Offering New Treatment Options for Patients with Liver Metastases from Colorectal Cancer

Recruiting · Phase 3 · Metastatic Colorectal Carcinoma and related conditions · 20 states

Check if I qualify View on ClinicalTrials.gov

About this trial

This trial compares two ways to treat patients with colorectal cancer that has spread to the liver and cannot be removed by surgery. One method includes pump chemotherapy given directly into the liver along with standard treatment. The goal is to see if adding this pump chemotherapy helps patients live longer and improves their overall health.

This is a Phase 3 trial, which means it is looking at how well the treatment works and how safe it is. The trial is regulated by the FDA and aims to include about 408 participants.

Who can join

Adults 18 and older can join if they have been diagnosed with colorectal cancer that has spread to the liver and cannot be surgically removed. They should not have any other cancer spread outside the liver and must have had some prior treatment. The trial team will check to see if each person meets the requirements.

Conditions

Metastatic Colorectal Carcinoma, Metastatic Malignant Neoplasm in the Liver, Stage IV Colorectal Cancer AJCC v8, Unresectable Colorectal Carcinoma

Age group

Adult, Older adult

Sex

All sexes

The study team makes the final call on eligibility.

What happens in the study

Participants will be randomly placed into one of two groups. In the first group, they will have a pump inserted to deliver chemotherapy directly to the liver, along with standard chemotherapy. In the second group, they will receive standard chemotherapy only. Everyone will have regular scans to monitor their progress.