Region Healthcare Corporation-Cancer CareFergus Falls, MinnesotaActive Not Recruiting
- Lakeland Hospital NilesNiles, MichiganSuspended
- Lakeland Medical Center Saint JosephSaint Joseph, MichiganSuspended
- Lakeview HospitalStillwater, MinnesotaSuspended
- Lankenau Medical CenterWynnewood, PennsylvaniaActive Not Recruiting
- Lehigh Valley Hospital-HazletonHazleton, PennsylvaniaSuspended
- Littleton Adventist HospitalLittleton, ColoradoSuspended
- Longmont United HospitalLongmont, ColoradoSuspended
- Low Country Cancer CareSavannah, GeorgiaSuspended
- LSU Health Sciences Center at ShreveportShreveport, LouisianaActive Not Recruiting
- Macomb Hematology Oncology PCWarren, MichiganSuspended
- Marie Yeager Cancer CenterSaint Joseph, MichiganSuspended
- McLaren Cancer Institute-BloomfieldBloomfield, MichiganSuspended
- Medical Center of Baton RougeBaton Rouge, LouisianaActive Not Recruiting
- Medical Oncology and Hematology Associates-Des MoinesDes Moines, IowaActive Not Recruiting
- Medical Oncology Hematology Consultants PANewark, DelawareSuspended
- Medical University of South CarolinaCharleston, South CarolinaActive Not Recruiting
- Memorial GYN PlusOoltewah, TennesseeSuspended
- Memorial HospitalChattanooga, TennesseeSuspended
- Memorial Hospital of CarbondaleCarbondale, IllinoisSuspended
- Memorial Medical CenterSpringfield, IllinoisSuspended
- Menorah Medical CenterOverland Park, KansasActive Not Recruiting
- Mercy Cancer Center-ElyriaElyria, OhioSuspended
- Mercy Clinic-Rolla-Cancer and HematologyRolla, MissouriSuspended
- Mercy Hospital JoplinJoplin, MissouriSuspended
- Mercy Hospital Oklahoma CityOklahoma City, OklahomaSuspended
- Mercy Hospital WashingtonWashington, MissouriSuspended
- Mercy Medical CenterDurango, ColoradoSuspended
- Mercyhealth Hospital and Cancer Center - JanesvilleJanesville, WisconsinActive Not Recruiting
- Methodist Medical Center of IllinoisPeoria, IllinoisSuspended
- Methodist West HospitalWest Des Moines, IowaActive Not Recruiting
- Miami Valley HospitalDayton, OhioActive Not Recruiting
- Miami Valley Hospital NorthDayton, OhioActive Not Recruiting
- Miami Valley Hospital SouthCenterville, OhioActive Not Recruiting
- Michigan Breast Specialists-Grosse Pointe WoodsGrosse Pointe Woods, MichiganSuspended
- Michigan Breast Specialists-Macomb TownshipMacomb, MichiganSuspended
- Michigan Breast Specialists-WarrenWarren, MichiganSuspended
- Middlesex HospitalMiddletown, ConnecticutSuspended
- Midlands Community HospitalPapillion, NebraskaSuspended
- Miller-Dwan HospitalDuluth, MinnesotaActive Not Recruiting
- Minimally Invasive Surgery HospitalLenexa, KansasActive Not Recruiting
- Missouri Baptist Outpatient Center-Sunset HillsSunset Hills, MissouriSuspended
- Missouri Baptist Sullivan HospitalSullivan, MissouriSuspended
- Mount Sinai Medical CenterMiami Beach, FloridaActive Not Recruiting
- Mountain Blue Cancer Care CenterGolden, ColoradoSuspended
- MultiCare Auburn Medical CenterAuburn, WashingtonSuspended
- MultiCare Deaconess Cancer and Blood Specialty Center - DowntownSpokane, WashingtonSuspended
- MultiCare Deaconess Cancer and Blood Specialty Center - NorthSpokane, WashingtonSuspended
- MultiCare Deaconess Cancer and Blood Specialty Center - ValleySpokane Valley, WashingtonSuspended
- MultiCare Gig Harbor Medical ParkGig Harbor, WashingtonSuspended
- MultiCare Good Samaritan HospitalPuyallup, WashingtonActive Not Recruiting
- MultiCare Tacoma General HospitalTacoma, WashingtonSuspended
- Munson Medical CenterTraverse City, MichiganSuspended
- New Ulm Medical CenterNew Ulm, MinnesotaSuspended
- Newland Medical Associates-ClarkstonClarkston, MichiganSuspended
- Newland Medical Associates-PontiacPontiac, MichiganSuspended
- Newton Medical CenterNewton, New JerseySuspended
- North Memorial Medical Health CenterRobbinsdale, MinnesotaSuspended
- North Star Lodge Cancer Center at Yakima Valley Memorial HospitalYakima, WashingtonSuspended
- Northwest Cancer ClinicKennewick, WashingtonActive Not Recruiting
- Northwest Medical Specialties PLLCTacoma, WashingtonSuspended
- NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer CenterNew York, New YorkActive Not Recruiting
- Ochsner Health Center-SummaBaton Rouge, LouisianaActive Not Recruiting
- Ochsner Hematology Oncology North Shore - Covington (West Region)Covington, LouisianaActive Not Recruiting
- Ochsner Medical Center JeffersonNew Orleans, LouisianaActive Not Recruiting
- Oklahoma Cancer Specialists and Research Institute-TulsaTulsa, OklahomaActive Not Recruiting
- Oncology Hematology Associates of Saginaw Valley PCSaginaw, MichiganSuspended
- Oncology Hematology Care Inc-KenwoodCincinnati, OhioActive Not Recruiting
- Onslow Memorial HospitalJacksonville, North CarolinaActive Not Recruiting
- Orion Cancer CareFindlay, OhioActive Not Recruiting
- OSF Saint Francis Medical CenterPeoria, IllinoisSuspended
- OSF Saint Francis Radiation Oncology at Pekin Cancer Treatment CenterPekin, IllinoisSuspended
- OSF Saint Francis Radiation Oncology at Peoria Cancer CenterPeoria, IllinoisSuspended
- Overlake Medical CenterBellevue, WashingtonSuspended
- Pacific Gynecology SpecialistsSeattle, WashingtonSuspended
- Pali Momi Medical Center‘Aiea, HawaiiSuspended
- Paoli Memorial HospitalPaoli, PennsylvaniaActive Not Recruiting
- Parker Adventist HospitalParker, ColoradoSuspended
- Parkland Health Center-Bonne TerreBonne Terre, MissouriSuspended
- PeaceHealth Saint John Medical CenterLongview, WashingtonSuspended
- PeaceHealth Southwest Medical CenterVancouver, WashingtonSuspended
- PeaceHealth United General Medical CenterSedro-Woolley, WashingtonSuspended
- Peninsula Cancer CenterPoulsbo, WashingtonActive Not Recruiting
- Penrose-Saint Francis HealthcareColorado Springs, ColoradoSuspended
- Phoenixville HospitalPhoenixville, PennsylvaniaSuspended
- Pocono Medical CenterEast Stroudsburg, PennsylvaniaSuspended
- Porter Adventist HospitalDenver, ColoradoSuspended
- Prisma Health Cancer Institute - EasleyEasley, South CarolinaSuspended
- Prisma Health Cancer Institute - GreerGreer, South CarolinaSuspended
- Prisma Health Cancer Institute - LaurensClinton, South CarolinaSuspended
- Prisma Health Cancer Institute - SenecaSeneca, South CarolinaSuspended
- Prisma Health Cancer Institute - SpartanburgBoiling Springs, South CarolinaSuspended
- Prisma Health Greenville Memorial HospitalGreenville, South CarolinaSuspended
- Providence Alaska Medical CenterAnchorage, AlaskaSuspended
- Providence Cancer Institute Clackamas ClinicClackamas, OregonSuspended
- Providence Newberg Medical CenterNewberg, OregonSuspended
- Providence Portland Medical CenterPortland, OregonSuspended
- Providence Regional Cancer PartnershipEverett, WashingtonSuspended
- Providence Regional Cancer System-AberdeenAberdeen, WashingtonSuspended
- Providence Regional Cancer System-CentraliaCentralia, WashingtonSuspended
- Providence Regional Cancer System-LaceyLacey, WashingtonSuspended
- Providence Regional Cancer System-SheltonShelton, WashingtonSuspended
- Providence Regional Cancer System-YelmYelm, WashingtonSuspended
- Providence Saint Joseph Medical Center/Disney Family Cancer CenterBurbank, CaliforniaSuspended
- Providence Saint Mary Regional Cancer CenterWalla Walla, WashingtonSuspended
- Providence Saint Vincent Medical CenterPortland, OregonSuspended
- Pulmonary Medicine Center of Chattanooga-HixsonHixson, TennesseeSuspended
- Queen's Cancer Cenrer - POB IHonolulu, HawaiiSuspended
- Queen's Cancer Center - KuakiniHonolulu, HawaiiSuspended
- Queen's Cancer Center - Pearlridge‘Aiea, HawaiiSuspended
- Queen's Medical CenterHonolulu, HawaiiSuspended
- Reid HealthRichmond, IndianaActive Not Recruiting
- Research Medical CenterKansas City, MissouriActive Not Recruiting
- Rice Memorial HospitalWillmar, MinnesotaSuspended
- Riddle Memorial HospitalMedia, PennsylvaniaActive Not Recruiting
- Ridgeview Medical CenterWaconia, MinnesotaSuspended
- Robert Wood Johnson University Hospital SomersetSomerville, New JerseyActive Not Recruiting
- Rocky Mountain Cancer Centers - PuebloPueblo, ColoradoSuspended
- Rocky Mountain Cancer Centers-LakewoodLakewood, ColoradoSuspended
- Rocky Mountain Cancer Centers-LongmontLongmont, ColoradoSuspended
- Rocky Mountain Cancer Centers-ParkerParker, ColoradoSuspended
- Rocky Mountain Cancer Centers-PenroseColorado Springs, ColoradoSuspended
- Rocky Mountain Cancer Centers-ThorntonThornton, ColoradoSuspended
- Rohnert Park Cancer CenterRohnert Park, CaliforniaActive Not Recruiting
- Rush - Copley Medical CenterAurora, IllinoisSuspended
- Rush-Copley Healthcare CenterYorkville, IllinoisSuspended
- Saint Alphonsus Cancer Care Center-CaldwellCaldwell, IdahoSuspended
- Saint Alphonsus Medical Center-Baker CityBaker City, OregonSuspended
- Saint Alphonsus Medical Center-OntarioOntario, OregonSuspended
- Saint Anthony HospitalLakewood, ColoradoSuspended
- Saint Catherine HospitalGarden City, KansasSuspended
- Saint Charles Health SystemBend, OregonSuspended
- Saint Charles Health System-RedmondRedmond, OregonSuspended
- Saint Clare HospitalLakewood, WashingtonSuspended
- Saint Elizabeth HospitalEnumclaw, WashingtonSuspended
- Saint Elizabeth Regional Medical CenterLincoln, NebraskaSuspended
- Saint Francis HospitalFederal Way, WashingtonSuspended
- Saint Francis Regional Medical CenterShakopee, MinnesotaSuspended
- Saint John Macomb-Oakland HospitalWarren, MichiganSuspended
- Saint John's Hospital - HealtheastMaplewood, MinnesotaSuspended
- Saint Joseph LondonLondon, KentuckySuspended
- Saint Joseph Mercy BrightonBrighton, MichiganSuspended
- Saint Joseph Mercy CantonCanton, MichiganSuspended
- Saint Joseph Mercy ChelseaChelsea, MichiganSuspended
- Saint Joseph Mercy OaklandPontiac, MichiganSuspended
- Saint Joseph Radiation Oncology Resource CenterLexington, KentuckySuspended
- Saint Joseph Regional Cancer CenterBryan, TexasSuspended
- Saint Luke's Cancer Institute - BoiseBoise, IdahoSuspended
- Saint Luke's Cancer Institute - FruitlandFruitland, IdahoSuspended
- Saint Luke's Cancer Institute - MeridianMeridian, IdahoSuspended
- Saint Luke's Cancer Institute - NampaNampa, IdahoSuspended
- Saint Luke's Cancer Institute - Twin FallsTwin Falls, IdahoSuspended
- Saint Luke's East - Lee's SummitLee's Summit, MissouriActive Not Recruiting
- Saint Luke's Hospital of Kansas CityKansas City, MissouriActive Not Recruiting
- Saint Luke's South HospitalOverland Park, KansasActive Not Recruiting
- Saint Mary Corwin Medical CenterPueblo, ColoradoSuspended
- Saint Mary's Oncology/Hematology Associates of MarletteMarlette, MichiganSuspended
- Saint Mary's Oncology/Hematology Associates of West BranchWest Branch, MichiganSuspended
- Saint Patrick Hospital - Community HospitalMissoula, MontanaSuspended
- Saint Peter's Community HospitalHelena, MontanaSuspended
- Sainte Genevieve County Memorial HospitalSainte Genevieve, MissouriSuspended
- Saints Mary and Elizabeth HospitalLouisville, KentuckySuspended
- Salina Regional Health CenterSalina, KansasSuspended
- Sanford Bismarck Medical CenterBismarck, North DakotaActive Not Recruiting
- Sanford Broadway Medical CenterFargo, North DakotaActive Not Recruiting
- Sanford Cancer Center Oncology ClinicSioux Falls, South DakotaActive Not Recruiting
- Sanford Joe Lueken Cancer CenterBemidji, MinnesotaActive Not Recruiting
- Sanford Roger Maris Cancer CenterFargo, North DakotaActive Not Recruiting
- Sanford USD Medical Center - Sioux FallsSioux Falls, South DakotaActive Not Recruiting
- SCL Health Saint Joseph HospitalDenver, ColoradoSuspended
- Self Regional HealthcareGreenwood, South CarolinaSuspended
- SIH Cancer InstituteCarterville, IllinoisSuspended
- Singing River HospitalPascagoula, MississippiActive Not Recruiting
- Siteman Cancer Center at Christian HospitalSt Louis, MissouriActive Not Recruiting
- Siteman Cancer Center at Saint Peters HospitalCity of Saint Peters, MissouriActive Not Recruiting
- Siteman Cancer Center at West County HospitalCreve Coeur, MissouriActive Not Recruiting
- Siteman Cancer Center-South CountySt Louis, MissouriActive Not Recruiting
- South Sacramento Cancer CenterSacramento, CaliforniaActive Not Recruiting
- Southeast Cancer CenterCape Girardeau, MissouriSuspended
- Southeastern Medical Oncology Center-ClintonClinton, North CarolinaActive Not Recruiting
- Southeastern Medical Oncology Center-GoldsboroGoldsboro, North CarolinaActive Not Recruiting
- Southeastern Medical Oncology Center-JacksonvilleJacksonville, North CarolinaActive Not Recruiting
- Southern Illinois University School of MedicineSpringfield, IllinoisSuspended
- Southwest Illinois Health Services LLPSwansea, IllinoisSuspended
- Southwest Oncology PCDurango, ColoradoSuspended
- Sparrow HospitalLansing, MichiganSuspended
- Spectrum Health Reed City HospitalReed City, MichiganSuspended
- Springfield ClinicSpringfield, IllinoisSuspended
- Springfield Regional Cancer CenterSpringfield, OhioActive Not Recruiting
- Springfield Regional Medical CenterSpringfield, OhioActive Not Recruiting
- Stamford Hospital/Bennett Cancer CenterStamford, ConnecticutActive Not Recruiting
- Stony Brook University Medical CenterStony Brook, New YorkActive Not Recruiting
- Straub Clinic and HospitalHonolulu, HawaiiSuspended
- Summit Cancer Care-CandlerSavannah, GeorgiaSuspended
- Swedish Cancer Institute-EdmondsEdmonds, WashingtonSuspended
- Swedish Medical Center-Ballard CampusSeattle, WashingtonSuspended
- Swedish Medical Center-Cherry HillSeattle, WashingtonSuspended
- Tacoma/Valley Radiation Oncology Centers-Gig HarborGig Harbor, WashingtonActive Not Recruiting
- Tacoma/Valley Radiation Oncology Centers-Jackson HallTacoma, WashingtonActive Not Recruiting
- Tacoma/Valley Radiation Oncology Centers-PuyallupPuyallup, WashingtonActive Not Recruiting
- Tacoma/Valley Radiation Oncology Centers-Saint Joe'sTacoma, WashingtonActive Not Recruiting
- The Cancer Center of Hawaii-LilihaHonolulu, HawaiiSuspended
- The Cancer Center of Hawaii-Pali Momi‘Aiea, HawaiiSuspended
- The Carle Foundation HospitalUrbana, IllinoisSuspended
- The Permanente Medical Group-Roseville Radiation OncologyRoseville, CaliforniaActive Not Recruiting
- TidalHealth Nanticoke / Allen Cancer CenterSeaford, DelawareSuspended
- TriHealth Cancer Institute-AndersonCincinnati, OhioSuspended
- TriHealth Cancer Institute-WestsideCincinnati, OhioSuspended
- Trinity Health Grand Rapids HospitalGrand Rapids, MichiganSuspended
- Trinity Health IHA Medical Group Hematology Oncology - BrightonBrighton, MichiganSuspended
- Trinity Health IHA Medical Group Hematology Oncology - CantonCanton, MichiganSuspended
- Trinity Health IHA Medical Group Hematology Oncology - Chelsea HospitalChelsea, MichiganSuspended
- Trinity Health Muskegon HospitalMuskegon, MichiganSuspended
- Trinity Health Saint Mary Mercy Livonia HospitalLivonia, MichiganSuspended
- UH Seidman Cancer Center at Lake Health Mentor CampusMentor, OhioSuspended
- UH Seidman Cancer Center at Southwest General HospitalMiddleburg Heights, OhioSuspended
- UMC Cancer Center / UMC Health SystemLubbock, TexasActive Not Recruiting
- Union HospitalTerre Haute, IndianaSuspended
- Unity HospitalFridley, MinnesotaSuspended
- University HospitalSan Antonio, TexasActive Not Recruiting
- University of California Davis Comprehensive Cancer CenterSacramento, CaliforniaActive Not Recruiting
- University of Hawaii Cancer CenterHonolulu, HawaiiSuspended
- University of IllinoisChicago, IllinoisActive Not Recruiting
- University of Michigan Health - WestWyoming, MichiganSuspended
- University of Oklahoma Health Sciences CenterOklahoma City, OklahomaActive Not Recruiting
- University of Texas Health Science Center at San AntonioSan Antonio, TexasActive Not Recruiting
- UofL Health Medical Center NortheastLouisville, KentuckySuspended
- Upper Valley Medical CenterTroy, OhioActive Not Recruiting
- Valley Medical CenterRenton, WashingtonSuspended
- Valley Radiation OncologyPeru, IllinoisSuspended
- Virginia Mason Bainbridge Island Medical CenterBainbridge Island, WashingtonActive Not Recruiting
- Virginia Mason Federal Way Medical CenterFederal Way, WashingtonActive Not Recruiting
- Virginia Mason Lynnwood Medical CenterLynnwood, WashingtonActive Not Recruiting
- Virginia Mason Medical CenterSeattle, WashingtonActive Not Recruiting
- Walter Knox Memorial HospitalEmmett, IdahoSuspended
- Washington University School of MedicineSt Louis, MissouriActive Not Recruiting
- Wayne HospitalGreenville, OhioActive Not Recruiting
- Wayne Memorial HospitalGoldsboro, North CarolinaActive Not Recruiting
- Welch Cancer CenterSheridan, WyomingSuspended
- West Michigan Cancer CenterKalamazoo, MichiganSuspended
- Western Illinois Cancer Treatment CenterGalesburg, IllinoisSuspended
- Wilcox Memorial Hospital and Kauai Medical ClinicLihue, HawaiiSuspended
South Korea1 location · 1 recruiting
- National Cancer Center-KoreaGoyang-si, Gyeonggi-doRecruiting
Puerto Rico11 locations
- Advance Oncology CenterAguadillaActive Not Recruiting
- Cancer Center-Metro Medical Center BayamonBayamónActive Not Recruiting
- Centro de Hematologia y Oncologia del SurSanta IsabelActive Not Recruiting
- Doctor's Cancer Center-AreciboAreciboActive Not Recruiting
- Doctors Cancer CenterManatiActive Not Recruiting
- Hematologia Oncologia San PabloBayamónActive Not Recruiting
- HIMA San Pablo Oncologic HospitalCaguasActive Not Recruiting
- Instituto Oncologia Moderna PoncePonceActive Not Recruiting
- Primary Care Physician GroupSan JuanActive Not Recruiting
- San Juan City HospitalSan JuanActive Not Recruiting
- San Juan Community Oncology GroupSan JuanActive Not Recruiting
Saudi Arabia1 location
- King Faisal Specialist Hospital and Research CentreRiyadhActive Not Recruiting
Who to ask about joining
Site Public Contact800-826-4673becomingapatient@coh.org
Site Public Contact323-865-0451
Site Public Contact925-957-5400
Who can join
Adults aged 18 and older can join, including both men and women. Participants must have HER-2 positive breast cancer that has spread and be starting or continuing trastuzumab-based treatment. They must also be at risk for heart problems. Some heart medications must not be taken before joining. The trial team will confirm each person's eligibility before they can participate.
What happens during the trial
Participants are divided into three groups. The first group receives carvedilol, taken twice a day, for up to 108 weeks. The second group receives no extra treatment for up to 108 weeks. The third group is observed without any new medications for the same time period. Everyone's heart health is monitored throughout the trial.
The trial team
The trial is run by the SWOG Cancer Research Network, with collaboration from the National Cancer Institute. Justin Floyd is the principal investigator leading the study.
Important dates
The trial started on November 1, 2017, and is expected to finish by September 15, 2027. It is currently enrolling new participants.
Additional information
The trial's ID number is NCT03418961. It is a Phase 3 study, meaning it is looking at how well the treatment works and its safety. The study is regulated by the FDA and aims to include about 491 participants.
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