Dr. John H. Sampson

Dr. John H. Sampson, MD, PhD, is an internationally recognized neurosurgeon and physician-scientist specializing in the treatment of malignant brain tumors, particularly glioblastoma. He serves as the Robert H. and Gloria Wilkins Distinguished Professor of Neurosurgery and Chair of the Department of Neurosurgery at Duke University School of Medicine. Dr. Sampson earned his medical degree and doctorate from the University of Manitoba and completed residency training in neurosurgery at Duke University, where he later joined the faculty. He is board-certified in Neurological Surgery and is regarded as a pioneer in immunotherapy for brain tumors.

A leader in translational neuro-oncology, Dr. Sampson has developed innovative approaches to harness the immune system against glioblastoma. He has led landmark clinical trials of peptide vaccines, engineered T-cell therapies, and checkpoint inhibitors, advancing the role of immunotherapy in central nervous system malignancies. His laboratory research focuses on tumor immunobiology, strategies to overcome the immunosuppressive brain tumor microenvironment, and biomarkers that guide therapeutic response. He has authored numerous high-impact publications and has contributed to shaping the national and international agenda for brain cancer research.

In addition to his research leadership, Dr. Sampson is a dedicated surgeon, educator, and mentor. He has trained neurosurgeons and physician-scientists who now hold leadership positions worldwide. He has served on advisory committees for the National Cancer Institute and other organizations, helping define the future of neuro-oncology research and treatment. Through his commitment to surgical excellence, innovation in immunotherapy, and mentorship, Dr. John Sampson continues to transform the landscape of brain tumor care.