About this trial
This clinical trial is looking at whether a steroid mouthwash called dexamethasone can prevent mouth sores caused by chemotherapy in adults with cancer. The study aims to find out if using this mouthwash before and during chemotherapy can lower the chance of developing moderate to severe mouth sores. Researchers will also check if it helps to reduce pain and improve comfort during treatment. Participants will use the mouthwash four times a day for up to 8 weeks while undergoing chemotherapy.
The trial's ID number is NCT07287826. This is a Phase 4 trial, which means it is looking at how well the treatment works and how safe it is. The study is FDA-regulated and aims to include at least 45 participants.
Who can join
Adults aged 18 and older with a confirmed cancer diagnosis who are scheduled to receive certain types of chemotherapy known to cause mouth sores can join. Those with current tobacco use, HIV/AIDS, gastrointestinal disorders, history of cold sores, active oral infections, or known allergies to dexamethasone cannot participate. The trial team will confirm who is eligible.
Condition
Oral Mucositis Due to Chemotherapy
Age group
Adult, Older adult
The study team makes the final call on eligibility.
What happens in the study
Everyone in the trial will receive the dexamethasone mouthwash. Participants will swish and spit 10 mL of this mouthwash four times a day for 8 weeks starting during their first week of chemotherapy. They will also complete a short weekly survey about their mouth discomfort during their treatment visits.
Where
This trial is running at 1 location in the United States. It is currently recruiting.
Woman's Hospital
Baton Rouge, Louisiana