Dr. Joseph A. Sparano

Dr. Joseph A. Sparano, MD, is a nationally distinguished medical oncologist and a leading authority in breast cancer and HIV-associated malignancies. He serves as Chief of the Division of Hematology and Medical Oncology at the Icahn School of Medicine at Mount Sinai, and Deputy Director of the Tisch Cancer Institute. Dr. Sparano earned his medical degree from New York Medical College and completed his residency and fellowship training in internal medicine and medical oncology at Montefiore Medical Center and Albert Einstein College of Medicine. Board-certified in Internal Medicine and Medical Oncology, he brings decades of clinical and academic leadership to translational cancer research and multidisciplinary oncology care.

Dr. Sparano is internationally recognized for his groundbreaking work in precision medicine, including his leadership of the landmark TAILORx trial. This pivotal study redefined how genomic profiling is used to guide adjuvant chemotherapy decisions in hormone receptor-positive, HER2-negative early breast cancer, significantly impacting treatment guidelines worldwide. He has also contributed to the development of predictive tools such as RSClin, and has led efforts to integrate circulating tumor DNA and other biomarkers into early detection and surveillance strategies. His research extends to understanding racial disparities in cancer outcomes and advancing therapeutic approaches for HIV-associated cancers, with a longstanding role as Chair of the AIDS Malignancy Consortium.

In addition to his clinical and research accomplishments, Dr. Sparano is a dedicated mentor and educator, having trained numerous fellows and junior investigators throughout his career. He has received multiple honors and awards for his contributions to oncology, including recognition from national organizations such as ASCO and AACR. Widely respected for his patient-centered approach and commitment to health equity, Dr. Sparano continues to shape the future of cancer treatment through clinical innovation, academic excellence, and leadership in national research initiatives.