Offering New Treatment Options for Patients with Liver Metastases from Colorectal Cancer
NCT05863195 · RecruitingThis trial compares two ways to treat patients with colorectal cancer that has spread to the liver and cannot be removed by surgery. One method includes pump chemotherapy given directly into the liver along with standard treatment. The goal is to see if adding this pump chemotherapy helps patients live longer and improves their overall health.
Locations and contact
This trial is running at 60 locations in the United States. 58 of them are currently recruiting.
United States60 locations · 58 recruiting
- Allegheny General HospitalPittsburgh, PennsylvaniaRecruiting
- Banner Boswell Medical CenterSun City, ArizonaRecruiting
- Banner MD Anderson Cancer CenterGilbert, ArizonaRecruiting
- Banner-University Medical Center PhoenixPhoenix, ArizonaRecruiting
- Corewell Health Grand Rapids Hospitals - Butterworth HospitalGrand Rapids, MichiganRecruiting
- Duke Cancer Center RaleighRaleigh, North CarolinaRecruiting
- Duke University Medical CenterDurham, North CarolinaRecruiting
- Emory Saint Joseph's HospitalAtlanta, GeorgiaRecruiting
- Emory University Hospital/Winship Cancer InstituteAtlanta, GeorgiaRecruiting
- Forbes HospitalMonroeville, PennsylvaniaRecruiting
- Fox Chase Cancer CenterPhiladelphia, PennsylvaniaRecruiting
- Indiana University/Melvin and Bren Simon Cancer CenterIndianapolis, IndianaRecruiting
- IU Health North HospitalCarmel, IndianaRecruiting
- Jefferson HospitalJefferson Hills, PennsylvaniaRecruiting
- Lehigh Valley Hospital-Cedar CrestAllentown, PennsylvaniaRecruiting
- Mayo Clinic in RochesterRochester, MinnesotaRecruiting
- Memorial Hospital EastShiloh, IllinoisRecruiting
- Memorial Sloan Kettering Basking RidgeBasking Ridge, New JerseyRecruiting
- Memorial Sloan Kettering BergenMontvale, New JerseyRecruiting
- Memorial Sloan Kettering Cancer CenterNew York, New YorkRecruiting
- Memorial Sloan Kettering CommackCommack, New YorkRecruiting
- Memorial Sloan Kettering MonmouthMiddletown, New JerseyRecruiting
- Memorial Sloan Kettering NassauUniondale, New YorkRecruiting
- Memorial Sloan Kettering WestchesterEast White Plains, New YorkRecruiting
- Mount Sinai HospitalNew York, New YorkRecruiting
- Northwestern UniversityChicago, IllinoisRecruiting
- Ohio State University Comprehensive Cancer CenterColumbus, OhioRecruiting
- Oregon Health and Science UniversityPortland, OregonRecruiting
- Parkland Memorial HospitalDallas, TexasRecruiting
- Roswell Park Cancer InstituteBuffalo, New YorkRecruiting
- Saint Elizabeth Youngstown HospitalYoungstown, OhioRecruiting
- Saint Vincent HospitalErie, PennsylvaniaRecruiting
- Siteman Cancer Center at Christian HospitalSt Louis, MissouriRecruiting
- Siteman Cancer Center at Saint Peters HospitalCity of Saint Peters, MissouriRecruiting
- Siteman Cancer Center at West County HospitalCreve Coeur, MissouriRecruiting
- Siteman Cancer Center-South CountySt Louis, MissouriRecruiting
- UCHealth University of Colorado HospitalAurora, ColoradoRecruiting
- UM Sylvester Comprehensive Cancer Center at AventuraAventura, FloridaRecruiting
- UM Sylvester Comprehensive Cancer Center at Coral GablesCoral Gables, FloridaRecruiting
- UM Sylvester Comprehensive Cancer Center at Deerfield BeachDeerfield Beach, FloridaRecruiting
- UM Sylvester Comprehensive Cancer Center at HollywoodHollywood, FloridaRecruiting
- UM Sylvester Comprehensive Cancer Center at KendallMiami, FloridaRecruiting
- UM Sylvester Comprehensive Cancer Center at PlantationPlantation, FloridaRecruiting
- University of Chicago Comprehensive Cancer CenterChicago, IllinoisRecruiting
- University of Kentucky/Markey Cancer CenterLexington, KentuckyRecruiting
- University of Miami Miller School of Medicine-Sylvester Cancer CenterMiami, FloridaRecruiting
- University of Michigan Rogel Cancer CenterAnn Arbor, MichiganRecruiting
- University of Wisconsin Carbone Cancer Center - Eastpark Medical CenterMadison, WisconsinRecruiting
- University of Wisconsin Carbone Cancer Center - University HospitalMadison, WisconsinRecruiting
- UT Southwestern Clinical Center at Richardson/PlanoRichardson, TexasRecruiting
- UT Southwestern Simmons Cancer Center - RedBirdDallas, TexasRecruiting
- UT Southwestern/Simmons Cancer Center-DallasDallas, TexasRecruiting
- UT Southwestern/Simmons Cancer Center-Fort WorthFort Worth, TexasRecruiting
- Vanderbilt University/Ingram Cancer CenterNashville, TennesseeRecruiting
- Wake Forest University Health SciencesWinston-Salem, North CarolinaRecruiting
- Washington University School of MedicineSt Louis, MissouriRecruiting
- West Penn HospitalPittsburgh, PennsylvaniaRecruiting
- Wexford Health and Wellness PavilionWexford, PennsylvaniaRecruiting
- Case Western Reserve UniversityCleveland, OhioActive Not Recruiting
- University of Alabama at Birmingham Cancer CenterBirmingham, AlabamaWithdrawn
Who can join
Adults 18 and older can join if they have been diagnosed with colorectal cancer that has spread to the liver and cannot be surgically removed. They should not have any other cancer spread outside the liver and must have had some prior treatment. The trial team will check to see if each person meets the requirements.
What happens during the trial
Participants will be randomly placed into one of two groups. In the first group, they will have a pump inserted to deliver chemotherapy directly to the liver, along with standard chemotherapy. In the second group, they will receive standard chemotherapy only. Everyone will have regular scans to monitor their progress.
The trial team
The trial is sponsored by the ECOG-ACRIN Cancer Research Group, with collaboration from the National Cancer Institute. Michael Lidsky is the principal investigator leading the study.
Important dates
The trial started on October 19, 2023, and is currently enrolling new participants. It is expected to be completed by June 30, 2034.
Additional information
This is a Phase 3 trial, which means it is looking at how well the treatment works and how safe it is. The trial is regulated by the FDA and aims to include about 408 participants.
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